Article
Immunology
Liping Xu, Xinwei Song, Qiaoding Dai, Tianrong Guan, Yan Zhang, Na Lin, Ji-an Wang
Summary: This case report highlights the efficacy of Belimumab in treating refractory Lupus Cystitis, with significant improvements in symptoms, urinary markers, and protein levels observed in the patient. No relapse of lupus cystitis or SLE activity occurred during the 10-month follow-up period, demonstrating positive outcomes with Belimumab treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Nicoleta Dima, Ioana Bratoiu, Ciprian Rezus, Alexandra Maria Burlui, Damiana Costin, Luana Andreea Macovei, Elena Rezus
Summary: Interstitial lung disease (ILD) is a serious manifestation of connective tissue diseases (CTD) that requires thorough evaluation and treatment. The prevalence of ILD in systemic lupus erythematosus (SLE) is still debated, but it is crucial to exclude an overlap syndrome for an accurate diagnosis. Increasing the identification of SLE-associated ILD cases is important, and various treatment options are being proposed. Systemic sclerosis (SSc)-associated ILD is a leading cause of mortality and should be investigated in all SSc patients. Progress has been made in the treatment of ILD, with tyrosine kinases inhibitor Nintedanib showing promising results in reducing the progression rate compared to placebo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Review
Chemistry, Medicinal
Salvatore Di Bartolomeo, Alessia Alunno, Francesco Carubbi
Summary: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with a wide range of clinical manifestations. The respiratory system can be involved in up to 50-70% of patients, with varying severity and treatment approaches depending on specific patterns.
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Wanxian Pang, Fengbiao Guo, Lawei Yang, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. This review explores the mechanisms of SLE pathogenesis, focusing on the impact of lifestyle factors. Studies have found associations between diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption, and SLE susceptibility. The review summarizes these relationships and outlines directions for future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Weijie Wang, Yongsheng Fan, Xinchang Wang
Summary: This review discusses the dual role of Lactobacillus in systemic lupus erythematosus (SLE), as it can both affect the development of SLE and have therapeutic and anti-inflammatory effects. The involvement of Lactobacillus in SLE sheds light on the understanding of its development and provides evidence for the development of microbiota-targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haitao Yu, Yasuo Nagafuchi, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease characterized by immune dysfunction. Clinical and immunological biomarkers are crucial for diagnosing, assessing, and controlling SLE, including novel biomarkers discovered through omics research.
Review
Immunology
Qian Chen, Jie Wang, Mengmeng Xiang, Yilun Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This review summarizes the potential links between ferroptosis and systemic lupus erythematosus (SLE), elucidates the role of ferroptosis in SLE pathogenesis, and proposes a new therapeutic strategy for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Swayanka Biswas, Katja Bieber, Rudolf Armin Manz
Summary: IL-10 is a cytokine that has pleiotropic effects on immune cells, including both suppressive and activating functions. It plays a dual role in Systemic lupus Erythematosus (SLE), inhibiting pro-inflammatory effector functions while also promoting extrafollicular antibody response. IL-10 is produced by B cells, myeloid cells, and certain T cell subsets, and it drives B cell responses, proliferation, class switching, and plasma cell formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Cristina Cocco, Elias Manca, Giulia Corda, Maria Maddalena Angioni, Barbara Noli, Mattia Congia, Francesco Loy, Michela Isola, Elisabetta Chessa, Alberto Floris, Lorena Lorefice, Luca Saba, Alessandro Mathieu, Gian Luca Ferri, Alberto Cauli, Matteo Piga
Summary: Brain-reactive autoantibodies are found in patients with SLE and NPSLE, with higher frequency and titers observed in NPSLE patients. The target antigens of these autoantibodies are still undetermined, but they likely include β2GPI.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai
Summary: This study investigated the alteration of oxylipins in the serum of systemic lupus erythematosus (SLE) patients and identified potential biomarkers for SLE classification. The results showed that certain oxylipins were correlated with lupus nephritis (LN) and SLE disease activity. Additionally, a combination of 5 oxylipins was found to have high accuracy in classifying SLE patients. The findings provide insights into the characteristics of SLE and the development of new tools for classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Multidisciplinary
Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown pathogenesis and heterogeneous clinical manifestations. By conducting glycomic analyses, we identified two N-glycans on serum immunoglobulin G (IgG) as excellent diagnostic biomarkers for SLE, with specificity and suitability for all stages of the disease. These findings are important for the early and precise diagnosis of SLE and provide insights into the pathogenic factors of the disease.
Article
Rheumatology
J. H. Koh, S. K. Kwok, J. Lee, C. N. Son, J-M Kim, H. O. Kim, S. H. Park, Y. K. Sung, J. Y. Choe, S. S. Lee, S. H. Park
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2017)
Article
Medicine, General & Internal
Seo Hwa Kim, Haneul Kim, Seungju Kim, Seungln Paek, Jung Hee Koh, Jennifer Lee, Yong-Won Cho, Sung-Hwan Park
JOURNAL OF KOREAN MEDICAL SCIENCE
(2018)
Article
Rheumatology
Jennifer Lee, Jung Hee Koh, Ji-Won Kim, Yoon-Kyoung Sung, Shin-Seok Lee, Jung Yoon Choe, Seung-Cheol Shim, Hyun-Sook Kim, Hae-Rim Kim, Ji-Min Kim, Sung Ryul Kwon, Hyun-Ok Kim, Kichul Shin, Chang Hoon Lee, So-Hyang Chung, Seung-Ki Kwok, Ji Hyeon Ju, Sung-Hwan Park
RHEUMATOLOGY INTERNATIONAL
(2018)
Article
Rheumatology
Jung Hee Koh, Eun-Kyoung Park, Han-Na Lee, Yunkyung Kim, Geun-Tae Kim, Young Sun Suh, Hyun-Ok Kim, Seung-Geun Lee
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Ji-Won Kim, Jin-Sun Kong, Saseong Lee, Seung-Ah Yoo, Jung Hee Koh, Jingchun Jin, Wan-Uk Kim
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Article
Medicine, General & Internal
Jung Hee Koh, Hanna Lee, Seung-Geun Lee
Summary: This study investigated the efficacy of intra-articular glucocorticoid injections (IAGI) in short- and long-term treatment of rheumatoid arthritis (RA). Results show that IAGI can help achieve early disease remission, particularly in the wrist joints, which are more prone to joint damage and require more aggressive treatment.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jung Hee Koh, Sang Jun Yoon, Mina Kim, Seonghun Cho, Johan Lim, Youngjae Park, Hyun-Sook Kim, Sung Won Kwon, Wan-Uk Kim
Summary: Changes in lipid profile in rheumatoid arthritis can serve as potential biomarkers for tracking and treating the disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Rheumatology
Youngjae Park, Mei-Ling Li, Ji-Won Kim, Jung Hee Koh, Yune-Jung Park, Wan-Uk Kim
Summary: Cumulative activity better reflects the radiographic progression of rheumatoid arthritis (RA) than measurement of activity at a single time point, and cumulative swollen joint count (SJC) shows the best predictive performance for radiographic progression.
JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Jung Hee Koh, Bong-Woo Lee, Wan-Uk Kim
JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jung Hee Koh, Yusun Lee, Hyoun-Ah Kim, Jinhyun Kim, Kichul Shin
Summary: This study investigated and compared remission rates in rheumatoid arthritis (RA) patients treated with different types of biologic or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) from 2013 to 2019. The results showed that using the clinical disease activity index (CDAI), simplified disease activity index (SDAI), or Boolean criteria to assess sustained remission was more stringent, but consistent with the DAS28-based criteria in RA patients treated with b/tsDMARDs.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Rheumatology
J. H. Koh, S-K Lee, J. Kim, H-A Kim, K. Shin, J-K Min
Summary: The study evaluated the clinical outcomes and safety of b/tsDMARDs in elderly RA patients, finding that male sex and non-smoking were associated with better treatment responses. ILD was identified as a key comorbidity affecting adverse events.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Jung Hee Koh, Saseong Lee, Hyun-Sook Kim, Kyuheon Lee, Chang Seop Lee, Seung-Ah Yoo, Naeun Lee, Wan-Uk Kim
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Medicine, General & Internal
Kyung Min Ko, Su-Jin Moon, Jung Hee Koh, Chi-Un Pae, Jun-Ki Min
YONSEI MEDICAL JOURNAL
(2020)
Article
Rheumatology
Dong Hyun Sohn, Hoim Jeong, Jong Seong Roh, Han-Na Lee, Eunsung Kim, Jung Hee Koh, Seung-Geun Lee
RHEUMATOLOGY INTERNATIONAL
(2018)
Editorial Material
Biochemistry & Molecular Biology
Jung Hee Koh, Wan-Uk Kim
EXPERIMENTAL AND MOLECULAR MEDICINE
(2017)