Article
Materials Science, Multidisciplinary
Lei Wang, Huazheng He, Xing Yang, Yinchang Zhang, Shouliang Xiong, Chao Wang, Xin Yang, Bo Chen, Qiang Wang
Summary: The study developed PEEK implants with antibacterial and osteogenic capabilities using bimetallic ions immersion method. The modified PEEK demonstrated enhanced antibacterial properties and promoted osteogenic differentiation in vitro and in vivo. Rat models showed limited bacterial infections and enhanced new bone formation with PEEK-PDA-Mn/Cu treatment compared to other PEEK implants.
MATERIALS TODAY ADVANCES
(2021)
Article
Biophysics
Xin Yang, Qiang Wang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Pingbo Chen, Congming Li, Lei Wang, Guohai Lu, Yaozeng Xu
Summary: In this study, a simply immersing method was used to fabricate dual-functional PEEK with antibacterial properties and enhanced bone integration. The modified PEEK demonstrated favorable biosafety, accelerated cell adhesion, and distribution, as well as wide antibacterial capabilities. The PEEK-PDA-Mn/Ag composite showed antibacterial and osseointegration-enhancing abilities in vivo.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
M. Borgolte, O. Riester, I. Quint, F. Blendinger, V. Bucher, S. Laufer, R. Csuk, L. Scotti, H. -p. Deigner
Summary: Chitosan derivatives with benzophenone groups were cross-linked by UV light to form coatings for PEEK substrates used in lumbar cages. The coated surface showed excellent antimicrobial properties against clinically relevant strains of bacteria and significantly reduced biofilm formation. The coatings exhibited good biocompatibility, low cytotoxicity, and strong antioxidant properties.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Yang Ji, Xiaoming Yu, Hao Zhu
Summary: In this study, pure Mg was successfully deposited on a PEEK substrate to improve the antibacterial properties of PEEK implants, achieving an antibacterial rate of 99%. The Mg coating demonstrates good biocompatibility and antibacterial properties.
Article
Chemistry, Inorganic & Nuclear
Hamed Barabadi, Faraz Mojab, Hossein Vahidi, Boshra Marashi, Niloufar Talank, Omid Hosseini, Muthupandian Saravanan
Summary: This study aimed to fabricate Zataria multiflora-derived silver nanoparticles (AgNPs) and compare their antibacterial and biofilm inhibitory activities against Staphylococcus aureus ATCC 25923 with commercial AgNPs. The plant-mediated fabricated AgNPs (P-AgNPs) exhibited significant antibacterial activity and biofilm inhibition at lower concentrations, showing stronger effects compared to commercial AgNPs.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Zhi Zheng, Pengjia Liu, Xingmin Zhang, Jingguo Xin, Yongjie Wang, Xiaosong Zou, Xiaohan Mei, Shuling Zhang, Shaokun Zhang
Summary: This article reviews the modification methods of PEEK in the last five years, including surface modification and composite material modification, in order to improve its biological activity and antibacterial properties. The researchers believe that these modification methods provide valuable guidance for the future design of PEEK orthopedic implants.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Physical
Shuai Zhang, Xinjin Liang, Xiao Teng, Geoffrey M. Gadd, John W. McGrath, Coin P. McCoy, Qi Zhao
Summary: In this study, a slippery liquid-infused silver-polytetrafluoroethylene (AgFP) coating was developed through a polycondensation process of 1H,1H,2H,2H-perfluorooctyltriethoxysilane (PFOTES) onto an electroless AgF sublayer. The AgFP coating exhibited high stability and excellent repellence against liquids with various surface tensions. The anti-biofouling properties of the coating were evaluated using different substances such as bacteria and proteins, and it showed enhanced anti-adhesion activity compared to traditional electroless coatings. The results suggest the potential application of the AgFP coating in biomedical devices to prevent infections.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Physical
Shuai Zhang, Xinjin Liang, Geoffrey Michael Gadd, Qi Zhao
Summary: A silver nanoparticle/polytetrafluorethylene (AgNP/PTFE) coating for metallic implants was fabricated to enhance antibacterial and corrosion resistance properties, demonstrating sustained release of silver ions to inhibit bacterial growth. The anti-adhesion mechanism was explained using DLVO and XDLVO theories, offering potential for preventing implant-associated infections.
APPLIED SURFACE SCIENCE
(2021)
Article
Engineering, Environmental
Xiang Lan, Hao Zhang, Haishan Qi, Simin Liu, Xiangyu Zhang, Lei Zhang
Summary: This study designs a triblock protein (MZAgP) consisting of zwitterionic peptide, mussel adhesive peptide, and silver-binding peptide. MZAgP can be easily attached to various substrates to form an antibacterial coating, which exhibits multiple functions including inhibiting bacterial growth, reducing bacterial and protein adhesion, and preventing biofilm formation. In vivo tests demonstrate that the coating can effectively restrain bacterial infections and alleviate foreign body response with excellent biocompatibility. This study reveals the potential of MZAgP as a multifunctional protein material for fabricating novel antibacterial coatings to relieve implant-associated infections.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Microbiology
Yingping Jang, Xiaoya Zhang, Rongxue Zhu, Songlin Li, Shiyu Sun, Wenqiang Li, Hao Liu
Summary: We successfully biosynthesized silver nanoparticles (LEVB-Ag NAPs) using Viola betonicifolia leaf extract and characterized their properties. The biosynthesized LEVB-Ag NAPs exhibited excellent antibacterial, antimycotic, biofilm inhibiting, and cytobiocompatible activities, making them a promising candidate for various therapeutic applications.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Anna Diez-Escudero, Elin Carlsson, Brittmarie Andersson, Josef D. Jarhult, Nils P. Hailer
Summary: Research has shown that silver-coated porous titanium scaffolds can inhibit the growth and biofilm formation of common PJI pathogens, while promoting normal metabolic activity and bone cell function in human osteoblasts. This technology has the potential to enhance osseointegration and reduce the risk of bacterial infections.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Krukiewicz, Alicja Kazek-Kesik, Monika Brzychczy-Wloch, Marek J. Los, Collins Njie Ateba, Parvaneh Mehrbod, Saeid Ghavami, Divine Yufetar Shyntum
Summary: Biofilms, formed by bacteria, fungi, or viruses, are complex structures that can be found in almost any part of the human body. The increase in biofilm-associated diseases is mainly attributed to the use of medical devices, which provide opportunities for clinically important bacteria and fungi to form biofilms. Due to their resistance to antibiotics and host immunity, biofilms are associated with the development and persistence of clinically important diseases, posing a significant burden on patients and healthcare systems. Therefore, it is crucial to develop innovative strategies to tackle biofilm growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Qiancun Wang, Chuanmei Zang, Yau Kei Chan, Song Wang, Weizhong Yang, Yi Deng, Tingting Zhu, Miaomiao He
Summary: A hydrogel coating-PEEK system with robust antibacterial properties has been developed, which shows great promise for preventing implant-related infection and has broad prospects in clinical applications.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Polymer Science
Deepak G. Prajapati, Abhijit Mishra
Summary: The synthesized AB polymer is a biomimetic antimicrobial agent with potent antibacterial activity, showing a 99% killing rate against Escherichia coli and Staphylococcus aureus. It can be used for coatings, antibacterial wipes, and cleaning bacterial-contaminated surfaces. The mechanism of action involves disrupting the bacterial membrane, leading to cell death. Cell viability experiments showed lower toxicity of the polymer towards lung carcinoma epithelial cells.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Hua Jin, Mengyao Cai, Fuquan Deng
Summary: This study investigates the antibacterial properties of AgNPs with different pretreatment methods and develops a GO/AgNPs nanocomposite for polyacrylate emulsion. The results show that UV irradiation better maintains the antibacterial properties of AgNPs, while GO improves their dispersibility and prevents oxidation. The leather finished with the PA/GO/AgNPs composite emulsion demonstrates a high bacteriostatic rate.
Article
Materials Science, Multidisciplinary
An Nguyen-My Le, Nam Minh-Phuong Tran, Thang Bach Phan, Phong A. Tran, Lam Dai Tran, Thi Hiep Nguyen
Summary: This study presented a bilayer hollow tube with a hydrophilic inner layer polyurethane/polycaprolactone/Poloxamer (PU/PCL/Poloxamer) for engineering small-diameter vascular grafts. The Poloxamer blended surface showed complicated attraction and repellent behaviors regulated by the dynamic of PEG chains, exhibiting high bioactive performance compared to other surfaces. Additionally, a hydrophobic outer layer PU/PCL was fabricated to prevent leakage and permeable transmembrane phenomenon in vascular engineering applications.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Shadi Houshyar, Amitava Bhattacharyya, Asma Khalid, Aaqil Rifai, Chaitali Dekiwadia, G. Sathish Kumar, Phong A. Tran, Kate Fox
Summary: The study incorporates functionalized nanodiamond and reduced graphene oxide into biodegradable polycaprolactone to develop a new multifunctional suture with temperature sensing capability and antibiotic coating function. The new suture enhances tensile strength and toughness, showing promise for monitoring and supporting wound closure.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Biomedical
J. L. Smith, N. Tran, T. Song, D. Liang, M. Qian
Summary: Conventional copper surfaces are known for their bactericidal properties, but the development of a micro-nano hierarchical copper structure with exceptional bactericidal efficacy can rapidly kill bacteria by destroying bacterial membrane integrity. This advancement paves the way for the practical use of copper as a low-cost antibiotic-free fast bactericidal material.
Article
Chemistry, Physical
Jiali Zhai, Sue Lyn Yap, Calum J. Drummond, Nhiem Tran
Summary: The study hypothesized that specific fatty acetates could induce the formation of unique structures in nanoparticles for sustained drug release. Experiment results demonstrated that precise control of nanoparticle phase transition pH could be achieved by doping specific fatty acetates, offering potential application in orally administrated formulations.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Electrochemistry
Indika Herath, Joseph Davies, Geoffrey Will, Phong A. Tran, Amar Velic, Madjid Sarvghad, Majedul Islam, Phani Kumari Paritala, Alka Jaggessar, Michael Schuetz, Kaushik Chatterjee, Prasad K. D. V. Yarlagadda
Summary: This study successfully developed nanostructured stainless steel for biomedical and hospital applications through optimized anodization conditions. The results demonstrate the potential of electrochemical treatment in restricting bacterial and viral adhesion on metal surfaces and highlight the importance of careful optimization for surface roughness and corrosion resistance.
ELECTROCHIMICA ACTA
(2022)
Article
Nanoscience & Nanotechnology
Sarigama Rajesh, Sheeana Gangadoo, Han Nguyen, Jiali Zhai, Chaitali Dekiwadia, Calum J. Drummond, James Chapman, Vi Khanh Truong, Nhiem Tran
Summary: This study presents a novel approach to improve the delivery of antifungal agent and combat the resistance of Cryptococcus neoformans. By encapsulating the agent in pH-sensitive lipid nanoparticles, the growth of resistant C. neoformans is inhibited. The nanoparticles exhibit different structures and charges at neutral and acidic pH, facilitating interaction with the fungal cell wall and leading to a significant decrease in the minimum inhibitory concentration of the agent. Microscopic observations support these findings, showing distortion and efflux of cytoplasmic molecules in fungal cells exposed to the nanoparticles. This represents a significant advancement in targeted antifungal therapy for combating resistance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Ceramics
Chaoqun Xia, Shi Liu, Baining Cui, Mingjun Li, Hongshui Wang, Chunyong Liang, Phong A. Tran, Yan Wang, Huan Zhou, Lei Yang
Summary: This study successfully suppressed the photocatalytic activity of zinc oxide (ZnO) by incorporating amorphous selenium (Se) nanoparticles, while maintaining its ultraviolet (UV) absorption property. The research also demonstrated the improved biocompatibility and bacteriostasis ability of ZnO-Se composite.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Muhammad Saqib, Phong A. Tran, Batur Ercan, E. Yegan Erdem
Summary: Janus particles have asymmetrical nature which make them superior to conventional particles. Microfluidic-based techniques are popular for their versatility and control over reaction conditions, leading to complex functionalities being imparted to the Janus particles.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
Sarigama Rajesh, Meike N. Leiske, Victoria Leitch, Jiali Zhai, Calum J. Drummond, Kristian Kempe, Nhiem Tran
Summary: This study found that lipidic poly(2-oxazoline) polymers can effectively stabilize cubosomes and be used to encapsulate hydrophobic drugs. Compared to commonly used polyethylene glycol stabilizers, these poly(2-oxazoline) polymers have less cytotoxic effects and significantly improve the solubility of poorly water-soluble cancer drugs.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Sarigama Rajesh, Jiali Zhai, Calum J. Drummond, Nhiem Tran
Summary: pH-responsive nanoparticles were developed for the selective delivery of a chemotherapeutic agent to tumours, reducing adverse effects. These nanoparticles exhibited a slow-releasing structure at physiological pH and a quick release structure at the acidic tumour pH. The study demonstrated the potential use of these pH-responsive nanoparticles in delivering and controlling the release of the potent drug SN-38 to tumour sites, addressing the solubility and stability issues of the drug.
Article
Materials Science, Biomaterials
Xudong Cai, Bo Fan, San H. Thang, Calum J. Drummond, Nhiem Tran, Jiali Zhai
Summary: Responsive nanoparticle delivery systems have potential for reducing off-target side effects in chemotherapeutic treatment. In this study, lipid-based cubosomes loaded with paclitaxel were formulated and stabilized by novel amphiphilic block copolymers containing pH-responsive and/or hydrogen peroxide-responsive blocks. The cubosomes demonstrated high encapsulation efficiency and controlled release of the drug in response to pH and H2O2 changes. In vitro cytotoxicity and cell uptake studies showed that the cubosomes had higher toxicity and cell internalization efficiency compared to free paclitaxel and cubosomes stabilized by non-responsive block copolymers. The results highlight the potential of responsive block copolymers in stabilizing lipid cubosomes and enhancing drug release and cellular uptake.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Pharmacology & Pharmacy
Tara Shabab, Onur Bas, Bronwin L. Dargaville, Akhilandeshwari Ravichandran, Phong A. Tran, Dietmar W. Hutmacher
Summary: This study combines melt-extrusion based 3D printing and porogen leaching to develop tunable multiphasic scaffolds for dental tissue regeneration. The scaffolds are highly adjustable in terms of mechanical properties, degradation kinetics, and surface morphology. The research also demonstrates improved cell attachment, proliferation, and extracellular matrix production on these multiscale scaffolds compared to single-scale counterparts, indicating their potential for enhanced tissue regeneration. Furthermore, the study explores the use of these scaffolds as drug delivery devices and shows that sustained drug release can be achieved. These findings strongly support further development of these scaffolds for dental tissue regeneration applications.
Article
Engineering, Biomedical
Sattwikesh Paul, Karsten Schrobback, Phong Anh Tran, Christoph Meinert, Jordan William Davern, Angus Weekes, Travis Jacob Klein
Summary: In this study, injectable and highly adhesive hydrogels were developed for cartilage repair and regeneration. These hydrogels showed improved mechanical properties and integration with surrounding cartilage. Preliminary results demonstrated their potential for tissue regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Sattwikesh Paul, Karsten Schrobback, Phong Anh Tran, Christoph Meinert, Jordan William Davern, Angus Weekes, Udhaya Nedunchezhiyan, Travis Jacob Klein
Summary: Untreated osteochondral defects can lead to osteoarthritis and pose significant challenges to patients and orthopedic surgeons. This study developed a GelMA-glycol chitosan (GelMA-GC) hydrogel that is biodegradable, biocompatible, mechanically robust, and highly adhesive for cartilage repair. The hydrogel showed promising results in terms of mechanical properties, chondrocyte viability, adhesive strength, and gene expression, suggesting its potential for tissue regeneration.
APL BIOENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Sarigama Rajesh, Sheeana Gangadoo, Han Nguyen, Jiali Zhai, Chaitali Dekiwadia, Calum J. Drummond, James Chapman, Vi Khanh Truong, Nhiem Tran
Summary: This study presents a novel approach using pH-sensitive lipid nanoparticles to deliver fluconazole and effectively inhibit the growth of resistant Cryptococcus neoformans. The nanoparticles change their structure and charge in response to the acidic environment, facilitating their interaction with the fungal cell wall. This targeted antifungal therapy represents a significant advancement in combating fungal antimicrobial resistance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
