Journal
MACROMOLECULAR BIOSCIENCE
Volume 15, Issue 9, Pages 1283-1295Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500085
Keywords
calcium phosphate bone cement; dendritic glycopolymer; drug release; polyelectrolyte complex
Funding
- German Research Foundation (DFG) [SFB/TR79]
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Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and cellulose sulfate, for the proteasome inhibitor bortezomib. Both DDS are able to induce short-term retarded release of bortezomib from calcium phosphate bone cement in comparison to a burst-release of the drug from bone cement alone. Different release parameters have been evaluated to get a first insight into the release mechanism from bone cements. In addition, biocompatibility of the calcium phosphate cement, modified with the new DDS was investigated using human mesenchymal stromal cells.
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