Article
Medicine, General & Internal
Marieta P. Theodorakopoulou, Artemios G. Karagiannidis, Maria-Eleni Alexandrou, Fotini Iatridi, Michalis Christodoulou, Theodoros Dimitroulas, Aikaterini Papagianni, Pantelis A. Sarafidis
Summary: This study examined the ambulatory central blood pressure and arterial stiffness parameters in patients with and without intradialytic hypertension (IDH). The results showed that IDH patients had higher levels of central blood pressure and arterial stiffness parameters compared to non-IDH patients. Additionally, the two groups displayed different trajectories over the 48-hour period, with IDH patients showing consistently high values. These findings suggest that increased arterial stiffness may be a significant factor associated with the high burden of cardiovascular disease in this population.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Konstantinos Markakis, Nikolaos Pagonas, Eleni Georgianou, Panagiota Zgoura, Benjamin J. Rohn, Sebastian Bertram, Maximilian Seidel, Sebastian Bettag, Hans-Joachim Trappe, Nina Babel, Timm H. Westhoff, Felix S. Seibert
Summary: The study found that in patients with shock, both oscillometric blood pressure monitoring devices were successful in completing hemodynamic assessments, but there were significant differences between invasive and non-invasive techniques. There were discrepancies in pulse wave velocity measurements between the two devices. Non-invasive peripheral blood pressure measurement may not always be successful in certain circumstances.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Minyoung Kim, Ruda Lee, Nyeonju Kang, Moon-Hyon Hwang
Summary: This study investigated the impact of limb-specific resistance training on arterial stiffness in young adults. Results showed that upper-limb resistance training could decrease central artery wave reflection and potentially improve local peripheral artery stiffness in healthy young adults.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Fabio Anastasio, Marzia Testa, Cinzia Ferreri, Arianna Rossi, Gaetano Ruocco, Mauro Feola
Summary: This study aimed to evaluate the prognostic role of arterial stiffness in heart failure patients. The results showed that arterial stiffness was inversely correlated with patient survival and could serve as a prognostic predictor. This study is important for understanding the pathogenesis and clinical outcome of heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Matthew P. Harber, Allison McCurry, Nicholas Carlini, Brandon Kistler, Bradley S. Fleenor
Summary: The study found that in healthy middle-aged men, pre-exercise caffeine ingestion led to higher central and peripheral systolic blood pressures, PWV, and AIx at 30 minutes post-exercise, indicating an increased left ventricular workload which may have implications for cardiovascular event risk.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Pediatrics
Emre Leventoglu, Bahar Buyukkaragoz, Emine Nur Sunar Yayla, Pelin Esmeray Senol, Sevcan A. Bakkaloglu
Summary: This study evaluated arterial stiffness indicators in patients with FMF and found that arterial stiffness is more pronounced in colchicine-resistant patients.
CLINICAL PEDIATRICS
(2023)
Article
Medicine, General & Internal
Paolo Salvi, Filippo Valbusa, Anna Kearney-Schwartz, Carlos Labat, Andrea Grillo, Gianfranco Parati, Athanase Benetos
Summary: This study found a significant inverse correlation between carotid-femoral pulse wave velocity and carotid distensibility, indicating a close relationship between aortic stiffness evaluated by the propagative method and local carotid cross-sectional distensibility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Fabian Tomschi, Hannah Ottmann, Wilhelm Bloch, Marijke Grau, Hans-Georg Predel
Summary: The study found no difference between athletes and controls in any parameter measured. Women exhibited lower brachial and central BP as well as AS values compared to men. Pulse wave velocity was positively correlated with age. Evaluation based on different sport categories showed that endurance athletes had lower BP and PWV compared to other athletes.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Yang Yao, Shuran Zhou, Jordi Alastruey, Liling Hao, Stephen E. Greenwald, Yuelan Zhang, Lin Xu, Lisheng Xu, Yudong Yao
Summary: This study aims to identify pulse wave features for a more accurate estimation of carotid-femoral pulse wave velocity (cfPWV) from a single radial pulse wave measurement. The results show that the amplitude ratio of the diastolic peak to the notch of the radial pulse waveform is correlated with cfPWV and this correlation may not be dependent on wave reflection.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Cindy Z. Kalenga, Jacqueline L. Hay, Kevin F. Boreskie, Todd A. Duhamel, Jennifer M. MacRae, Amy Metcalfe, Kara A. Nerenberg, Magali Robert, Sofia B. Ahmed
Summary: Oral estrogen therapy is associated with increased blood pressure while non-oral estrogen therapy is not. The use of oral estrogen is also associated with higher aortic pulse wave velocity and augmentation index, although these associations are no longer significant after adjusting for covariates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jordana B. Cohen, Gary F. Mitchell, Dipender Gill, Stephen Burgess, Mahboob Rahman, Thomas Hanff, Vasan S. Ramachandran, Karen Mutalik, Raymond R. Townsend, Julio A. Chirinos
Summary: In this study, we used prospective cohort data and Mendelian randomization analyses to show that greater large artery stiffness (LAS) is associated with an increased risk of developing type 2 diabetes. LAS may play an important role in glucose homeostasis and could serve as a useful marker for future diabetes risk.
CIRCULATION RESEARCH
(2022)
Article
Urology & Nephrology
Mohamed Mamdouh Elsayed, Elhassan Mohamed Ayman
Summary: Atorvastatin may have a potential role in delaying arterial stiffness progression in hemodialysis patients, as it can help maintain stable arterial stiffness parameters while the placebo treatment group showed a significant increase. This suggests that atorvastatin may have a potential role in delaying arterial stiffness progression in hemodialysis patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreira, Timothy Collier, Andrew L. Clark, Mamas A. Mamas, Hans-Peter Brunner-La Rocca, Stephane Heymans, Arantxa Gonzalez, Fozia Z. Ahmed, Johannes Petutschnigg, Blerim Mujaj, Joe Cuthbert, Philippe Rouet, Pierpaolo Pellicori, Beatrice Mariottoni, Franco Cosmi, Frank Edelmann, Lutgarde Thijs, Jan A. Staessen, Mark Hazebroek, Job Verdonschot, Patrick Rossignol, Nicolas Girerd, John G. Cleland, Faiez Zannad
Summary: The study examined the effects of spironolactone on blood pressure in patients at risk for heart failure, finding that it had a significant blood pressure-lowering effect, especially in those with lower baseline blood pressure levels. Spironolactone may be considered for blood pressure management in patients at risk for developing heart failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Peripheral Vascular Disease
Lucas S. Aparicio, Qi-Fang Huang, Jesus D. Melgarejo, Dong-Mei Wei, Lutgarde Thijs, Fang-Fei Wei, Natasza Gilis-Malinowska, Chang-Sheng Sheng, Jose Boggia, Teemu J. Niiranen, Augustine N. Odili, Katarzyna Stolarz-Skrzypek, Jessica Barochiner, Daniel Ackermann, Kalina Kawecka-Jaszcz, Valerie Tikhonoff, Zhen-Yu Zhang, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Aletta E. Schutte, Wen-Yi Yang, Antti M. Jula, Angela J. Woodiwiss, Murielle Bochud, Gavin R. Norton, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: The IDCARS database includes 10,930 subjects from 13 studies across different regions, with prevalence rates of office hypertension and diabetes mellitus reported. The central and peripheral systolic/diastolic blood pressure, as well as aortic pulse wave velocity, were measured. Longitudinal studies showed a median follow-up of 4.2 years, with cardiovascular events and deaths reported during the follow-up period. The IDCARS database provides valuable information for investigating central hemodynamic measurements and may inform guidelines for managing hypertension.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Agnieszka Latosinska, Rosa Maria Bruno, Marco Pappaccogli, Alessandra Bacca, Christophe Beauloye, Pierre Boutouyrie, Hakim Khettab, Jan A. Staessen, Stefano Taddei, Laurent Toubiana, Miikka Vikkula, Harald Mischak, Alexandre Persu
Summary: This study investigates the use of urinary proteomics in the diagnosis of FMD and develops a classifier to distinguish FMD patients from healthy controls and other diseases. Furthermore, the study finds a positive correlation between the proteomic score and the arterial geometry and mechanics in FMD patients.
Article
Cardiac & Cardiovascular Systems
Blerim Mujaj, Zhen-Yu Zhang, Wen-Yi Yang, Lutgarde Thijs, Fang-Fei Wei, Peter Verhamme, Christian Delles, Javed Butler, Peter Sever, Roberto Latini, John G. F. Cleland, Faiez Zannad, Jan A. Staessen
Summary: This study found that aspirin use was associated with incident HF in patients at risk, independent of other risk factors. In the absence of conclusive trial evidence, caution should be exercised in prescribing aspirin to patients at risk of HF or with HF.
Article
Peripheral Vascular Disease
Yi-Bang Cheng, Lutgarde Thijs, Lucas S. Aparicio, Qi-Fang Huang, Fang-Fei Wei, Yu-Ling Yu, Jessica Barochiner, Chang-Sheng Sheng, Wen-Yi Yang, Teemu J. Niiranen, Jose Boggia, Zhen-Yu Zhang, Katarzyna Stolarz-Skrzypek, Natasza Gilis-Malinowska, Valerie Tikhonoff, Wiktoria Wojciechowska, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Kalina Kawecka-Jaszcz, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: This study investigated the relationship between cardiovascular risk and central and brachial systolic pressure and proposed thresholds to differentiate hypertension from normal blood pressure. Regardless of brachial blood pressure status, central hypertension was associated with increased cardiovascular and cerebrovascular risk, highlighting the importance of controlling central hypertension.
Article
Cardiac & Cardiovascular Systems
Dongmei Wei, Jesus D. Melgarejo, Lutgarde Thijs, Xander Temmerman, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Jan A. Staessen, Peter Verhamme, Zhen-Yu Zhang
Summary: This study aimed to identify a urinary proteomic profile associated with arterial stiffness and adverse outcomes. The researchers found that a PWV-derived urinary proteomic score (PWV-UP) was highly associated with arterial stiffness and could serve as a biomarker. They also discovered that PWV-UP was associated with all-cause mortality and cardiovascular mortality, indicating the involvement of multifaceted pathological processes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Peripheral Vascular Disease
Jessica Barochiner, Lucas S. Aparicio, Rocio Martinez, Jose Boggia
Summary: Home blood pressure monitoring (HBPM) is an independent predictor of cardiovascular events in hypertensives under treatment. The study found that continuously monitoring blood pressure over a short period of time, especially by discarding the first day's measurements and analyzing measurements from different time periods, can provide a more accurate prediction of cardiovascular events.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Pediatrics
Liselotte Van Loo, Karel Allegaert, Elena Levtchenko, Zhenyu Zhang, Jan A. Staessen, Anke Raaijmakers
Summary: This study investigated endothelial integrity in healthy controls and extremely low birth weight (ELBW) survivors. The results suggest that perfused boundary region (PBR) may not be a suitable biomarker for endothelial integrity in ELBW survivors, despite observations of changes in blood pressure and vascularization. These findings highlight the importance of studying and understanding the complex structure of the endothelial glycocalyx in ELBW survivors.
PEDIATRIC RESEARCH
(2023)
Article
Peripheral Vascular Disease
Ben Grobman, Ruth-Alma N. Turkson-Ocran, Jan A. Staessen, Yu-Ling Yu, Lewis A. Lipsitz, Kenneth J. Mukamal, Stephen P. Juraschek
Summary: Using data from the Syst-Eur trial, this study examined the effect of hypertension treatment on the incidence of orthostatic hypotension based on different body positions. The results showed that active hypertension treatment did not increase the risk of orthostatic hypotension, regardless of the testing protocol used.
Review
Spectroscopy
De-Wei An, Yu-Ling Yu, Dries S. S. Martens, Agnieszka Latosinska, Zhen-Yu Zhang, Harald Mischak, Tim S. S. Nawrot, Jan A. A. Staessen
Summary: Using urinary proteomics profiling (UPP) as an example, this review presents a workflow for analyzing omics data in large study populations. The workflow includes planning and considering sample size, data preprocessing, statistical steps for data curation, selecting covariables, relating outcomes to markers, demonstrating the added value of UPP markers, and pathway analysis. The review also touches on multiomics studies and machine learning. In conclusion, analyzing adverse health outcomes in relation to omics biomarkers requires careful planning, data preparation, statistical analysis, and presentation.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Jill Vanthienen, Marine Vassilev Petrov, Thuy Mai Luu, Anik Cloutier, Anke Raaijmakers, Jan A. Staessen, Zhenyu Zhang, Thomas Salaets, Annouschka Laenen, Anne Smits, Anne-Monique Nuyt, Adrien Flahault, Karel Allegaert
Summary: The study found no significant difference in QT(c-Bazett) intervals between former preterm and/or extremely low birth weight cases and term-born controls.
Article
Peripheral Vascular Disease
Yu-Ling Yu, De-Wei An, Wen-Yi Yang, Peter Verhamme, Karel Allegaert, Tim S. Nawrot, Jan A. Staessen
Summary: The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure and renal function responses in workers without previous occupational lead exposure over a period of 6 years. The results showed that there was no significant correlation between the changes in blood pressure and renal function and the increase in blood lead level. Therefore, it can be concluded that modern lead-handling facilities operating under current safety rules are safe.
JOURNAL OF CLINICAL HYPERTENSION
(2023)