Article
Nutrition & Dietetics
Ashraf Khalifa, Abdullah Sheikh, Hairul Islam Mohamed Ibrahim
Summary: Fermented camel's milk enriched with Bacillus amyloliquefaciens (BEY) shows preventive efficacy against colitis and immune modulatory effects. The study demonstrates that BEY reduces colitis symptoms, improves body weight and colon length, and attenuates inflammatory markers. This suggests that BEY could be used as a probiotic-based diet to control inflammatory bowel syndrome in mammals.
Article
Biochemistry & Molecular Biology
Simarjot Kaur Sandhu, Suneel Kumar, Jayant Raut, Mandeep Singh, Sandeep Kaur, Garima Sharma, Tomas L. Roldan, Sonia Trehan, Jennifer Holloway, Gabriella Wahler, Jeffrey D. Laskin, Patrick J. Sinko, Francois Berthiaume, Bozena Michniak-Kohn, Praveen Rishi, Narayanan Ganesh, Indu Pal Kaur
Summary: This study aimed to develop high drug-loaded curcumin solid lipid nanoparticles (CSLNs) for wound healing, showing superior drug release properties and antimicrobial effects. The CSLNs exhibited excellent safety, stability, controlled release, and disruption of mature biofilms, both in vitro and in vivo.
Article
Food Science & Technology
Xuxiu Lu, Mingfei Liu, Hui Dong, Jinlai Miao, Dimitrios Stagos, Ming Liu
Summary: In this study, it was found that Xantho-humol (XN) alleviates oxidative damage and accelerates diabetic wound healing through Nrf2 activation. In vitro experiments demonstrated that XN reduced cytotoxicity, ROS production, cell apoptosis caused by hydrogen peroxide, as well as cell damage induced by high glucose. Mechanistic studies revealed that XN stabilized Nrf2 and promoted its nuclear translocation by activating AMPK alpha and covalently modifying Keap1. In vivo, XN increased Nrf2 expression and accelerated diabetic wound healing.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Wenqian Zhang, Lang Chen, Yuan Xiong, Adriana C. Panayi, Abudula Abududilibaier, Yiqiang Hu, Chenyan Yu, Wu Zhou, Yun Sun, Mengfei Liu, Hang Xue, Liangcong Hu, Chenchen Yan, Xuedong Xie, Ze Lin, Faqi Cao, Bobin Mi, Guohui Liu
Summary: Ulcers are a common complication of diabetes with high recurrence rates, and oxidative stress is identified as a key factor in impaired wound healing. Various antioxidant therapies have been proposed in the past 5 years to target oxidative stress and improve diabetic wound healing outcomes. These therapies include targeting Nrf2 and NF kappa B pathways, as well as utilizing vitamins, enzymes, hormones, medicinal plants, and biological materials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Microbiology
Aicha Chouikhi, Naourez Ktari, Sana Bardaa, Amina Hzami, Sirine Ben Slima, Imen Trabelsi, Abdeslam Asehraou, Riadh Ben Salah
Summary: The study revealed that the LC38 strain isolated from camel milk is sensitive to several antibiotics, has no haemolytic activity, and exhibits antimicrobial activities against six pathogenic bacteria. It also showed strong autoaggregation ability, high surface hydrophobicity, and has the potential to adhere to epithelial cells and form biofilms.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Immunology
Wenxv Jin, Xiong Chen, Lingguo Kong, Chongqing Huang
Summary: The impaired wound healing in diabetic patients is attributed to diabetes-associated angiopathy, with pericytes playing a critical role in stabilization of formed vessels. Inflammatory pericytes in diabetic patients exhibit impaired growth potential, oxidative stress, and apoptosis, which can be alleviated by specific expression of antioxidant gene OXR1. Furthermore, in vivo gene therapy targeting inflammatory pericytes improves wound healing in a type 2 diabetes mouse model by enhancing blood flow.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shiyan Li, Xiaofeng Ding, Hao Zhang, Youjun Ding, Qian Tan
Summary: IL-25 plays a role in the treatment of diabetic wounds by promoting macrophage and fibroblast activation, affecting inflammation resolution through multiple signaling pathways, and improving angiogenesis and collagen alignment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amira M. Shaban, Mai Raslan, Safa H. Qahl, Khaled Elsayed, Mohamed Sayed Abdelhameed, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Ola Hammouda, Mohammed A. El-Magd
Summary: The contradictory effects of extracellular vesicles, such as exosomes (EXOs), on diabetes and diabetic nephropathy (DN) have been observed. Some studies suggest that EXOs, including camel milk EXOs, are involved in the pathogenesis of DN, while others reveal ameliorative effects. This study evaluates the effect of camel milk and its EXOs on a rat model of DN induced by streptozotocin. The results show that treatment with camel milk and/or its EXOs ameliorated DN by reducing kidney function parameters, restoring redox balance, downregulating DN-related gene expression, and decreasing renal damage.
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Giuseppe Caruso, Basma G. Eid, Usama A. Fahmy, Osama A. A. Ahmed, Ashraf B. Abdel-Naim, Abdulmohsin J. Alamoudi, Shareefa A. Alghamdi, Hadeel Al Sadoun, Basmah M. Eldakhakhny, Filippo Caraci, Wesam H. Abdulaal
Summary: The study investigates the potential of a nanoconjugate of CTX and MEL loaded in hydroxypropyl methylcellulose gel to improve wound healing in diabetic rats. The results show that the nanocomplex enhances epithelium regeneration, reduces oxidative stress, decreases pro-inflammatory cytokines, and increases collagen expression, highlighting its promising application in wound healing research.
Review
Medicine, Research & Experimental
Qinzhi Yang, Dan Fang, Jinxiang Chen, Shaorun Hu, Ni Chen, Jun Jiang, Min Zeng, Mao Luo
Summary: Diabetes is a chronic disease that causes blood glucose imbalance and organ damage. Diabetic wound formation involves complex mechanisms related to oxidative stress. Recent studies have shown the critical role of long noncoding RNAs (lncRNAs) in regulating diabetic wound healing and oxidative stress.
Article
Cell & Tissue Engineering
Chenyang Liu, Yan Xu, Yichi Lu, Pan Du, Xiaoxiao Li, Chengchun Wang, Peng Guo, Ling Diao, Guozhong Lu
Summary: The study demonstrates that S-IT MSCs can effectively induce M2 polarization of macrophages via IL-6 dependent signaling pathways and accelerate wound healing. Results show that S-IT MSCs significantly enhance the ability of M2 phenotype to promote vascularization and collagen deposition, ultimately improving wound healing quality.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Sang Hoon Jeong, Sunah Cheong, Tae Yeon Kim, Hyunsik Choi, Sei Kwang Hahn
Summary: Diabetic wound patients often suffer from bacterial infections and delayed healing due to hyperglycemia. We developed a injectable hydrogel platform that can release antimicrobial peptides (AMPs) in response to infection-related materials. The AMPs are released from the hydrogel only when both matrix metalloproteinases (MMPs) and reactive oxygen species (ROS) are present, ensuring controlled release without cytotoxicity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Sang Hoon Jeong, Sunah Cheong, Tae Yeon Kim, Hyunsik Choi, Sei Kwang Hahn
Summary: Diabetic wound patients often experience delayed healing and bacterial infections due to high blood sugar levels. Antimicrobial peptides (AMPs) have been explored but their stability and toxicity have limited their use for chronic wound healing in diabetics. In this study, a controlled AMP-releasing hydrogel platform was developed that could respond to infection-related materials. The hydrogel was created by mixing hyaluronic acid modified with cyclodextrin (HA-CD) and adamantane (Ad-HA). AMP was released from the hydrogel only when exposed to both MMP and ROS, allowing for controlled release without cytotoxicity. The AMP-tethered hydrogel showed enhanced stability and antimicrobial activity compared to native AMP. This research demonstrates the potential of sHG-AMP for diabetic chronic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Medicinal
Nancy S. Younis, Maged E. Mohamed, Nermin A. El Semary
Summary: This study demonstrates that the cyanobacterium Synechocystis sp. can produce silver nanoparticles with antibacterial, antioxidant, anti-inflammatory, and angiogenesis promoting effects in diabetic wounded animals.
Article
Biochemical Research Methods
Hossam Ebaid, Mohamed Habila, Iftekhar Hassan, Jameel Al-Tamimi, Mohamed S. Omar, Ahmed Rady, Ibrahim M. Alhazza
Summary: The study found that AgNPs-curcumin could prevent CCl4-induced hepatic injury by reducing oxidative imbalance, liver dysfunction, and tissue destruction. Furthermore, AgNPs-curcumin also mitigated DNA damage caused by CCl4 exposure.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Multidisciplinary Sciences
Iftekhar Hassan, Hossam Ebaid, Jameel Al-Tamimi, Mohamed A. Habila, Ibrahim M. Alhazza, Ahmed M. Rady
Summary: The study found that selenium nanoparticles can have a positive effect on the offspring of diabetic mother rats, improving renal function and reducing diabetic-related complications by reorganizing the cellular redox status.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Environmental Sciences
Jameel Al-Tamimi, Hossam Ebaid, Iftekhar Hassan, Ibrahim M. Alhazza, Waleed Hailan, Mohammed Al-Khalifa
Summary: The study evaluated the antioxidant and anti-inflammatory properties of Samsum ant venom extract in carbon tetrachloride-induced spleen toxicity, showing that the extract reduced oxidative stress and restored spleen structure and function.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hossam Ebaid, Jameel Al-Tamimi, Mohamed Habila, Iftekhar Hassan, Ahmed Rady, Ibrahim M. Alhazza
Summary: This study assessed the protective effects of silver nanoparticles with curcumin against CCl4-induced kidney injury in mice. The results showed significant restoration of oxidative balance and kidney structure and function by AgNP-curcumin, with a decrease in DNA damage.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Hossam Ebaid, Jameel Al-Tamimi, Iftekhar Hassan, Mohamed A. Habila, Ahmed M. Rady, Ibrahim M. Alhazza, Ashraf M. Ahmed
Summary: Selenium nanoparticles have protective effects against CCl4-induced liver injury, improving oxidative stress and restoring liver function.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Mohd Shahnawaz Khan, Alya Alomari, Shams Tabrez, Iftekhar Hassan, Rizwan Wahab, Sheraz Ahmad Bhat, Nouf Omar Alafaleq, Nojood Altwaijry, Gouse M. Shaik, Syed Kashif Zaidi, Wessam Nouh, Majed S. Alokail, Mohamed A. Ismael
Summary: The study synthesized silver nanoparticles using plant extract and evaluated their anticancer potential. Results indicate that AgNPs have promising therapeutic effects against breast and colorectal cancers, possibly through inducing cell death via increased ROS production.
Article
Parasitology
Lamjed Mansour, Aouatef Thabet, Jameel Al-Tamimi, Saber Nahdi, Suliman Alomar, Abdel-Azeem S. Abdel-Baki
Summary: Two myxosporean species were found in the gallbladder of the European pilchard from the Southern shores of the Mediterranean Sea, belonging to the genera Ceratomyxa and Coccomyxa, described using morphological and molecular phylogenetic tools. The SSU rDNA sequences of these species were obtained and positioned in the phylogenetic tree, showing relationships with other myxozoan sequences.
ACTA PARASITOLOGICA
(2022)
Article
Environmental Sciences
Ibrahim M. Alhazza, Hossam Ebaid, Mohamed S. Omar, Iftekhar Hassan, Mohamed A. Habila, Jameel Al-Tamimi, Mohamed Sheikh
Summary: The study found that selenium nanoparticles (SeNPs) have a protective effect against kidney injury in streptozocin-induced diabetic rats, improving symptoms such as polyuria, delayed gestation, and abnormal pancreatic beta-cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Samir A. E. Bashandy, Hossam Ebaid, Jameel Al-Tamimi, Omar A. -H. Ahmed-Farid, Enayat A. Omara, Ibrahim M. Alhazza
Summary: The study showed that melatonin can reduce oxidative stress caused by potassium dichromate, restore reproductive system markers, and physiological levels affected by potassium dichromate.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Faizan Abul Qais, Mohammad Shavez Khan, Iqbal Ahmad, Fohad Mabood Husain, Rais Ahmad Khan, Iftekhar Hassan, Syed Ali Shahzad, Walaa AlHarbi
Summary: This study demonstrated the significant inhibitory effect of coumarin on QS-regulated virulent traits of Gram-negative bacteria, including the suppression of various virulence factors and biofilm formation. Computational studies revealed that coumarin may inhibit quorum sensing activity through multiple mechanisms.
Article
Chemistry, Medicinal
Iftekhar Hassan, Hossam Ebaid, Ibrahim M. Alhazza, Jameel Al-Tamimi, Ahmed M. Rady
Summary: The present study investigated the potential of combining the anticancer drug 5-FU with copper and its chelating agent, disulfiram, in treating hepatocellular carcinoma in rats. The combination treatment showed significant improvement in most parameters, improving histological details and triggering apoptosis in cancer cells to a remarkable extent. Manipulating copper levels greatly enhances the antineoplastic activity of 5-FU and sensitizes cancer cells to the increased efficacy of the drug.
Article
Biochemistry & Molecular Biology
Ibrahim M. M. Alhazza, Iftekhar Hassan, Hossam Ebaid, Jameel Al-Tamimi, Zafrul Hasan
Summary: This study investigates the therapeutic potential of zinc oxide nanoparticles (ZnO NPs) against potassium bromate (PB)-induced nephrotoxicity in Swiss albino rats, and the results demonstrate the significant ameliorative efficacy of ZnO NPs in treating PB-induced kidney toxicity.
Article
Environmental Sciences
Iftekhar Hassan, Jameel Al-Tamimi, Hossam Ebaid, Mohamed A. Habila, Ibrahim M. Alhazza, Ahmed M. Rady
Summary: This study investigates the role of silver nanoparticles decorated with curcumin in enhancing the efficacy of metformin and countering drug-induced hepatotoxicity in chronic diabetes. The results show that the nanoparticles can relieve oxidative stress, toxic burden, and inflammation, leading to the restoration of liver function.
