Review
Cardiac & Cardiovascular Systems
Rebecca Angoff, Ramya C. Mosarla, Connie W. Tsao
Summary: AoS is a maladaptive response to hemodynamic stress, associated with increased afterload for the heart, making it a marker of cardiovascular health and metabolic dysfunction. Research on biomarkers linked to increased AoS may provide insights into future pathophysiologic pathways and therapeutic targets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Olga Vriz, Lucio Mos, Paolo Palatini
Summary: This study assessed the effects of leisure time versus vigorous long-term dynamic physical activity on carotid stiffness in individuals with normal blood pressure and hypertension. The results showed that leisure time physical activity had a beneficial effect on carotid artery stiffness in hypertensive individuals, while high-intensity chronic physical activity did not provide any benefits to vascular functions. Among individuals with normal blood pressure, there was a gradual reduction in carotid stiffness from sedentary individuals to competitive athletes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Norsuhana Omar, Boon Seng Yeoh, Kalaivani Chellappan, Sara Zijiun Chui, Norizam Salamt, Amilia Aminuddin
Summary: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity in Malaysia and worldwide. The prevalence of risk factors such as hypertension, dyslipidemia, smoking, and obesity has contributed to this trend. Increased physical activity, as assessed by pulse wave velocity (PWVCF), augmentation index (AI), and finger photoplethysmography fitness (PPGF) index, has been associated with improved CVD risk factors. However, the effects of long-term exercise on PPGF index are still unclear.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Agne Laucyte-Cibulskiene, Chen-Huan Chen, John Cockroft, Pedro G. Cunha, Maryam Kavousi, Aleksandras Laucevicius, Maria Lorenza Muiesan, Ernst R. Rietzschel, Ligita Ryliskyte, Irina D. Strazhesko, Charalambos Vlachopoulos, Jorge Cotter, Ekatherina N. Dudinskaya, Nichola Gale, Fariba Ahmadizar, Francesco U. S. Mattace-Raso, Maggie Munnery, Pedro Oliveira, Anna Paini, Massimo Salvetti, Olga N. Tkacheva, Edward G. Lakatta, Peter M. Nilsson, Angelo Scuteri
Summary: This study aimed to investigate the effect of metabolic syndrome (MetS) and its components on central blood pressure (CBP). The results showed that individuals with MetS were 50% more likely to have higher CBP. Furthermore, specific clusters of MetS components were found to be associated with higher CBP, with some associations being more significant in women.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Maria Karolina Ferreira de Sousa, Raissa de Melo Silva, Yuri Alberto Freire, Gabriel Costa Souto, Marcyo Camara, Ludmila Lucena Pereira Cabral, Geovani Araujo Dantas Macedo, Eduardo Caldas Costa, Ricardo Santos Oliveira
Summary: This study examined the associations between physical activity and cardiorespiratory fitness with vascular health phenotypes in older adults. The results showed that poor cardiorespiratory fitness, but not physical activity, was associated with the unhealthiest vascular health phenotype in older adults.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Keeron Stone, Simon Fryer, James Faulkner, Michelle L. Meyer, Kevin Heffernan, Anna Kucharska-Newton, Gabriel Zieff, Craig Paterson, Kunihiro Matsushita, Timothy M. Hughes, Hirofumi Tanaka, Lee Stoner
Summary: The study found no significant relationship between aortic-femoral arterial stiffness gradient (af-SG) and mean arterial pressure (MAP) in healthy older adults, as well as adults with hypertension and diabetes, indicating that af-SG may be considered as a MAP independent index of arterial health and cardiovascular disease (CVD) risk in older adults.
JOURNAL OF HYPERTENSION
(2021)
Review
Physiology
Amilia Aminuddin, Muhammad Fakhrurrazi Noor Hashim, Nur Aina Syazana Mohd Zaberi, Lee Zheng Wei, Beh Ching Chu, Nur Amalina Jamaludin, Norizam Salamt, Nur Aishah Che Roos, Azizah Ugusman
Summary: The study found a negative correlation between arterial stiffness and muscle indices in both healthy individuals and those with cardiovascular disease or risk factors. However, most of the studies were cross-sectional, highlighting the need for future prospective studies to confirm this association.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Hung-Ju Ko, Chuan-Chuan Liu, Po-Jui Hsu, Kuang-Chun Hu, Chung-Lieh Hung, Lo-Yip Yu, Yun-Chieh Huang, Shou-Chuan Shih
Summary: This study compared the role of baPWV with other risk indicators in identifying subclinical vascular disease and found that baPWV has clinical utility in improving prognosis for high-risk subjects.
Article
Peripheral Vascular Disease
Keeron Stone, Simon Fryer, Michelle L. Meyer, Anna Kucharska-Newton, James Faulkner, Gabriel Zieff, Craig Paterson, Daniel Credeur, Kunihiro Matsushita, Timothy M. Hughes, Hirofumi Tanaka, Lee Stoner
Summary: The study compared the associations of af-SG and cfPWV with age, CVD risk factors, and CVD status. The results showed that af-SG and cfPWV had similar associations with age and CVD risk factors, but differed in terms of BMI. A low af-SG was associated with diabetes, coronary heart disease, heart failure, and stroke, while a high cfPWV was only associated with diabetes.
JOURNAL OF HYPERTENSION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zheng-Qiu Zhu, Ling-Shan Chen, Xue-Zhong Jiang, Yi-Yun Wu, Chong Zou, Yun Luan, Hui Gao, Ping Dai, Xue-Hui Ma, Lin-Lin Wu, Hui-Juan Sun, Yin-Ping Wang, Fei Zou, Fu-Ming Liu, Hui Huang
Summary: The study found that many individuals without conventional cardiovascular risk factors have carotid stiffening, with age, male sex, and body mass index being independently associated with carotid stiffening.
EUROPEAN RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luca D'Onofrio, Rocco Amendolara, Carmen Mignogna, Gaetano Leto, Lida Tartaglione, Sandro Mazzaferro, Ernesto Maddaloni, Raffaella Buzzetti
Summary: This study evaluated CHIT activity as an early biomarker of arterial stiffness in T2D patients without overt vascular complications. The results showed no association between CHIT activity and arterial stiffness, but the high-PWV group had other CVD risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Carl Grabitz, Katharina M. Sprung, Laura Amagliani, Nima Memaran, Bernhard M. W. Schmidt, Uwe Tegtbur, Jeannine von der Born, Arno Kerling, Anette Melk
Summary: The aim of this study was to investigate early markers and drivers of cardiovascular disease in young athletes pursuing a career in competitive sports. The study found a higher prevalence of elevated blood pressure and abnormal vascular structure in athletes, despite regular physical exercise and absence of obesity. The association between raised hemoglobin levels and altered vascular properties suggests potential adverse effects on vascular health. Thorough medical examinations in seemingly healthy children and young adults in this population are crucial.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hannes Holm, Ruan Kruger, Amra Jujic, Zohra Lamiral, Aletta Sophia Uys, Nicolas Girerd, Martin Magnusson
Summary: Ventricular-arterial coupling (VAC) has independent diagnostic and prognostic value for cardiovascular (CV) risk stratification. In this study, the associations of VAC with anthropometric and CV risk factors were investigated in young individuals without overt CV disease. The results showed that higher values of PWV/GLS, indicating worse VAC, were associated with older age, male sex, and a higher prevalence of CV risk factors. These findings suggest that PWV/GLS may serve as a useful tool for assessing cardiovascular risk in young adults. Rating: 8 out of 10.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Brittany A. Matenchuk, Katelyn Fujii, Rachel J. Skow, Frances Sobierajski, Christina MacKay, Craig D. Steinback, Margie H. Davenport
Summary: The objective of this study was to investigate the relationship between moderate-to-vigorous physical activity (MVPA) and arterial stiffness in pregnancy. The study found a significant association between meeting MVPA guidelines and reduced arterial stiffness in pregnancy.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Health Care Sciences & Services
Byung Sik Kim, Yonggu Lee, Jin-Kyu Park, Young-Hyo Lim, Jeong-Hun Shin
Summary: This study investigated the association between ePWV and cardiovascular disease outcomes in Korean adults. The findings suggest that higher ePWV is associated with increased risk of cardiovascular mortality and adverse cardiovascular outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Physiology
Rosaly Correa-De-Araujo, Andrea P. Rossi, Mauro Zamboni, Odessa Addison, Iva Miljkovic, Bret Goodpaster
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neuroimaging
Matteo Bonatti, Fabio Lombardo, Riccardo Valletta, Alessio Comai, Benedetto Petralia, Giacomo Avesani, Enrica Franchini, Andrea Rossi, Nicoletta De Santis, Massimo Guerriero, Federica Ferro
Summary: This study assessed the impact of sarcopenia and myosteatosis on neurological outcomes and mortality in patients with successfully reperfused acute ischemic stroke. The results showed that low masseter attenuation was an independent negative predictor for 90-day mortality and poor neurological outcome.
NEURORADIOLOGY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Valentina Muollo, Toni Tatangelo, Laura Ghiotto, Valentina Cavedon, Chiara Milanese, Mauro Zamboni, Federico Schena, Andrea P. Rossi
Summary: This study investigated the association between handgrip strength and muscle function of the lower limbs, as well as predictors of appendicular lean mass index in older adults with obesity. Results showed that handgrip strength was weakly associated with lower limbs muscle function and physical performance, while BMI was a significant predictor for ALMI in both genders. In the group of men, markers related to strength and power of the lower limbs were found to better explain variations in ALMI compared to handgrip strength.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Endocrinology & Metabolism
Laura Ghiotto, Valentina Muollo, Toni Tatangelo, Federico Schena, Andrea P. Rossi
Summary: Engagement in physical exercise, particularly resistance training, can improve or maintain physical performance in adults with sarcopenic obesity. Future research should focus on the impact of different types of training (aerobic, power training, combined modalities). Additionally, longer intervention periods and follow-up studies are needed to gain a better understanding of the effectiveness of exercise on physical function in adults with sarcopenic obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Fantin, Anna Giani, Arianna Franconi, Elena Zoico, Silvia Urbani, Andrea P. P. Rossi, Gloria Mazzali, Mauro Zamboni
Summary: Arterial stiffness and subendocardial perfusion impairment are important factors in heart failure outcomes. This study found that carotid-femoral pulse wave velocity (PWVcf) is a valid predictor of 30-day readmission in patients with heart failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Andrea P. Rossi, Katia Donadello, Vittorio Schweiger, Giulia A. Zamboni, Zeno Dalla Valle, Mauro Zamboni, Enrico Polati, Leonardo Gottin
Summary: This study analyzed the impact of epicardial adipose tissue (EAT) on the risk of mortality and pulmonary embolism in critically ill COVID-19 patients. The results showed that patients with higher EAT volume and lower EAT density should be carefully monitored and managed to prevent serious consequences and increase in hospital treatment costs.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Geriatrics & Gerontology
Toni Tatangelo, Valentina Muollo, Laura Ghiotto, Federico Schena, Andrea P. Rossi
Summary: Handgrip strength is a widely used and convenient tool for assessing muscle and physical function. However, there is controversy regarding its use for evaluating overall muscle function, especially in the lower limbs. Lower limb muscle strength and physical performance decline with age, but it is challenging to quantify this decline in routine settings. This review explores the association between handgrip strength, lower limb muscle strength, and physical performance in older adults, and provides directions for future research.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Nutrition & Dietetics
Andrea P. Rossi, Valentina Muollo, Zeno Dalla Valle, Silvia Urbani, Massimo Pellegrini, Marwan El Ghoch, Gloria Mazzali
Summary: This review investigates the relationship between COVID-19, body composition, and nutritional status. The findings suggest that obesity and the distribution of body fat play a crucial role in the severity of COVID-19. High volumes of epicardial adipose tissue and reduced muscle mass increase the risk of infection and death. Malnutrition is also prevalent, highlighting the need for further research on optimizing nutritional status to preserve muscle mass.
Article
Medicine, General & Internal
Francesco Fantin, Anna Giani, Monica Trentin, Andrea P. Rossi, Elena Zoico, Gloria Mazzali, Rocco Micciolo, Mauro Zamboni
Summary: The study evaluated the relationship between arterial stiffness indexes, comorbidity burden, and aging. It found significant correlations between arterial stiffness indexes and both age and comorbidity burden. Arterial stiffness parameters can provide additional insights into patients with significant comorbidity burdens as they age.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Mauro Zamboni, Gloria Mazzali, Anna Brunelli, Tanaz Saatchi, Silvia Urbani, Anna Giani, Andrea P. Rossi, Elena Zoico, Francesco Fantin
Summary: Due to aging, there are changes in body composition, with a decrease in muscle mass and an increase in adipose tissue. This redistribution of adipose tissue to visceral areas and ectopic storage in organs contribute to the development of sarcopenic obesity. Understanding the crosstalk between dysfunctional adipose and muscle cells can help in developing prevention strategies and treatments for this condition.
Article
Geriatrics & Gerontology
Angela Martini, Francesco Fantin, Maicol Cavedon, Mauro Zamboni, Silvia Urbani, Anna Giani, Piero Brandimarte, Andrea Petronio Rossi
Summary: The study demonstrates that using the MePill device can significantly improve adherence to prescribed therapy and reduce re-hospitalization rate in elderly patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Health Care Sciences & Services
Massimo Pellegrini, Leila Itani, Andrea P. Rossi, Dima Kreidieh, Dana El Masri, Hana Tannir, Marwan El Ghoch
Summary: This paper reviews the literature on sarcopenic obesity (SO) in young and middle-aged female adults with obesity in weight management settings, highlighting the screening and diagnostic methods for patients and the importance of timely management of obesity-related comorbidities associated with SO.
Article
Geriatrics & Gerontology
Francesca Remelli, Elisa Maietti, Pasquale Abete, Giuseppe Bellelli, Mario Bo, Antonio Cherubini, Francesco Corica, Mauro Di Bari, Marcello Maggio, Maria Rosaria Rizzo, Andrea P. Rossi, Francesco Landi, Stefano Volpato
Summary: This study investigated the prevalence of sarcopenic obesity in older individuals according to EWGSOP2 and FNIH criteria. Results showed different prevalence rates of obesity and diabetes based on the two definitions, with diabetic patients more likely to be sarcopenic according to FNIH criteria.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Valentina Muollo, Andrea Zignoli, Laura Ghiotto, Chiara Milanese, Mauro Zamboni, Federico Schena, Andrea Petronio Rossi
Summary: The study compared bilateral lower limb torque in elderly individuals with and without obesity, finding that those with obesity had lower KF/KE ratio and muscle quality.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)