Article
Medicine, General & Internal
Na Wang, Dandan Shi, Na Li, Hongyuan Qi
Summary: VEGF and sFlt-1 can be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta.
ANNALS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Adrian C. Eddy, Chun Yi Chiang, Augustine Rajakumar, Frank T. Spradley, Patricia Dauer, Joey P. Granger, Sarosh Rana
Summary: Preeclampsia is a dangerous complication of pregnancy that can lead to maternal death and long-term complications. This study aimed to find new compounds to reduce placental sFlt-1 and discovered that luteolin showed the most potent inhibition of sFlt-1 release, with over 95% reduction. Luteolin was found to reduce sFlt-1 through inhibition of HIF-1 alpha, possibly via the Akt pathway.
Article
Medicine, General & Internal
Ece Ocal, Veysel Toprak, Senem Alkan Akalin, Firat Asir, Engin Deveci
Summary: This study aimed to investigate the expression of Beclin1 and tumor necrosis factor (TNF)-a in normotensive and preeclamptic placentas of pregnant women patients. The results showed an increase in degenerated decidua cells and inflammation in the preeclampsia group. Therefore, Beclin1 and TNF-a signals may be used as markers affecting the fetal structure of blood flow in preeclamptic placentas.
Article
Biochemistry & Molecular Biology
Adrian C. C. Eddy, Chun Yi Chiang, Augustine Rajakumar, Frank T. T. Spradley, Patricia Dauer, Joey P. P. Granger, Sarosh Rana
Summary: Preeclampsia is a serious complication of pregnancy that can lead to maternal death and long-term complications. This study aimed to identify new compounds that can reduce sFlt-1 and inhibit HIF-1a, a prohypertensive factor. The natural compound luteolin showed the strongest inhibition of sFlt-1 release, with over 95% reduction compared to the control group. Luteolin also reduced HIF-1a expression through the Akt pathway. This makes luteolin a potential novel treatment for preeclampsia.
Article
Pharmacology & Pharmacy
Meng-Yan Deng, Khalil Ali Ahmad, Qiao-Qiao Han, Zi-Ying Wang, Rana Muhammad Shoaib, Xin-Yan Li, Yong-Xiang Wang
Summary: The study showed that thalidomide alleviates neuropathic pain by upregulating spinal microglial IL-10 and beta-endorphin expression rather than downregulating TNF alpha expression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Article
Immunology
Yusha Wang, Jun Wang, Wenjie Zheng, Jiahui Zhang, Jinbo Wang, Taijie Jin, Panfeng Tao, Yibo Wang, Chenlu Liu, Jiqian Huang, Pui Y. Lee, Xiaomin Yu, Qing Zhou
Summary: A novel missense variant in IL-1R1 was identified in a patient with CRMO, leading to unopposed IL-1 signaling. Researchers designed an IL-1 therapeutic that effectively targets IL-1-driven diseases.
Article
Immunology
Alexandria Lozowchuk, Judith E. Carroll, Calvin Hobel, Mary Coussons-Read, Christine Dunkel Schetter, Kharah M. Ross
Summary: This study explored the relationship between partner relationship quality and inflammatory markers IL-6, IL-10, and TNF-alpha during pregnancy and the postpartum period. The findings suggest that lower partner support may be associated with reduced inflammation regulation, with potential consequences for maternal health and well-being.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Developmental Biology
Fengyuan Zhang, Mengqi Gu, Pengzheng Chen, Shuting Wan, Qian Zhou, Yuan Lu, Lei Li
Summary: This study found that the concentrations of sFlt-1 and PLGF, as well as the sFlt-1/PLGF ratio, can help distinguish patients with placenta accreta from those with placenta previa.
Article
Plant Sciences
Ilin Kandilarov, Petya Gardjeva, Maria Georgieva-Kotetarova, Hristina Zlatanova, Natalia Vilmosh, Ivanka Kostadinova, Mariana Katsarova, Kiril Atliev, Stela Dimitrova
Summary: This study aimed to investigate the effects of two combined plant extracts, rich in flavonoids, on cytokine levels in rats subjected to acute and chronic stress models. The results showed that these combined extracts had a more pronounced effect in reducing cytokine levels compared to individual plant extracts.
Review
Biochemistry & Molecular Biology
Katrin Witte, Robert Sabat, Ellen Witte-Haendel, Kamran Ghoreschi, Kerstin Wolk
Summary: Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease characterized by painful skin lesions in various areas of the body. It affects about 1% of the population and is associated with comorbidities such as metabolic syndrome. Current therapeutic options for HS are limited, and novel treatment options are needed. Recent research suggests that immune mediators IL-1 beta, IL-17A, and G-CSF play a key role in the development of HS. Phytomedical drugs, which have potent immunoregulatory properties, have not been considered as a treatment for HS. This review explores the potential of targeting the IL-1/IL-17/G-CSF axis for an integrated phytomedical treatment of HS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kangkang Huang, Yunlai Liang, Yating Ma, Jiahui Wu, Huidan Luo, Bin Yi
Summary: This study discovered significant variations in adiponectin, nesfatin-1, IL-6, and TNF-alpha levels among healthy individuals, prediabetic patients, and type 2 diabetes mellitus patients, indicating a gradual change during the progression from a healthy condition to diabetes via prediabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Afifa Noor, Muhammad Ihsan Ullah
Summary: The current study evaluated the anti-arthritic activity of n-hexane and aqueous extracts of Cassia absus seeds. The extracts showed significant inhibition of paw edema and reduction in paw size and joint diameter. The extracts also improved the levels of inflammatory and oxidative biomarkers. Polymerase chain reaction investigation revealed the modulation of various inflammatory factors by the extracts. In conclusion, Cassia absus can effectively alleviate arthritis symptoms by modulating oxidative and inflammatory biomarkers.
INFLAMMOPHARMACOLOGY
(2023)
Article
Peripheral Vascular Disease
Rugina Neuman, Milan D. Baars, Langeza Saleh, Michelle Broekhuizen, Daan Nieboer, Jerome Cornette, Sam Schoenmakers, Michel Verhoeven, Birgit C. P. Koch, Henk Russcher, Sjoerd A. A. van den Berg, Anton H. van den Meiracker, Willy Visser, A. H. Jan Danser
Summary: This study investigated the effect of the proton pump inhibitor omeprazole on circulating levels of sFlt-1, PlGF, and ET-1 in women with confirmed preeclampsia. The results showed that omeprazole did not alter these levels, suggesting that it is not a suitable treatment for this syndrome.
Article
Infectious Diseases
Catalina Tovar Acero, Javier Ramirez-Montoya, Maria Camila Velasco, Paula A. Aviles-Vergara, Dina Ricardo-Caldera, Miquel Duran-Frigola, Gustavo Quintero, Myriam Elena Cantero, Juan Rivera-Correa, Ana Rodriguez, Maria Fernanda Yasnot-Acosta
Summary: This study evaluated the cytokine profile of P. vivax malaria patients and identified several cytokines and chemokines that are associated with disease severity. These molecules could potentially serve as biomarkers for severity in P. vivax malaria.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Review
Immunology
Lena Erlandsson, Asa Naav, Annemarie Hennessy, Daniel Vaiman, Magnus Gram, Bo Akerstrom, Stefan R. Hansson
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Immunology
Gabriele Bobek, Laura Surmon, Katrina M. Mirabito, Angela Makris, Annemarie Hennessy
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2015)
Article
Public, Environmental & Occupational Health
Seyed Morteza Shamshirgaran, Louisa Jorm, Hilary Bambrick, Annemarie Hennessy
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
(2015)
Article
Obstetrics & Gynecology
Shikha Aggarwal, Angela Makris, Annemarie Hennessy
HYPERTENSION IN PREGNANCY
(2015)
Article
Obstetrics & Gynecology
Rita Machaalani, Emma Ghazavi, Rona Victoria David, Tina Hinton, Angela Makris, Annemarie Hennessy
HYPERTENSION IN PREGNANCY
(2015)
Article
Obstetrics & Gynecology
Jane Tooher, Charlene Thornton, Angela Makris, Robert Ogle, Andrew Korda, John Horvath, Annemarie Hennessy
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Kristen R. Yeung, Christine L. Chiu, Ruth Pidsley, Angela Makris, Annemarie Hennessy, Joanne M. Lind
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Article
Peripheral Vascular Disease
Angela Makris, Kristen R. Yeung, Shirlene M. Lim, Neroli Sunderland, Scott Heffernan, John F. Thompson, Jim Iliopoulos, Murray C. Killingsworth, Jim Yong, Bei Xu, Robert F. Ogle, Ravi Thadhani, S. Ananth Karumanchi, Annemarie Hennessy
Article
Multidisciplinary Sciences
Kristen R. Yeung, Christine L. Chiu, Suzanne Pears, Scott J. Heffernan, Angela Makris, Annemarie Hennessy, Joanne M. Lind
Review
Obstetrics & Gynecology
Renuka Shanmugalingam, Nina Reza Pour, Siang Chye Chuah, Thi Mong Vo, Roy Beran, Annemarie Hennessy, Angela Makris
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Obstetrics & Gynecology
Charlene Thornton, Jane Tooher, Robert Ogle, Peter von Dadelszen, Angela Makris, Annemarie Hennessy
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2016)
Review
Obstetrics & Gynecology
Suzanne Pears, Angela Makris, Annemarie Hennessy
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2018)
Article
Developmental Biology
R. Machaalani, E. Ghazavi, T. Hinton, A. Makris, A. Hennessy
Review
Peripheral Vascular Disease
Katrina Chau, Mikala Welsh, Angela Makris, Annemarie Hennessy
Summary: This review discusses recent advances in understanding the nature of placental dysfunction causing preeclampsia and other hypertensive disorders of pregnancy, specifically focusing on the contributions of animal studies. The translation of data regarding newly discovered pathological pathways, particularly the angiogenic pathway, into clinical practice is also discussed.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Obstetrics & Gynecology
Memory M. Ngwira, Luis A. Gadama, Renuka Shanmugalingam, Angela Makris, Annemarie Hennessy
Summary: This study investigated the knowledge and barriers to the use of calcium and aspirin for preventing preeclampsia among healthcare workers and key policy informants in Malawi. The findings showed that doctors had better knowledge compared to nurses and policy informants, and identified barriers included lack of knowledge, late diagnosis, scarcity of calcium tablets, and delays in implementing guidelines.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
