Journal
HYPERTENSION IN PREGNANCY
Volume 27, Issue 1, Pages 39-48Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10641950701825838
Keywords
preeclampsia; tumor necrosis factor alpha; TNF-alpha; obesity; BMI
Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD030367] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000005] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000056] Funding Source: NIH RePORTER
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NCRR NIH HHS [M01 RR000056-390762, M01 RR000056, 5 M01 RR 00056] Funding Source: Medline
- NICHD NIH HHS [2 P01 HD 30367, P01 HD030367-06, P01 HD030367] Funding Source: Medline
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Objectives: We hypothesized that TNF-alpha would be higher in obese versus lean women with preeclampsia. Methods: Total plasma TNF-alpha was measured in a nested case-control study of 123 nulliparous lean and obese control women and women with preeclampsia. Results: Adjusted mean TNF-alpha concentrations were 0.97 +/- 0.11 (pg/mL +/- SEM) in lean controls, 1.01 +/- 0.10 in obese controls, 1.43 +/- 0.11 in lean women with preeclampsia and 1.16 +/- 0.11 in obese women with preeclampsia. Pregnancy outcome was the single predictor of TNF-alpha concentration in the general linear regression model (p = 0.04). Conclusion: TNF-alpha concentration was higher in preeclampsia compared with control subjects. Obesity was not associated with higher TNF-alpha concentrations in either preeclampsia or control subjects.
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