Article
Chemistry, Physical
Hideyuki Sugioka, Hiroki Yoshijima
Summary: In this study, it was found that artificial cilia made up of three beams with different lengths arranged in parallel can exhibit metachronal motion through induced charge electro-osmosis (ICEO) induced by AC electric fields. The recovery of the ICEO cilia's beams upon suddenly turning off the electric fields was also observed to be almost simultaneous. These findings, discussed using a mathematical model, are valuable for designing ICEO cilia and advancing innovative microfluidic applications in the future.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Hideyuki Sugioka, Taiki Kado, Hiroya Nakamura
Summary: The study found that conductive carbon mesh made through induced charge electro-osmosis under DC electric fields shows great stretchability, with potential applications as a stretchable actuator under AC electric fields. This finding has important implications for future microfluidic circuits.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
R. Balaji, J. Prakash, Dharmendra Tripathi, O. Anwar Beg
Summary: This article develops a mathematical model to investigate the squeezing flow between two parallel rotating plates coated with a special fluid under the application of electric and magnetic fields. By numerical simulations and graphical visualization, the characteristics of the squeezing flow are analyzed, providing a useful benchmark and new research direction.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Mechanics
Lingqi Zhao, Xin Zhong, Huicheng Feng
Summary: This paper experimentally observed that chaotic induced-charge electro-osmosis (ICEO) is stable in weak electric fields and becomes chaotic in strong electric fields. The observed chaotic ICEO flow is irregular and unstable across the whole velocity field, and the chaos degree grows with increasing electric field.
Article
Mechanics
Raul Fernandez-Mateo, Hywel Morgan, Antonio Ramos, Pablo Garcia-Sanchez
Summary: We experimentally investigate the repulsion between charged microscopic particles and the channel walls during electrophoresis in microfluidic devices. This repulsion is primarily caused by hydrodynamic interactions arising from flow vortices induced by the slip velocity on the particle surface due to the electric field. Measurement of wall-particle separation allows us to infer the maximum slip velocity on the particle surface, including very small velocities that are otherwise difficult to directly measure. The data at low electric field amplitudes agree with theoretical predictions based on Concentration Polarization Electro-osmosis (CPEO), but the predictions of CPEO theory break down for higher electric fields. Furthermore, we show that strong electric fields can disrupt the quadrupolar flow structures, leading to a weaker wall repulsion.
Article
Chemistry, Multidisciplinary
Riccardo Zamboni, Carlos Sebastian-Vicente, Cornelia Denz, Joerg Imbrock
Summary: This study presents an electro-coalescence method for microfluidic droplet surfactant-stabilized emulsion based on light-induced virtual electrodes. By adjusting the exposure time, droplet pairs can be selectively coalesced or the entire emulsion can be dispersed.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Ruixing Yu, Bowen Ji, Lingqi Zhao, Xin Zhong, Huicheng Feng
Summary: In this study, the phenomenon of induced-charge electro-osmosis (ICEO) in cetyl-trimethylammonium bromide (CTAB) solutions was found to take several seconds to fully develop after the application of an electric field, contrary to previous research. A phenomenological model for ICEO of CTAB solutions was proposed, explaining the slow development as a result of the thixotropic behavior of CTAB solutions. Additionally, variations in ICEO velocity were observed with changes in CTAB concentration, viscosity, electrical conductivity, and electric field frequency.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Physics, Multidisciplinary
Evgeniy Boyko, Vesna Bacheva, Michael Eigenbrod, Federico Paratore, Amir D. Gat, Steffen Hardt, Moran Bercovici
Summary: By injecting momentum in a region surrounding an object in microscale flow, both cloaking and shielding conditions can be achieved, with the ability to dynamically switch between different states demonstrated both theoretically and experimentally.
PHYSICAL REVIEW LETTERS
(2021)
Article
Chemistry, Physical
Huicheng Feng, Lingqi Zhao, Xin Zhong, Xingfeng Lei, Teck Neng Wong
Summary: The study found that induced-charge electro-osmosis velocity initially increases and then decreases with increasing sodium chloride concentration, with the peak velocity concentration varying with electric field strength. As electric field frequency increases, ICEO velocity reaches a maximum, with the frequency of peak velocity determined by microfluidic chip geometry and ion concentration. Additionally, inflowoutflow asymmetry and vortex positions were observed in ICEO, showing a dependence on electric field and NaCl concentration.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Analytical
Xiaoming Chen, Shun Liu, Xu-guang Hu, Tengteng Liu, Mo Shen, Yun Peng, Sheng Hu, Yong Zhao
Summary: Manipulation of micro- and nanoscale objects using induced-charge electro-osmotic (ICEO) vortices is a promising approach for detection and sensing applications. However, the current throughput of this method is limited. To overcome this constraint, a novel method using parallel ICEO vortices is proposed, which allows for higher throughput without compromising efficiency. This method can be applied in disease diagnosis and environmental monitoring by integrating with simple and economical sensors.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Hideyuki Sugioka, Hiroya Nakamura
Summary: Controlling the self-organizing structure is crucial for the application of self-organizing materials. In this study, a weaving method of carbon fibers using induced-charge electro-osmosis (ICEO) was reported. The researchers demonstrated that low-density carbon fibers with a dendritic structure can be grown by applying a DC voltage, and shrink irreversibly when an AC voltage is applied, leading to the formation of a weaving structure. The mechanism of the DC-AC weaving phenomenon related to dielectrophoresis and ICEO phenomena was clarified through visualization. This technology offers a different design strategy to improve the structure of self-organizing materials for microfluidic circuits.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Multidisciplinary Sciences
A. Abbasi, Kamel Al-Khaled, M. Ijaz Khan, Shahid Farooq, Waseh Farooq, Sami Ullah Khan, F. Mabood, Taseer Muhammad
Summary: The numerical simulations investigated the electro-osmotic peristaltic flow of Prandtl fluid with tiny particles in a planner channel, taking into account slip effects, magnetic force, and Joule heating. The study found that the concentration profile decreases with concentration slip, while an increasing trend is observed for the Soret number.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Maliha Saleem Bakhshi, Mohsin Rizwan, Ghulam Jilany Khan, Hong Duan, Kefeng Zhai
Summary: In this study, a novel two-stage, label-free, rapid, and continuous CTC separation device based on hydrodynamic inertial focusing and dielectrophoretic separation is proposed. The device can effectively separate CTCs from other blood cells, yielding viable CTCs with high efficiency.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Geological
Qiyun Gan, Jian Zhou, Yanli Tao, Yicheng Jiang
Summary: This study investigates the influencing mechanisms of electrochemical processes on the electrode-clay interface in electro-osmotic drainage technology. A proposed interfacial resistance model based on electrochemical theory is validated through chamber tests. The results show that the current density on the electrode surface is the most critical factor affecting interfacial resistance, along with other factors such as electrode material, surface status, pH of the pore solution, soil void ratio, conductive properties, and adsorption properties.
Article
Biophysics
Daniel E. Hagness, Ying Yang, Richard D. Tilley, J. Justin Gooding
Summary: Affinity biosensors play a crucial role in various areas of human health, such as clinical diagnosis and pharmaceuticals, by utilizing specific binding between target analytes and biological ligands. Electrokinetic phenomena have been investigated as a viable option to improve the performance of affinity biosensors for higher sensitivity and lower detection limit.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Meng-Shiue Lee, Wensyang Hsu, Hong-Yuan Huang, Hsueh-Yang Tseng, Chia-Tung Lee, Chung-Yu Hsu, Yi-Chueh Shieh, Shih-Hung Wang, Da-Jeng Yao, Cheng-Hsien Liu
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Chemistry, Analytical
Yu-Shih Chen, Chen-Kuo Tung, Tzu-Hsuan Dai, Xiaohong Wang, Chau-Ting Yeh, Shih-Kang Fan, Cheng-Hsien Liu
Summary: A liver-lobule-mimicking labchip was developed to pattern and culture NIH/3T3 and C3A cells, maintaining high cell viability and biomimicking liver-lobule pattern under different GelMA culturing-microenvironments. Urea assays showed that cells cultured in 5% GelMA chamber had high activity and urea secretion levels, preserving the liver-lobule pattern effectively.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yu-Shih Chen, Tzu-Wei Lo, Hong-Yuan Huang, Lien-Min Li, Yi-Wen Wang, Da-Jeng Yao, Wen-Syang Hsu, Cheng-Hsien Liu
Summary: The combination of In Vitro Fertilization (IVF) and microfluidic technology offers a promising solution to infertility by enhancing the success rate of IVF and accelerating embryo growth and development. By utilizing a microfluidic embryo lab chip for co-cultivation, researchers observed faster embryo growth rates and higher blastocyst development rates compared to traditional culture methods.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yu-Shih Chen, Ling-Yi Ke, Sung-Yang Wei, Madhu Shree Poddar, Cheng-Hsien Liu
Summary: The research successfully fabricated photopolymerized hydrogel microstructures with complex fine patterns by utilizing optofluidic thin-film lithography combined with PDMS thin-film characteristics. The design principle is based on the physical characteristics of UV light attenuation and refraction.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Cell Biology
Gaurav Pendharkar, Yen-Ta Lu, Chia-Ming Chang, Meng-Ping Lu, Chung-Huan Lu, Chih-Chen Chen, Cheng-Hsien Liu
Summary: The article introduces a three-layered integrated Microfluidic Flip-Chip (MFC) for cell fusion, which combines passive hydrodynamic phenomenon and gravitational sedimentation for efficient cell pairing and fusion. The MFC can be tuned for pairing and fusion of cells with a similar protocol for different cell types, and can be easily disconnected from the test setup for further analysis.
Review
Chemistry, Analytical
Parvaneh Sardarabadi, Amir Asri Kojabad, Davod Jafari, Cheng-Hsien Liu
Summary: Liquid biopsy is a promising non-invasive method for monitoring disease progression and treatment response in NSCLC patients. Biosensors based on signal transduction methods can provide quantitative analysis of biomarkers in liquid biopsy specimens for improved lung cancer treatment monitoring.
Review
Biochemistry & Molecular Biology
Anand Baby Alias, Shubhanvit Mishra, Gaurav Pendharkar, Chi-Shuo Chen, Cheng-Hsien Liu, Yi-Ju Liu, Da-Jeng Yao
Summary: Microalgae are a significant source of renewable, sustainable and economical biofuels, with vast potential applications in energy, pharmaceutical and nutraceutical industries. The utilization of microfluidic technology plays a vital role in microalgal processes and applications in biofuels and biosensing.
Article
Chemistry, Analytical
Gaurav Pendharkar, Yen-Ta Lu, Chia-Ming Chang, Meng-Ping Lu, Cheng-Hsien Liu
Summary: This study introduces an insulator-based dielectrophoretic microfluidic lab-chip that can precisely pair cells and achieve cell fusion with high efficiency. The chip demonstrates high cell fusion yields and maintains cell viability, making it a promising tool for cell fusion research.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Yu-Shuang Lee, Yen-Ta Lu, Chia-Ming Chang, Cheng-Hsien Liu
Summary: This paper introduces an integrated finger-powered cell-sorting microsystem chip that can separate TIICs from a suspension of solid tumors. The system is simple and efficient, with high purity and recovery rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Han-Jung Liao, Jean An Chieh, Yu-Chen Chen, Kang-Yun Lee, Yao-Fei Chan, Shu-Chuan Ho, Wei-lun Sun, Yu-Shiuan Wang, Wan-Chen Huang, Wei-Chiao Chang, Cheng-Hsien Liu
Summary: Immunotherapy enhances T cell activity to treat cancer, with drugs disrupting the PD-1-PD-L1 interaction showing promise. A microfluidic device was developed to mimic tumor tissue environment and test multiple drug concentrations efficiently, showing cell survival and T cell infiltration.
2021 21ST INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS)
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Yu-Chen Chen, Han-Jung Liao, Jean-An Chich, Pin-Tzu Lai, Yi-Ying Liang, Kang-Yun Lee, Wei-Lun Sun, Shu-Chuan Ho, Yu-Shiuan Wang, Wan-Chen Huang, Wei-Chiao Chang, Sung-Yang Wei, Cheng-Hsien Liu
Summary: This study developed a novel microfluidic device combining GelMA and collagen biomaterials for patterning and cultivation of cancer cells in a 3D environment. Experimental results demonstrated the potential of this device for future clinical cancer research applications and exploration of interactions between cell models and drugs.
2021 21ST INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS)
(2021)
Article
Biochemical Research Methods
Chung Hsiang Lu, Ting-Sheng Shih, Po-Chen Shih, Gaurav Prashant Pendharkar, Cheng-En Liu, Chi-Kuan Chen, Long Hsu, Hwan-You Chang, Chia-Ling Yang, Cheng-Hsien Liu
Proceedings Paper
Engineering, Electrical & Electronic
Gaurav Pendharkar, Meng-Ping Lu, Chia-Ming Chang, Chieh-An Jean, Yu-Chen Chen, Yen-Ta Lu, Cheng-Hsien Liu
2019 20TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS & EUROSENSORS XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Shalaka Bhosale, Mushou Chen, Cheng-Hsien Liu
2019 20TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS & EUROSENSORS XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Chung-Yu Chou, Yen-Ta Lu, Chia-Ming Chang, Cheng-Hsien Liu
2018 13TH ANNUAL IEEE INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS (NEMS 2018)
(2018)