Article
Surgery
Mustafa Vayvada, Abdurrahim Gordebil, Ertan Saribas, Yesim Uygun Kizmaz, Sevinc Citak, Murat Ersin Cardak, Atakan Erkilic, Erdal Tasci
Summary: This study retrospectively evaluated the outcomes of lung transplantation in patients with non-cystic fibrosis bronchiectasis. Among the 11 patients who underwent bilateral lung transplantation, the hospital mortality rate was 18.2% and the 1-year mortality rate was 27.2%. Lung transplantation can improve the quality of life and increase survival in these patients.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Respiratory System
Wang Chun Kwok, James Chung Man Ho, Terence Chi Chun Tam, Mary Sau Man Ip, David Chi Leung Lam
Summary: The study revealed that patients with longer duration of non-cystic fibrosis bronchiectasis and those on proton pump inhibitors (PPIs) are more likely to have Pseudomonas aeruginosa colonization, leading to more extensive lung involvement and higher risks of exacerbation requiring hospitalization.
RESPIRATORY RESEARCH
(2021)
Article
Medicine, General & Internal
Seung Jun Lee, Jong Hwan Jeong, Manbong Heo, Sunmi Ju, Jung-Wan Yoo, Yi Yeong Jeong, Jong Deog Lee
Summary: In patients with non-CF bronchiectasis, serum fibrinogen level is significantly associated with the severity and exacerbation of the disease, while adiponectin and angiopoietin-2 are not. High fibrinogen levels and Pseudomonas colonization are independent risk factors for future exacerbation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Chun-Yu Lin, Meng-heng Hsieh, Yueh-Fu Fang, Chien-Wei Peng, Jia-Shiuan Ju, Yu-Lun Lo, Shu-Min Lin, Horng-Chyuan Lin
Summary: The BSI, FACED score, and DSP showed similar predictive power for mortality in non-CF bronchiectasis patients. However, DSP did not correlate with acute exacerbations and emergency department visits.
ANNALS OF MEDICINE
(2021)
Article
Microbiology
Chun-Yu Lin, Hung-Yu Huang, Meng-Heng Hsieh, Yueh-Fu Fang, Yu-Lun Lo, Shu-Min Lin, Yu-Tung Huang, Chih-Hsin Yeh, Chun-Hua Wang, Horng-Chyuan Lin
Summary: This study investigated the impact of nontuberculous mycobacteria (NTM) in non-cystic fibrosis bronchiectasis in Taiwan. The results showed that NTM were associated with frequent exacerbations and mortality in non-cystic fibrosis bronchiectasis patients, especially when coexisting with Pseudomonas aeruginosa and fungus. Additionally, the presence of single or multiple NTM isolates was an independent risk factor for mortality.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pediatrics
Kang Zhu, Yingkang Jin
Summary: SLC26A4 gene mutations are closely related to Pendred syndrome and bronchiectasis. The mutations disrupt the ion transport of chloride, iodide, and bicarbonate, leading to the acidification of airway surface fluid, compromised airway defense, and increased thickness of the fluid. This study describes the first case of co-occurrence of Pendred syndrome and non-cystic fibrosis bronchiectasis, highlighting the importance of considering the possibility of bronchiectasis in patients with SLC26A4 gene mutations.
FRONTIERS IN PEDIATRICS
(2023)
Review
Medicine, General & Internal
Salony Verma, Joseph L. Mathew, Pallab Ray
Summary: Cystic fibrosis (CF) bronchiectasis and non-CF bronchiectasis may have differences in microbial communities and antibiotic susceptibility patterns, studying these differences could help improve the management of both conditions.
SYSTEMATIC REVIEWS
(2021)
Article
Pediatrics
Hulya Nilgun Gurses, Hikmet Ucgun, Melih Zeren, Hilal Denizoglu Kulli, Erkan Cakir
Summary: This study compared the efficacy of comprehensive respiratory physiotherapy (CRP) in children with cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis (NCFB). Both groups showed significant improvements in pulmonary function, exercise capacity, and respiratory and peripheral muscle strength after 8 weeks of CRP. The NCFB group had further improvements in maximum expiratory pressure, exercise capacity, and peripheral muscle strength compared to the CF group.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Cardiac & Cardiovascular Systems
Saveria Sangiovanni, Eliana Morales, Liliana Fernandez-Trujillo
Summary: Inhaled tobramycin can temporarily decrease P. aeruginosa density in sputum and reduce hospital admissions in NCFBE patients, but has limited impact on eradicating the bacteria and frequency of exacerbations.
RESPIRATORY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ling Lin, Yixian Zhou, Guilan Quan, Xin Pan, Chuanbin Wu
Summary: The inhalable ciprofloxacin hydrochloride microparticles (CMs) based on silk fibroin (SF) and mannitol (MAN) were designed to improve therapeutic efficiency in non-cystic fibrosis bronchiectasis (NCFB) by enhancing drug loading efficiency and penetration through mucus. These microparticles demonstrated excellent biocompatibility and antibacterial effects, making them a potential pulmonary drug delivery system for NCFB treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, General & Internal
Frederic Schlemmer, Agnes Hamzaoui, Sonia Zebachi, Aurelie Le Thuaut, Gilles Mangiapan, Isabelle Monnet, Amel Boudjema, Laurence Jabot, Bruno Housset, Sylvie Bastuji-Garin, Laurence Bassinet, Bernard Maitre
Summary: This study aimed to develop a clinical score to identify adult patients with bronchiectasis who are at higher risk of having cystic fibrosis or primary ciliary dyskinesia. Through diagnostic work-ups and logistic-regression analyses, specific factors associated with CF/PCD diagnosis were identified and a score was validated in a second cohort. The results showed that age at symptom onset, chronic ENT symptoms, digestive symptoms, and specific microbial isolates from sputum were significantly associated with CF or PCD diagnosis, with the developed score demonstrating good performance in identifying high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Radmila Choate, Timothy R. Aksamit, David Mannino, Doreen Addrizzo-Harris, Alan Barker, Ashwin Basavaraj, Charles L. Daley, M. Leigh Anne Daniels, Edward Eden, Angela DiMango, Kevin Fennelly, David E. Griffith, Margaret M. Johnson, Michael R. Knowles, Pamela J. McShane, Mark L. Metersky, Peadar G. Noone, Anne E. O'Donnell, Kenneth N. Olivier, Matthias A. Salathe, Andreas Schmid, Byron Thomashow, Gregory Tino, Kevin L. Winthrop, Glenda Stone
Summary: This study investigated the association between presence of Pseudomonas aeruginosa (PA) and disease severity in patients with non-cystic fibrosis bronchiectasis (NCFB) within the US Bronchiectasis and Nontuberculous mycobacteria (NTM) Research Registry (BRR). The presence of PA was common in patients with NCFB, and those with PA had significantly greater severity of bronchiectasis and lower lung function compared to those without PA.
RESPIRATORY MEDICINE
(2021)
Article
Immunology
Fengming Ding, Lei Han, Yishu Xue, Iris Tingshiuan Yang, Xinxin Fan, Rong Tang, Chen Zhang, Miao Zhu, Xue Tian, Ping Shao, Min Zhang
Summary: The study found that antibiotic-resistant MDR Pseudomonas aeruginosa is predisposed to lasR mutation through upregulated efflux pump activity, suggesting that anti-QS therapy combined with efflux pump inhibitors might be a potential strategy for NCFB patients facing MDR Pseudomonas aeruginosa infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Linsey King, Helen White, Ian Clifton, Giulia Spoletini, Theocharis Ispoglou, Daniel G. Peckham
Summary: This study aimed to investigate the nutritional status and intakes in patients with bronchiectasis, finding that most patients did not meet energy requirements but exceeded protein RNI, with inadequate intake of vitamin D. BMI masked functional, body composition, and nutritional deficits in patients, especially in the younger PCD subgroup.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Jong Hwan Jeong, Manbong Heo, Eun Ji Kim, Young-Sool Hah, I. Re Heo, Tae Hoon Kim, Ho Cheol Kim, Sunmi Ju, Jung Wan Yoo, Yi Yeong Jeong, Jong Deog Lee, Seung Jun Lee
Summary: The study revealed that serum level of HGF is closely associated with disease severity and future risk of exacerbations in patients with non-CF bronchiectasis. Patients with high HGF levels had a significantly shorter time to first exacerbation, and high serum HGF level was identified as an independent predictor of future exacerbations.
RESPIRATORY MEDICINE
(2021)
Article
Emergency Medicine
Onur Balaban, Mumin Hakim, Hina Walia, Dmitry Tumin, Meredith Lind, Joseph D. Tobias
PEDIATRIC EMERGENCY CARE
(2020)
Article
Health Care Sciences & Services
Asad A. Khawaja, Dmitry Tumin, Ralph J. Beltran, Joseph D. Tobias, Joshua C. Uffman
Summary: General anesthesia or sedation for pediatric radiological studies is generally safe with a low incidence of adverse events, but there are opportunities for improvement in anesthetic complications to further enhance safety in this setting.
JOURNAL OF PATIENT SAFETY
(2021)
Article
Pediatrics
Danielle Goetz, Benjamin T. Kopp, Ann Salvator, Melissa Moore-Clingenpeel, Karen McCoy, Daniel H. Leung, Margaret Kloster, Bonnie R. Ramsey, Sonya H. Heltshe, Drucy Borowitz
PEDIATRIC PULMONOLOGY
(2019)
Correction
Multidisciplinary Sciences
Kaivon Assani, Mia F. Tazi, Amal O. Amer, Benjamin T. Kopp
Article
Respiratory System
Benjamin T. Kopp, James Fitch, Lisa Jaramillo, Chandra L. Shrestha, Frank Robledo-Avila, Shuzhong Zhang, Sabrina Palacios, Fred Woodley, Don Hayes, Santiago Partida-Sanchez, Octavio Ramilo, Peter White, Asuncion Mejias
JOURNAL OF CYSTIC FIBROSIS
(2020)
Article
Respiratory System
Benjamin L. Wisniewski, Chandra L. Shrestha, Shuzhong Zhang, Rohan Thompson, Myron Gross, Judith A. Groner, Karan Uppal, Octavio Ramilo, Asuncion Mejias, Benjamin T. Kopp
JOURNAL OF CYSTIC FIBROSIS
(2020)
Article
Pediatrics
Brett R. Loman, Chandra L. Shrestha, Rohan Thompson, Judith A. Groner, Asuncion Mejias, Kathryn L. Ruoff, George A. O'Toole, Michael T. Bailey, Benjamin T. Kopp
PEDIATRIC PULMONOLOGY
(2020)
Letter
Hematology
Brett R. Loman, Chandra L. Shrestha, Kavitha Kotha, Abena Minta, Shuzhong Zhang, Asuncion Mejias, Michael T. Bailey, Susan Creary, Benjamin T. Kopp
AMERICAN JOURNAL OF HEMATOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Devi Jaganathan, Emanuela M. Bruscia, Benjamin T. Kopp
Summary: Cystic fibrosis is a disease caused by mutations in the CFTR gene, resulting in chronic inflammation and lung function decline. Macrophages play a crucial role in CF and the mutant CFTR affects phagocytosis, which is linked to disease progression. A better understanding of the interaction between CFTR and macrophages during phagosome formation could contribute to the development of new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Sabrina Palacios, Katelyn Krivchenia, Mariah Eisner, Bailey Young, Octavio Ramilo, Asuncion Mejias, Simon Lee, Benjamin T. Kopp
Summary: This study is the largest to date on long-term pulmonary sequelae in pediatric patients after COVID-19. Identified clinical phenotypes and risk factors require further study and treatment.
PEDIATRIC PULMONOLOGY
(2022)
Letter
Pediatrics
Eric S. Mull, Sarah Cohen, Ashish George, Katelyn Krivchenia, Stephen Druhan, Peter B. Baker, Benjamin Kopp
PEDIATRIC PULMONOLOGY
(2023)
Article
Hematology
Rachel N. Zeno, Joseph Stanek, Courtney Pugh, Michelle Gillespie, Benjamin T. Kopp, Susan Creary
Summary: An interdisciplinary clinic providing pulmonary care for people with sickle cell disease (pwSCD) was created in 2014 to address health care access barriers. The study found that pwSCD had significantly fewer hospitalizations for acute chest syndrome, asthma, and vaso-occlusive episodes in the 2 years after their initial SCD-pulmonary clinic visit compared with the 2 years before. This suggests that implementing a multidisciplinary SCD-pulmonary clinic can improve patient management and usage of acute care.
Letter
Respiratory System
Theresa A. Laguna, Benjamin T. Kopp, D'Ann Brown-Janowiak, Nancy Guerrero, Liliana Rose, Brandie Wagner, Paul E. Moore
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Devika R. Rao, Benjamin Kopp, Rory John Kamerman-Kretzmer, Folashade Afolabi, Deborah R. Liptzin, Vivek Balasubramaniam, S. Christy Sadreameli
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Respiratory System
A. Parker Ruhl, S. Christy Sadreameli, Julian L. Allen, Debra P. Bennett, Andrew D. Campbell, Thomas D. Coates, Dapa A. Diallo, Joshua J. Field, Elizabeth K. Fiorino, Mark T. Gladwin, Jeffrey A. Glassberg, Victor R. Gordeuk, Leroy M. Graham, Anne Greenough, Jo Howard, Gregory J. Kato, Jennifer Knight-Madden, Benjamin T. Kopp, Anastassios C. Koumbourlis, Sophie M. Lanzkron, Robert Liem, Roberto F. Machado, Alem Mehari, Claudia R. Morris, Folasade O. Ogunlesi, Carol L. Rosen, Kim Smith-Whitley, Danna Tauber, Nancy Terry, Swee Lay Thein, Elliott Vichinsky, Nargues A. Weir, Robyn T. Cohen, Elizabeth S. Klings
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2019)