Journal
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
Volume 61, Issue 6, Pages 1658-1663Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TIM.2012.2188350
Keywords
Cavitation; drug delivery; piezopolymer; therapy for wounds; ultrasound transducer
Funding
- Faculty of Pharmacy, Magna Graecia University of Catanzaro (UMG), Catanzaro, Italy
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Ultrasound energy at frequencies lower than 200 kHz has recently been used in the medical field to improve transdermal drug transport and to achieve a more suitable therapeutic approach. Low-frequency ultrasound energy was shown to be more effective than high-frequency ultrasound energy, so low-frequency ultrasound is attracting its share of attention in the medical field. In this paper, we take into consideration the most promising applications of low-frequency ultrasound with emphasis on transducer technology and measurements. In particular, a piezopolymer transducer is proposed, originally aimed at emulating the biosonar of bats, which has a low acoustic impedance in correspondence to biological tissue. The transducer is light, small, and inexpensive and could be used for medical applications, a possibility of which is a potential device for improving the cutaneous passage of drug compounds.
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