Journal
IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
Volume 32, Issue 9, Pages 1307-1320Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TCAD.2013.2260192
Keywords
Biochips; microfluidics; pin assignment
Categories
Funding
- National Science Foundation [CCF-0914895]
- Direct For Computer & Info Scie & Enginr
- Division Of Computer and Network Systems [1135853] Funding Source: National Science Foundation
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Digital microfluidic biochips are being increasingly used for biotechnology applications. The number of control pins used to drive electrodes is a major contributor to the fabrication cost for disposable biochips in a highly cost-sensitive market. Most prior work on pin-constrained biochip design determines the mapping of a small number of control pins to a larger number of electrodes according to the specific schedule of fluid-handling operations and routing paths of droplets. Such designs are, therefore, specific to the bioassay application, hence sacrificing some of the flexibility associated with digital microfluidics. We propose a design method to generate an application-independent pin-assignment configuration with a minimum number of control pins. Layouts of commercial biochips and laboratory prototypes are used as case studies to evaluate the proposed design method for determining a suitable pin-assignment configuration. Compared with previous pin-assignment algorithms, the proposed method can reduce the number of control pins and facilitate the general-purpose use of digital microfluidic biochips for a wider range of applications.
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