Article
Virology
Aslihan Kiraz, Ozlem Sezer, Adem Alemdar, Sezin Canbek, Nilgun Duman, Atil Bisgin, Tulin Cora, Hatice Ilgin Ruhi, Mahmut Cerkez Ergoren, Bilgen Bilge Geckinli, Sebnem Ozemri Sag, Hilmi Erdem Gozden, Ozlem Oz, Zuhal Mert Altintas, Sinem Yalcintepe, Adem Keskin, Ayseguel Yabaci Tak, Seyma Aktas Paskal, Ugur Fahri Yurekli, Mercan Demirtas, Emine Unal Evren, Abdullah Hanta, Mueserref Basdemirci, Kaya Suer, Burhan Balta, Nadir Kocak, Halil Guerhan Karabulut, Havva Cobanogullari, Esra Arslan Ates, Sevcan Tug Bozdogan, Damla Eker, Sadiye Ekinci, Sueleyman Nergiz, Timur Tuncali, Serap Yagbasan, Ceren Alavanda, Nuket Yurur Kutlay, Hakan Evren, Murat Erdogan, Sule Altiner, Tamer Sanlidag, Gizem Akinci Gonen, Arzu Vicdan, Nazan Eras, Hatice Kocak Eker, Ozgur Balasar, Gulten Tuncel, Munis Dundar, Hakan Gurkan, Sehime Gulsun Temel
Summary: This study examined the impact of hereditary thrombophilia factors Prothrombin (FII) and Factor V Leiden (FVL) genotypes on the severity of COVID-19 disease and the development of thrombosis. FVL gene variation was found to be associated with disease severity and thrombus formation in COVID-19 patients, while Prothrombin mutations had no impact on disease severity. Therefore, possible FVL gene mutations should be investigated in COVID-19 patients and appropriate treatment should be initiated early in FVL-positive patients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Biology
Minerva Codruta Badescu, Lacramioara Ionela Butnariu, Alexandru Dan Costache, Liliana Gheorghe, Petronela Nicoleta Seritean Isac, Adriana Chetran, Sabina Andreea Leanca, Irina Afrasanie, Stefania-Teodora Duca, Eusebiu Vlad Gorduza, Irina Iuliana Costache, Ciprian Rezus
Summary: Factor V Leiden and prothrombin G20210A are the most common hereditary thrombophilias and their relationship with acute myocardial infarction is still uncertain. Screening should be implemented in select cases and followed by optimal control of traditional cardiovascular risk factors for prevention. Extended dual antiplatelet therapy may be considered due to the lower bleeding risk conferred by FV Leiden.
Article
Genetics & Heredity
Mihael Tsalta-Mladenov, Mariya Levkova, Silva Andonova
Summary: This meta-analysis investigates the role of inherited thrombophilia predisposition in young adults with ischemic strokes. The results indicate that genetic markers, such as factor V Leiden, factor II prothrombin, protein C, protein S, and antithrombin, are all risk factors for ischemic stroke in this population. The findings suggest that testing for these markers could improve the quality of care.
Article
Health Care Sciences & Services
Petra Riedlova, Dagmar Kramna, Silvie Ostrizkova, Hana Tomaskova, Vitezslav Jirik
Summary: Screening for factor V Leiden and factor II prothrombin in young women using ddPCR may effectively prevent TED and be cost-effective in the Czech Republic. The cost-benefit analysis suggests that screening for these genetic risk factors before starting OCs could significantly reduce treatment costs associated with TED.
Article
Obstetrics & Gynecology
A. I. Lokki, Z. Ren, M. Triebwasser, E. Daly, M. Perola, K. Auro, R. Burwick, J. E. Salmon, M. Daly, H. Laivuori, J. P. Atkinson, A. Java, S. Meri
Summary: The study investigated the role of genetic variants in complement proteins in pre-eclampsia. Five rare variants in complement factor H (CFH) were identified in women with severe and complicated pre-eclampsia, while no variants were found in controls. These results suggest that complement dysregulation due to mutations in CFH is among the pathophysiological mechanisms underlying severe pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
Jiajia Song, Xianping Huang, Panpan Zhou, Ting Xu, Zhangye Xu
Summary: This study found that maternal GNB3 C825T polymorphism may be a risk factor for pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Medicine, Research & Experimental
Frank S. Fan
Summary: Factor V Leiden, a mutant gene defect, exists mainly in Caucasians but is almost absent in Asians. This distribution imbalance may be linked to the Black Death pandemic in fourteenth-century Europe, which exerted selective pressure on the factor V Leiden mutation, providing an evolutionary advantage.
MEDICAL HYPOTHESES
(2023)
Article
Medicine, General & Internal
Abdulghani Msalati, Abdulla Bashein, Murad Ghrew, Ibtesam Khalil, Khaled Sedaa, Abushawashi Ali, Ahmed Zaid
Summary: The study found, for the first time, the presence of FVL and PGM mutations among Libyan DVT and MI patients, with FVL mutation significantly associated with DVT but not with MI. The results do not support the association of PGM G20210A mutation with DVT or MI.
LIBYAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Bakhtawar K. Mahmoodi, Niclas Eriksson, Gerrit J. A. Vos, Karina Meijer, Agneta Siegbahn, Stefan James, Lars Wallentin, Jurrien M. ten Berg
Summary: In patients with acute coronary syndrome, factor V Leiden mutation does not increase the risk of ST-segment-elevation myocardial infarction (STEMI) or affect peak cardiac necrosis markers levels.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Genetics & Heredity
Fahimeh Afzaljavan, Asma Khorshid Shamshiri, Abbas Eslami, Reza Ashari, Alireza Pasdar
Summary: This study conducted a systematic review to evaluate the association of different genetic markers with stroke risk in the Iranian population. The findings suggest that some genetic variants are significantly associated with stroke risk, but further confirmation is needed in larger cohorts.
Article
Obstetrics & Gynecology
Jose Rojas-Suarez, Javier A. Carvajal, Maria P. Echavarria, Isabella Ramos, Maria A. Zambrano, Maria A. Hincapie, Evelyn E. Pena, Laura Libreros, Maria F. Escobar
Summary: Two distinct subphenotypes of severe early-onset pre-eclampsia were identified in a Latin American cohort. Subphenotype 2, characterized by poorer hemodynamic indicators at admission, was associated with worse maternal outcomes and appeared less modifiable after hospital treatment.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Health Care Sciences & Services
Lyle G. Best, Marcia O'Leary, Rae O'Leary, Wendy Lawrence, Dara G. Torgerson
Summary: The proper communication of clinically actionable findings to participants of genetic research is essential but challenging. This study documents the return of individual genetic results in a rural American Indian community and provides insight for other investigators on how to approach this ethically. Extensive consultation with the IRB, tribal government, and local clinicians was conducted, and two participants were notified of clinically actionable genetic variants. One participant welcomed this information while the other declined further follow-up.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Yue Ma, Mingyue Ma, Shenglong Ye, Yuanying Liu, Xueqing Zhao, Yongqing Wang
Summary: IL-17 rs763780, IL-27 rs153109, and IL-27 rs17855750 polymorphisms are not significantly associated with RPL and PE, while IL-17 rs2275913 polymorphism is associated with the susceptibility to recurrent pregnancy loss.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Medicine, General & Internal
Tamara Perez-Jeldres, Fabien Magne, Gabriel Ascui, Danilo Alvares, Matias Orellana, Manuel Alvarez-Lobos, Cristian Hernandez-Rocha, Lorena Azocar, Nataly Aguilar, Alberto Espino, Ricardo Estela, Sergio Escobar, Alejandra Zazueta, Pablo Baez, Veronica Silva, Andres de la Vega, Elizabeth Arriagada, Carolina Pavez-Ovalle, Alejandro Diaz-Asencio, Dante Travisany, Juan Francisco Miquel, Eduardo J. Villablanca, Mitchell Kronenberg, Maria Leonor Bustamante
Summary: This study investigated the genetic risk variants of IBD in a Chilean cohort, finding an association between Native American ancestry and IBD risk. Variants associated with IBD risk in this Andean region were related to myeloid cells and the innate immune response.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Jaskamal Padda, Khizer Khalid, Ayushi Mohan, Sindhu Pokhriyal, Nitya Batra, Gazala Hitawala, Ayden Charlene Cooper, Gutteridge Jean-Charles
Summary: Factor V Leiden (FVL) G1619A mutation and prothrombin gene (PTG) G20210A are the most common inherited thrombophilias, with prevalence in Caucasians but controversial regarding routine screening. The association and conclusions vary among different ethnic groups and studies, necessitating further high-quality research for conclusive results.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Nursing
Lisa M. Blair, Jodi L. Ford, P. Cristian Gugiu, Rita H. Pickler, Cindy L. Munro, Cindy M. Anderson
Article
Nursing
Kristen R. Choi, Kathryn Records, Lisa Kane Low, Jeanne L. Alhusen, Carole Kenner, Joan Rosen Bloch, Shahirose Sadrudin Premji, Jean Hannan, Cindy M. Anderson, Seonae Yeo, M. Cynthia Logsdon
JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING
(2020)
Article
Public, Environmental & Occupational Health
Carmen Giurgescu, Liying Zhang, Mercedes A. Price, Rhonda K. Dailey, Heather A. Frey, Deborah S. Walker, Shannon N. Zenk, Christopher G. Engeland, Cindy M. Anderson, Dawn P. Misra
PUBLIC HEALTH NURSING
(2020)
Article
Nursing
Alexandra L. Nowak, Carmen Giurgescu, Jodi L. Ford, Amy Mackos, Joyce Ohm, Alai Tan, Maciej Pietrzak, Cindy M. Anderson
Summary: Epigenetic modifications can modify gene expression without changing the gene sequence, providing potential biomarkers for identifying health risks in African American women. Research on preterm birth in this population is still limited, with a need for deeper understanding of the biological pathways involved.
WESTERN JOURNAL OF NURSING RESEARCH
(2022)
Article
Nursing
Carmen Giurgescu, Ana Carolina Wong, Brooke Rengers, Sarah Vaughan, Alexandra L. Nowak, Mercedes Price, Rhonda K. Dailey, Cindy M. Anderson, Deborah S. Walker, Dawn P. Misra
Summary: The study revealed that pregnant Black women faced challenges of perceived stress, depressive symptoms, and loneliness during the COVID-19 pandemic, with respondents being more likely to experience anxiety and stress during this period. Lack of social support also contributed to increased levels of perceived stress and depressive symptoms.
WESTERN JOURNAL OF NURSING RESEARCH
(2022)
Editorial Material
Medicine, General & Internal
Rosemary D. Higgins, Abhik Das
Article
Nursing
Alexandra L. Nowak, Cindy M. Anderson, Jodi L. Ford, Amy Mackos, Joyce Ohm, Nadia Saadat, Alai Tan, Yihong Zhao, Dawn P. Misra, Carmen Giurgescu
Summary: The preterm birth rate has been increasing in the United States, particularly among non-Hispanic Black women. Previous research suggests a link between psychological stress and preterm birth in Black women, but the biological pathways involved are unclear. This study identified differentially methylated DNA sites associated with preterm birth in pregnant Black women, providing a potential avenue for reducing the disparity in preterm birth rates.
BIOLOGICAL RESEARCH FOR NURSING
(2022)
Article
Immunology
Shannon L. Gillespie, Lisa M. Christian, Amy R. Mackos, Timiya S. Nolan, Kaboni W. Gondwe, Cindy M. Anderson, Mark W. Hall, Karen Patricia Williams, George M. Slavich
Summary: Although the biological mechanisms underlying the higher risk of morbidity and mortality among Black American mothers and infants compared to their White counterparts remain largely unknown, this study found that lifetime stressor exposure, perceived stressor severity, and systemic inflammatory markers were interrelated factors. Exposure to more chronic stressors and higher overall perceived stressor severity were associated with higher levels of the inflammatory marker IL-18, while exposure to fewer acute stressors and higher acute perceived stressor severity were associated with higher IL-18 levels. Additionally, pregnant women who went on to give birth prematurely had higher levels of the inflammatory marker IL-6.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Nursing
Cindy Anderson
WESTERN JOURNAL OF NURSING RESEARCH
(2022)
Review
Public, Environmental & Occupational Health
Melanie Nadeau, Kathryn Wise, Vianca Farfan Cuela, Devon Olson, Karan Saravana
Summary: This article aims to identify the cancer-related risk and protective factors among American Indian youth and share the results with tribal communities to improve surveillance efforts.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Melanie Nadeau, Lyle G. Best, Marilyn G. Klug, Kathryn Wise
Summary: Very little is known about the breast cancer risk profile among American Indian women. This retrospective case control study explored the association of common risk factors among American Indian women with and without breast cancer, showing weak positive associations between some risk factors and breast cancer. The study found nulliparity to be the only consistently significant risk factor.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Katherine A. Hirchak, Melanie Nadeau, Angel Vasquez, Alexandra Hernandez-Vallant, Kyle Smith, Cuong Pham, Karen Anderson Oliver, Paulette Baukol, Karen Lizzy, Racquel Shaffer, Jalene Herron, Aimee N. C. Campbell, Kamilla L. Venner
Summary: American Indian/Alaska Native (AI/AN) communities are disproportionately impacted by the opioid overdose epidemic. However, there is a lack of research on effectively implementing treatments for opioid use disorder (OUD) within these communities. This study describes the process of developing an implementation intervention for AI/AN clinical programs to improve the delivery of medications for treating OUD.
AMERICAN JOURNAL OF COMMUNITY PSYCHOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ashley S. Felix, Timiya S. Nolan, LaShaunta M. Glover, Mario Sims, Daniel Addison, Sakima A. Smith, Cindy M. Anderson, Barbara J. Warren, Cheryl Woods-Giscombe, Darryl B. Hood, Karen Patricia Williams
Summary: This study examined whether resilience modified the association between coping with repeated stressors and cardiovascular disease (CVD) in African Americans. The results showed that high allostatic load (AL) was associated with coronary heart disease and heart failure in women, and heart failure in both men and women. Among men, low resilience was associated with higher stroke risk, and high AL was associated with greater heart failure in men with high resilience.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Review
Nursing
Cheryl L. Woods-Giscombe, Karen Patricia Williams, Jamie Conklin, Adam Dodd, Lilian Bravo, Avery M. Anderson, Taleah Frazier, Ganga Bey, Millicent N. Robinson, Barbara J. Warren, Kathy D. Wight, Ashley S. Felix, Cindy M. Anderson, Darryl B. Hood
Summary: The study on resilience and health in African American women highlights the limitations of traditional approaches in capturing the experiences of this group. A more comprehensive conceptualization of resilience is needed, taking into account culturally-relevant components such as spirituality/religion, strength, survival, active coping, and social support.
ARCHIVES OF PSYCHIATRIC NURSING
(2023)
Article
Public, Environmental & Occupational Health
Nicole Redvers, Melanie Nadeau, Donald Prince
Summary: Urban Indigenous populations in Canada experience health and social disparities, with limited access to land-based healing programs. The urban land-based healing camp in Yellowknife could serve as a model for similar initiatives elsewhere. This effort expands knowledge on land-based healing in urban Indigenous high-risk settings.
INTERNATIONAL JOURNAL OF INDIGENOUS HEALTH
(2021)
