Regulation of hematopoietic stem cell integrity through p53 and its related factors

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress

(2015) A. R. D. Delbridge et al.   BLOOD

Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation

(2015) Masayuki Yamashita et al.   Cell Stem Cell

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

(2015) Xiongwei Cai et al.   Cell Stem Cell

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal

(2015) Uta Rabenhorst et al.   Cell Reports

Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence

(2014) Y. Qing et al.   BLOOD

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation

(2014) Yujiao Jia et al.   FASEB JOURNAL

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

(2014) Diogo Fonseca-Pereira et al.   NATURE

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?

(2014) K Brinkmann et al.   Cell Death & Disease

The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity

(2013) V. Pant et al.   GENES & DEVELOPMENT

Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target

(2013) J G Harb et al.   LEUKEMIA

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells

(2012) T. Asai et al.   BLOOD

Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia

(2012) Takaomi Sanda et al.   CANCER CELL

Thrombopoietin-Increased DNA-PK-Dependent DNA Repair Limits Hematopoietic Stem and Progenitor Cell Mutagenesis in Response to DNA Damage

(2012) Bérengère de Laval et al.   Cell Stem Cell

Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf

(2012) Verena Labi et al.   EMBO Molecular Medicine

MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma

(2012) S-S Wenzel et al.   LEUKEMIA

BCL2A1a Over-Expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation

(2012) Jean-Yves Métais et al.   PLoS One

Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

(2012) M. Jan et al.   Science Translational Medicine

Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

(2011) E. Nitta et al.   BLOOD

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

(2011) G. Chan et al.   BLOOD

DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

(2011) Cedric Blanpain et al.   Cell Stem Cell

An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence

(2011) Arnaud M Vigneron et al.   EMBO JOURNAL

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

(2011) Y. V. Wang et al.   GENES & DEVELOPMENT

Cell cycle regulation in hematopoietic stem cells

(2011) Eric M. Pietras et al.   JOURNAL OF CELL BIOLOGY

The emerging role of p53 in stem cells

(2011) Giuseppina Bonizzi et al.   TRENDS IN MOLECULAR MEDICINE

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose  -irradiation

(2010) H. Yu et al.   BLOOD

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

(2010) L. Shao et al.   BLOOD

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

(2010) K. J. Campbell et al.   BLOOD

miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal

(2010) Antonio Herrera-Merchan et al.   CELL CYCLE

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal

(2010) Michael Milyavsky et al.   Cell Stem Cell

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

(2010) Hussein A. Abbas et al.   Cell Stem Cell

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP

(2010) A. M. Vigneron et al.   GENES & DEVELOPMENT

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

(2010) V. Labi et al.   GENES & DEVELOPMENT

Apoptosis-promoted tumorigenesis:  -irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

(2010) E. M. Michalak et al.   GENES & DEVELOPMENT

Genome-wide identification of TAL1's functional targets: Insights into its mechanisms of action in primary erythroid cells

(2010) M. T. Kassouf et al.   GENOME RESEARCH

Puma is required for p53-induced depletion of adult stem cells

(2010) Dongping Liu et al.   NATURE CELL BIOLOGY

Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration

(2009) Y. Kubota et al.   BLOOD

The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development

(2009) N. K. Wilson et al.   BLOOD

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development

(2008) Verena Labi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis

(2008) S. P. Garrison et al.   MOLECULAR AND CELLULAR BIOLOGY

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY