Article
Cardiac & Cardiovascular Systems
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal
Summary: Angiotensin II (Ang II) is a key component of the renin-angiotensin-aldosterone system and is associated with cardiopathology. High levels of Ang II have been linked to inflammatory conditions such as coronary heart disease, obesity, and type 2 diabetes. This study evaluated the cellular effects of Ang II on THP-1-derived macrophages, showing that it stimulates differentiation markers and proinflammatory markers while decreasing an M2 marker. Ang II also induces calcium overload, increases reactive oxygen species, and arrests cells in the G1 phase, primarily through the angiotensin II type 1 receptor (AT1R).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Urology & Nephrology
Daniel E. Leisman, Tiago D. Fernandes, Vanesa Bijol, Mabel N. Abraham, Jake R. Lehman, Matthew D. Taylor, Christine Capone, Omar Yaipan, Rinaldo Bellomo, Clifford S. Deutschman
Summary: The study found that sepsis reduces the expression of renal angiotensin II receptors, leading to changes in kidney blood flow and creatinine levels. Both mouse models and clinical observations suggest that angiotensin II prevents these functional changes, while AT1R blockade exacerbates them.
KIDNEY INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Zhongping Shi, Jun Wang, Shanjiang Chen, Haiyue Dai, Yiwei Huang
Summary: This study aims to evaluate the relationship between AT1R gene A1166C polymorphism and arteriosclerosis by using pulse wave velocity as an index. The research includes searching multiple databases, limiting language and study types, to provide evidence on the genetic tendency of arteriosclerosis.
Review
Biochemistry & Molecular Biology
Xi Zhang, Suli Zhang, Meili Wang, Hao Chen, Huirong Liu
Summary: Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. However, there have been no clinical trials on allosteric modulators of AT1R. This review summarizes the different allosteric modes of AT1R and discusses the future of drug design targeting AT1R allostery.
CELL AND BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Anastasios Lymperopoulos, Jordana Borges, Alexandra M. Carbone, Natalie Cora, Anastasiya Sizova
Summary: The angiotensin II type 1 receptor, essential in the cardiovascular system, has been extensively studied for its physiological and pathophysiological roles. Biased AT(1) receptor ligands have been developed to selectively activate beta-arrestin transduction pathways. However, the focus on G(q) or beta-arrestins tends to neglect other non-Gq-, non beta-arrestin-dependent signaling modalities employed by the versatile AT(1) receptor in cardiovascular tissues.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Elizabeth K. M. Johnstone, Mohammed Akli Ayoub, Rebecca J. Hertzman, Heng B. See, Rekhati S. Abhayawardana, Ruth M. Seeber, Kevin D. G. Pfleger
Summary: This study investigated the heteromerization of AT(2) and B-2 receptors in HEK293FT cells. The results demonstrated the functional interaction between these receptors and the differences in signaling, providing important evidence for studying GPCR pharmacology and signaling diversity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aurelie Philippe, Gunnar Kleinau, Jason Jannis Gruner, Sumin Wu, Daniel Postpieszala, David Speck, Harald Heidecke, Simon J. Dowell, Gabriela Riemekasten, Peter W. Hildebrand, Julian Kamhieh-Milz, Rusan Catar, Michal Szczepek, Duska Dragun, Patrick Scheerer
Summary: This study investigates the effects of AT(1)R-Abs on G-protein signaling and cell proliferation, as well as the involvement of extracellular receptor loops. The results show that AT(1)R-Abs activate G(q/11) signaling, leading to cell proliferation and inhibiting receptor internalization. Additionally, ligand-independent activation of G(i) signaling by AT(1)R has a negative effect on cell proliferation. The study also identifies the involvement of certain extracellular receptor loops in the interaction between AT(1)R and antibodies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Daniel Fernandes, Leticia Kramer Pacheco, Regina Sordi, Karin Scheschowitsch, Gustavo Campos Ramos, Jamil Assreuy
Summary: A study found that early and partial blockade of the AT 1 receptor with a low dose of losartan can counteract sepsis-induced refractoriness to vasoconstrictors, providing an opportunity to improve the outcome of this condition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Robert Eckenstaler, Jana Sandori, Michael Gekle, Ralf A. Benndorf
Summary: The AT(1) receptor plays a significant role in cardiovascular and renal diseases, and is a major target for angiotensin receptor blockers such as sartans. Recent studies have provided new insights into the structure and biased signaling of this receptor, which could lead to the development of novel therapeutic approaches.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kohei Karasaki, Hiroki Kokubo, Batmunkh Bumdelger, Nobuchika Kaji, Chiemi Sakai, Mari Ishida, Masao Yoshizumi
Summary: This study found that Angiotensin II type 1 receptor blockers (ARBs) can prevent the progression of abdominal aortic aneurysm (AAA) by upregulating angiotensin (1-7), suggesting that angiotensin (1-7) may play a key role in mediating the protective effect of ARBs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Na-Na Sun, Yue Zhang, Wen-Hui Huang, Bo-Jun Zheng, Si-Yi Jin, Xu Li, Ying Meng
Summary: The study reveals the crucial role of exosomes in mediating communication between macrophages and lung fibroblasts, leading to pulmonary fibrosis. The presence of Ang II in exosomes from macrophages creates a positive feedback loop.
CHINESE MEDICAL JOURNAL
(2021)
Article
Physiology
Juliano Zequini Polidoro, Nancy Amaral Reboucas, Adriana Castello Costa Girardi
Summary: The study demonstrates that ATRAP attenuates Ang II-induced inhibition of ROMK in collecting duct cells by reducing c-Src activation and blocking ROMK internalization.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Jelle R. Miedema, Matthijs L. Janssen, Jan von der Thuesen, Henrik Endeman, Anton W. Langerak, Merel E. Hellemons, Els van Nood, Bas W. A. Peeters, Sara J. Baart, Marco W. J. Schreurs
Summary: This study aimed to determine whether antibodies against AT1R and ETAR are specifically related to COVID-19 disease pathogenesis or increased during any severe respiratory illness. The results showed significantly increased AT1R and ETAR antibody titers in COVID-19 patients compared to controls, while these titers were not correlated with inflammatory markers or long-term symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Pei Lin, Po-Hsun Huang, Chi-Yu Chen, I-Shiang Tzeng, Meng-Yu Wu, Jia-Shiong Chen, Jaw-Wen Chen, Shing-Jong Lin
Summary: Abdominal aortic aneurysm (AAA) is a cardiovascular disease that causes vascular dilatation in the infrarenal aorta, leading to a high risk of death. The pathogenesis of AAA involves oxidative stress, inflammation, and vascular smooth muscle cell dysregulation. Tributyrin (TB) has a potential protective effect against AAA by inhibiting HDAC activity and attenuating the AngII-induced AT1R signaling cascade. This study provides insights into the potential therapeutic role of TB in the treatment of AAA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Civieri, Laura Iop, Francesco Tona
Summary: This review summarizes the current evidence regarding the effects of AT1R-AAs and ETAR-AAs in cardiovascular pathologies, highlighting their roles in heart transplantation and mechanical circulatory support, preeclampsia, and acute coronary syndromes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hitomi Okubo, Kentaro Murakami, Hiroki Inagaki, Yasuyuki Gondo, Kazunori Ikebe, Kei Kamide, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Satoshi Sasaki, Takeshi Nakagawa, Mai Kabayama, Ken Sugimoto, Hiromi Rakugi, Yoshinobu Maeda, Madoka Ogawa, Yoshiko Lily Ishioka, Chisato Inomatae, Taiji Ogawa, Ken-ichi Matsuda, Hirochika Ryuno, Ryosuke Oguro, Koichi Yamamoto, Yasushi Takeya, Yoichi Takami, Norihisa Ito
JOURNAL OF ORAL REHABILITATION
(2019)
Article
Geriatrics & Gerontology
Masaaki Isaka, Ken Sugimoto, Yukiko Yasunobe, Hiroshi Akasaka, Taku Fujimoto, Hitomi Kurinami, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2019)
Article
Peripheral Vascular Disease
Sadayoshi Ito, Hiroshi Itoh, Hiromi Rakugi, Yasuyuki Okuda, Satoru Yamakawa
JOURNAL OF HUMAN HYPERTENSION
(2019)
Article
Geriatrics & Gerontology
Taro Kojima, Toshifumi Matsui, Yusuke Suzuki, Yasushi Takeya, Naoki Tomita, Koichi Kozaki, Masafumi Kuzuya, Hiromi Rakugi, Hiroyuki Arai, Masahiro Akishita
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2020)
Review
Geriatrics & Gerontology
Masafumi Kuzuya, Kaoruko Aita, Yoko Katayama, Tomohiro Katsuya, Mitsunori Nishikawa, Satoshi Hirahara, Hisayuki Miura, Hiromi Rakugi, Masahiro Akishita
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2020)
Article
Geriatrics & Gerontology
Ken Sugimoto, Hiroshi Ikegami, Yasunori Takata, Tomohiro Katsuya, Masahiro Fukuda, Hiroshi Akasaka, Yasuharu Tabara, Haruhiko Osawa, Yoshihisa Hiromine, Hiromi Rakugi
Summary: The study in Japan found that improving glycemic control and insulin use were significantly associated with increased skeletal muscle mass and gait speed in patients with type 2 diabetes.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Review
Peripheral Vascular Disease
Kazuomi Kario, Satoshi Hoshide, Koichi Yamamoto, Ayako Okura, Hiromi Rakugi
Summary: Differences in the epidemiology and phenotypes of hypertension in Japan compared with Western countries suggest that local data should be the basis for optimal pharmacological management. Japan has a large body of evidence supporting treatment guidelines and BP targets specific for Japanese patients with hypertension. The use of combination therapy and monitoring home BP are key recommendations in Japan, consistent with international guidelines.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Editorial Material
Peripheral Vascular Disease
Yuichiro Yano, Akira Nishiyama, Toshihiko Ishimitsu, Naoki Kashihara, Hiromi Rakugi, Kouichi Tamura, Hiroshi Itoh, Takuya Tsuchihashi, Atsushi Sakima, Hisatomi Arima, Tetsutaro Matayoshi, Yutaka Imai, Katsuyuki Miura, Takashi Hisamatsu, Kei Asayama, Takayoshi Ohkubo, Kouihci Node, Kazuomi Kario
JOURNAL OF HUMAN HYPERTENSION
(2021)
Article
Geriatrics & Gerontology
Hiromi Rakugi, Ken Sugimoto, Hidenori Arai, Koichi Kozaki, Yasumoto Matsui, Katsuyoshi Mizukami, Yasumasa Ohyagi, Jiro Okochi, Masahiro Akishita
Summary: Falls in long-term care facilities are often treated as accidents despite being a common geriatric syndrome. The causes of falls are diverse and complex, making their occurrence rate dependent on individual susceptibility. Falls can lead to fractures, intracranial hemorrhage, and even death among older adults, emphasizing the need for fall risk assessment and appropriate interventions. In response to the frequent occurrence of falls in long-term care facilities, the Japan Geriatrics Society and the Japan Association of Geriatric Health Services Facilities have issued statements on falls as a geriatric syndrome based on scientific evidence.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Yoshihisa Hiromine, Shinsuke Noso, Hiromi Rakugi, Ken Sugimoto, Yasunori Takata, Tomohiro Katsuya, Masahiro Fukuda, Hiroshi Akasaka, Haruhiko Osawa, Yasuharu Tabara, Hiroshi Ikegami
Summary: This study found that the prevalence of sarcopenia was higher in older adults with type 1 diabetes compared to those with type 2 diabetes. The difference was most prominent in the frequency of low handgrip strength. Poor glycemic control was revealed to be a primary risk factor for sarcopenia in diabetes mellitus.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Peripheral Vascular Disease
Shintaro Sakaguchi, Ryuji Okamoto, Chisa Inoue, Masaharu Akao, Kohei Kamemura, Isao Kurihara, Yoshiyu Takeda, Youichi Ohno, Nobuya Inagaki, Hiromi Rakugi, Takuyuki Katabami, Mika Tsuiki, Akiyo Tanabe, Kouichi Tamura, Satoshi Fujita, Yutaka Yano, Kaoru Dohi, Mitsuhide Naruse
Summary: This study investigated the factors associated with comorbid atrial fibrillation (AF) and cardiovascular events in patients with primary aldosteronism (PA), as well as the effect of PA treatment. The study found that age, sex, cardiothoracic ratio, and history of coronary artery disease and heart failure were associated with AF, and PA patients with AF had a higher frequency of cardiovascular events. After PA treatment, AF, in addition to age, duration of hypertension, body mass index, and chronic kidney disease, was an independent prognostic factor for cardiovascular events. The incidence of cardiovascular events was lower in PA patients with AF compared to AF patients without PA.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Immunology
Hironori Nakagami, Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Futoshi Nakagami, Shigeto Hamaguchi, Hisao Yoshida, Hideo Okuno, Shota Yoshida, Ryo Nakamaru, Serina Yokoyama, Taku Fujimoto, Kazuhiro Hongyo, Yukihiro Akeda, Ryuichi Morishita, Kazunori Tomono, Hiromi Rakugi
Summary: This study assessed the safety and immunogenicity of an intradermal COVID-19 DNA vaccine. The results showed that there were no notable safety issues with the vaccine and some subjects exhibited a cellular immune response after intradermal inoculation, although significant antibody production was not observed.
Letter
Geriatrics & Gerontology
Yasuhiro Yamaguchi, Jiro Okochi, Tomohiko Urano, Takae Ebihara, Takafumi Kadono, Hidenori Arai, Katsuya Iijima, Shinya Ishii, Masafumi Kuzuya, Hiromi Rakugi, Masahiro Akishita, Kentaro Higashi, Koichi Kozaki
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Peripheral Vascular Disease
Seiji Umemoto, Toshio Ogihara, Masunori Matsuzaki, Hiromi Rakugi, Kazuyuki Shimada, Koichi Hayashi, Hirofumi Makino, Yasuo Ohashi, Takao Saruta
Summary: The study evaluated the effects of three benidipine-based regimens on vascular and renal events in hypertensive patients, finding no significant differences in the occurrence of these events among the three treatment groups.
CURRENT HYPERTENSION REVIEWS
(2021)
Review
Medicine, Research & Experimental
Koichi Yamamoto, Hikari Takeshita, Hiromi Rakugi