Article
Computer Science, Interdisciplinary Applications
Jun Yeon Won, Haewook Park, Seungeun Lee, Jeong-Whan Son, Yina Chung, Guen Bae Ko, Kyeong Yun Kim, Junghyun Song, Seongho Seo, Yeunchul Ryu, Jun-Young Chung, Jae Sung Lee
Summary: A PET insert was developed for simultaneous brain imaging in 7T MR imaging scanners, featuring high-resolution and depth-of-interaction capabilities. By utilizing novel digitalization methods and high-definition transmission interfaces, a system-level imaging with 12.6% energy resolution was achieved.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Oncology
Pedro Fragoso Costa, Walter Jentzen, Alissa Brahmer, Ilektra-Antonia Mavroeidi, Fadi Zarrad, Lale Umutlu, Wolfgang P. Fendler, Christoph Rischpler, Ken Herrmann, Maurizio Conti, Robert Seifert, Miriam Sraieb, Manuel Weber, David Kersting
Summary: New-generation SiPM-based PET/CT systems with higher detector sensitivity have improved lesion detectability and image quality. This study aimed to determine the lowest PET acquisition time and optimize image reconstruction parameters using phantom imaging. Patient data were also evaluated to confirm the results.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ian Alberts, Christos Sachpekidis, George Prenosil, Marco Viscione, Karl Peter Bohn, Clemens Mingels, Kuangyu Shi, Ali Ashar-Oromieh, Axel Rominger
Summary: This study aimed to establish the feasibility of shorter acquisition times in digital PET/CT for tumor detection and lesion contrast. Results showed that new-generation digital PET scanners are able to produce clinically adequate images with shorter acquisitions, with only a small variation in semi-quantitative parameters.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Engineering, Biomedical
Charlotte Thyssen, Karel Deprez, Pieter Mollet, Roel Van Holen, Stefaan Vandenberghe
Summary: This study investigates a novel readout and event positioning scheme for monolithic PET detectors based on time-over-threshold (ToT). By measuring pulse width above a certain threshold and utilizing mean nearest neighbour approach for event positioning, the study evaluates positioning accuracy and uniformity through Monte Carlo simulations. Results suggest ToT as a valuable alternative to pulse-integration for monolithic PET detectors, offering advantages of lower power consumption and compactness.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Ao Qiu, Lin Wan, Yiqing Ling, Qingguo Xie
Summary: The multiple voltage threshold (MVT) digitizer is used for data acquisition in gamma cameras and has been employed in various nuclear science applications. However, its energy nonlinearity limits the dynamic range of energy. To overcome this, we propose a novel method to calibrate the nonlinearity by obtaining the scatter plot from the digitizer energy to pulse energy. We demonstrate this method using a gamma camera and show that it improves the accuracy of energy measurement.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Article
Instruments & Instrumentation
K. Hu, X. Cheng, Y. Shao, L. Yuan
Summary: The compact and multi-functional front-end readout electronics system for a SiPM based PET detector is developed based on the latest SDM circuit. The system includes analog and digital boards for charge integration and data transferring respectively. The system has demonstrated good performance for PET application with improved input signal polarity and dual functionality.
JOURNAL OF INSTRUMENTATION
(2021)
Article
Instruments & Instrumentation
Hesham H. Shaker, H. Kasban, A. A. Saleh, M. Dessouky
Summary: Recently, analog gamma spectrometers have been replaced by digital ones due to their durability, flexibility, and compact size. The digital pulse processing (DPP) unit is the main component of the digital gamma spectrometer. The use of ARM Cortex-M-based microcontroller units for implementing the DPP unit has gained attention due to their advanced features and low cost. This study proposes an implementation of the DPP unit using the ARM Cortex-M3-based microcontroller unit, specifically targeting the sodium iodide detector. Despite a sampling rate of less than 2 MS/s, experimental results demonstrate its capability to handle input count rates up to 47 kC/s using a proposed method for pulse height extraction.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Instruments & Instrumentation
D. Villamarin, T. Martinez, J. Plaza, D. Cano-Ott, E. Gonzalez, V. Alcayne, V. Becares, E. Mendoza, A. Perez de Rada, J. Garcia
Summary: A dedicated digital data acquisition (DAQ) system has been developed for innovative nuclear data measurements. It has high resolution and sampling rate, allowing reliable measurements and precise synchronization with other subsystems.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2023)
Article
Instruments & Instrumentation
T. Teixeira, L. Andrade, J. M. de Seixas
Summary: Energy reconstruction in calorimeters operating in high luminosity particle colliders presents a significant challenge, with methods based on signal deconvolution being proposed for improved performance. Techniques using Sparse Representation algorithms have been found to be effective in online environments, showing potential for implementation in modern FPGAs.
JOURNAL OF INSTRUMENTATION
(2021)
Article
Engineering, Biomedical
Emilie Gaudin, Christian Thibaudeau, Louis Arpin, Jean-Daniel Leroux, Maxime Toussaint, Jean-Francois Beaudoin, Jules Cadorette, Maxime Paille, Catherine M. Pepin, Konin Koua, Jonathan Bouchard, Nicolas Viscogliosi, Caroline Paulin, Rejean Fontaine, Roger Lecomte
Summary: LabPET II is a new PET technology platform designed for high-resolution imaging, achieving submillimetric spatial resolution in preclinical and clinical settings. Results show promising capabilities for biomolecular imaging in preclinical research, with submillimetric resolution achieved in hot spot phantoms and exceptional contrast for tiny bone structures in mice.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Instruments & Instrumentation
M. Wang, Z. Bian, Y. Wang, D. Li, X. Li, J. Cai, P. Wang, B. Wang, X. Cao, Z. Zhang, P. Kuang, F. Liu, H. Zhang, X. Yu, T. Chen, X. Yun, L. Wei
Summary: This research develops an electronic system using DRS4 chips and modular design to improve the time resolution of positron burst annihilation lifetime measurements. After calibration and processing, the coincidence time resolution of the system with other channels is 21 ps. It is successfully applied to evaluate a 64-pixel detector module.
JOURNAL OF INSTRUMENTATION
(2022)
Article
Multidisciplinary Sciences
Philip Krause, Edith Rogers, Muhammad Danang Birowosuto, Qibing Pei, Etiennette Auffray, Andrey N. Vasil'ev, Gregory Bizarri
Summary: Despite the clinical acceptance of ToF-PET, there is still a gap between the technology's performance and the end-user's needs. The concept of heterostructured detectors has been proposed to bypass the current performance limitations. Based on Monte Carlo simulations, a survey of heterostructure performance versus detector design is presented, enabling the establishment of design rules for the development of improved detectors.
Article
Instruments & Instrumentation
T. Muscheid, A. Boebel, N. Karcher, T. Vanat, L. Ardila-Perez, I. Cjeviakov, M. Schleicher, M. Zimmer, M. Blazer, O. Sander
Summary: This article presents the joint development of a heterogeneous MPSoC board called DTS-100G by DESY and KIT, which can be used as a crucial component in the DAQ chain for various physics experiments.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vinicius P. V. Alves, Samuel Brady, Nadeen Abu Ata, Yinan Li, Joseph MacLean, Bin Zhang, Susan E. Sharp, Andrew T. Trout
Summary: The study found that in children and young adults undergoing imaging with a 25-cm FOV digital PET scanner, acquisition time or administered FDG activity may be decreased by approximately 33% without significantly impacting image quality.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Instruments & Instrumentation
Junqi Dong, Zhu Wang, Yuan Liao, Mengxin Zhang, Qiufei Qian, Fenghua Zou, Yundong Shao, Wusheng Zou, Rui Xiong
Summary: In this article, we describe the implementation of a fully digital Coincidence Doppler Broadening (CDB) spectrometer, which consists of two HPGe detectors, a fully digital processing and acquisition board, and a dedicated software system. The Field Programmable Gate Array (FPGA) on the board extracts energy and time stamp information from the detectors and communicates with the software to produce single channel spectra and 2D coincidence spectra. We designed a specific instruction set for the CDB Spectrometer and the FPGA controller module to ensure full control and configurability. The implemented trapezoidal pulse shaping algorithm improves the Doppler-broadened spectrum, as shown by an increase in the peak-to-background ratio from 7.0 x 105 to 1.9 x 106, as determined by a 2D Gaussian fitting on the coincidence spectra.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Instruments & Instrumentation
H. Kim, Y. Hua, H-T Chen, H-M Tsai, C-T Chen, G. Karczmar, X. Fan, D. Xi, Q. Xie, C-Y Chou, C-M Kao
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2020)
Article
Instruments & Instrumentation
H. Kim, B. Epel, S. Sundramoorthy, H-M Tsai, E. Barth, I Gertsenshteyn, H. Halpern, Y. Hua, Q. Xie, C-T Chen, C-M Kao
Summary: This study developed a combined PET and EPRI imaging system to accurately assess tumor hypoxia, aiming to validate the accuracy of PET imaging through the simultaneous use of EPRI. The results demonstrate the potential application of this combined imaging system for evaluating tumor hypoxia.
JOURNAL OF INSTRUMENTATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Heejong Kim, Chien-Min Kao, Yuexuan Hua, Qingguo Xie, Chin-Tu Chen
Summary: The trend in PET instrumentation is the use of SiPMs for high resolution and TOF detection, with a focus on maintaining fast timing properties. A stripline-based readout method has been developed to achieve accurate pixel discrimination and minimal energy resolution degradation, while compromising slightly on TOF resolution. Strategies using the readout are discussed to reduce the number of electronic channels needed in a PET system.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Inna Gertsenshteyn, Boris Epel, Amandeep Ahluwalia, Heejong Kim, Xiaobing Fan, Eugene Barth, Marta Zamora, Erica Markiewicz, Hsiu-Ming Tsai, Subramanian Sundramoorthy, Lara Leoni, John Lukens, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Mihai Giurcanu, Brian B. Roman, Gregory Karczmar, Chien-Min Kao, Howard Halpern, Chin-Tu Chen
Summary: This study compared FMISO PET images with pO(2) EPRI in mouse models to identify the optimal FMISO threshold for locating tumor hypoxia, showing a high overall hypoxia similarity between the two imaging methods. Additionally, the correlations between PET/EPRI hypoxia images and vascular permeability and extracellular-extravascular space from DCE-MRI were evaluated.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Physics, Multidisciplinary
Kihong Son, Jin Sung Kim, Chien-Min Kao, Seungryong Cho
Summary: This study presents a sequentially processed image reconstruction algorithm (SPIRA) for in-beam TOF-PET in particle therapy, which has the potential to provide real-time dose-guidance for monitoring radiation treatment. Simulation results show that SPIRA achieves better resolution and contrast recovery compared to conventional image reconstruction methods.
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
(2022)
Article
Neurosciences
Hannah J. Zhang, Matthew Zammit, Chien-Min Kao, Anitha P. Govind, Samuel Mitchell, Nathanial Holderman, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Xiaoxi Zhuang, Jogeshwar Mukherjee, Chin-Tu Chen, William N. Green
Summary: The distribution of nicotine and other nicotinic receptor ligands in the brain is investigated. Ligands with high pKa and affinity for cc4P2Rs, like varenicline, are trapped in intracellular acidic vesicles in vitro, while nicotine, with lower pKa and affinity, is not trapped. In vivo imaging of PET ligands in mouse brain reveals that the trapping organelle is Golgi satellites (GSats) and provides insights into the subcellular distribution of these ligands.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Matthew Zammit, Chien-Min Kao, Hannah J. Zhang, Hsiu-Ming Tsai, Nathanial Holderman, Samuel Mitchell, Eve Tanios, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, William N. Green, Jogeshwar Mukherjee, Chin-Tu Chen
Summary: This study investigates the kinetic analysis of PET radioligand binding in mice using an image-derived arterial input function. The results suggest that using an image-derived input function provides suitable results compared to reference tissue-based methods. The chemical properties of 2-FA and Nifene are suitable for studying receptor response to nicotine addiction and smoking cessation therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jason P. Meier, Hannah J. Zhang, Richard Freifelder, Mohammed Bhuiyan, Phillip Selman, Megan Mendez, Pavithra H. A. Kankanamalage, Thomas Brossard, Antonino Pusateri, Hsiu-Ming Tsai, Lara Leoni, Sagada Penano, Kaustab Ghosh, Brittany A. Broder, Erica Markiewicz, Amy Renne, Walter Stadler, Ralph Weichselbaum, Jerry Nolen, Chien-Min Kao, Satish K. Chitneni, David A. Rotsch, Russell Z. Szmulewitz, Chin-Tu Chen
Summary: In the field of nuclear medicine, Sc-43 and Sc-47 have shown promise as candidates for cancer diagnosis and therapy due to their favorable properties and shared pharmacokinetics. However, before widespread evaluation can occur, a production method must be established, and their labeling and imaging capabilities studied. This study presents a simple method for producing Sc-43 and investigates its imaging capabilities, as well as successful chemical separation and purification methods for Sc-43 and Sc-47, and their conjugation with PSMA-617 for imaging tumor xenografts.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhiqiang Xin, Chien-Min Kao, Yuqing Liu, Xun Chen, Labao Zhang, Peiheng Wu, Qingguo Xie
Summary: This study investigates the impact of mixing detectors with different time resolutions on image quality through computer simulation. The results show that symmetric heterogeneous configurations can achieve comparable or better imaging results with fewer detectors, while asymmetric heterogeneous configurations can improve image quality locally with only a few detectors. This study demonstrates the value of using heterogeneous detector groups for achieving high effective system sensitivity by balancing the tradeoff between coincidence time resolution and detection efficiency.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Inna Gertsenshteyn, Eugene Barth, Heejong Kim, Boris Epel, Lara Leoni, Hsiu-Ming Tsai, John Lukens, Subramanian Sundramoorthy, Mihai Giurcanu, Amandeep Ahluwalia, Xiaobing Fan, Erica Markiewicz, Marta Zamora, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Chien-Min Kao, Howard Halpern, Chin-Tu Chen
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Inna Gertsenshteyn, Boris Epel, Eugene Barth, Lara Leoni, Erica Markiewicz, Hsiu-Ming Tsai, Xiaobing Fan, Mihai Giurcanu, Darwin Bodero, Marta Zamora, Subramanian Sundramoorthy, Heejong Kim, Richard Freifelder, Mohammed Bhuiyan, Anna Kucharski, Gregory Karczmar, Chien-Min Kao, Howard Halpern, Chin-Tu Chen
Summary: This study aimed to enhance the spatial accuracy of F-18 MISO PET imaging of hypoxia by using DCE MRI as a basis for modifying PET images and EPR pO(2) as the reference standard. Results showed significant improvement in the overlap of hypoxic regions between EPR and PET images after implementing a preliminary DCE MRI correction to PET data in mouse models.
RADIOLOGY-IMAGING CANCER
(2021)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Brittany Broder, Mohammed Bhuiyan, Hannah Zhang, Richard Freifelder, Hsiu-Ming Tsai, Anna Kucharski, Lara Leoni, Samuel Mitchell, Darwin Bodero, Chien-Min Kao, Chin-Tu Chen
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Liang, Jing Li, Emanuele Antonecchia, Yiqing Ling, Zhen Li, Wenchang Xiao, Qian Chu, Lin Wan, Xia Hu, Shuangxue Han, Jarmo Teuho, Lu Wan, Peng Xiao, Chien-Min Kao, Juhani Knuuti, Nicola D'Ascenzo, Qingguo Xie
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicola D'Ascenzo, Emanuele Antonecchia, Min Gao, Xiangsong Zhang, Gerhard Baumgartner, Andreas Brensing, Zhen Li, Qiong Liu, Georg Rose, Xinchong Shi, Bo Zhang, Chien-Min Kao, Jiazuan Ni, Qingguo Xie
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2020)
Article
Materials Science, Multidisciplinary
Yin Fang, Endao Han, Xin-Xing Zhang, Yuanwen Jiang, Yiliang Lin, Jiuyun Shi, Jiangbo Wu, Lingyuan Meng, Xiang Gao, Philip J. Griffin, Xianghui Xiao, Hsiu-Ming Tsai, Hua Zhou, Xiaobing Zuo, Qing Zhang, Miaoqi Chu, Qingteng Zhang, Ya Gao, Leah K. Roth, Reiner Bleher, Zhiyuan Ma, Zhang Jiang, Jiping Yue, Chien-Min Kao, Chin-Tu Chen, Andrei Tokmakoff, Jin Wang, Heinrich M. Jaeger, Bozhi Tian
