Review
Chemistry, Multidisciplinary
Simona Summonte, Giuseppe Francesco Racaniello, Angela Lopedota, Nunzio Denora, Andreas Bernkop-Schnuerch
Summary: Thiomers, such as thiolated hyaluronic acid and chitosan, are widely studied for their high reactivity in hydrogel synthesis. They exhibit in situ gelling properties and can undergo various click reactions, making them versatile materials for tissue engineering, regenerative medicine, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Polymer Science
Elena Ruxandra Radu, Stefan Ioan Voicu, Vijay Kumar Thakur
Summary: Polymeric membranes are selective materials used in a wide range of applications that require separation processes. Due to their remarkable properties, they are also used in biomedical applications to replace the function of organs associated with physiological separations. This review examines various biomedical applications of polymer membranes, including hemodialysis, artificial lung, artificial liver, artificial pancreas, and drug delivery systems.
Review
Pharmacology & Pharmacy
Ana Figueiras, Catia Domingues, Ivana Jarak, Ana Isabel Santos, Ana Parra, Alberto Pais, Carmen Alvarez-Lorenzo, Angel Concheiro, Alexander Kabanov, Horacio Cabral, Francisco Veiga
Summary: Nanomedicine, specifically the study of polymeric micelles (PMs), has emerged as a significant area of medicine in the last decade. PMs are colloidal dispersions of amphiphilic compounds that assemble into a core-shell structure, with a hydrophobic core and a hydrophilic shell. They improve the solubility and stability of drugs and can be absorbed and transported to the therapeutic target. PMs have high load capacity and are synthesized using a reproducible and cost-effective method. pH and temperature are commonly studied stimuli for enhanced drug release.
Article
Materials Science, Multidisciplinary
Ricardo Donate, Ruben Paz, Rocio Moriche, Maria Jesus Sayagues, Maria Elena Aleman-Dominguez, Mario Monzon
Summary: Despite the lack of functionalities in current biomaterials for osseous diseases treatment, the development of piezoelectric scaffolds shows promise for improved bone regeneration. These scaffolds can positively influence stem cell proliferation and differentiation, and various mechanical stimuli can activate their piezoelectric effect. Biocompatible, piezoelectric polymers are being explored for additive manufacturing of composite scaffolds, with the addition of piezoceramic nanoparticles enhancing their properties. These scaffolds also have potential for real-time monitoring.
MATERIALS & DESIGN
(2023)
Review
Polymer Science
Cheirmadurai Kalirajan, Amey Dukle, Arputharaj Joseph Nathanael, Tae-Hwan Oh, Geetha Manivasagam
Summary: This review summarizes recent advancements in the preparation of smart polymeric biomaterials with self-healing and shape memory properties. It also discusses novel approaches for developing various forms of polymeric biomaterials and highlights their applications in soft and hard tissue engineering. It underlines the future directions of polymeric biomaterials for successful clinical implications.
Review
Biochemistry & Molecular Biology
Sonia Trombino, Roberta Sole, Federica Curcio, Roberta Cassano
Summary: The development of biomedical applications involves researchers from various fields and the use of biocompatible materials. Polymeric membranes have gained popularity due to their ability to meet the requirements of tissue engineering and controlled drug release. The biomedical application of hydrogel membranes has faced challenges in the past but is now proving to be a promising field. Technological innovations in membrane hydrogels have helped resolve various clinical problems.
Article
Materials Science, Multidisciplinary
Chunyang Ma, Hetong Wang, Yongjie Chi, Yanling Wang, Le Jiang, Nan Xu, Qiong Wu, Qingling Feng, Xiaodan Sun
Summary: Collagen fibers in the body have a complex arrangement, which plays an important role in cell adhesion, migration, proliferation, and secretion. Oriented collagen fiber scaffolds have shown exciting results in tissue repair. Bone is crucial for bearing loads in the human body, and the arrangement of collagen fibers in bone significantly affects its mechanical properties and physiological functions. Oriented collagen fiber scaffolds can promote new bone growth and induce cells to secrete oriented extracellular matrix. However, the complex arrangement of collagen fibers in bone poses challenges for bone tissue repair and bionics.
APPLIED MATERIALS TODAY
(2021)
Review
Materials Science, Multidisciplinary
Wanke Cheng, Ying Zhu, Geyuan Jiang, Kaiyue Cao, Suqing Zeng, Wenshuai Chen, Dawei Zhao, Haipeng Yu
Summary: Novel biomedical materials based on cellulose show promising applications in the diagnosis/treatment of diseases and tissue repair. By modifying cellulose fibers or macromolecules, cellulose derivatives can be dispersed in water or organic solvents, making them suitable for developing unique cellulose-based biomedical materials. These materials exhibit biocompatibility, tissue non-toxicity, and designability, and have been applied in nutraceuticals, wound dressings, drug delivery, tissue engineering, electronic skin, and bioassays. Key technologies and strategies are highlighted to further expand the application prospects of cellulose-based materials in the biological and biomedical field.
PROGRESS IN MATERIALS SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Wen Tang, Juan Wang, Huiwen Hou, Yan Li, Jie Wang, Jiaai Fu, Lu Lu, Didi Gao, Zengmei Liu, Feiyan Zhao, Xinqing Gao, Peixue Ling, Fengshan Wang, Feng Sun, Haining Tan
Summary: Chitin is a natural polysaccharide derived from marine crustaceans, and chitosan is a modified form of chitin with a reduced acetyl group. Chitosan has gained significant attention for its biodegradability, biocompatibility, hypoallergenic properties, and various biological activities. However, its limited solubility in water and organic solvents has restricted its application range. Consequently, extensive chemical modifications and the development of chitosan derivatives have expanded its potential applications, particularly in the pharmaceutical field. This review paper summarizes the recent applications of chitosan and its derivatives in medical materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Anjum Hamid Rather, Taha Umair Wani, Rumysa Saleem Khan, Bishweshwar Pant, Mira Park, Faheem A. Sheikh
Summary: Essential oils embedded in polymeric nanofibers fabricated by electrospinning show antimicrobial, anti-inflammatory, and antioxidant properties, reducing the need for synthetic drugs in various industries. These nanofibers enhance barrier properties against light, oxygen, and heat in food packaging, while also increasing shelf-life of food products. The controlled release of naturally derived chemical compounds in these nanofibers prevents degradation and makes them effective as active packaging materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Materials Science, Paper & Wood
Hadi Seddiqi, Erfan Oliaei, Hengameh Honarkar, Jianfeng Jin, Lester C. Geonzon, Rommel G. Bacabac, Jenneke Klein-Nulend
Summary: Cellulose, the most abundant polysaccharide on Earth, can be sourced from various natural materials such as wood, plants, bacteria, algae, and tunicates. This review provides an extensive survey on cellulose and its derivatives, highlighting recent developments in preparation methods for novel properties beneficial for biomedical applications. Despite cellulose's potential for various fields, its extensive use has mainly been limited to industry, prompting a focus on recent advancements for biomedical applications.
Review
Engineering, Biomedical
Wei Zhao, Chengbin Yue, Liwu Liu, Yanju Liu, Jinsong Leng
Summary: As a smart material, shape memory polymer (SMP) has great potential in the biomedical field. It offers superior adaptability, biocompatibility, adjustable biodegradability, and mechanical properties, making it ideal for medical devices. Additionally, 4D printing technology, based on smart materials and 3D printing, breaks through the technical barriers of personalized customization and provides new opportunities for biomedical development.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Humira Assad, Arvina Assad, Ashish Kumar
Summary: The field of 3D bio-printing has been extensively used to improve the usability and performance of scaffolds filled with cells. Many tissues and organs have been produced via 3D bio-printing and can serve as building blocks for repair and regeneration, as well as in vitro models for pharmacokinetics and drug screening. The research focuses on novel biomaterials with quick cross-linking capabilities, a wider variety of acceptable 3D-printed materials, better printing resolution, and biomaterial compatibility.
Review
Chemistry, Medicinal
Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Soo-Jin Heo, Won-Kyo Jung
Summary: PDRN, derived from DNA, has demonstrated wound healing and anti-inflammatory properties in various studies. Through activation of receptors and promotion of cellular activity, PDRN has been widely applied clinically for its therapeutic effects.
Article
Cell & Tissue Engineering
Jeong Chan Lee, Il Won Suh, Chan Hee Park, Cheol Sang Kim
Summary: Research on bio-piezoelectric materials is actively conducted since applying electrical stimulation can promote cell growth, proliferation, and tissue regeneration. In this study, a composite material of PVDF and SF was prepared through electrospinning technology. Results showed that adding an appropriate amount of SF could improve the tensile strength, enhance cell proliferation rate, and generate a voltage similar to that of a conventional PVDF-only electrospinning mat.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
