Article
Oncology
Lisanne P. Zijlker, Alexander M. M. Eggermont, Alexander C. J. van Akkooi
Summary: Is there any benefit of continuing routine wide local excision (WLE) for primary stage I/II cutaneous melanoma? A review found no solid prospective evidence to support the use of WLE as a routine approach for completely excised primary cutaneous melanoma. It is recommended to conduct a prospective randomized trial to compare the classical 2-step approach with WLE to abolish the routine practice of WLE in the future.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Sarah Hanna, Serigne N. Lo, Robyn PM. Saw
Summary: Comparing narrow (1-2 cm) and wide (3-5 cm) excision margins, no significant differences were found in locoregional or distant recurrence, metastasis, death, or death due to melanoma. Wide margins (2-5 cm) increased the need for surgical reconstruction.
Article
Oncology
Norma E. Farrow, Jina Kim, Steven Wolf, Samantha M. Thomas, Lindsay Olson, Paul J. Mosca, Georgia M. Beasley, Elisabeth T. Tracy
Summary: Although adult guidelines are often applied to children, age-specific surgical margins have not been defined for pediatric melanoma. This study suggests that wide excision (>1 cm) does not appear to be associated with improved survival in children with melanoma, and more narrow margins (<= 1 cm) may be acceptable.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Otorhinolaryngology
Arya W. Namin, Lauren Welby, Austin T. Baker, Laura M. Dooley
Summary: This retrospective cohort study analyzed the National Cancer Database to identify clinicopathologic features associated with positive margins after surgical treatment of cutaneous melanoma of the head and neck. Increasing age, female sex, specific subsites, ulceration status, different subtypes, and pT classification were found to be significantly associated with positive margins following surgery.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Dermatology
Jonas A. Adalsteinsson, Victoria J. Stoj, Haitham Algzlan, Helen Swede, Richard L. Torbeck, Desiree Ratner
Summary: The literature on Mohs micrographic surgery and staged excision for primary cutaneous melanoma has not been critically reviewed for bias. Of the 48 studies reviewed, 97.9% had serious or critical bias, with poorly defined outcomes being the most common cause. The least frequent form of bias observed was change in intervention. Clear tumor classifications, longer follow-up times, and prospective, randomized study designs are needed to improve the quality of future research.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Surgery
Megan L. Burger, James M. Haggerty, Shengxuan Wang, Jacqueline C. Oxenberg
Summary: This study retrospectively evaluated the impact of depth of excision on recurrence of melanoma. It found that factors such as age, gender, location and type of lesions were associated with recurrence, while biopsy type and depth of excision were not.
Article
Dermatology
Jaclyn Rosenthal Himeles, Maressa C. Criscito, Nayoung Lee, Mary L. Stevenson, John A. Carucci
Summary: There is controversy regarding the optimal surgical modality and recommended margins for treating melanoma in situ (MIS) and invasive melanoma (IM). Staged excision provides excellent margin control and low recurrence rates, but approximately 10% of cases require margins greater than the current recommendations. Additionally, a higher percentage of complex repairs were performed.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Polymer Science
Majd Al-Naji, Helmut Schlaad, Markus Antonietti
Summary: This article discusses recent approaches to reduce the carbon footprint of typical mass polymers by using the biorefinery concept, which involves replacing fossil monomers with those made from regrowing dendritic biomass. New and green catalytic synthetic routes for lactic acid, isosorbide, 2,5-furandicarboxylic acid, and p-xylene are presented, as well as unconventional lignocellulosic biomass-derived monomers like alpha-methylene-gamma-valerolactone and levoglucosenol. The differences in catalytic unit operations of the biorefinery and the challenges that must be addressed during the synthesis of each monomer are also discussed.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Review
Dermatology
Elliott H. Campbell, Olivia M. Crum, Cynthia J. Chelf, Addison M. Demer, Jerry D. Brewer
Summary: Current consensus guidelines have discouraged the use of sub-0.5-cm (in situ) and sub-1-cm (invasive) margins when performing Mohs micrographic surgery (Mohs) for melanoma, with minimal evidence to guide this recommendation.
DERMATOLOGIC SURGERY
(2023)
Article
Immunology
Sonia T. Almeida, Ana Cristina Paulo, Filipe Froes, Herminia de Lencastre, Raquel Sa-Leao
Summary: The study found that the pneumococcal carrier state in healthy adults is more dynamic than generally assumed, with frequent acquisition and often long duration of carriage. This suggests that some adults may act as reservoirs of pneumococci, impacting the potential herd effects achievable through children vaccination depending on the community's social structure. These findings are important for designing strategies to prevent pneumococcal disease in adults.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Oncology
Stergios Boussios, Elie Rassy, Eleftherios Samartzis, Michele Moschetta, Matin Sheriff, Jose Alejandro Perez-Fidalgo, Nicholas Pavlidis
Summary: Melanoma of unknown primary site (MUP) accounts for 3-4% of all melanomas and presents mostly in lymph nodes, subcutaneous sites, and visceral organs. MUP and stage-matched melanoma of known primary site (MKP) share similar prognostic factors, but treatment outcomes vary.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marta Osrodek, Michal Wozniak
Summary: Despite recent advances in the treatment of cutaneous melanoma, challenges remain, including resistance to conventional chemotherapy and limited efficacy of immune checkpoint inhibitors in only a small subset of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Erin Tababa, Hansje-Eva Teulings, Jag Bhawan
Summary: The study found that the measured and adjusted median histologic margins in WLE specimens for both MMIS and T1 type MM were significantly narrower than the recommended surgical margins, which may reflect intentional or unintentional deviation from the recommended guidelines by clinicians.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2021)
Article
Engineering, Industrial
Xingzhi Wang, Yuchen Wang, Fei Tao, Ang Liu
Summary: Big data plays a crucial role in smart customisation, and the integration of physical and virtual entities through digital twin technology enhances responsiveness and predictability in the customisation process.
JOURNAL OF MANUFACTURING SYSTEMS
(2021)
Review
Neurosciences
Sauson Soldozy, Kathleen M. Mulligan, David X. Zheng, Melissa A. Levoska, Christopher R. Cullison, Turki Elarjani, Daniel G. Eichberg, Leonel E. Ampie, Ashish H. Shah, Kaan Yagmurlu, Mark E. Shaffrey, Jeffrey F. Scott, Ricardo J. Komotar
Summary: Current evidence for oncolytic virotherapy treatment of melanoma is mostly limited to T-VEC, with a lack of data specifically regarding brain tumor metastasis. Despite promising findings, further investigation is needed.
