Article
Biochemistry & Molecular Biology
Adrian C. Eddy, Chun Yi Chiang, Augustine Rajakumar, Frank T. Spradley, Patricia Dauer, Joey P. Granger, Sarosh Rana
Summary: Preeclampsia is a dangerous complication of pregnancy that can lead to maternal death and long-term complications. This study aimed to find new compounds to reduce placental sFlt-1 and discovered that luteolin showed the most potent inhibition of sFlt-1 release, with over 95% reduction. Luteolin was found to reduce sFlt-1 through inhibition of HIF-1 alpha, possibly via the Akt pathway.
Article
Biochemistry & Molecular Biology
Adrian C. C. Eddy, Chun Yi Chiang, Augustine Rajakumar, Frank T. T. Spradley, Patricia Dauer, Joey P. P. Granger, Sarosh Rana
Summary: Preeclampsia is a serious complication of pregnancy that can lead to maternal death and long-term complications. This study aimed to identify new compounds that can reduce sFlt-1 and inhibit HIF-1a, a prohypertensive factor. The natural compound luteolin showed the strongest inhibition of sFlt-1 release, with over 95% reduction compared to the control group. Luteolin also reduced HIF-1a expression through the Akt pathway. This makes luteolin a potential novel treatment for preeclampsia.
Article
Cell Biology
Tsung-Lin Cheng, Chung-Hwan Chen, Meng-Hsing Wu, Chao-Han Lai, Ko-Hung Lee, Sheng-Hsiang Lin, Ai-Li Shiau, Chao-Liang Wu, Lin Kang
Summary: The study found that levels of FGL1 protein in serum and placenta were significantly upregulated in patients and mice with PE. FGL1 treatment decreased maternal hypertension and proteinuria, decreased fetal weight in PE mice, downregulated proinflammatory cytokine levels, and maintained the balance between antiangiogenic and proangiogenic substances in the placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Na Wang, Dandan Shi, Na Li, Hongyuan Qi
Summary: VEGF and sFlt-1 can be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta.
ANNALS OF MEDICINE
(2021)
Article
Medicine, General & Internal
Hiroaki Tanaka, Kayo Tanaka, Sho Takakura, Naosuke Enomoto, Tomoaki Ikeda
Summary: This study suggests that sFlt-1 may be useful in predicting the timing of pregnancy termination in patients with preeclampsia. However, further research is needed to confirm these findings and determine the optimal timing for pregnancy termination in order to reduce severe maternal complications.
FRONTIERS IN MEDICINE
(2022)
Article
Developmental Biology
S. Rowson, M. Reddy, D. L. De Guingand, A. Langston-Cox, S. A. Marshall, F. da Silva Costa, K. R. Palmer
Summary: This study found that using placental-specific sFLT-1 e15a performs comparably to total sFLT-1 in diagnosing preeclampsia, which is particularly helpful in diagnosing early-onset preeclampsia.
Review
Peripheral Vascular Disease
Sapna Ramdin, Sooraj Baijnath, Thajasvarie Naicker, Nalini Govender
Summary: This review discusses the value of rodent models in studying preeclampsia (PE) and compares various models to identify different characteristics of this disorder.
CURRENT HYPERTENSION REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Karla Cecilia Marrufo-Gallegos, Jose Rafael Villafan-Bernal, Salvador Espino-y-Sosa, Guadalupe Estrada-Gutierrez, Iris Paola Guzman-Guzman, Raigam Jafet Martinez-Portilla, Johnatan Torres-Torres
Summary: The early identification of women at risk of preeclampsia is important, and this study aimed to determine relevant biomarkers for predicting preeclampsia. Serum creatine kinase, soluble tyrosine protein kinase receptor (sTIE2), and anti-angiogenic factor soluble c-Met (sMet) were found to be significantly different between women with and without preeclampsia, indicating their potential as biomarkers. However, other kinases and phosphatases were not found to be different between the two groups. Rating: 7
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Agata Sakowicz, Michalina Bralewska, Piotr Kamola, Tadeusz Pietrucha
Summary: In vivo studies on gestational pathology often use small mammals as models due to their similarities to humans in terms of reproductive cycle and placental development. However, there are differences in the process of vessel remodeling and trophoblast invasion between these animals and humans, limiting their use in studying preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Obstetrics & Gynecology
Bhavisha A. Bakrania, Eric M. George, Joey P. Granger
Summary: Animal models play a critical role in investigating the pathogenesis and treatment options for preeclampsia. They allow researchers to study the detailed mechanisms of this disease and are important tools in the search for novel therapies.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Developmental Biology
Qing Zuo, Yanfeng Zou, Shiyun Huang, Tianjun Wang, Yetao Xu, Tingting Zhang, Min Zhang, Zhiping Ge, Ziyan Jiang
Summary: Aspirin reduces trophoblast apoptosis in preeclampsia by inactivating the NF-kappa B signaling pathway and reversing endothelial dysfunction and oxidative stress caused by sFlt-1. This treatment significantly improves the condition of patients with preeclampsia.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Biotechnology & Applied Microbiology
Ross McNally, Abdelrahim Alqudah, Emma M. McErlean, Claire Rennie, Nabila Morshed, Amy Short, Kristine McGrath, Olga Shimoni, Tracy Robson, Helen O. McCarthy, Lana McClements
Summary: This study developed a new model of preeclampsia by modulating the circulating protein sFlt-1 associated with the pregnancy complication using a safe and effective approach. The new model shows promise for testing and developing treatments for preeclampsia.
Review
Pharmacology & Pharmacy
Li Liao, Xingtao Zhao, Mengting Zhou, Ying Deng, Yunxia Li, Cheng Peng
Summary: sFlt-1 is associated with various angiogenesis-related diseases, such as pre-eclampsia, perinatal cardiomyopathy, diabetic nephropathy, hypertension, tumor, atherosclerosis, etc. Its regulatory mechanisms in these diseases are mainly related to the bioavailability of VEGF and vascular endothelial cell integrity.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Developmental Biology
Fengyuan Zhang, Mengqi Gu, Pengzheng Chen, Shuting Wan, Qian Zhou, Yuan Lu, Lei Li
Summary: This study found that the concentrations of sFlt-1 and PLGF, as well as the sFlt-1/PLGF ratio, can help distinguish patients with placenta accreta from those with placenta previa.
Article
Peripheral Vascular Disease
Angela Makris, Kristen R. Yeung, Shirlene M. Lim, Neroli Sunderland, Scott Heffernan, John F. Thompson, Jim Iliopoulos, Murray C. Killingsworth, Jim Yong, Bei Xu, Robert F. Ogle, Ravi Thadhani, S. Ananth Karumanchi, Annemarie Hennessy
Article
Multidisciplinary Sciences
Kristen R. Yeung, Christine L. Chiu, Suzanne Pears, Scott J. Heffernan, Angela Makris, Annemarie Hennessy, Joanne M. Lind
Review
Obstetrics & Gynecology
Renuka Shanmugalingam, Nina Reza Pour, Siang Chye Chuah, Thi Mong Vo, Roy Beran, Annemarie Hennessy, Angela Makris
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Neurosciences
Genevieve Z. Steiner, Francesca M. Fernandez, Madilyn Coles, Diana Karamacoska, Emma Barkus, Samantha J. Broyd, Nadia Solowij, Owen T. Watson, Christine L. Chiu, Joanne M. Lind, Robert J. Barry
Review
Obstetrics & Gynecology
Suzanne Pears, Angela Makris, Annemarie Hennessy
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2018)
Article
Developmental Biology
R. Machaalani, E. Ghazavi, T. Hinton, A. Makris, A. Hennessy
Article
Biotechnology & Applied Microbiology
Nerissa L. Hearn, Aaron S. Coleman, Vincent Ho, Christine L. Chiu, Joanne M. Lind
Article
Genetics & Heredity
Nerissa L. Hearn, Christine L. Chiu, Joanne M. Lind
BMC MEDICAL GENOMICS
(2020)
Article
Multidisciplinary Sciences
Nikita Roy, Robert J. Barry, Francesca E. Fernandez, Chai K. Lim, Mahmoud A. Al-Dabbas, Diana Karamacoska, Samantha J. Broyd, Nadia Solowij, Christine L. Chiu, Genevieve Z. Steiner
SCIENTIFIC REPORTS
(2020)
Article
Environmental Sciences
Morwenna Kirwan, Christine L. Chiu, Mellissa Hay, Thomas Laing
Summary: This study evaluated the efficacy of a community-based exercise and lifestyle intervention program called "Beat It" in improving anthropometric and physical fitness outcomes in older adults with type 2 diabetes mellitus. Significant improvements in waist circumference and physical fitness were observed post-program, indicating that participation in the program can improve important health outcomes in older adults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Peripheral Vascular Disease
Katrina Chau, Mikala Welsh, Angela Makris, Annemarie Hennessy
Summary: This review discusses recent advances in understanding the nature of placental dysfunction causing preeclampsia and other hypertensive disorders of pregnancy, specifically focusing on the contributions of animal studies. The translation of data regarding newly discovered pathological pathways, particularly the angiogenic pathway, into clinical practice is also discussed.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Health Care Sciences & Services
Morwenna Kirwan, Christine L. Chiu, Thomas Laing, Noureen Chowdhury, Kylie Gwynne
Summary: The COVID-19 pandemic resulted in changes to the delivery of health programs and services. In Australia, a national lockdown led to the closure of exercise clinics and fitness centers, which affected the in-person delivery of the Beat It program. To address this, Beat It was adapted to a fully web-based program. This study aimed to assess whether the online program produced comparable health outcomes to the in-person program in improving physical fitness and waist circumference in older adults with T2DM.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Obstetrics & Gynecology
Memory M. Ngwira, Luis A. Gadama, Renuka Shanmugalingam, Angela Makris, Annemarie Hennessy
Summary: This study investigated the knowledge and barriers to the use of calcium and aspirin for preventing preeclampsia among healthcare workers and key policy informants in Malawi. The findings showed that doctors had better knowledge compared to nurses and policy informants, and identified barriers included lack of knowledge, late diagnosis, scarcity of calcium tablets, and delays in implementing guidelines.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Clinical Neurology
Genevieve Z. Steiner-Lim, Alan Bensoussan, Elana R. Andrews-Marney, Mahmoud A. Al-Dabbas, Adele E. Cave, Christine L. Chiu, Katerina Christofides, Frances M. De Blasio, Lauren S. Dewsbury, Naomi L. Fagan, Jack S. Fogarty, Lena C. Hattom, Mark I. Hohenberg, Deyyan Jafar, Diana Karamacoska, Chai K. Lim, Jianxun Liu, Najwa-Joelle Metri, D. Vincent Oxenham, Holly Ratajec, Nikita Roy, Danielle G. Shipton, David Varjabedian, Dennis H. Chang
Summary: This study evaluated the cognitive efficacy and safety of SaiLuoTong (SLT) in patients with mild cognitive impairment (MCI). The results showed that SLT may be useful in supporting memory retrieval and executive function in MCI patients.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2023)
Article
Education & Educational Research
Jake Meincke, Kylie Gwynne, Christine L. Chiu, Alexandra J. Bhatti, Vita Christie, Jordan Janszen, Leah Nazareth, Isabella Needham, Morwenna Kirwan
Summary: This study examines the effectiveness of incorporating an authentic assessment task to enhance health-seeking behaviors among undergraduate health science students. The results indicate that students showed willingness and capability to improve their health-related behaviors, particularly an increase in fruit consumption. However, no significant changes were observed in stress and sleep patterns.
EDUCATION SCIENCES
(2023)
