Article
Oncology
Pannaga Malalur, Manas Agastya, Sandhya Wahi-Gururaj, Chad L. Cross, Delva Deauna-Limayo, Edwin C. Kingsley
Summary: The study indicates that patients with hematologic malignancies make significant lifestyle changes post-diagnosis, with smoking reduction being the most prominent. Utilization of support systems correlates with improved diet and decreased smoking years.
Article
Biotechnology & Applied Microbiology
Alessia Gravina, Grigol Tediashvili, Raja Rajalingam, Zoe Quandt, Chad Deisenroth, Sonja Schrepfer, Tobias Deuse
Summary: Engineered overexpression of CD64 protects cells from antibody-mediated killing, enhancing the efficacy of allogeneic cell therapeutics for cancer therapy or regenerative medicine.
NATURE BIOTECHNOLOGY
(2023)
Article
Hematology
Jian Mao, Rong Dai, Rui-Chan Du, Yan Zhu, Li-Ping Shui, Xiao-Hua Luo
Summary: Hematologic changes in recovered COVID-19 patients are associated with disease severity and clinical outcomes, suggesting the need for further exploration of underlying mechanisms.
ANNALS OF HEMATOLOGY
(2021)
Article
Immunology
Jingquan He, Donger Tang, Dongzhou Liu, Xiaoping Hong, Chiyu Ma, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Jie Du, Lin Kang, Lianghong Yin, Qianjin Lu, Yong Dai
Summary: Proteomics and metabolomics analyses of serum from SLE patients and healthy individuals revealed significant changes in 90 proteins and 76 metabolites. Several apolipoproteins and a metabolite were associated with disease activity, while others were correlated with renal function. Using these significantly changed molecules, a random forest model identified potential biomarkers for SLE diagnosis.
CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Jiram Torres-Ruiz, Marina Rull-Gabayet, Nancy R. Mejia-Dominguez, Daniel Alberto Carrillo-Vazquez, Juan Alberto Reyes-Islas, Fabiola Cassiano-Quezada, Jennifer Cuellar-Rodriguez, Juan Sierra-Madero, Jessica Marquez Sanchez, Jesus Salvador Serrano-Garcia, Alexia Esquinca Gonzalez, Guillermo Juarez-Vega, Miguel Tapia-Rodriguez, Diana Gomez-Martin
Summary: This study aims to investigate the relationship between disease activity in systemic lupus erythematosus (SLE) and functional parameters of innate immunity. The results show that disease activity plays a key role in regulating respiratory burst, phagocytosis, and production of neutrophil extracellular traps in SLE patients. Additionally, the proportion of monocyte subsets varies according to SLE disease activity.
CLINICAL RHEUMATOLOGY
(2023)
Article
Immunology
Lijuan Jiang, Xiaoxiao Han, Wenlin Qiu, Tong Yu, Ruizhi Feng, Xuefei Wang, Xiaoru Duan, Guo-Min Deng
Summary: This study investigated the role of CD64 in SLE patients and animal models. The results showed that CD64 expression was increased in SLE patients and correlated with SLE progression and related indicators. In animal models, CD64 was associated with lupus pathogenesis and played a regulatory role in skin inflammation induced by lupus serum.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Gordana Petrovic, Srdjan Pasic, Ivan Soldatovic
Summary: The study aims to evaluate the impact of antiphospholipid antibodies on the clinical manifestations and outcomes of childhood-onset systemic lupus erythematosus (cSLE) patients. The presence of antiphospholipid antibodies is associated with higher disease activity and greater tissue damage in cSLE patients. Patients with antiphospholipid antibodies have a more than two-fold increased risk of tissue damage compared to those without.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Hend Mehawed Soliman, Balsam Sherif Fahmy, Moataz Gamal Ali, Eman Shafik Shafie
Summary: This study revealed a relationship between serum prolactin levels and juvenile SLE disease, with a significant correlation between hyperprolactinemia and neurological manifestations in SLE patients.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Lei Zhang, Jie-Yuan Cui, Lin Zhang
Summary: This retrospective real world clinical study investigated the effectiveness and safety of sirolimus in childhood-onset systemic lupus erythematosus. The study found that sirolimus was associated with a decrease in disease activity and the ability to tolerate tapering of oral glucocorticoid dose.
Article
Oncology
Qian Wang, Nan Zhang, Li Liu, Linlu Ma, Yuxin Tan, Xiaoyan Liu, Jinxian Wu, Guopeng Chen, Xinqi Li, Yuxing Liang, Fuling Zhou
Summary: By investigating the immunophenotypic molecules CD11b and CD64, it was found that CD11b(+)CD64(+) is associated with the prognosis and leukemogenesis of AML, and has potential biological functions including immune checkpoint regulation, tumor microenvironment alteration, and drug sensitivity.
Article
Medical Laboratory Technology
Zhicheng Ye, Tao Zhang, Menghua Xu, Jin Xu
Summary: This study evaluated sST2 as a potential biomarker in pediatric systemic lupus erythematosus (SLE) patients, and found that sST2 levels were associated with disease activity and other laboratory test results.
CLINICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Jiarong Li, Xuan Wang, Tingting Xie, Wei Lin, Hui Yang, Tianwen Li, Ke Xu, Bingjie Zhang, Xiaoye Qu, Huali Zhang, Wangbin Ning, Sijia Liu, Tong Li, Xiaoxia Zuo, Shaohui Liu, Weiru Zhang
Summary: Hypothyroidism is more prevalent in patients with SLE, and it is associated with conditions like high blood pressure, renal disorder, high serum creatinine, and high SLEDAI score. Factors such as albumin, platelet count, serum creatinine, and anti-dsDNA antibodies are correlated with hypothyroidism. Free tri-iodothyronine is negatively correlated with SLEDAI score.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Cell Biology
Da-Cheng Wang, Wang-Dong Xu, Zhen Qin, Lu Fu, You-Yu Lan, Xiao-Yan Liu, An-Fang Huang
Summary: This study established a machine learning model to identify SLE patients with high disease activity by selecting features like hematuria, proteinuria, and pyuria. The model's performance was evaluated, with the LGB model showing the best results and naive bayes performing the worst.
INFLAMMATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Liyan Li, Qianwei Miao, Fanqiang Meng, Baoqi Li, Tianyuan Xue, Tianliang Fang, Zhirang Zhang, Jinxie Zhang, Xinyu Ye, Yang Kang, Xingding Zhang, Qian Chen, Xin Liang, Hongbo Chen, Xudong Zhang
Summary: By overexpressing CD64 on cell membrane nanovesicles and encapsulating PD-L1 antibody and chemotherapeutic agent CP, the CD64-NVs-aPD-L1-CP can simultaneously disrupt the immunosuppressive effect of PD-L1, decrease the inhibition of Tregs, enhance the tumor elimination by T cells, suppress tumor growth, and extend survival time, making them charismatic carriers for combined cancer immunotherapy.
Article
Immunology
Jianming Wu, Yunfang Li, Aaron Rendahl, Maneesh Bhargava
Summary: This study identified three novel FCGR1A genetic variants and found that these variants were associated with CD64 expression level, phagocytosis, and immune response. Furthermore, FCGR1A genotypes were also associated with sarcoidosis susceptibility and severity. These findings suggest the potential role of FCGR1A genetic variants in immune response and the development of sarcoidosis.
FRONTIERS IN IMMUNOLOGY
(2022)