Article
Biochemistry & Molecular Biology
Jeremie Joffre, Judith Hellman
Summary: Endothelial cells undergo phenotypic and functional modifications during sepsis and acute inflammation, leading to microvascular dysfunction and multiorgan failure, with oxidative stress playing a crucial role. Future research directions include understanding the role of oxidative stress in endothelial cells and targeting the therapeutic potential and issues in sepsis and septic shock.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Hematology
Lauren G. Poole, Anna K. Kopec, Dafna J. Groeneveld, Asmita Pant, Kevin S. Baker, Holly M. Cline-Fedewa, Matthew J. Flick, James P. Luyendyk
Summary: This study investigated the mechanisms of fibrin polymerization and cross-linking in acute liver injury induced by acetaminophen overdose. It was found that deficiency in FXIII dramatically reduced fibrin(ogen) cross-linking, while the impact on fibrin(ogen) deposition and cross-linking was less significant in Fib(AEK) mice. The presence of oxidative mediators in the injured liver was proposed as a factor affecting fibrin polymerization without affecting FXIII-mediated cross-linking.
Article
Biochemistry & Molecular Biology
P. Aravind, Sarojini R. Bulbule, N. Hemalatha, R. L. Babu, K. S. Devaraju
Summary: The study analyzed the gene expression of major calcium binding proteins under oxidative stress, revealing enhanced expression of certain proteins and down-regulation of others. Additionally, Akt protein expression was enhanced in most stress inducers except under hyperglycemic conditions.
Review
Biochemistry & Molecular Biology
Carolina Di Fabrizio, Veronica Giorgione, Asma Khalil, Colin E. Murdoch
Summary: Human pregnancy can be affected by various pathologies, including gestational diabetes mellitus and hypertensive disorders, which can have severe consequences. Health issues during pregnancy and postpartum contribute significantly to maternal mortality and morbidity. This review focuses on the latest evidence on oxidative stress in pregnancy complications, early diagnosis, and potential therapies.
Article
Nutrition & Dietetics
Natasya Prameswari, Rima Irwinda, Noroyono Wibowo, Yudianto Budi Saroyo
Summary: This study found differences in amino acid concentrations between severe preeclampsia patients and normal pregnant women. Glutamate and methionine were associated with preeclampsia. Further research on the role of amino acids in the pathomechanism of preeclampsia is recommended.
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Rosario Lizio, Paola Di Pietro, Michele Ciccarelli, Antonio Damato, Eleonora Venturini, Patrizia Iannece, Eduardo Sommella, Pietro Campiglia, Philipp Ockermann, Carmine Vecchione
Summary: The research demonstrated that Healthberry 865(R) has a significant vasodilatory effect on resistance artery function in mice, mediated by nitric oxide release through the PI3K/Akt signaling pathway. It also exerts an antioxidant effect by modulating NADPH oxidase. The selective action of different anthocyanins mediates the cardiovascular properties of Healthberry 865(R), reducing oxidative stress and improving nitric oxide bioavailability.
Article
Biochemistry & Molecular Biology
Xin Shi, Panpan Li, Hanhan Liu, Verena Prokosch
Summary: This article reviews the impact of oxidative stress (OS) on endothelial dysfunction (ED) in the retina and explores the mechanistic links between the two and their role in different retinal neurodegenerative diseases. Understanding the role of endothelial function may lead to new therapeutic approaches.
Review
Biochemistry & Molecular Biology
Ramana Vaka, Evangeline Deer, Babbette LaMarca
Summary: Despite extensive research, the pathogenesis of preeclampsia (PE) remains unclear and lacks FDA-approved treatments. Mitochondrial oxidative stress has been identified as a crucial factor in PE development and holds potential as a target for therapy.
Review
Biochemistry & Molecular Biology
Cristina Carresi, Rocco Mollace, Roberta Macri, Miriam Scicchitano, Francesca Bosco, Federica Scarano, Anna Rita Coppoletta, Lorenza Guarnieri, Stefano Ruga, Maria Caterina Zito, Saverio Nucera, Micaela Gliozzi, Vincenzo Musolino, Jessica Maiuolo, Ernesto Palma, Vincenzo Mollace
Summary: Atherothrombosis, a complex artery disorder, is a major cause of morbidity and mortality worldwide. Imbalance between oxidative stress and antioxidant defenses triggers cellular events leading to vascular wall remodeling and thrombus formation. Emerging studies focus on clotting activation and defective autophagy as potential therapeutic targets for atherosclerotic disease.
Article
Chemistry, Analytical
Xiao Wang, Xuechuan Wang, Qingxin Han
Summary: Mercury is a toxic heavy metal pollutant that poses serious threats to the environment and organism health. Oxidative stress caused by Hg2+ exposure results in the production of reactive oxygen and nitrogen species, damaging the health of organisms. Developing an efficient screening method to monitor the fluctuations in Hg2+ and ONOO- levels is crucial.
ANALYTICA CHIMICA ACTA
(2023)
Article
Pharmacology & Pharmacy
Yunxia Luo, Hansen Chen, Bun Tsoi, Qi Wang, Jiangang Shen
Summary: Ethanol extract of DSS is effective in reducing infarct sizes and improving neurological deficit scores in post-ischemic stroke rats; it attenuates apoptotic cell death by down-regulating cleaved-caspase 3 and Bax expression, up-regulating bcl-2, and decreasing oxidative/nitrosative stress. Additionally, DSS increases the expression of SIRT1 in the brain, leading to neuroprotective effects against cerebral ischemic-reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Chia-Chi Liu, YunJia Zhang, Angela Makris, Helge H. Rasmussen, Annemarie Hennessy
Summary: The study compared the glutathionylation of the beta(1) subunit of the Na+-K+ pump in placentas from healthy pregnancies and preeclampsia. The results showed a significant increase in GSS-beta(1) levels in preeclamptic placentas, providing new insights into the mechanism of Na+-K+ pump dysfunction in preeclampsia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Materials Science, Biomaterials
Ping Huang, Zihong Li, Li Nong, Jie Cheng, Weiying Lin
Summary: Aging is a natural process characterized by the decline of physiological functions in the body's organs and tissues. Oxidative stress, caused by active nitrogen substances like ONOO-, is considered to be the main cause of aging. Detecting changes in ONOO- in aging cells is important for studying senescence. In this study, we developed a fluorescent probe FLASN based on flavonol that can detect and treat ONOO- in cells. Our results showed that FLASN can effectively detect ONOO- in cells and reduce its production stimulated by metformin. This study provides a new perspective on the role of ONOO- in senescence and the potential therapeutic effect of flavonol.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Hematology
Marco Orlandi, Stefano Masi, Devina Bhowruth, Yago Leira, Georgios Georgiopoulos, Derek Yellon, Aroon Hingorani, Scott T. Chiesa, Derek J. Hausenloy, John Deanfield, Francesco D'Aiuto
Summary: The study showed that remote ischemic preconditioning (RIPC) can prevent acute endothelial dysfunction in patients with periodontitis following exposure to an acute inflammatory stimulus by modulating inflammation and oxidation processes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liping Huang, Yanlin Ma, Lu Chen, Jiang Chang, Mei Zhong, Zhijian Wang, Ying Sun, Xia Chen, Fei Sun, Lu Xiao, Jianing Chen, Yingjun Lai, Chuming Yan, Xiaojing Yue
Summary: Preeclampsia is a life-threatening disease in pregnant women associated with mitochondrial-mediated placental oxidative stress. The down-regulation of Rnd3 in primary trophoblasts from PE patients leads to excessive ROS generation, cell apoptosis, and mitochondrial damage. Rnd3 acts as a protective factor in placental mitochondria through the PPARγ-UCP2 signaling pathway.
Review
Public, Environmental & Occupational Health
Ayah Abdul-Hussein, Ayesha Kareem, Shrankhala Tewari, Julie Bergeron, Laurent Briollais, John R. G. Challis, Sandra T. Davidge, Claudio Delrieux, Isabel Fortier, Daniel Goldowitz, Pablo Nepomnaschy, Ashley Wazana, Kristin L. Connor
Summary: This study conducted a Rapid Evidence Review within the DOHaD framework, finding that the majority of DOHaD research data come from high-income countries, with studies examining social determinants of health and paternal influences being underrepresented. Only 23% of the articles explored resiliency factors.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Esha Ganguly, Raven Kirschenman, Floor Spaans, Claudia D. Holody, Thomas E. J. Phillips, C. Patrick Case, Christy-Lynn M. Cooke, Michael P. Murphy, Helene Lemieux, Sandra T. Davidge
Summary: Complications associated with prenatal hypoxia can lead to increased placental oxidative stress, impacting fetal development. A placenta-targeted treatment strategy using nMitoQ was found to improve placental mitochondrial function in both male and female placentae exposed to prenatal hypoxia. This strategy could potentially enhance placental function in complicated pregnancies by reducing oxidative stress.
Article
Physiology
Laura Marcela Reyes, Charlotte W. Usselman, Rshmi Khurana, Radha S. Chari, Michael K. Stickland, Sandra T. Davidge, Colleen G. Julian, Craig D. Steinback, Margie H. Davenport
Summary: This study found that women with preeclampsia had higher baseline mean arterial pressure, noradrenaline concentrations, and MSNA occurrence probability compared to controls, but no significant difference in baseline MSNA levels between the two groups. The chemoreflex does not contribute to increased MSNA in women with preeclampsia.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nataliia Hula, Floor Spaans, Jennie Vu, Anita Quon, Raven Kirschenman, Christy-Lynn M. Cooke, Tom J. Phillips, C. Patrick Case, Sandra T. Davidge
Summary: Offspring born from pregnancies complicated by prenatal hypoxia are at higher risk of cardiovascular disease in adulthood. Cardiac tolerance to ischemia/reperfusion (I/R) insult is decreased in both male and female offspring exposed to hypoxia during fetal life, but can be improved by maternal treatment with nMitoQ. The molecular mechanisms underlying the improved cardiac tolerance to I/R may involve changes in the levels/phosphorylation of proteins important for intracellular Ca2+ cycling.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Sara Abdulrhim, Sowndramalingam Sankaralingam, Mohamed Izham Mohamed Ibrahim, Mohammed Issam Diab, Mohamed Abdelazim Mohamed Hussain, Hend Al Raey, Mohammed Thahir Ismail, Ahmed Awaisu
Summary: The study explored the value of Collaborative Care Model (CCM) in diabetes care from the perspective of patients and healthcare professionals in a primary healthcare (PHC) setting. Participants generally had a positive perception of CCM but identified barriers such as undesirable attributes of HCPs and patients, unsupportive hospital system, and high workload that must be addressed before implementing the model in other PHC settings.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Infectious Diseases
Hager ElGeed, Yaw Owusu, Sara Abdulrhim, Ahmed Awaisu, Vyas S. Kattezhathu, Palli Valapila Abdulrouf, Sowndramalingam Sankaralingam
Summary: The study revealed that while community pharmacists in Qatar are prepared to engage with patients, the majority still require additional training related to COVID-19. It was found that the country from which pharmacists obtained their degree and the type of pharmacy they work in influenced their perceptions towards emergency preparedness.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2021)
Article
Medicine, General & Internal
Kalyanaraman Kumaran, Ghattu Krishnaveni, Kumar Gavali Suryanarayana, Manohar Prabhu Prasad, Antonisamy Belavendra, Stephanie Atkinson, Ramaswamy Balasubramaniam, Robert H. J. Bandsma, Zulfiqar A. Bhutta, Giriraj Ratan Chandak, Elena M. Comelli, Sandra T. Davidge, Cindy-Lee Dennis, Geoffrey L. Hammond, Prabhat Jha, K. S. Joseph, Sadhana R. Joshi, Murali Krishna, Kang Lee, Stephen Lye, Patrick McGowan, Pablo Nepomnaschy, Vivek Padvetnaya, Saumyadipta Pyne, Harshpal Singh Sachdev, Sirazul Ameen Sahariah, Nalini Singhal, Jacquetta Trasler, Chittaranjan S. Yajnik, Janis Baird, Mary Barker, Marie-Claude Martin, Nusrat Husain, Daniel Sellen, Caroline H. D. Fall, Prakesh S. Shah, Stephen G. Matthews
Summary: The study protocol describes a comprehensive intervention to reduce non-communicable disease risks in children through a village-based cluster randomised design in rural India. The multifaceted intervention includes measures to optimize nutrition, parenting programme, lifestyle behavior change intervention, and environmental pollution reduction. The study will collect various biospecimens to assess intervention effects and conduct intention-to-treat analysis and process and economic evaluations.
Review
Biochemistry & Molecular Biology
Jamie Strain, Floor Spaans, Mohamed Serhan, Sandra T. Davidge, Kristin L. Connor
Summary: Exposome research aims to understand the various environmental exposures that impact human health, particularly the mechanism behind obesity. Maternal metabolic exposome and early environmental exposures increase the risk of offspring obesity through mechanisms such as epigenetic modifications, altered placental function, changes in gut microbiome and breast milk composition, and metabolic inflammation affecting development of the central appetite system, adipose tissues, and liver.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Physiology
Mazhar Pasha, Amy L. Wooldridge, Raven Kirschenman, Floor Spaans, Sandra T. Davidge, Christy-Lynn M. Cooke
Summary: The study found that advanced maternal age is associated with heightened blood pressure in non-pregnant rats, and different responses in endothelium-dependent relaxation to vasodilators and big endothelin-1, indicating compensatory mechanisms in vascular function in aged rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Afraa Abbas, Samaher Al-Shaibi, Sowndramalingam Sankaralingam, Ahmed Awaisu, Vyas S. Kattezhathu, Supakit Wongwiwatthananukit, Yaw B. Owusu
Summary: This study reveals a high prevalence of pDDIs in prescriptions dispensed in community pharmacies, emphasizing the importance of utilizing DDI checkers. It is recommended that community pharmacists pay attention to using these tools to ensure effective communication of pDDIs with prescribers for appropriate action.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Article
Pharmacology & Pharmacy
Sara Abdulrhim, Ahmed Awaisu, Mohamed Izham Mohamed Ibrahim, Mohammad Issam Diab, Mohamed Abdelazim Mohamed Hussain, Hend Al Raey, Mohammed Thahir Ismail, Sowndramalingam Sankaralingam
Summary: Pharmacist-involved collaborative care in a primary healthcare setting significantly improved diabetes-related outcomes, including reducing HbA(1)c levels, blood pressure, lipid profile, and body mass index. Future studies should investigate the long-term impact of this care model.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Article
Biochemistry & Molecular Biology
Nataliia Hula, Ricky Liu, Floor Spaans, Mazhar Pasha, Anita Quon, Raven Kirschenman, Christy-Lynn M. Cooke, Sandra T. T. Davidge
Summary: Prenatal hypoxia predisposes offspring to cardiovascular dysfunction in adulthood, impairing endothelium-dependent vasodilation and increasing PGHS-dependent vasoconstriction. Additionally, prenatal hypoxia enhances the contribution of endothelium-dependent hyperpolarization to coronary artery vasodilation.
Article
Biochemistry & Molecular Biology
Paulami Chatterjee, Claudia D. Holody, Raven Kirschenman, Murilo E. Graton, Floor Spaans, Tom J. Phillips, C. Patrick Case, Stephane L. Bourque, Helene Lemieux, Sandra T. Davidge
Summary: Prenatal hypoxia impairs cardiac mitochondrial function in adult female offspring, but this can be improved with prenatal treatment using a nanoparticle-encapsulated mitochondrial antioxidant. The study found that prenatal hypoxia did not affect cardiac mitochondrial function in male offspring, while it decreased the capacity of certain mitochondrial pathways in females. However, treatment with nMitoQ increased respiratory coupling efficiency in female offspring exposed to prenatal hypoxia. This suggests that targeting placental oxidative stress in prenatal hypoxia may reduce the risk of cardiovascular disease in adult offspring by improving cardiac mitochondrial function, specifically in females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Do, Luke Eckersley, Lily Lin, Sandra T. Davidge, Michael K. Stickland, Tiina Ojala, Jesus Serrano-Lomelin, Lisa K. Hornberger
Summary: The study revealed that children of diabetic mothers continue to exhibit interventricular septal thickening and increased aortic stiffness in early childhood, which is correlated with maternal blood sugar control. Compared to children from healthy pregnancies, the offspring of diabetic mothers show significant cardiovascular abnormalities.
Review
Medicine, Research & Experimental
Stephane L. Bourque, Sandra T. Davidge
