Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 54, Issue -, Pages 84-93Publisher
ELSEVIER
DOI: 10.1016/j.msec.2015.04.021
Keywords
Biomimetic peptide; Peptide coating; Titanium coating; Hydroxyapatite coating; Implant coating
Categories
Funding
- National Institute of Health Research Surgical Reconstruction and Microbiology Research Centre
- Engineering and Physical Sciences Research Council Institutional Sponsorship Fund [EP/K503472/1]
- University of Birmingham
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Current processes for coating titanium implants with ceramics involve very high energy techniques with associated high cost and disadvantages such as heterogeneity of the coatings, phase transformations and inability to coat complex structures. In order to address the above problems, we propose a biomimetic hydroxyapatite coating process with the use of peptides that can bind both on titanium surfaces and hydroxyapatite. The peptides enabled homogeneous coating of a titanium surface with hydroxyapatite. The hydroxyapatite-peptide sandwich coating showed no adverse effects on cell number or collagen deposition. This makes the sandwich coated titanium a good candidate for titanium implants used in orthopaedics and dentistry. (C) 2015 Elsevier B.V. All rights reserved.
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