Article
Psychiatry
Yong Wu, Lu Wang, Chu-Yi Zhang, Ming Li, Yi Li
Summary: This study found that the genetic architectures of different definitions of depression are distinct, and they have different genetic correlations and causality with other psychiatric traits. Functional mapping analysis also revealed different genes and pathways associated with different definitions of depression. Therefore, genetic studies of depression should be conducted more cautiously.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Chang Peng, Tengyun Guo, Junhan Cheng, Mengni Wang, Fajuan Rong, Shiyang Zhang, Yafei Tan, Hongli Ding, Yan Wang, Yizhen Yu
Summary: This study explores the relationship between Internet addiction (IA) and aggression. The results show that IA is a strong predictor of aggression, but not all sub-types of aggression contribute to IA. Female individuals with IA are more likely to have increased risk of anger and indirect aggression, while having decreased risk of physical and verbal aggression compared to male individuals with IA.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Plant Sciences
Nannan An, Nan Lu, Bojie Fu, Weiliang Chen, Maierdang Keyimu, Mengyu Wang
Summary: Fine roots play an important role in plant ecological strategies, adaptation to environmental constraints, and ecosystem functions. This study explores the covariation of root traits in different plant growth forms, mycorrhizal types, and biomes. The results reveal three independent dimensions of root trait covariation, influenced by biome and mycorrhizal type. Herbaceous and ectomycorrhizal species show a consistent pattern with the root economics spectrum.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Li Liu, Dan Wang, Jinping Hua, Xianhui Kong, Xuwen Wang, Juan Wang, Aijun Si, Fuxiang Zhao, Wenhao Liu, Yu Yu, Zhiwen Chen
Summary: In this study, three carbon-chain extension genes associated with fatty acid synthesis in upland cotton were cloned and characterized. These genes play important roles in oil accumulation in cotton seeds and fiber elongation. The expression patterns of these genes varied during different stages of seed development, and their overexpression resulted in increased oil content.
Article
Agronomy
Jiangfan Yu, Xinjian Tan, Dunyuan Huang, Qiuping Zhong, Ping Gu, Youcheng Zhou, Linqing Cao, Liyun Wang, Xirui Wan, Chuansong Chen, Yaqi Yuan, Hongyan Guo, Chao Yan, Jinfeng Wang, Xiaoning Ge
Summary: This study investigated the genetic differences among 24 populations of Gynura procumbens from different geographical regions using ITS and trnL-trnF sequences. The results showed that the trnL-trnF sequence had strong identification abilities in genetic difference research and populations collected from Taiwan and Indonesia shared similar genetic relationships.
GENETIC RESOURCES AND CROP EVOLUTION
(2023)
Article
Endocrinology & Metabolism
Ibrar Rafique, Asif Mir, Shajee Siddiqui, Muhammad Arif Nadeem Saqib, Asher Fawwad, Luc Marchand, Muhammad Adnan, Muhammad Naeem, Abdul Basit, Constantin Polychronakos
Summary: This study aimed to identify genetic variants responsible for monogenic forms of diabetes in the Pakistani population, revealing a wide spectrum of potentially causative variants. The study found novel variants not commonly seen in European populations, shedding light on the role of different genes in MODY patients and their management and diagnosis.
WORLD JOURNAL OF DIABETES
(2021)
Article
Ecology
Cyril Hammoud, Konstantinos Kougioumoutzis, Kenneth F. Rijsdijk, Stylianos M. Simaiakis, Sietze J. Norder, Johannes Foufopoulos, Elisavet Georgopoulou, Emiel E. Van Loon
Summary: Research on the impact of late Quaternary sea-level fluctuations on species richness patterns in the Aegean archipelago reveals significant changes in geography since the Last Glacial Maximum, affecting both native and endemic species diversity. The over-representation of native species and under-representation of endemics on land-bridge islands suggests a difference in the influence of sea-level changes on continental archipelagos compared to oceanic systems. Episodic connections with the mainland have profound effects on the biota of land-bridge islands, highlighting the importance of past and present geographic settings on chorological groups.
ECOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Rui Marcalo, Sonya Neto, Miguel Pinheiro, Ana J. Rodrigues, Nuno Sousa, Manuel A. S. Santos, Paula Simao, Carla Valente, Lilia Andrade, Alda Marques, Gabriela R. Moura
Summary: This study reveals a high genetic heterogeneity for COVID-19 susceptibility and severity across global populations, and it suggests that the prognosis of patients with COPD is not related to genetic risk.
Article
Medicine, General & Internal
Xiaomin Zhao, Xuying Li, Yi Liu, Kathleen Calzone, Juan Xu, Xueling Xiao, Honghong Wang
Summary: The level of genomic knowledge among nurses in mainland Chinese tertiary hospitals was moderate, and the genomic competency of cancer hospital nurses was comparable to that of general hospital nurses.
Article
Biochemistry & Molecular Biology
Ana Paula Machado, Alexandros Topaloudis, Tristan Cumer, Eleonore Lavanchy, Vasileios Bontzorlos, Renato Ceccherelli, Motti Charter, Nicolaos Kassinis, Petros Lymberakis, Francesca Manzia, Anne-Lyse Ducrest, Melanie Dupasquier, Nicolas Guex, Alexandre Roulin, Jerome Goudet
Summary: The study of insular populations is crucial for the development of evolutionary theory, as successful colonization of an island is influenced by various factors. This study on barn owls from Crete and Cyprus revealed that these populations have distinct genetic characteristics and demographic histories. The research provides empirical evidence for the impact of stochastic processes on isolated populations in island-mainland systems.
Article
Genetics & Heredity
Elena Bernabeu, Oriol Canela-Xandri, Konrad Rawlik, Andrea Talenti, James Prendergast, Albert Tenesa
Summary: Sex-stratified GWAS analyses of 530 traits within 452,264 individuals of European ancestry from the UK Biobank provide insights into the scope of genotype by sex interactions and the genetics of sex differences. Small yet widespread differences in genetic architecture across traits were found, emphasizing the importance of considering sex-aware analyses in future studies to understand sex-specific molecular mechanisms.
Article
Microbiology
Amanda C. Shaver, Janneke Wit, Clayton Dilks, Timothy Crombie, Hanchen Li, Raffi Aroian, Erik Andersen
Summary: Treatment of parasitic nematode infections in humans and livestock is becoming a challenge due to the increasing anthelmintic resistance. However, the use of Caenorhabditis elegans as a model organism has provided insights into the molecular targets of anthelmintic drugs. By studying genetically diverse strains of C. elegans, researchers were able to identify variations in anthelmintic responses and quantify the contribution of genetics to resistance. This study highlights the importance of using genetically diverse models to understand anthelmintic resistance.
Article
Endocrinology & Metabolism
James E. Faber, Hua Zhang, James G. Xenakis, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Wojciech Rzechorzek
Summary: Collateral blood flow varies greatly among humans and mice, which is caused by genetic background-dependent differences. The use of closely related inbred strains limits the understanding of this variation. The Collaborative Cross (CC) multiparent mouse genetic reference panel was developed to address this limitation. This study provides a comprehensive set of candidate genes for future investigations of collateral insufficiency.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Joseph A. Kendra, Kentaro Tohma, Lauren A. Ford-Siltz, Cara J. Lepore, Gabriel Parra
Summary: Noroviruses, especially the GII.4 genotype, are the main cause of acute gastroenteritis. Antigenic analysis on a virus-like particle panel representing major chronological GII.4 variants shows complex genetic determinants associated with antigenic diversification. Multiple coevolving amino acid changes, primarily at antigenic sites, contribute to the antigenic properties observed over the evolution of GII.4 variants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Piya Changmai, Yutthaphong Phongbunchoo, Jan Koci, Pavel Flegontov
Summary: Thailand is a linguistically diverse country with over 60 languages from five language families. The Kra-Dai language family is the most prevalent, with Thai being the official language. Previous genetic studies on Thai populations have revealed a complex population structure and provided hypotheses on the country's population history. In this study, the authors re-analyzed genome-wide genetic data on Thai populations, focusing on 14 Kra-Dai-speaking groups. The results show evidence of South Asian ancestry in certain Kra-Dai and Austroasiatic-speaking populations, as well as bidirectional admixture between Southern Thai and an Austronesian-speaking group from Southern Thailand. These findings challenge previous genetic analyses and highlight the close genetic relationship between Nayu and Austronesian-speaking groups from Island Southeast Asia.
SCIENTIFIC REPORTS
(2023)