Article
Pharmacology & Pharmacy
Daniel Fernandes, Leticia Kramer Pacheco, Regina Sordi, Karin Scheschowitsch, Gustavo Campos Ramos, Jamil Assreuy
Summary: A study found that early and partial blockade of the AT 1 receptor with a low dose of losartan can counteract sepsis-induced refractoriness to vasoconstrictors, providing an opportunity to improve the outcome of this condition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Richard Perryman, Alexander Renziehausen, Hamidreza Shaye, Androniki D. Kostagianni, Antonis D. Tsiailanis, Thomas Thorne, Maria Chatziathanasiadou, Gregory B. Sivolapenko, Mohamed Ahmed El Mubarak, Gye Won Han, Barbara Zarzycka, Vsevolod Katritch, Guillaume Lebon, Cristiana Lo Nigro, Laura Lattanzio, Sophie Morse, James J. Choi, Kevin O'Neill, Zoi Kanaki, Apostolos Klinakis, Tim Crook, Vadim Cherezov, Andreas G. Tzakos, Nelofer Syed
Summary: This study reveals that AT(2)R is a therapeutic target for GBM and AngII promotes proliferation through this receptor. EMA401 and its derivative A3E can inhibit the proliferation and invasiveness of GBM, and show enhanced penetration in the CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Peripheral Vascular Disease
Mario Zanaty, Fernando A. C. Seara, Pablo Nakagawa, Guorui Deng, Natalia M. Mathieu, Kirthikaa Balapattabi, Sadashiva S. Karnik, Justin L. Grobe, Curt D. Sigmund
Summary: The study found that intracerebroventricular administration of TRV027 can increase aversion to saline and lower blood pressure in a model of salt-sensitive hypertension. Both TRV027 and losartan increased aversion to saline, with a more pronounced effect on highly aversive saline solutions.
Article
Cardiac & Cardiovascular Systems
Hikari Takeshita, Koichi Yamamoto, Masaki Mogi, Yu Wang, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masatsugu Horiuchi, Hiromi Rakugi
Summary: The dual deletion of AT2 and Mas in mice exacerbates aging-associated muscle weakness, with increased activation of RAS, inflammation, and aging-related gene expression in skeletal muscles. Specific muscle phenotypes were absent in single deletions of the receptors, indicating a complementary role of AT2 and Mas in preventing local RAS activation during aging.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Physiology
Julia Schrankl, Michaela Fuchs, Katharina Broeker, Christoph Daniel, Armin Kurtz, Charlotte Wagner
Summary: This study investigated the cell-specific localization of AT(1) receptor expression in rodent and human kidneys, revealing conserved AT(1) receptor mRNA expression sites in the (juxta)glomerular areas and tubulointerstitium across species, potentially serving as main target sites for ANG II in adult kidneys.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal
Summary: Angiotensin II (Ang II) is a key component of the renin-angiotensin-aldosterone system and is associated with cardiopathology. High levels of Ang II have been linked to inflammatory conditions such as coronary heart disease, obesity, and type 2 diabetes. This study evaluated the cellular effects of Ang II on THP-1-derived macrophages, showing that it stimulates differentiation markers and proinflammatory markers while decreasing an M2 marker. Ang II also induces calcium overload, increases reactive oxygen species, and arrests cells in the G1 phase, primarily through the angiotensin II type 1 receptor (AT1R).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Mari Sotozawa, Sho Kinguchi, Hiromichi Wakui, Kengo Azushima, Kengo Funakoshi, Waki Nakajima, Tomoyuki Miyazaki, Takuya Takahashi, Kouichi Tamura
Summary: The renin-angiotensin system in the brain plays a crucial role in hypertension. ATRAP, a protein that regulates the AT1R signaling pathway, has unknown pathophysiological function in the brain. This study found that enhancing ATRAP expression in the PVN can suppress Ang II-induced hypertension.
HYPERTENSION RESEARCH
(2023)
Review
Cell Biology
Maksymilian Ziaja, Kinga Anna Urbanek, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The renin-angiotensin system (RAS) is not only involved in regulating cardiovascular function, but also plays a complex role in various processes such as memory and cancer. Maintaining the balance between individual elements of the RAS system is crucial for achieving homeostasis, and any disturbance in their expression or activity can lead to pathological processes.
Article
Physiology
Yong Zhang, Benard O. Ogola, Laxmi Iyer, Vardan T. Karamyan, Thomas Thekkumkara
Summary: The therapeutic potential of 2-Methoxyestradiol (2ME2) in cardiovascular disease is evident from its ability to attenuate blood pressure and resting heart rate in hypertensive rats by downregulating angiotensin receptors and causing weight loss.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Daniel E. Leisman, Tiago D. Fernandes, Vanesa Bijol, Mabel N. Abraham, Jake R. Lehman, Matthew D. Taylor, Christine Capone, Omar Yaipan, Rinaldo Bellomo, Clifford S. Deutschman
Summary: The study found that sepsis reduces the expression of renal angiotensin II receptors, leading to changes in kidney blood flow and creatinine levels. Both mouse models and clinical observations suggest that angiotensin II prevents these functional changes, while AT1R blockade exacerbates them.
KIDNEY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Laale F. Alawi, Sanjeev Dhakal, Sana E. Emberesh, Harshal Sawant, Anhar Hosawi, Unmesha Thanekar, Nadja Grobe, Khalid M. Elased
Summary: Activation of the renin angiotensin system is crucial in blood pressure regulation, and AT1R deletion can alleviate hypertension and proteinuria without affecting renal ACE2, NEP, and KIM-1 expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Yuanyuan Liu, Haomeng Hao, Tingting Lan, Rui Jia, Mingya Cao, Liang Zhou, Zhiming Zhao, Wensen Pan
Summary: The local Renin-Angiotensin System (RAS) plays a role in the female reproductive system, regulating follicle development and physiological functions of the placenta and uterus. Ang II and Ang-(1-7) have similar functions in this system and can influence the occurrence and development of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Konstantinos Papadopoulos, Alexandra Papadopoulou, Tar-Choon Aw
Summary: Type 2 diabetes is a lifelong disease that requires innovative pharmacological interventions. Understanding the role of miRNA, particularly miR-155, is crucial in the pathogenesis of T2DM. Reduced levels of miR-155 in aging, obesity, and T2DM contribute to insulin resistance and glucose dysregulation. Restoring miR-155 levels through various treatments may be a potential therapeutic option.
WORLD JOURNAL OF DIABETES
(2023)
Article
Biochemistry & Molecular Biology
Goeran Tornling, Rohit Batta, Dan Salvail, Johan Raud, Christopher P. Denton
Summary: Substantial evidence suggests that the renin-angiotensin system and the angiotensin II type 2 receptor play a role in pulmonary hypertension. The study evaluated the effect of the AT(2)R agonist C21 in a rat model of hypoxia-induced PH. The results showed that C21 improved cardiac function, reduced right ventricular hypertrophy, and decreased vessel wall thickness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Liina Laukkanen, Cassiano R. A. F. Diniz, Sebastien Foulquier, Jos Prickaerts, Eero Castren, Plinio C. Casarotto
Summary: Our study demonstrated that C21 facilitated the effect of BDNF by increasing TRKB levels on the cell surface, leading to reduced freezing time in mice in a BDNF-dependent manner, without a general anxiolytic-like effect.