Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Fabio Anastasio, Marzia Testa, Cinzia Ferreri, Arianna Rossi, Gaetano Ruocco, Mauro Feola
Summary: This study aimed to evaluate the prognostic role of arterial stiffness in heart failure patients. The results showed that arterial stiffness was inversely correlated with patient survival and could serve as a prognostic predictor. This study is important for understanding the pathogenesis and clinical outcome of heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Article
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
Summary: This study investigated the association between long-term glycemic variability and arterial stiffness in patients with type 1 diabetes. The results showed that the variability of HbA1c was significantly correlated with arterial stiffness. Importantly, this association was independent of the HbA1c mean.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Zhenyu Chu, Yao Wei, Yan Hao, Jun Wang, Fang Huang, Miao Hou
Summary: This meta-analysis showed that fish oil supplementation has a beneficial effect on pulse wave velocity, especially in low dosage, short time, low DHA to EPA ratio, and among young participants.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Mohamed Mamdouh Elsayed, Elhassan Mohamed Ayman
Summary: Atorvastatin may have a potential role in delaying arterial stiffness progression in hemodialysis patients, as it can help maintain stable arterial stiffness parameters while the placebo treatment group showed a significant increase. This suggests that atorvastatin may have a potential role in delaying arterial stiffness progression in hemodialysis patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Paolo Salvi, Filippo Valbusa, Anna Kearney-Schwartz, Carlos Labat, Andrea Grillo, Gianfranco Parati, Athanase Benetos
Summary: This study found a significant inverse correlation between carotid-femoral pulse wave velocity and carotid distensibility, indicating a close relationship between aortic stiffness evaluated by the propagative method and local carotid cross-sectional distensibility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
A. Colak, M. E. Ozpelit, M. Birlik, E. Ozpelit
Summary: The prognostic value of arterial stiffness (AS) parameters in predicting all-cause mortality in systemic sclerosis (SSc) patients was investigated. The results showed that AS parameters were not associated with all-cause mortality. Large-scale studies are needed to determine the exact mechanisms of cardiovascular mortality in SSc patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Endocrinology & Metabolism
Athanasios Christoforidis, Irene Georeli, Meropi Dimitriadou, Assimina Galli-Tsinopoulou, Stella Stabouli
Summary: Compared to healthy controls, youths with T1DM show increased arterial stiffness, either as increased carotid-femoral pulse wave velocity or increased augmentation index, early in their course of life.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Peripheral Vascular Disease
Stamatia Samara, Anastasia Vemmou, Aikaterini Kyrkou, Christos Papamichael, Eleni Korompoki, George Ntaios, Efstathios Manios, Kimon Stamatelopoulos, Athanase D. Protogerou, Konstantinos Vemmos
Summary: The present study provides evidence on the importance of aortic stiffness and pressure wave reflections in predicting long-term outcomes of stroke patients. The combination of high aortic stiffness and low pressure wave reflections is associated with increased risk of mortality, cardiovascular events, stroke recurrence, and poor functional outcome.
JOURNAL OF HYPERTENSION
(2022)
Article
Cell Biology
Klaas F. Franzen, Moritz Meusel, Julia Engel, Tamara Roecker, Daniel Droemann, Friedhelm Sayk
Summary: PE-induced hypertension results in a strong reflex-mediated decrease in cardiac output, and has stronger effects on PWV, AIx, total peripheral resistance, and pulse pressure compared to Ang II at equal mean aortic BP. Furthermore, there are minimal changes in circulating markers of endothelial function in response to both vasoactive infusions.
Article
Chemistry, Multidisciplinary
Minyoung Kim, Ruda Lee, Nyeonju Kang, Moon-Hyon Hwang
Summary: This study investigated the impact of limb-specific resistance training on arterial stiffness in young adults. Results showed that upper-limb resistance training could decrease central artery wave reflection and potentially improve local peripheral artery stiffness in healthy young adults.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Konstantinos Markakis, Nikolaos Pagonas, Eleni Georgianou, Panagiota Zgoura, Benjamin J. Rohn, Sebastian Bertram, Maximilian Seidel, Sebastian Bettag, Hans-Joachim Trappe, Nina Babel, Timm H. Westhoff, Felix S. Seibert
Summary: The study found that in patients with shock, both oscillometric blood pressure monitoring devices were successful in completing hemodynamic assessments, but there were significant differences between invasive and non-invasive techniques. There were discrepancies in pulse wave velocity measurements between the two devices. Non-invasive peripheral blood pressure measurement may not always be successful in certain circumstances.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Sport Sciences
Yu Lun Tai, Erica M. Marshall, Jason C. Parks, J. Derek Kingsley
Summary: This study compared the effects of upper- and lower-body resistance exercise with and without blood flow restriction on hemodynamics and pulse wave reflection. The results showed that regardless of upper- or lower-body exercise, the cardiovascular responses were similar between BFR and without BFR conditions. Upper-body resistance exercise placed greater stress on pulse wave reflection, while lower-body exercise resulted in greater responses in blood pressure.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Respiratory System
Alexandra Lenoir, Andreas Christe, Lukas Ebner, Catherine Beigelman-Aubry, Pierre-Olivier Bridevaux, Martin Brutsche, Christian Clarenbach, Berra Erkosar, Christian Garzoni, Thomas Geiser, Sabina A. Guler, Dik Heg, Frederic Lador, Marco Mancinetti, Sebastian R. Ott, Lise Piquilloud, Maura Prella, Yok-Ai Que, Christophe von Garnier, Manuela Funke-Chambour
Summary: This study aimed to investigate lung function and radiological abnormalities over 12 months in patients after severe and non-severe COVID-19. The study found that patients with severe COVID-19 had lower lung function after one year compared to non-severe patients, although the severe disease group had a greater extent of recovery.
Review
Cardiac & Cardiovascular Systems
Thomas Rothe, Christophe von Garnier, Pierre-Olivier Bridevaux, Florian Charbonnier, Christian Clarenbach, Pietro Gianella, Anja Jochmann, Lukas Kern, Pavlov Nikolay, Claudia Steurer-Stey, Joerg D. Leuppi
Summary: Over 20 years ago, the concept of asthma control and its measurement tools were developed. The term clinically significant asthma exacerbation was introduced to differentiate between loss of control and exacerbation, but sometimes the distinction is not clear. This review explores the significance of understanding the differences in exacerbations between early allergic asthma and adult eosinophilic asthma, and why it matters in clinical practice and dealing with health insurers.
RESPIRATORY MEDICINE
(2023)
Article
Physiology
Manuel Kuhn, Sibylle Vollenweider, Christian F. F. Clarenbach, Dario Kohlbrenner
Summary: This study aimed to compare the performance of the 1-minute sit-to-stand test (1MSTST) between a standardized modality and an individualized modality, and investigate the influence of tibia and femur length on the test performance. The results showed that the individualized modality led to more repetitions compared to the traditional starting position, and this difference in performance was explained by differences in tibia length. It is recommended to use individualized 1MSTST to enable more valid comparisons across populations and study samples.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Letter
Respiratory System
Marc Miravitlles, Alice M. Turner, Maria Torres-Duran, Hanan Tanash, Carlota Rodriguez-Garcia, Jose Luis Lopez-Campos, Jan Chlumsky, Catarina Guimaraes, Juan Luis Rodriguez-Hermosa, Angelo Corsico, Cristina Martinez-Gonzalez, Jose Maria Hernandez-Perez, Ana Bustamante, David G. Parr, Francisco Casas-Maldonado, Ana Hecimovic, Wim Janssens, Beatriz Lara, Miriam Barrecheguren, Cruz Gonzalez, Jan Stolk, Cristina Esquinas, Christian F. Clarenbach
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Stefan Malesevic, Noriane A. Sievi, Patrick Baumgartner, Katharina Roser, Grit Sommer, Doerthe Schmidt, Florence Vallelian, Ilijas Jelcic, Christian F. Clarenbach, Malcolm Kohler
Summary: An increasing number of SARS-CoV-2 patients experience long-lasting symptoms, even after a mild acute infection. These symptoms, known as Long-Covid syndrome, can have a significant impact on the patients' quality of life.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Stefan Malesevic, Noriane A. Sievi, Dorthe Schmidt, Florence Vallelian, Ilijas Jelcic, Malcolm Kohler, Christian F. Clarenbach
Summary: This study followed up with post-COVID-19 patients who initially had mild or moderate acute COVID-19 without hospitalization. After 6 months, there were significant improvements in physical aspects of health-related quality of life (HRQoL) for these patients, but no significant change in mental health. Further research is needed to identify potential predictors for individualized care and early interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Noriane A. Sievi, Jerome Sepin, Maurice Roeder, Thomas Brack, Martin H. Brutsche, Martin Frey, Sarosh Irani, Jorg D. Leuppi, Robert Thurnheer, Christian F. Clarenbach, Malcolm Kohler
Summary: This study evaluated whether longitudinal assessment of predictors provides additional information on the mortality risk in COPD compared to cross-sectional analysis. The results showed that predictors of mortality in COPD are not time dependent, and cross-sectional measured predictors still have stable effect estimates over time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Stefan Malesevic, Noriane A. Sievi, Jonas Herth, Felix Schmidt, Dorthe Schmidt, Florence Vallelian, Ilijas Jelcic, Lisa Jungblut, Thomas Frauenfelder, Malcolm Kohler, Katharina Martini, Christian F. Clarenbach
Summary: It was discovered that more than half of the patients with initially mild or moderate infection showed abnormal findings on chest CT at follow-up. However, it was found that respiratory symptoms of these patients were not related to any chest CT findings. Therefore, routine chest CT follow-up is not recommended for this patient group unless there are other indications.
Article
Respiratory System
Pieter-Jan Gijs, Cecile Daccord, Eric Bernasconi, Martin Brutsche, Christian F. Clarenbach, Katrin Hostettler, Sabina A. Guler, Louis Mercier, Niki Ubags, Manuela Funke-Chambour, Christophe von Garnier
Summary: Azithromycin has significant effects on the diversity and composition of the lung microbiota in idiopathic pulmonary fibrosis (IPF), altering the temporal and spatial dynamics between the upper and lower airway microbiota. These findings highlight the potential therapeutic role of azithromycin in IPF.
Article
Critical Care Medicine
Daniel D. Fraughen, Auyon J. Ghosh, Brian D. Hobbs, Georg-Christian Funk, Tobias Meischl, Christian F. Clarenbach, Noriane A. Sievi, Karin Schmid-Scherzer, Oliver J. McElvaney, Mark P. Murphy, Adam D. Roche, Louise Clarke, Matthew Strand, Florian Vafai-Tabrizi, Geraldine Kelly, Cedric Gunaratnam, Tomas P. Carroll, Noel G. McElvaney
Summary: This real-world study demonstrates the survival advantage of IV-AAT in severe AATD patients. This improved survival is not related to the decline in lung function FEV1. Patients are divided into two major phenotypes, lung indexes and non-lung indexes, which have implications for clinical trial design, especially when FEV1 is the primary endpoint.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Christine Huebsch, Christian Clarenbach, Paul Chadwick, Matthias Peterer, Sonja Beckmann, Rahel Naef, Gabriela Schmid-Mohler
Summary: In order to improve inpatient care and self-management in patients with severe acute exacerbations of COPD, a nurse-led behavioral intervention was implemented. This study aimed to assess the implementation outcomes from the perspective of healthcare professionals who delivered it. The results showed that the overall acceptability, appropriateness, and feasibility of the intervention were rated high to very high. Enablers to implementation included the recognition of the need for specialized care, sufficient knowledge of the intervention by healthcare professionals, and strong interprofessional collaboration. Main barriers included the lack of resources from resident physicians and difficulties in adaptability.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Respiratory System
Diana Zanolari, Daniela Handler-Schuster, Christian Clarenbach, Gabriela Schmid-Mohler
Summary: The aim of this study was to identify the sources of illness-related emotional distress among individuals living with mild to severe chronic obstructive pulmonary disease (COPD). Interviews were conducted with eleven COPD patients, and framework analysis was used to analyze the data. The study identified six main sources of COPD-related emotional distress, as well as sources of non-COPD-related distress. The findings highlight the importance of carefully assessing emotional distress in COPD patients and providing tailored interventions.
CHRONIC RESPIRATORY DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick Baumgartner, Protazy Rejmer, Martin Osswald, Stefan Malesevic, Noriane A. Sievi, Maurice Roeder, Jonas Herth, Simon F. Staempfli, Christian F. Clarenbach, Felix C. Tanner, Thomas Gaisl, Malcolm Kohler
Summary: Thoracic aortic aneurysms (TAA) can have fatal complications such as rupture and dissection. This study aimed to assess if there are differences in wall properties between patients with TAA and a matched control group. The results showed that patients with TAA had comparable arterial wall properties to the matched control group. Further investigation is needed to determine if increased central arterial stiffness is a relevant factor in the emergence of TAA.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Respiratory System
Manuel Kuhn, Elif Nalbant, Dario Kohlbrenner, Mitja Alge, Laura Kuett, Alexandra Arvaji, Noriane A. Sievi, Erich W. Russi, Christian F. Clarenbach
Summary: This study developed a small wearable cough detector (SIVA-P3) that uses deep neural networks for automatic cough counting. The results showed that SIVA-P3 has high performance for cough detection in an outpatient setting, allowing continuous monitoring of cough for days or weeks.
Article
Medicine, General & Internal
Yin Ting Lam, Eva S. L. Pedersen, Leonie D. Schreck, Leonie Husler, Helena Koppe, Fabien N. Belle, Christian Clarenbach, Philipp Latzin, Claudia E. Kuehni, Myrofora Goutaki
Summary: This study assessed the physical activity, respiratory physiotherapy practices, and nutritional status among individuals with primary ciliary dyskinesia (PCD) in Switzerland. The findings revealed that professional respiratory physiotherapy, exercise recommendations, and nutritional advice were often not implemented in the care of PCD patients. The establishment of specialized centers with multidisciplinary teams, including physiotherapists and nutrition consultants, could greatly improve the quality of life for PCD patients.
SWISS MEDICAL WEEKLY
(2022)
