Review
Immunology
Lijun Zhang, Lei Dai, Deyuan Li
Summary: Selective autophagy, particularly mitophagy, plays a crucial role in maintaining cellular homeostasis by removing excess protein aggregates and damaged mitochondria. Dysfunctional mitophagy can lead to neurodegeneration, while efficient mitophagy responses can prevent the accumulation of damaged mitochondria and provide neuroprotective effects. Targeting mitophagy may hold potential for the treatment of neurodegenerative diseases and acute brain injuries, despite the complex and sometimes dual nature of its mechanisms.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Medicine, Research & Experimental
Concetta Schiano, Livio Luongo, Sabatino Maione, Claudio Napoli
Summary: Neurological diseases are a leading cause of acquired disability and death globally. The Mediator complex is a multiprotein complex that regulates the interaction between transcription factors and RNA Polymerase II in eukaryotes. Mutations in MED subunits have been associated with various genetic diseases, including Alzheimer's Disease.
Article
Public, Environmental & Occupational Health
Yi Huang, Yongan Li, Haiyan Pan, Liyuan Han
Summary: This study aimed to determine the incidence and DALYs of neurological disorders worldwide. The highest incidence rates were observed in East Asia, tropical Latin America, Southern Latin America, and Western Europe. Control measures are needed to address the increasing incidence rates in China, Ecuador, and Italy.
JOURNAL OF GLOBAL HEALTH
(2023)
Review
Cell Biology
Yangtao Liu, Pengwei Wang, Guofang Jin, Peijie Shi, Yonghui Zhao, Jiayi Guo, Yaling Yin, Qianhang Shao, Peng Li, Pengfei Yang
Summary: Bexarotene is a RXR agonist approved for cutaneous T-cell lymphoma treatment. It also shows promising potential in neurological diseases such as stroke, traumatic brain injury, Parkinson's disease, and especially Alzheimer's disease (AD). Its mechanisms of action include inhibiting Ass production and aggregation, activating LXR/RXR heterodimers, regulating neuroinflammation, and ultimately improving cognitive function.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Eun Jung Choi, Robyn Westmacott, Fenella J. Kirkham, Amanda Robertson, Prakash Muthusami, Manohar Shroff, Mahendranath Moharir, Tricia Williams, Peter Dirks, Daune MacGregor, Mahmoud Slim, Elizabeth Pulcine, Ishvinder Bhathal, Matsanga Leyila Kaseka, Andrea Kassner, William Logan, Gabrielle deVeber, Nomazulu Dlamini
Summary: This study examined the relationship between regional hemodynamics and cognitive functions in children with moyamoya disease. The results showed abnormal frontal hemodynamics in all cases, regardless of stroke history and comorbidity. Additionally, occipital lobe hemodynamics were also abnormal in children with syndromic moyamoya. Both idiopathic and syndromic moyamoya exhibited executive function deficits, while intellectual ability was impaired in syndromic moyamoya, even without stroke. The analysis revealed that right parietal and white matter hemodynamics explained executive dysfunction, while posterior circulation hemodynamics predicted intellectual ability, suggesting a compensatory role of parietal and posterior hemodynamics in overcoming frontal vulnerability and cognitive impairment.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Clinical Neurology
Alvin S. Das, Morgan McKeown, Stephanie A. Jordan, Karen Li, Robert W. Regenhardt, Steven K. Feske
Summary: This study investigated the risk factors for neurological complications in patients with left-sided infective endocarditis (IE), finding that vegetation size was associated with stroke, mycotic aneurysm was the primary risk factor for intraparenchymal hemorrhage, and prosthetic valves and Staphylococcus aureus infection were related to cerebral microbleeds (CMB).
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Alvin S. Das, Morgan McKeown, Stephanie A. Jordan, Karen Li, Robert W. Regenhardt, Steven K. Feske
Summary: This study investigated the risk factors for different neurological complications in patients with left-sided infective endocarditis (IE), revealing associations between large vegetation size and stroke, mycotic aneurysms and intraparenchymal hemorrhage, as well as prosthetic valves and Staphylococcus aureus infection with cerebral microbleeds (CMB).
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Melissa D. Stockbridge, Julius Fridriksson, Souvik Sen, Leonardo Bonilha, Argye E. Hillis
Summary: This is a forthcoming multicenter, prospective, randomized, double-blind placebo-controlled trial investigating the augmentative effects of escitalopram on language therapy in individuals with post-stroke aphasia. The study aims to examine the drug's independent effect on language, its association with lesion location, and its impact on functional connectivity. The trial plans to enroll 88 participants and assess language improvement through drug therapy and language treatment.
Review
Biochemistry & Molecular Biology
Hilda Martinez-Coria, Isabel Arrieta-Cruz, Roger Gutierrez-Juarez, Hector Eduardo Lopez-Valdes
Summary: Aging leads to reduced homeostasis, increased risk of brain diseases, and death. Chronic inflammation, increased secretion of proinflammatory cytokines, and inflammatory markers are key characteristics of aging. Several neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are associated with aging. Flavonoids, commonly found in plant-based foods, have been studied for their anti-inflammatory effects in vitro and in animal models of stroke and neurodegenerative diseases. However, evidence from human studies is limited. This review highlights the potential of individual natural molecules to modulate neuroinflammation and discusses future research directions for developing new therapeutic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Sergio A. Ramirez-Salazar, Cherie Herren, Jessica McCartney, Jorge G. Ortiz Garcia
Summary: Dietary interventions can play a role in the pathophysiology of common neurological disorders, with plant-based, low-fat, high-fiber diets potentially reducing the burden of these diseases. Common neurological disorders share similar pathophysiological mechanisms, and dietary interventions can influence these processes to improve clinical outcomes.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Medicine, General & Internal
Jordi Kuehne Escola, Bessime Bozkurt, Bastian Brune, Woon Hyung Chae, Lennart Steffen Milles, Doreen Pommeranz, Lena Brune, Philipp Dammann, Ulrich Sure, Cornelius Deuschl, Michael Forsting, Clemens Kill, Christoph Kleinschnitz, Martin Koehrmann, Benedikt Frank
Summary: Stroke mimics are common in the emergency department, and early detection is crucial for initiating appropriate treatment. This study compared the frequency, clinical characteristics, and predictors of non-neurological and neurological stroke mimics in patients with suspected stroke. The results highlighted the importance of awareness of underlying etiologies and differences in clinical characteristics for optimal care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Seyed Hamidreza Rastegar-Moghaddam, Alireza Ebrahimzadeh-Bideskan, Sara Shahba, Amir Mohammad Malvandi, Abbas Mohammadipour
Summary: This article discusses the protective and therapeutic effects of miR-22 on neurological diseases and injuries, as well as its correlation with other diseases. The research provides a new therapeutic perspective for the application of miR-22 in treating neurological disorders.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Immunology
Austin P. Passaro, Abraham L. Lebos, Yao Yao, Steven L. Stice
Summary: Neuroinflammation plays a crucial role in neurological disorders, with recent recognition of the importance of interactions between central and peripheral immune cells. Traditional approaches often separate these systems, but there is significant crosstalk between central and peripheral immune cells in the context of neurological disorders. Targeting these interactions may offer a potential improved therapeutic strategy for addressing failures in clinical translation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Feng Chen, Huiyi Chen, Yanting Chen, Wenyan Wei, Yuanhong Sun, Lu Zhang, Lili Cui, Yan Wang
Summary: Communication between neurons relies on synaptic vesicle exocytosis, a process facilitated by the SNARE complex. Dysfunction of the SNARE complex in synapses may contribute to abnormal neurotransmission and lead to synaptic dysfunction. Research suggests that the SNARE complex could be a significant molecular target in neurological diseases.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Xiuqi Chen, Wenbo Sun, Ping Zhong, Danhong Wu
Summary: This meta-analysis investigated the safety and efficacy of CSF therapy for stroke patients, finding no statistical differences in prognosis but an increase in CD34(+) cell counts in the periphery blood at day 5. These results suggest that CSF may play a role in stroke recovery, although its efficacy in this regard requires further examination.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biophysics
Dmitriy A. Yablonskiy, Alexander L. Sukstanskii, James D. Quirk
NMR IN BIOMEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander L. Sukstanskii, Jie Wen, Anne H. Cross, Dmitriy A. Yablonskiy
MAGNETIC RESONANCE IN MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Wen, Alexander L. Sukstanskii, Dmitriy A. Yablonskiy
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Biochemical Research Methods
Dmitriy A. Yablonskiy, Alexander L. Sukstanskii
JOURNAL OF MAGNETIC RESONANCE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Biao Xiang, Jie Wen, Anne H. Cross, Dmitriy A. Yablonskiy
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2019)
Article
Multidisciplinary Sciences
Jie Wen, Manu S. Goyal, Serguei V. Astafiev, Marcus E. Raichle, Dmitriy A. Yablonskiy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Medicine, General & Internal
Serguei V. Astafiev, Jie Wen, David L. Brody, Anne H. Cross, Andrey P. Anokhin, Kristina L. Zinn, Maurizio Corbetta, Dmitriy A. Yablonskiy
Article
Radiology, Nuclear Medicine & Medical Imaging
Max Torop, Satya V. V. N. Kothapalli, Yu Sun, Jiaming Liu, Sayan Kahali, Dmitriy A. Yablonskiy, Ulugbek S. Kamilov
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Physics, Applied
Alexander L. Sukstanskii, Dmitriy A. Yablonskiy
LOW TEMPERATURE PHYSICS
(2020)
Article
Neurosciences
Dmitriy A. Yablonskiy, Jie Wen, Satya V. V. N. Kothapalli, Alexander L. Sukstanskii
Summary: Non-heme iron is crucial for the structure and functioning of biological tissues, with imbalances potentially leading to neurological disorders. This paper introduces an MRI method that can evaluate the contributions of non-heme iron in the nervous system and assess tissue neuronal density simultaneously.
Article
Neurosciences
Sayan Kahali, Marcus E. Raichle, Dmitriy A. Yablonskiy
Summary: This study used MRI techniques to investigate the relationship between resting-state functional networks and brain cellular constituents, finding that brain cellular composition significantly influences the strength of functional network connections. Different functional networks exhibit a broad distribution of properties, with visual networks with high neuronal density and balanced cellular composition in the DMN showing distinct connectivity characteristics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaojian Xu, Satya V. V. N. Kothapalli, Jiaming Liu, Sayan Kahali, Weijie Gan, Dmitriy A. Yablonskiy, Ulugbek S. Kamilov
Summary: This study introduces two novel learning-based networks for removing motion artifacts in MRI data and estimating quantitative motion- and B0-inhomogeneity-corrected R2* maps. Experimental results demonstrate the effectiveness of these networks in suppressing motion artifacts and preserving image details. Additionally, these networks exploit spatial patterns in the data and offer high computational speed, making them valuable for clinical applications.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Biao Xiang, Matthew R. Brier, Manasa Kanthamneni, Jie Wen, Abraham Z. Snyder, Dmitriy A. Yablonskiy, Anne H. Cross
Summary: This study evaluated qGRE-derived R2t* as an imaging biomarker of progressive multiple sclerosis (MS) and found that reductions in R2t* were associated with neurological impairment. R2t* performed better than other imaging measures in assessing disease progression.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander L. Sukstanskii, Dmitriy A. Yablonskiy
Summary: This paper introduces a lateral diffusion model (LDM) that explains the T-2 and T-1 MRI relaxation properties of macromolecular-bound protons by their dipole-dipole interaction modulated by the lateral diffusion of long lipid molecules forming cellular and myelin membranes. The LDM-derived analytical equations shed new light on relationships between MT parameters and microstructure of cellular and myelin membranes.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biophysics
Sayan Kahali, Satya V. V. N. Kothapalli, Xiaojian Xu, Ulugbek S. S. Kamilov, Dmitriy A. A. Yablonskiy
Summary: This study introduces a deep learning-based method called DANSE for reconstructing quantitative maps of biological tissue properties using MRI. The DANSE method uses a convolutional neural network to estimate R2t* and R2' maps directly from gradient-recalled echo (GRE) magnitude images, reducing sensitivity to noise and magnetic field inhomogeneities. The DANSE model provides improved noise suppression and computational speed compared to traditional methods.
NMR IN BIOMEDICINE
(2023)
