Journal
IEEE TRANSACTIONS ON MEDICAL IMAGING
Volume 31, Issue 11, Pages 2120-2132Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2012.2213828
Keywords
Fluorescence; Karhunen-Loeve (KL) transform; pharmacokinetics; tomography
Categories
Funding
- National Basic Research Program of China (973) [2011CB707701]
- National Major Scientific Instrument and Equipment Development Project [2011YQ030114]
- National Natural Science Foundation of China [81071191, 60831003, 30930092, 30872633]
- Beijing Natural Science Foundation [3111003]
- Tsinghua-Yue-Yuen Medical Science Foundation
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Dynamic fluorescence diffuse optical tomography (FDOT) is important for the research of drug delivery, medical diagnosis, and treatment. Conventionally, dynamic tomographic images are reconstructed frame-by-frame, independently. This approach fails to account for the temporal correlations in measurement data. Ideally, the entire image sequence should be considered as a whole and a 4-D reconstruction should be performed. However, the fully 4-D reconstruction is computationally intensive. In this paper, we propose a new 4-D reconstruction approach for dynamic FDOT, which is achieved by applying a temporal Karhunen-Loeve (KL) transformation to the imaging equation. By taking advantage of the decorrelation and compression properties of the KL transformation, the complex 4-D optical reconstruction problem is greatly simplified. To evaluate the performance of the method, simulation, phantom, and in vivo experiments (N = 7) are performed on a hybrid FDOT/X-ray computed tomography imaging system. The experimental results indicate that the reconstruction images obtained by the KL method provide good reconstruction quality. Additionally, by discarding high-order KL components, the computation time involved with fully 4-D reconstruction can be greatly reduced in contrast to the conventional frame-by-frame reconstruction.
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