Article
Oncology
Ke Chen, Yu Pan, Chao-jie Huang, Qi-long Chen, Ren-chao Zhang, Miao-zun Zhang, Guan-yu Wang, Xian-fa Wang, Yi-ping Mou, Jia-fei Yan
Summary: Comparing laparoscopic pancreatic resection with open surgery for pancreatic ductal adenocarcinoma, it was found that laparoscopic procedures have advantages in terms of surgical and oncological outcomes. However, both approaches showed similar postoperative outcomes and long-term survival among patients.
Article
Oncology
Mushegh A. Sahakyan, Caroline S. Verbeke, Tore Tholfsen, Dejan Ignjatovic, Dyre Kleive, Trond Buanes, Kristoffer Lassen, Bard I. Rosok, Knut Jorgen Labori, Bjorn Edwin
Summary: The study found that the status of resection margins in DP surgeries for PDAC depends on the meticulousness and standardization of pathology examination, and involvement of the anterior pancreatic surface affects prognosis.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Qingbo Feng, Chuang Jiang, Xuping Feng, Yan Du, Wenwei Liao, Hongyu Jin, Mingheng Liao, Yong Zeng, Jiwei Huang
Summary: This meta-analysis found no significant differences in operative time, tumor size, and lymph node dissection between RDP and LDP, but RDP may have a higher R0 resection rate compared to LDP.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Maia Blomhoff Holm, Caroline Sophie Verbeke
Summary: Pancreatic cancer has a poor prognosis, and surgical resection is the only curative treatment option. However, there is limited data on the prognostic impact of the resection margin status in distal pancreatectomy specimens, and the existing studies show divergent results due to small sample sizes and heterogeneity in pathology examination practices.
Article
Oncology
M. Korrel, S. Lof, J. van Hilst, A. Alseidi, U. Boggi, O. R. Busch, S. van Dieren, B. Edwin, D. Fuks, T. Hackert, T. Keck, I Khatkov, G. Malleo, I Poves, M. A. Sahakyan, C. Bassi, M. Abu Hilal, M. G. Besselink
Summary: This international study identified factors such as resection of Gerota's fascia, R0 resection, and decreased lymph node ratio as predictors for improved overall survival after distal pancreatectomy for pancreatic ductal adenocarcinoma. Surgeons should focus on achieving R0 resection and adequate lymphadenectomy, with consideration of Gerota's fascia resection in their routine surgical approach.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jaewoo Kwon, Sung Ryol Lee, Seo Young Park, Jae Hoon Lee, Ki Byung Song, Dae Wook Hwang, Jun Ho Shin, Song Cheol Kim
Summary: This study found that R1 resection margin after distal pancreatectomy was associated with poor survival and early recurrence. There was no significant difference in recurrence pattern between R0 and R1. Among the recurrence patterns, peritoneal carcinomatosis showed the worst prognosis.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Oncology
Ji-Hye Jung, So-Jeong Yoon, Ok-Joo Lee, Sang-Hyun Shin, Jin-Seok Heo, In-Woong Han
Summary: This study aimed to evaluate the R0 resection rate and postoperative outcomes of completion total pancreatectomy (cTP) performed due to intraoperative positive margin. The study found that the R0 rate of cTP in cases with positive resection margin was 84% and the overall 5-year survival rate was 8%. Compared to the pancreaticoduodenectomy (PD) R0 group, the 5-year survival rate was significantly lower in the cTP R0 group.
Article
Surgery
Hussein H. Khachfe, Abdulrahman Y. Hammad, Samer AlMasri, Annissa deSilva, Jasmine Kraftician, Kenneth K. Lee, Amer H. Zureikat, Alessandro Paniccia
Summary: This study aimed to investigate the impact of obesity on adverse postoperative outcomes in patients undergoing distal pancreatectomy for pancreatic ductal adenocarcinoma (PDAC). The results showed a significantly higher risk of postoperative pancreatic fistula in obese patients. Therefore, obesity should be considered as a risk factor in fistula risk calculators for this procedure.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Veterinary Sciences
Yusuke Tsukada, Young Tae Park, Ikki Mitsui, Masahiro Murakami, Atsushi Tsukamoto
Summary: This case report describes a rare case of sclerosing encapsulating peritonitis (SEP) in a French Bulldog with pancreatic ductal adenocarcinoma. The dog presented with chronic vomiting and imaging results revealed peritoneal effusion with a thickened peritonium. The dog ultimately died due to peritoneal dissemination and distant metastasis of the pancreatic adenocarcinoma.
BMC VETERINARY RESEARCH
(2022)
Article
Oncology
Piera Leon, Fabio Giannone, Giulio Belfiori, Massimo Falconi, Stefano Crippa, Ugo Boggi, Francesca Menonna, Abdul Rahman Al Sadairi, Tullio Piardi, Laurent Sulpice, Andrea Gardini, Valentina Sega, Mircea Chirica, Ferruccio Ravazzoni, Giusy Giannandrea, Patrick Pessaux, Vito de Blasi, Francis Navarro, Fabrizio Panaro
Summary: CR-POPF is a major complication after DP but it did not affect the postoperative therapeutic path or long-term oncologic outcomes. The study found that CR-POPF was not a predictive factor for disease recurrence and was not associated with an increased incidence of peritoneal or local relapse.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Toshitaka Sugawara, Daisuke Ban, Jo Nishino, Shuichi Watanabe, Aya Maekawa, Yoshiya Ishikawa, Keiichi Akahoshi, Kosuke Ogawa, Hiroaki Ono, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe
Summary: The model utilizing multiple preoperative factors can enhance the prediction of early resectable PDAC recurrence, aiding in the adjustment of treatment strategies.
Article
Oncology
Danilo Hackner, Mirianna Hobbs, Susanne Merkel, Timo Siepmann, Christian Krautz, Georg F. Weber, Robert Gruetzmann, Maximilian Brunner
Summary: This retrospective study aimed to evaluate the impact of age on postoperative short-term and long-term outcomes in patients undergoing curative pancreatic resection for pancreatic ductal adenocarcinoma (PDAC). The study found that despite older age, pancreatic resections had comparable short-term outcomes. However, age significantly influenced overall and disease-free survival in PDAC patients undergoing primary resection in curative intent, emphasizing the importance of individualizing treatment decisions based on age.
Article
Gastroenterology & Hepatology
Dakyum Shin, Jaewoo Kwon, Jae Hoon Lee, Seo Young Park, Yejong Park, Woohyung Lee, Ki Byung Song, Dae Wook Hwang, Song Cheol Kim
Summary: This study investigated the efficacy and feasibility of robotic distal pancreatectomy (RDP) for pancreatic ductal adenocarcinoma (PDAC). The results showed that RDP had longer operative time, higher cost, but a higher likelihood of achieving R0 margins compared to laparoscopic distal pancreatectomy (LDP). The postoperative survival was similar between the two groups.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Article
Surgery
Giuseppe Malleo, Laura Maggino, Gabriella Lionetto, Alex Patton, Salvatore Paiella, Antonio Pea, Alessandro Esposito, Luca Casetti, Claudio Luchini, Aldo Scarpa, Claudio Bassi, Roberto Salvia
Summary: This study analyzed a large dataset without any censored events to evaluate the survival outcomes of pancreatic ductal adenocarcinoma patients after pancreatectomy. The results showed a 5-year empirical survival rate of 27.5% and a time-varying structure of prognostic variables. Unobserved tumor characteristics were found to have a substantial impact on disease progression.
Article
Surgery
Sanne Lof, Maarten Korrel, Jony van Hilst, Alma L. Moekotte, Claudio Bassi, Giovanni Butturini, Ugo Boggi, Safi Dokmak, Bjorn Edwin, Massimo Falconi, David Fuks, Matteo de Pastena, Alessandro Zerbi, Marc G. Besselink, Mohammed Abu Hilal
Summary: The study found that elective conversion in MIDP for PDAC was associated with comparable short-term and oncological outcomes compared to ODP, but emergency conversions led to worse short- and long-term outcomes. It is important to carefully select patients and consider early conversion when unexpected intraoperative findings are encountered.
Article
Surgery
C. Maulat, J. -M. Regimbeau, E. Buc, E. Boleslawski, J. Belghiti, J. Hardwigsen, E. Vibert, J. -R. Delpero, E. Tournay, C. Arnaud, B. Suc, P. Pessaux, F. Muscari
BRITISH JOURNAL OF SURGERY
(2020)
Article
Gastroenterology & Hepatology
Nicolas Tabchouri, Morgane Bouquot, Helene Hermand, Olivier Benoit, Jean-Christophe Loiseau, Safi Dokmak, Beatrice Aussilhou, Sebastien Gaujoux, Olivier Turrini, Jean Robert Delpero, Alain Sauvanet
Summary: This study developed a predictive risk score for POPF following PD, which could more specifically identify low-risk patients compared to existing scores. Preoperative radiation therapy was identified as an independent protective factor.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Jonathan Garnier, Fabien Robin, Jacques Ewald, Ugo Marchese, Damien Bergeat, Karim Boudjema, Jean-Robert Delpero, Laurent Sulpice, Olivier Turrini
Summary: The study showed that a preoperative CA19-9 value of >= 450 U/mL is the only preoperative factor independently associated with overall survival of < 1 year in patients undergoing complex vascular resection.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jonathan Garnier, Eddy Traversari, Jacques Ewald, Ugo Marchese, Jean-Robert Delpero, Olivier Turrini
Summary: This study investigated the efficacy of using PTFE grafts during pancreatectomy for PV-SMV reconstruction. Results showed a 68% patency rate for PTFE grafts in these cases, with severe morbidity and mortality rates of 21% and 10% respectively. Patients undergoing distal pancreatectomy had a higher late thrombosis rate compared to those undergoing pancreatoduodenectomy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Salvatore Paiella, Luca Casetti, Jacques Ewald, Ugo Marchese, Mirko D'Onofrio, Jonathan Garnier, Luca Landoni, Marine Gilabert, Gessica Manzini, Alessandro Esposito, Erica Secchettin, Giuseppe Malleo, Gabriella Lionetto, Matteo De Pastena, Claudio Bassi, Jean Robert Delpero, Roberto Salvia, Olivier Turrini
Summary: This study examined the safety and feasibility of using the new ablative technique imILT protocol for treating LAPC in two high-volume European institutions. The results showed a high completion rate of the procedure with some late pancreatic fistulas as adverse events.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Jonathan Garnier, Jacques Ewald, Ugo Marchese, Jean-Robert Delpero, Olivier Turrini
Summary: Emergency completion pancreatectomy after pancreatoduodenectomy is a technically demanding procedure. The four-step standardized technique used in this study appears to be relatively safe and reproducible, especially for young surgeons. Intraoperative blood loss and operative duration were relatively low, with some patients experiencing mortality during the perioperative period.
Article
Gastroenterology & Hepatology
Anais Palen, Jonathan Garnier, Christian Hobeika, Jacques Ewald, Emilie Gregoire, Jean-Robert Delpero, Yves P. Le Treut, Olivier Turrini, Jean Hardwigsen
Summary: The research found that performing MH with IVC resection on ICC patients did not significantly impact postoperative survival and recurrence rates, and did not increase the overall complication rate. However, patients who underwent IVC resection required more extensive hepatectomies and had higher rates of blood transfusions.
Editorial Material
Oncology
Jonathan Garnier, Eddy Traversari, Jacques Ewald, Ugo Marchese, Jean-Robert Delpero, Olivier Turrini
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Medicine, General & Internal
Ugo Marchese, Stylianos Tzedakis, Einas Abou Ali, Olivier Turrini, Jean-Robert Delpero, Romain Coriat, David Fuks
Summary: Parenchymal sparing duodenal and pancreatic resection are safe procedures aimed at reducing long-term endocrine and exocrine dysfunction, particularly for benign or borderline malignant tumors. This option is associated with low rates of severe surgery-related early postoperative complications and in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Renato Micelli Lupinacci, Matthieu Faron, Philippe Bachellier, Alain Sauvanet, Alain Beauchet, Yves-Patrice Le Treut, Mustapha Adham, Jean-Yves Mabrut, Jean-Robert Delpero, Francois Paye
Summary: Acute pancreatitis as an initial clinical presentation of pancreatic ductal adenocarcinoma does not impact postoperative complications and survival rates after pancreatic resection.
WORLD JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Jonathan Garnier, Jacques Ewald, Flora Poizat, Eddy Traversari, Ugo Marchese, Anais Palen, Jean Robert Delpero, Olivier Turrini
Summary: This study evaluated the resection margin status of patients with PDAC and DC using a standardized specimen protocol analysis. The R1 resection rate was comparable between the two groups, and venous groove was the most common type of resection margin. R1 resection margin did not influence patient survival in either group.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Fabien Robin, Zine-Eddine Khene, Marie Livin, Corentin Sumner, Pauline Houssel-Debry, Laurent Sulpice, Karim Boudjema
Summary: This study found that radiomic analysis of donor-liver CT scans can predict the occurrence of early posttransplant allograft dysfunction. Radiomic features, combined with clinical risk factors, provide an accurate biomarker for predicting EAD.
Article
Medicine, General & Internal
Alexandre Thobie, Fabien Robin, Benjamin Menahem, Jean Lubrano, Karim Boudjema, Arnaud Alves, Olivier Dejardin, Laurent Sulpice
Summary: This retrospective study focused on the impact of post-pancreatectomy hemorrhage (PPH) on long-term survival after pancreatoduodenectomy (PD) for cancer. The results showed that PPH significantly increased mortality rate and severe postoperative complication rate, but after 6 months, PPH had no impact on mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Public, Environmental & Occupational Health
Jonathan Garnier, Djamel Mokart, Jacques Ewald, Bernard Lelong, Cecile De Chaisemartin, Ugo Marchese, Helene Meillat, Jerome Guiramand, Abdallah Al Farai, Jean-Robert Delpero, Olivier Turrini
HEALTH SCIENCE REPORTS
(2021)