Article
Spectroscopy
Hugh J. Byrne, Isha Behl, Genecy Calado, Ola Ibrahim, Mary Toner, Sheila Galvin, Claire M. Healy, Stephen Flint, Fiona M. Lyng
Summary: Vibrational spectroscopy, whether based on infrared absorption or Raman scattering, has increasingly attracted attention for biomedical applications. Proof of concept explorations have shown potential for diagnosis of oral potentially malignant disorders and cancer. Raman microspectroscopy is being widely applied for analysis of histological, cytological, and saliva samples, with future prospects for routine in vivo screening.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemical Research Methods
Iwan W. Schie, Clara Stiebing, Juergen Popp
Summary: Different optical modalities have their own advantages and disadvantages in medical diagnostics. While a single modality can only provide a limited view on a specific aspect of a sample, multimodal optical systems can combine multiple advantages to offer a more comprehensive assessment of the sample.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Review
Biochemical Research Methods
Soumyabrata Banik, Sindhoora Kaniyala Melanthota, Arbaaz, Joel Markus Vaz, Vishak Madhwaraj Kadambalithaya, Iftak Hussain, Sibasish Dutta, Nirmal Mazumder
Summary: Smartphone-based imaging devices have a wide range of biomedical applications, including histopathological examination, detection of bacteria and viruses, food technology, and routine diagnosis. The optical arrangement of these devices can be adjusted based on specific requirements, enhancing their versatility and applicability in various settings. These devices are also enhanced with deep learning methods to improve efficiency.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Baptiste Moeglen Paget, Keertana Vinod Ram, Shuyan Zhang, Jayakumar Perumal, Sylvain Vedraine, Georges Humbert, Malini Olivo, U. S. Dinish
Summary: Photonic crystal fibers (PCFs) have unique light-guiding properties and have been widely studied for biomedical applications. PCF-based fluorescence sensors offer highly sensitive detection of biomolecules at low sample volumes. This review discusses recent advancements in fluorescence detection using different PCF configurations and compares them with conventional fluorescence methods. Prospective applications of PCF-based fluorescence sensing and their potential use as optofluidic biopsy needles for clinically relevant biomarker detection are also discussed.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Review
Chemistry, Analytical
Lingyu Shen, Chuanxin Teng, Zhuo Wang, Hongyi Bai, Santosh Kumar, Rui Min
Summary: This article presents an overview of integrated sensors and transmitters in multimaterial optical fibers, discussing their fabrication and postprocessing techniques. It also explores the applications of semiconductor optical fibers in biomedical fields.
Review
Physics, Applied
Nabeel Aslam, Hengyun Zhou, Elana K. Urbach, Matthew J. Turner, Ronald L. Walsworth, Mikhail D. Lukin, Hongkun Park
Summary: Quantum sensors with high sensitivity have opened up new possibilities in biomedical applications. This Review presents the current status of quantum sensing and evaluates the path towards real-world applications at the molecular, cellular, and organism scale. Quantum sensors are transitioning from laboratories to the real world, as evidenced by the growing number of start-ups in this field. The atomic scale and coherence properties of quantum sensors enable unprecedented spatial resolution and sensitivity. Biomedical applications could benefit from these quantum technologies, but evaluating the potential impact of the techniques is often challenging. This Review sheds light on these questions by presenting the current status of quantum sensing applications and discussing their path towards commercialization. Two promising quantum sensing platforms, optically pumped atomic magnetometers and nitrogen-vacancy centers in diamond, are highlighted. The broad spectrum of biomedical applications is emphasized through four case studies ranging from brain imaging to single-cell spectroscopy.
NATURE REVIEWS PHYSICS
(2023)
Article
Oncology
David Reichert, Lisa I. Wadiura, Mikael T. Erkkilae, Johanna Gesperger, Alexandra Lang, Thomas Roetzer-Pejrimovsky, Jessica Makolli, Adelheid Woehrer, Marco Wilzbach, Christoph Hauger, Barbara Kiesel, Marco Andreana, Angelika Unterhuber, Wolfgang Drexler, Georg Widhalm, Rainer A. Leitgeb
Summary: Optical imaging of autofluorescence is a powerful tool for monitoring metabolic changes and transformation in brain tumors. The increase in protein-bound FMN fluorescence in brain tumors indicates a shift toward a more glycolytic metabolism. These metrics show promise for machine learning based brain tumor classification.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Teodoro Garcia-Millan, Javier Ramos-Soriano, Mattia Ghirardello, Xia Liu, Cristina Manuela Santi, Jean-Charles Eloi, Natalie Pridmore, Robert L. Harniman, David J. Morgan, Stephen Hughes, Sean A. Davis, Thomas A. A. Oliver, Kathreena M. Kurian, M. Carmen Galan
Summary: This study presents a new type of fluorescent probe material called nontoxic carbon dots, which can be used in biomedical diagnostic applications. The researchers successfully synthesized carbon dots with high emission efficiency and dual-emission properties, and analyzed their composition and properties using various analytical techniques. Furthermore, the utility of this fluorescent probe was demonstrated in clinical settings, where it was used for immunohistochemical staining of human brain tissues and achieved dual-channel detection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Kamel Guedri, Adnan, Zehba Raizah, Elsayed Tag Eldin, M. A. El-Shorbagy, Waseem Abbas, Umar Khan
Summary: This study explores the extensive applications of nanofluids in biomedical engineering, the electronics industry, and applied thermal and mechanical engineering, as well as the interaction between Al2O3-Fe3O4 hybrid nanoparticles and blood. Mathematical modeling and numerical techniques are used to understand the actual behavior under different parameter ranges.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Ruihao Ding, Danqing Liu, Yu Feng, Haoxin Liu, Hongrui Ji, Liangcan He, Shaoqin Liu
Summary: Optical imaging has a wide range of applications in the biomedical field, providing visualization of physiological processes and aiding in disease diagnosis and treatment. Unexcited light source imaging technologies, such as chemiluminescence imaging, bioluminescence imaging and afterglow imaging, have gained attention due to their lack of excitation light interference, high sensitivity, and high signal-to-noise ratio. This review highlights the latest advances in unexcited light source imaging technology for biomedical applications, discussing the design strategies of luminescent probes, their applications in various imaging modalities, and the future prospects of unexcited light source imaging for medical applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Aizong Shen, Lei Zhang, Yanbo Xie, Xueyu Zhu, Jinming Hu, Shiyong Liu
Summary: Synthetic polymers have been widely used in biomedical fields for imaging and therapeutic purposes. Discrete polymers, characterized by precise molecular weight and no molecular weight distribution, have shown promising potential in optical imaging, magnetic resonance imaging, and therapeutic applications. The development of efficient synthetic strategies and further (pre)clinical studies are needed to facilitate the clinical translation of discrete polymers into precision nanomedicines.
Review
Biotechnology & Applied Microbiology
Pisrut Phummirat, Nicholas Mann, Daryl Preece
Summary: Optical tweezers have been proven as a useful tool for improving human understanding of the microscopic world with broad applications across science since their inception. In recent years, they have found appealing applications in the field of biomedical engineering, particularly with the utilization of metallic nanostructures like gold nanoparticles. Recent research progress in utilizing optically trapped gold nanomaterials for bioengineering problems has been highlighted, with discussions on challenges and future directions in this field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yinglong Wu, Fang Zeng, Yanli Zhao, Shuizhu Wu
Summary: Optoacoustic imaging is a hybrid biomedical imaging technique that uses contrast agents to generate ultrasound waves in tissues, producing high-resolution images. Multispectral optoacoustic imaging can discriminate signals from different contrast agents and enable specific agent identification in tissues, as well as simultaneous molecular and physiological imaging. Contrast agents play essential roles in optoacoustic imaging, with various new agents being explored and applied in recent years.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Tomasz Koczorowski, Arleta Glowacka-Sobotta, Stepan Sysak, Dariusz T. Mlynarczyk, Roman Lesyk, Tomasz Goslinski, Lukasz Sobotta
Summary: This study gathers and analyzes the latest research results on BODIPY-conjugated metallic nanoparticles, exploring their practicality in the diagnosis and treatment of tumor ailments as well as in sensing of heavy metals, and presents specific examples.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Sergio A. Bernal-Chavez, Maria Luisa Del Prado-Audelo, Isaac H. Caballero-Floran, David M. Giraldo-Gomez, Gabriela Figueroa-Gonzalez, Octavio D. Reyes-Hernandez, Manuel Gonzalez-Del Carmen, Maykel Gonzalez-Torres, Hernan Cortes, Gerardo Leyva-Gomez
Summary: Nanoparticles have great potential for various biomedical applications, but their in vivo use requires sterility. Different sterilization methods can impact the physicochemical properties of nanoparticles.
Article
Dentistry, Oral Surgery & Medicine
B. J. Merema, J. Kraeima, M. J. H. Witjes, N. B. van Bakelen, F. K. L. Spijkervet
Summary: This study validated the accuracy of patient-specific TMJ-TJR prosthesis in a clinical setting, demonstrating that surgical planning and placement of G-TMJ-TJR prosthesis can be predictably and accurately performed.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Joep Kraeima, Haye H. Glas, Bram Barteld Jan Merema, Arjan Vissink, Fred K. L. Spijkervet, Max J. H. Witjes
Summary: This paper reviews the latest methods for 3D virtual surgical planning in oral squamous cell carcinoma surgery, including image multi-modality fusion and new technological strategies. These strategies aim to improve the accuracy, predictability, and safety of treatment.
Editorial Material
Dentistry, Oral Surgery & Medicine
Max J. H. Witjes, Arjan Vissink
Article
Biochemical Research Methods
Anouk L. Post, Dirk J. Faber, Henricus J. C. M. Sterenborg, Ton G. van Leeuwen
Summary: The study developed a model for spectral measurements and validated it through simulations. Experimental validation was conducted to assess the model's feasibility, and a parameterization method was proposed to prevent overfitting. The parameterization improved fitting speed and enabled single fiber measurements.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Review
Emergency Medicine
Nick Assink, Inge H. F. Reininga, Kaj ten Duis, Job N. Doornberg, Harm Hoekstra, Joep Kraeima, Max J. H. Witjes, Jean-Paul P. M. de Vries, Frank F. A. IJpma
Summary: This systematic review provides an overview of the current applications of 3D technologies in surgical management of tibial plateau fractures. The study found that 3D-assisted surgery can reduce operation time, blood loss, and fluoroscopy frequency, with no significant differences in functional outcomes.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Health Care Sciences & Services
Bingjiang Qiu, Jiapan Guo, Joep Kraeima, Haye Hendrik Glas, Weichuan Zhang, Ronald J. H. Borra, Max Johannes Hendrikus Witjes, Peter M. A. van Ooijen
Summary: This study proposed a novel CNN-based 3D mandible segmentation method, named RCNNSeg, which can accurately segment detailed anatomical structures on complete 3D CT scans. By adopting the structure of recurrent neural networks, RCNNSeg achieves connectivity between adjacent nodes, and the evaluation results demonstrate the superiority of RCNNSeg over EDCNN-based methods on two datasets.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Health Care Sciences & Services
Bingjiang Qiu, Hylke van der Wel, Joep Kraeima, Haye Hendrik Glas, Jiapan Guo, Ronald J. H. Borra, Max Johannes Hendrikus Witjes, Peter M. A. van Ooijen
Summary: Medical imaging techniques, such as computed tomography and magnetic resonance imaging, are crucial in oral and maxillofacial surgery, but segmentation of the mandible remains challenging due to complex structures and high attenuation materials that cause noise and artifacts. With advancements in computer vision, automatic segmentation algorithms have been developed to tackle this issue.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
J. Vonk, F. J. Voskuil, J. G. de Wit, W. T. Heeman, W. B. Nagengast, G. M. van Dam, R. A. Feijen, A. G. W. Korsten-Meijer, B. van der Vegt, M. J. H. Witjes
Summary: The study investigated the potential application of VEGF-targeted near-infrared fluorescent tracer in SNIP surgery, demonstrating the real-time localization of SNIP tissue during surgery through fluorescence molecular imaging to improve the completeness of surgical resection.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Lone E. Forner, Francois J. Dieleman, Richard J. Shaw, Anastasios Kanatas, Chris J. Butterworth, Goran Kjeller, Jan Alsner, Jens Overgaard, Soren Hillerup, Ole Hyldegaard, Per Arnell, Christian von Buchwald, Johannes H. A. M. Kaanders, Ludi E. Smeele, Lena Specht, Jorgen Johansen, Max J. H. Witjes, Matthias A. W. Merkx, Erik C. Jansen
Summary: This study investigated the effect of hyperbaric oxygen treatment on osteoradionecrosis (ORN) of the mandible through two randomized controlled multicentre trials. The results showed that hyperbaric oxygen did not significantly improve the healing outcome of ORN after surgical removal of necrotic bone. However, it was associated with improved xerostomia, salivary flow rate, and dysphagia.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Esther Kho, Behdad Dashtbozorg, Joyce Sanders, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke van Duijnhoven, Henricus J. C. M. Sterenborg, Theo J. M. Ruers
Summary: Developing algorithms for analyzing hyperspectral images as an intraoperative tool for margin assessment during breast-conserving surgery requires a dataset with reliable histopathologic labels. By comparing tissue slices and lumpectomy datasets, using wavelengths with appropriate penetration depth to develop tissue classification algorithms was explored. Spectral differences between tissue slices and lumpectomy datasets were observed, affecting the discrimination of different tissue types.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Floris J. Voskuil, Jasper Vonk, Bert van der Vegt, Schelto Kruijff, Vasilis Ntziachristos, Pieter J. van der Zaag, Max J. H. Witjes, Gooitzen M. van Dam
Summary: In this Perspective, the current clinical standards for intraoperative tissue analysis are described, along with potential clinical implementations of intraoperative imaging for pathology-assisted surgery. Different clinical settings and tumor types determine the choice of intraoperative imaging techniques and contrast agents.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Oncology
Willem H. Schreuder, Astrid Lipplaa, Arjen H. G. Cleven, Henk van den Berg, Peter H. Bisschop, Renate T. de Jongh, Max J. H. Witjes, Peter A. W. H. Kessler, Matthias A. W. Merkx, Esther Edelenbos, Cornelis Klop, Ruud Schreurs, Anneke M. Westermann, Jacqueline M. Tromp, Henriette Levenga, Hans Gelderblom, Jan de Lange
Summary: This study retrospectively evaluated the efficacy and safety of a one-year denosumab protocol in giant cell lesions of the jaw (GCLJ). The results showed a 100% objective tumor response rate and a median progression-free survival of 50.4 months. The treatment was well tolerated with no interruptions due to toxicity. However, the high relapse rate after treatment cessation remains a major obstacle for denosumab to become the standard treatment for GCLJ.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Emergency Medicine
Nick Assink, Joep Kraeima, Anne M. L. Meesters, Mostafa El Moumni, Eelke Bosma, Robert J. Nijveldt, Sven H. van Helden, Jean-Paul P. M. de Vries, Max J. H. Witjes, Frank F. A. IJpma
Summary: A novel 3D measurement method was developed to assess fracture displacement and its association with the risk of conversion to total knee arthroplasty (TKA). The study found that an initial 3D gap area ≥550 mm² was independently associated with conversion to TKA. Different prognostic groups based on the range of 3D gap area were identified, and the survival rate of the knee without conversion to TKA was assessed through Kaplan-Meier curves.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Emergency Medicine
Nick Assink, Miriam G. E. Oldhoff, Kaj ten Duis, Joep Kraeima, Job N. Doornberg, Max J. H. Witjes, Jean-Paul P. M. de Vries, Anne M. L. Meesters, Frank F. A. IJpma
Summary: This study aimed to assess whether patient-specific osteosyntheses could facilitate proper fracture reduction in medial tibial plateau fractures. Custom-made osteosynthesis plates with drilling guides were used to accurately place screws and improve fracture reduction and tibial alignment.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Oncology
Lisanne L. de Boer, Esther Kho, Koen K. van de Vijver, Marie-Jeanne T. F. D. Vranken Peeters, Frederieke van Duijnhoven, Benno H. W. Hendriks, Henricus J. C. M. Sterenborg, Theo J. M. Ruers
Summary: DRS has the potential to guide surgeons intraoperatively by characterizing tissue and discriminating between healthy and malignant tissues, including diseases like ductal carcinoma in situ. However, further research is needed to fully understand its optical characteristics and capabilities in characterizing mixed tissue types.
BREAST CANCER RESEARCH
(2021)
