Article
Oncology
George Molina, Thomas E. Clancy, Thomas C. Tsai, Miranda Lam, Jiping Wang
Summary: Analysis of data from patients with borderline resectable pancreatic adenocarcinoma showed that non-White patients were less likely to undergo pancreatic resection compared to White patients. This racial disparity was attributed to variation in care within hospitals, but disappeared if non-White patients received neoadjuvant therapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Seiko Hirono, Manabu Kawai, Ken-ichi Okada, Motoki Miyazawa, Yuji Kitahata, Rryohei Kobayashi, Shinya Hayami, Masaki Ueno, Hiroki Yamaue
Summary: The study revealed that locoregional recurrence most commonly occurred around the superior mesenteric artery after upfront pancreatoduodenectomy for pancreatic ductal adenocarcinoma. Lymph node metastasis was identified as an independent risk factor for both locoregional and distant recurrences, while non-completion of postoperative adjuvant therapy was a risk factor for distant recurrence.
Article
Surgery
Shinjiro Kobayashi, Takehito Otsubo, Hiroshi Nakano, Satoshi Koizumi, Kazunari Nakahara
Summary: The study demonstrated that Artery-first approach pancreatoduodenectomy (AFA-PD) with complete lymphadenectomy around the entire superior mesenteric artery (SMA) can prolong overall survival and reduce recurrence rate in pancreatic ductal adenocarcinoma (PDAC) patients.
WORLD JOURNAL OF SURGERY
(2021)
Review
Surgery
Junji Yamamoto, Hiroki Kudo, Yusuke Kyoden, Yoshinori Ajiro, Masaya Hiyoshi, Takayuki Okuno, Hiroshi Kawasaki, Masaru Nemoto, Fuyo Yoshimi
Summary: This study reviews approaches for pancreaticoduodenectomy (PD) with a focus on SMA-first methods, where the superior mesenteric artery (SMA) is dissected first to assess pancreatic cancer involvement early in the operation. These approaches are classified based on the side of mesocolon access and direction of approach (right or left, anterior or posterior), with steps numbered according to a timeline and anatomical division of the SMA.
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Rigiroli, Jocelyn Hoye, Reginald Lerebours, Kyle J. Lafata, Cai Li, Mathias Meyer, Peijie Lyu, Yuqin Ding, Fides R. Schwartz, Niharika B. Mettu, Sabino Zani, Sheng Luo, Desiree E. Morgan, Ehsan Samei, Daniele Marin
Summary: Analyzing radiomic features of preoperative CT images can improve the detection of superior mesenteric artery involvement in patients with pancreatic ductal adenocarcinoma. In a retrospective study, a model with five features showed better performance compared to radiologist assessment.
Article
Medicine, General & Internal
Kosei Takagi, Yuzo Umeda, Ryuichi Yoshida, Tomokazu Fuji, Kazuya Yasui, Jiro Kimura, Nanako Hata, Kento Mishima, Takahito Yagi, Toshiyoshi Fujiwara
Summary: This study presents surgical strategies for dissecting around the superior mesenteric artery (SMA) in robotic pancreatoduodenectomy (RPD). Depending on the case, different approaches can be selected, including a right approach and a combined left and right approach. Surgeons can choose the most appropriate surgical approach by considering demographic, anatomical, and oncological factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Keon Jang, Jae Ho Byun, Ji Hun Kang, Jung Hee Son, Jin Hee Kim, Seung Soo Lee, Hyoung Jung Kim, Changhoon Yoo, Kyu-pyo Kim, Seung-Mo Hong, Dong-Wan Seo, Song Cheol Kim, Moon-Gyu Lee
Summary: The study evaluated the ability of CT-determined resectability to predict R0 resection in patients with PDAC after neoadjuvant FOLFIRINOX chemotherapy, finding a relatively low sensitivity and specificity. Low-contrast enhancement of soft tissue contacting artery may enhance the ability of CT to predict R0 resection.
EUROPEAN RADIOLOGY
(2021)
Review
Surgery
Hunter Chalfant, Morgan Bonds, Kristina Scott, Anna Condacse, Isabel S. Dennahy, W. Taylor Martin, Cooper Little, Barish H. Edil, Lacey R. McNally, Ajay Jain
Summary: A diagnosis of pancreatic cancer is associated with a low 5-year survival rate of less than 10%. Detecting pancreatic cancer is challenging due to its retroperitoneal location and lack of symptoms until advanced stages. Current imaging techniques have limited accuracy in determining vascular involvement, but new fluorescence and optoacoustic imaging techniques may provide more accurate staging and individualized treatment plans.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Nicolae Bacalbasa, Irina Balescu, Valentin Varlas, Mihai Dimitriu, Cristian Balalau, Florentina Furtunescu, Florentina Gherghiceanu, Daniel Radavoi, Camelia Diaconu, Ovidiu Stiru, Cornel Savu, Vladislav Brasoveanu, Ioan Cordos
Summary: This case demonstrates that pancreatoduodenectomy en bloc with superior mesenteric vein resection and jejunal portal anastomosis is feasible in patients with borderline resectable pancreatic head carcinoma invading the superior mesenteric vein, despite being technically more demanding. It may offer a chance for long-term survival.
Article
Oncology
Rachna Gorbudhun, Pranav H. Patel, Eve Hopping, Joseph Doyle, Georgios Geropoulos, Vasileios K. Mavroeidis, Sacheen Kumar, Ricky H. Bhogal
Summary: The use of chemotherapy followed by chemoradiotherapy prior to surgery for patients with pancreatic cancer in contact with major abdominal blood vessels improves the ability to completely resect the tumor, leading to increased patient survival after surgery.
Article
Gastroenterology & Hepatology
Andrew L. Coveler, Venu G. Pillarisetty, Wui-Jin Koh, David B. Zhen, James O. Park, Gentry G. King, Jonathan G. Sham, Lindsay M. Hannan, Gary N. Mann, Kelsey K. Baker, Mary W. Redman, Paul E. Swanson, E. Gabriela Chiorean, Sam H. Whiting
Summary: This study evaluated the effect of multiagent perioperative therapy on overall survival in potentially resectable pancreatic ductal adenocarcinoma (PDA) patients. The results showed a promising survival of 58 months for patients who underwent surgical resection, which may represent another treatment option for PDA.
Article
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the impact of changes in body composition on postoperative outcomes in patients with PDAC undergoing neoadjuvant chemoradiotherapy. The results showed that loss of skeletal muscle mass during NACRT was an independent risk factor for survival in PDAC patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Laura Maggino, Giuseppe Malleo, Stefano Crippa, Giulio Belfiori, Sara Nobile, Giulia Gasparini, Gabriella Lionetto, Claudio Luchini, Paola Mattiolo, Marco Schiavo-Lena, Claudio Doglioni, Aldo Scarpa, Claudio Bassi, Massimo Falconi, Roberto Salvia
Summary: This study investigated the incidence and pattern of recurrence in patients with initially resectable and borderline resectable pancreatic ductal adenocarcinoma who received post-neoadjuvant pancreatectomy. The results showed that preoperative tumor size <20 mm, normal posttreatment CA19.9 and Delta CA19.9 > 50% were associated with longer recurrence-free survival (RFS) in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hironobu Suto, Minoru Oshima, Yasuhisa Ando, Hiroyuki Matsukawa, Shigeo Takahashi, Toru Shibata, Hideki Kamada, Hideki Kobara, Tsutomu Masaki, Kensuke Kumamoto, Yasuyuki Suzuki, Keiichi Okano
Summary: The benefit of preoperative treatment followed by pancreatic resection in older patients with PDAC remains unclear. This study showed that preoperative treatment followed by curative resection could be safely performed in older patients, with similar outcomes as younger patients. Although older patients had a higher frequency of postoperative complications, the prognosis was similar.
Article
Medicine, General & Internal
Federica Vernuccio, Carlo Messina, Valeria Merz, Roberto Cannella, Massimo Midiri
Summary: The article discusses the increasing incidence and mortality of pancreatic ductal adenocarcinoma over time, highlighting the importance of a multidisciplinary team in the management of patients. It also covers advancements in the molecular basis of the disease, diagnostic tools for staging, and the management of resectable or borderline resectable pancreatic cancer.
Article
Gastroenterology & Hepatology
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate-Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara
Summary: Through the analysis of molecular abnormalities and tumor immune microenvironment in nonviral hepatocellular carcinoma, we identified the link between intratumoral steatosis and immune-exhausted immunotherapy-susceptible microenvironment.
Article
Gastroenterology & Hepatology
Tsuyoshi Takeda, Takashi Sasaki, Takeshi Okamoto, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Yosuke Inoue, Yu Takahashi, Akio Saiura, Naoki Sasahira
Summary: This study evaluated the outcomes and factors associated with overall survival of pancreatic cancer patients with liver metastasis. The results showed that oligometastasis had a more favorable overall survival compared to other types of metastases. Age, performance status, prognostic score, and serum carbohydrate antigen level were identified as significant prognostic factors. Surgical resection may provide additional survival benefits for highly selected patients.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Oncology
Atsushi Takahashi, Ryuji Yoshioka, Mamiko Miyashita, Haruka Tanaka, Masaru Oba, Hirofumi Ichida, Hiroshi Imamura, Yoshihiro Mise, Akio Saiura
Summary: Sequential treatment consisting of PVE followed by preoperative chemotherapy is a feasible and effective strategy for patients with perihilar biliary tract cancer.
Article
Surgery
Sho Kiritani, Junichi Arita, Yuichiro Mihara, Rihito Nagata, Akihiko Ichida, Yoshikuni Kawaguchi, Takeaki Ishizawa, Nobuhisa Akamatsu, Junichi Kaneko, Kiyoshi Hasegawa
Summary: A retrospective study was conducted to determine the prognostic classification of resected pancreatic neuroendocrine neoplasms based on the presence of lymphatic invasion and venous invasion. The study revealed that lymphovascular invasion is an independent prognostic factor for recurrence-free survival, and a new classification system based on lymphovascular invasion status can guide the management of these tumors after curative-intent surgery.
Article
Gastroenterology & Hepatology
Atsushi Takahashi, Yoshihiro Mise, Genki Watanabe, Ryuji Yoshioka, Yoshihiro Ono, Yosuke Inoue, Hiromichi Ito, Yu Takahashi, Seiji Kawasaki, Akio Saiura
Summary: This study compared the surgical outcomes of conventional distal pancreatectomy (cDP) and radical antegrade modular pancreatosplenectomy (RAMPS) in patients with left-sided pancreatic cancer. The results showed that RAMPS is superior to cDP in achieving local control of the disease.
Editorial Material
Oncology
Sho Kiritani, Tomohiko Iwano, Kentaro Yoshimura, Ryo Saito, Takashi Nakayama, Daisuke Yamamoto, Hiroyuki Hakoda, Genki Watanabe, Nobuhisa Akamatsu, Junichi Arita, Junichi Kaneko, Sen Takeda, Daisuke Ichikawa, Kiyoshi Hasegawa
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sho Kiritani, Tomohiko Iwano, Kentaro Yoshimura, Ryo Saito, Takashi Nakayama, Daisuke Yamamoto, Hiroyuki Hakoda, Genki Watanabe, Nobuhisa Akamatsu, Junichi Arita, Junichi Kaneko, Sen Takeda, Daisuke Ichikawa, Kiyoshi Hasegawa
Summary: In this study, the combination of probe electrospray ionization-mass spectrometry (PESI-MS) and machine learning was used to diagnose the malignant conversion of intraductal papillary mucinous neoplasm (IPMN) in pancreatic tumors. The results showed that PESI-MS combined with machine learning could effectively discriminate different classes of IPMN tumors and had the advantage of rapid analysis.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kaito Fukuda, Yoshikuni Kawaguchi, Satoru Abe, Yuta Kobayashi, Harufumi Maki, Nobuhisa Akamatsu, Junichi Kaneko, Junichi Arita, Kiyoshi Hasegawa
Summary: This study evaluated the application of methylene blue (MB) fluorescence imaging in hepatobiliary and pancreatic surgery and the safety of intraoperative MB administration in Japanese patients without methemoglobinemia. The results showed that MB fluorescence imaging could effectively visualize blood vessels and tumors, and the use of MB as a fluorophore in Japanese patients without methemoglobinemia was safe.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Yasutaka Masuda, Sho Kiritani, Junichi Arita, Akihiko Ichida, Yoshikuni Kawaguchi, Nobuhisa Akamatsu, Junichi Kaneko, Kiyoshi Hasegawa
Summary: This case highlights the importance of active monitoring of glycemic state and pH after TP due to the potential deterioration caused by TP itself and the lingering effects of anesthesia.
SURGICAL CASE REPORTS
(2023)
Editorial Material
Oncology
Fumihiro Kawano, Hiromichi Ito, Atsushi Oba, Yoshihiro Ono, Takafumi Sato, Yosuke Inoue, Yoshihiro Mise, Akio Saiura, Yu Takahashi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Fumihiro Kawano, Hiromichi Ito, Atsushi Oba, Yoshihiro Ono, Takafumi Sato, Yosuke Inoue, Yoshihiro Mise, Akio Saiura, Yu Takahashi
Summary: The clinical implications of the proximal bile duct margin status in resection of perihilar cholangiocarcinoma (PHCC) were evaluated in this study. The study found that an initial positive proximal hepatic duct margin was associated with poor long-term outcomes for patients with resectable PHCC. Additional resection after achieving a negative margin had minimal impact on survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuhi Yoshizaki, Yoshikuni Kawaguchi, Yusuke Seki, Shu Sasaki, Akihiko Ichida, Nobuhisa Akamatsu, Junichi Kaneko, Junichi Arita, Kiyoshi Hasegawa
Summary: This study compared the survival outcomes of surgery alone, surgery and posthepatectomy chemotherapy, and prehepatectomy chemotherapy and surgery in patients with resectable colorectal liver metastases (CLM). It was found that posthepatectomy chemotherapy prolongs the time to recurrence, while prehepatectomy chemotherapy does not significantly affect survival.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Infectious Diseases
Noriko Koishi, Hiroshi Sasano, Toshihiro Yoshizawa, Mika Shikuri, Hiroshi Matsumoto, Mai Suzuki, Yukiko Fukui, Masayoshi Chonan, Toshimi Kimura, Hirofumi Ichida, Akio Saiura, Toshio Naito
Summary: Post-operation, an 80-year-old woman developed a fever and blood culture showed Raoultella ornithinolytica producing metallo-beta-lactamase. Therapeutic drug monitoring-based dosing design for aminoglycoside antimicrobial agents can decrease adverse events and ensure appropriate treatment.
CASE REPORTS IN INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Tsuyoshi Hamada, Hiroki Oyama, Yousuke Nakai, Shuichi Tange, Junichi Arita, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, Hirofumi Kogure, Suguru Mizuno, Kei Saito, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Naminatsu Takahara, Mariko Tanaka, Keisuke Tateishi, Tetsuo Ushiku, Kiyoshi Hasegawa, Mitsuhiro Fujishiro
Summary: This study investigated the long-term effects of dilation of the main pancreatic duct (MPD) on intraductal papillary mucinous neoplasms (IPMNs) and found that MPD dilation was associated with higher incidence and prevalence of pancreatic carcinoma.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tomoharu Yamada, Naoto Fujiwara, Naoto Kubota, Yuki Matsushita, Takuma Nakatsuka, Shigeyuki Kurosaki, Tatsuya Minami, Ryosuke Tateishi, Akihiko Ichida, Junichi Arita, Kiyoshi Hasegawa, Kazuhiko Koike, Mitsuhiro Fujishiro, Hayato Nakagawa
Summary: The combination therapy of Lenvatinib and immune checkpoint inhibitors (ICIs) did not show synergy in treating unresectable HCC, as revealed by a phase III clinical trial. It was found that Lenvatinib induced the "excluded condition" in HCC, which reduced the efficacy of ICIs.
HEPATOLOGY COMMUNICATIONS
(2023)