Journal
IEEE TRANSACTIONS ON NANOBIOSCIENCE
Volume 9, Issue 1, Pages 38-43Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2009.2035446
Keywords
DNA; dynamic programming; message passing; nanotechnology
Funding
- National Science Foundation (NSF) [EIA0130385, MRI-0421099, CCF-0407218]
- National Research Initiative (NRI) of the United States Department of Agriculture Cooperative State Research, Education, and Extension Service (USDA-CSREES) [2005-35603-15902]
- Air Force Office of Scientific Research, Rome Laboratory (AFOSR-Rome Labs)
- Arkansas Biosciences Institute (ABI)
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Independent sets of DNA oligonucleotides, which only bind with their Watson-Crick complements, have potential use in self-assembly of nanostructures, since they minimize errors and inefficiency from unwanted binding. A software tool implemented a thermodynamic model for DNA duplex formation and was used to generate large independent sets of DNA oligonucleotides. The principle of the approach was experimentally verified on a sample set of oligonucleotides.
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