Article
Endocrinology & Metabolism
Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem
Summary: Diabetic nephropathy is a common microvascular complication in type 1 diabetes mellitus. Urinary markers of renal damage or oxidative stress may signal early stages of DN, but their association with blood pressure patterns and glycemic variability in children is not yet well understood. This study found that while microalbuminuria was negative, urinary NGAL/Cr and pentosidine/Cr ratios were significantly elevated in diabetic patients. Additionally, poor nocturnal systolic blood pressure dipping was found in nearly half of the cases, and urinary NGAL/Cr negatively correlated with this dipping pattern. Both NGAL/Cr and pentosidine/Cr ratios were also higher in the high glycemic variability group. Overall, this pilot study highlights the potential role of ABPM and urinary markers in the early detection of diabetic nephropathy, with glycemic variability possibly playing a role in the disease process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Nobuko Kitagawa, Noriyuki Kitagawa, Emi Ushigome, Hidetaka Ushigome, Isao Yokota, Naoko Nakanishi, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: The study found that IH-HSBP was associated with an increased risk of diabetic nephropathy among type 2 diabetes mellitus patients with normal or mildly increased albuminuria in the medium to long term. The results support and strengthen previous reports, suggesting that IH-HSBP might be a useful marker in disease prognostication.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Nadia Boubouchairopoulou, Angeliki Ntineri, Anastasios Kollias, Antonios Destounis, George S. Stergiou
Summary: This study compared blood pressure variability (BPV) among different measurement methods and found that out-of-office BPV was higher than office BPV, with ambulatory BP monitoring giving the highest values. There was weak association among BPV indices assessed using different methods, but stronger agreement between out-of-office BPV indices in identifying individuals with high BPV. Older age was independently associated with increased office BPV, while older age, female sex, smoking, and overweight/obesity were determinants of increased out-of-office BPV. The study suggests that choosing the BPV index may be less important compared to the method of measurement, and office and out-of-office BP measurements can complement each other in assessing BPV.
HYPERTENSION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Ming-Hui Hung, Chin-Chou Huang, Chia-Min Chung, Jaw-Wen Chen
Summary: This study found that short-term blood pressure variability was not strongly associated with hypertensive nephropathy in Han Chinese individuals with hypertension, while 24-hour average blood pressure was more closely related to hypertensive nephropathy.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Fosca Quarti-Trevano, Raffaella Dell ' Oro, Jennifer Vanoli, Michele Bombelli, Rita Facchetti, Giuseppe Mancia, Guido Grassi
Summary: This study found that there is no significant association between chronic coffee consumption and blood pressure changes, particularly when assessed through 24-hour ambulatory and home blood pressure monitoring. However, consuming coffee during the day can cause a slight increase in blood pressure, which disappears at night.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Subin Lim, Se Hwa Chung, Ju Hyeon Kim, Yong Hyun Kim, Eung Ju Kim, Hyung Joon Joo
Summary: Metabolic abnormalities are common in diabetic patients, and visit-to-visit variabilities in measurements such as blood pressure, blood glucose, and cholesterol levels may be potential risk factors for cardiovascular events.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Urology & Nephrology
Chen Tang, Xiao-Yan Zhang, Ji-Cheng Lv, Su-Fang Shi, Xu-Jie Zhou, Li-Jun Liu, Hong Zhang
Summary: The visit-to-visit variability in blood pressure is associated with the progression of IgA nephropathy, particularly in patients with higher standard deviation of systolic blood pressure.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Peripheral Vascular Disease
Daisuke Suzuki, Satoshi Hoshide, Kazuomi Kario
Summary: This study investigated whether the prognostic power of home blood pressure for cardiovascular disease events differs across subjects with different diabetic status. The study found that both prediabetes and diabetes are risk factors for cardiovascular disease events, and elevated home blood pressure contributes to increased risk in diabetic patients.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Tae-Hyun Yoo, Soon Jun Hong, Sunggyun Kim, Seokjoon Shin, Dong Ki Kim, Jung Pyo Lee, Sang Youb Han, Sangho Lee, Jong Chul Won, Young Sun Kang, Jongha Park, Byoung-Geun Han, Ki-Ryang Na, Kyu Yeon Hur, Yong-Jin Kim, Sungha Park
Summary: This study compares the antiproteinuric effects of fimasartan and losartan in patients with diabetic kidney disease. The results show that fimasartan significantly reduces albuminuria compared to losartan, even after adjusting for systolic blood pressure levels. There were no significant differences in adverse events between the two drugs.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Takuro Kubozono, Yuichi Akasaki, Shin Kawasoe, Satoko Ojima, Takeko Kawabata, Hyuma Makizako, So Kuwahata, Toshihiro Takenaka, Mayuka Maeda, Seisuke Fujiwara, Ken Miyagawa, Yoshiyuki Ikeda, Mitsuru Ohishi
Summary: This study found that the day-to-day blood pressure variability (BPV) of systolic blood pressure is independently associated with cardiac biomarkers NT-pro BNP, liver index Fib4, and renal function eGFR, but not with troponin T. In contrast, diastolic BPV was not found to be associated with eGFR.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Kazuomi Kario, Naoko Tomitani, Takeshi Fujiwara, Yukie Okawara, Hiroshi Kanegae, Satoshi Hoshide
Summary: This study investigated the association between pathological threshold or frequency of peak home blood pressure (BP) and cardiovascular events in hypertensive patients. It found that peak home BP was strongly associated with the risk of stroke, coronary artery disease (CAD), and atherosclerotic cardiovascular disease (ASCVD). A peak home systolic BP above 175 mmHg was identified as an early and strong novel risk factor for stroke.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Konstantinos Manousopoulos, Eleni Koroboki, Gerassimos Barlas, Aikaterini Lykka, Nefeli Tsoutsoura, Konstantina Flessa, Ioannis Kanakakis, Ioannis Paraskevaidis, Nikolaos Zakopoulos, Efstathios Manios
Summary: The study compared the association of ambulatory and home blood pressure variability (BPV) with left ventricular mass index (LVMI) in chronic kidney disease (CKD) patients, finding that ambulatory BPV, specifically the 24-hour systolic blood pressure (SBP) time rate variation, was independently associated with LVMI, regardless of average blood pressure values. This suggests that dynamic BPV may be a more significant predictor of LVMI in CKD patients compared to home BPV.
HYPERTENSION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Kazuomi Kario, Naoko Tomitani, Yukie Okawara, Hiroshi Kanegae, Satoshi Hoshide
Summary: The therapeutic range of home systolic blood pressure is associated with cardiovascular events, with a lower TTR being associated with a higher risk.
HYPERTENSION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Nicoline Callesen Do, Marianne Vestgaard, Bjorg Asbjornsdottir, Lise Lotte Torvin Andersen, Dorte Moller Jensen, Lene Ringholm, Peter Damm, Elisabeth Reinhardt Mathiesen
Summary: In women with preexisting diabetes, both home blood pressure and office blood pressure are positively associated with the development of preeclampsia, and their predictive abilities are comparable. Home blood pressure is lower than office blood pressure in both early and late pregnancy, and the difference increases with increasing office blood pressure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Peripheral Vascular Disease
Yoshikatsu Suzuki, Keiichi Matsubara, Kazushi Watanabe, Kanji Tanaka, Tamao Yamamoto, Tomoyoshi Nohira, Kazuya Mimura, Hirotada Suzuki, Fumiaki Hamada, Shintarou Makino, Keiko Koide, Haruki Nishizawa, Katsuhiko Naruse, Yukiko Mikami, Ikuno Kawabata, Jun Yoshimatsu, Kohta Suzuki, Shigeru Saito
Summary: In recent times, home blood pressure monitoring (HBPM) has replaced clinic BP monitoring for diagnosing hypertensive disorders of pregnancy (HDP). A multicenter study was conducted on pregnant Japanese women in the non-high risk group for HDP, where they self-measured and recorded their daily HBP. The study found that HBP was appropriate during the 17-21st weeks of gestation and increased after 24 weeks, returning to non-pregnant levels 4 weeks postpartum. The study also identified cut-off values for HBP during gestation and observed that women who developed HDP had higher systolic and diastolic HBP compared to normal pregnancies.
HYPERTENSION RESEARCH
(2022)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Yukiko Kobayashi, Ayumi Kaji, Ryosuke Sakai, Takuro Okamura, Naoko Nakanishi, Saori Majima, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahide Hamaguchi, Masahiro Yamazaki, Wataru Aoi, Masashi Kuwahata, Michiaki Fukui
Summary: This study showed that household income was related to dietary fiber intake and dietary acid load in men but not in women.
Article
Nutrition & Dietetics
Ayasa Nitta, Saeko Imai, Shizuo Kajiayama, Mikuko Matsuda, Takashi Miyawaki, Shinya Matsumoto, Shintaro Kajiyama, Yoshitaka Hashimoto, Neiko Ozasa, Michiaki Fukui
Summary: This study aimed to evaluate the effect of dietitian-led medical nutrition therapy on glycemic control in patients with type 2 diabetes. The results showed that patients in the intervention group had a significant improvement in glycemic control after 5 years, compared to the control group. Additionally, dietary intake in the intervention group also showed improvement.
Article
Nutrition & Dietetics
Shinnosuke Hata, Takuro Okamura, Ayaka Kobayashi, Ryo Bamba, Tomoki Miyoshi, Hanako Nakajima, Nobuko Kitagawa, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Hiroshi Takakuwa, Ryoichi Sasano, Masahide Hamaguchi, Michiaki Fukui
Summary: This study compared the effects of luseogliflozin and a low-carbohydrate diet on sarcopenic obesity. The results showed that luseogliflozin could prevent sarcopenic obesity by improving amino acid metabolism.
Article
Nutrition & Dietetics
Hiroyuki Tominaga, Masahide Hamaguchi, Shinto Ando, Megumi Minamida, Yuriko Kondo, Kazuki Hamada, Tetsuya Nojiri, Michiaki Fukui
Summary: The study found that individuals with type 2 diabetes preferred to choose lower-carbohydrate and lower-calorie food menus at home using online diet management applications. This preference could help improve sustained self-management and quality of life.
Article
Environmental Sciences
Takuro Okamura, Masahide Hamaguchi, Yuka Hasegawa, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Ryoichi Sasano, Yuki Nakanishi, Hiroshi Seno, Hirohisa Takano, Michiaki Fukui
Summary: The study found that microplastics can cause metabolic disturbances, such as diabetes and nonalcoholic fatty liver disease, in mice on a high-fat diet. The results highlight the importance of reducing oral exposure to microplastics through environmental measures to improve metabolic disturbance under high-fat diet conditions.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Nutrition & Dietetics
Hanako Nakajima, Hiroshi Okada, Ayaka Kobayashi, Fuyuko Takahashi, Takuro Okamura, Yoshitaka Hashimoto, Naoko Nakanishi, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Michiaki Fukui
Summary: This study aimed to identify the serum metabolites associated with sarcopenic risk in Japanese patients with type 2 diabetes. The relationship between dietary protein intake and the metabolites concerning sarcopenia was analyzed, and the factors affecting sarcopenic risk were clarified. Leucine and glutamic acid were found to be useful biomarkers for sarcopenia.
Article
Geriatrics & Gerontology
Takuro Okamura, Masahide Hamaguchi, Hanako Nakajima, Nobuko Kitagawa, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Ryoichi Sasano, Michiaki Fukui
Summary: This study aimed to clarify the effect of milk on the prevention of sarcopenic obesity in db/db mice. The results showed that milk administration increased muscle mass and strength, and decreased visceral fat mass in the mice. Fecal microbiota transplantation from mice fed milk improved sarcopenic obesity and glucose intolerance. The findings suggest that milk consumption not only increases nutrient intake but also alters the intestinal environment, contributing to the improvement of sarcopenic obesity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Endocrinology & Metabolism
Yoshitaka Hashimoto, Masahide Hamaguchi, Michiaki Fukui
Summary: The number of patients with type 2 diabetes mellitus is increasing, and prevention and management are important. Fermented soybean food modifies gut microbiota-related metabolites by altering dysbiosis. Fermented soybean foods also have antioxidant, anti-inflammatory, and anti-diabetic effects.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Dan Imai, Emi Ushigome, Masahide Hamaguchi, Satoru Hashimoto, Michiaki Fukui
Summary: This study aimed to investigate the rates of different diabetes status in severe COVID-19 patients and the factors associated with bleeding complications. The results showed that glycated hemoglobin level and renal failure were significantly correlated with bleeding complications. Additional attention to the course of COVID-19 is recommended for patients with diabetes, especially those with COVID-19-related diabetes, to reduce the risk of bleeding complications.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Yuta Yoshimura, Yoshitaka Hashimoto, Hiroshi Okada, Maya Takegami, Hanako Nakajima, Tomoki Miyoshi, Takashi Yoshimura, Masahiro Yamazaki, Masahide Hamaguchi, Michiaki Fukui
Summary: This study aimed to investigate the effects of dapagliflozin on skeletal muscle mass in individuals with type 1 diabetes, as well as the impact of good glycemic control on skeletal muscle mass. The findings suggest that dapagliflozin treatment may lead to loss of skeletal muscle mass in non-obese individuals and older men. However, good glycemic control during treatment may prevent the onset and progression of sarcopenia.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Shintaro Kajiyama, Naoko Nakanishi, Shinta Yamamoto, Takahiro Ichikawa, Takuro Okamura, Yoshitaka Hashimoto, Noriyuki Kitagawa, Masahide Hamaguchi
Summary: This study investigated the relationship between nutritional status and low phase angle (PhA). It was found that dietary habits and serum nutritional markers were related to PhA. Low PhA values were associated with poor exercise habits and lower body mass index in males. Total energy intake was significantly correlated with PhA in males, with the low-PhA group having lower total energy and carbohydrate intake.
Article
Nutrition & Dietetics
Saeko Imai, Shizuo Kajiyama, Kaoru Kitta, Takashi Miyawaki, Shinya Matsumoto, Neiko Ozasa, Shintaro Kajiyama, Yoshitaka Hashimoto, Michiaki Fukui
Summary: People with fast eating habits have an increased risk of diabetes and obesity. A study found that consuming vegetables first, regardless of eating speed, can improve postprandial blood glucose and insulin levels. Compared to consuming carbohydrates first, the food order of vegetables first resulted in significantly lower standard deviation, large amplitude of excursion, and incremental area under the curve for blood glucose and insulin.
