Article
Cardiac & Cardiovascular Systems
Zoe H. Adams, Hazel C. Blythe, Nisha Charkoudian, Timothy B. Curry, Michael J. Joyner, Adrian H. Kendrick, Angus K. Nightingale, Ana P. Abdala Sheikh, Emma C. Hart
Summary: Respiratory modulation of sympathetic nerve activity is reduced in postmenopausal females, which is associated with higher resting blood pressure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Neurosciences
Joseph C. Watso, Mu Huang, Gilbert Moralez, Matthew N. Cramer, Joseph M. Hendrix, Frank A. Cimino, Luke N. Belval, Carmen Hinojosa-Laborde, Craig G. Crandall
Summary: The study found that low dose ketamine administration can reduce pain perception and some cardiovascular responses, but does not affect muscle sympathetic nerve activity burst frequency. This suggests that low dose ketamine is effective in pain management.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cardiac & Cardiovascular Systems
Jeremy A. Bigalke, John J. Durocher, Ian M. Greenlund, Manda Keller-Ross, Jason R. Carter
Summary: Chronic anxiety is prevalent and associated with an increased risk of cardiovascular disease. This study reveals an independent relationship between trait anxiety, resting blood pressure, and muscle sympathetic nerve activity (MSNA) in healthy adults without cardiometabolic disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Massimo Nardone, Carlin Katerberg, Anthony V. Incognito, Andr E. L. Teixeira, Lauro C. Vianna, Philip J. Millar
Summary: The signal-averaged sympathetic transduction of blood pressure is inversely related to resting muscle sympathetic nerve activity burst frequency in healthy cohorts. The methodological limitations in the analysis of MSNA transduction at different levels of absolute blood pressure are still unclear. Further research is needed to understand the timing relationship between MSNA bursts and blood pressure fluctuations.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Sport Sciences
Megan M. Wenner, Jody L. Greaney, Evan L. Matthews, Shane Mcginty, Jasdeep Kaur, Wanpen Vongpatanasin, Paul J. Fadel
Summary: Postmenopausal women display exaggerated blood pressure and muscle sympathetic nerve activity responses during exercise compared to young women. Estradiol administration attenuates these responses.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Medicine, Research & Experimental
Katarina Babarikova, Pavel Svitok, Libor Kopkan, Michal Zeman, Lubos Molcan
Summary: This study analyzed the impact of cross-fostering on cardiovascular parameters in hypertensive TGR and normotensive HanSD offspring, and found that cross-fostering can reduce sympathovagal balance in hypertensive TGR offspring and transiently decrease plasma Ang II levels and MR expression.
Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Physiology
Andre L. Teixeira, Jordan B. B. Lee, Massimo Nardone, Jamie F. F. Burr, Philip J. J. Millar
Summary: The sympathetic nervous system plays a crucial role in cardiovascular regulation, particularly in response to acute stress. The relationship between renal and leg vasoconstriction at rest or during sympathetic stressors is not yet known. This study aimed to investigate the relationships between muscle sympathetic nerve activity (MSNA), leg vascular conductance (LVC), and renal vascular conductance (RVC) in young healthy adults, both at rest and during laboratory-based stressors. The findings revealed differential control of regional sympathetic vasoconstriction at rest and during stress in young healthy humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Luke. S. Dunaway, Marie Billaud, Edgar Macal, Miranda. E. Good, Christopher. B. Medina, Ulrike Lorenz, Kodi Ravichandran, Michael Koval, Brant. E. Isakson
Summary: This study suggests that Panx1 in smooth muscle cells plays a role in regulating sympathetic nerve constriction and blood pressure. The findings also demonstrate the feasibility of using Panx1-mouse models to test potential drugs for hypertension.
Review
Biochemistry & Molecular Biology
Lu Qin, Jian Cui, Jianhua Li
Summary: This review discusses the impact of sympathetic nerve activity on blood pressure in patients with peripheral artery disease and the related neural mechanisms, and proposes intervention strategies to improve the deleterious effects of exercise-induced blood pressure changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Lyndsey N. Matus, Olivia D. Flessland, Patrick J. Mueller
Summary: The RVLM may contribute to sex-based differences in CVD, with female rats showing greater sympathetic activity and lower resting blood pressure following activation. Sedentary conditions promote higher sympathetic output regardless of age and sex, while the interaction between female reproductive cycle and sedentary conditions plays a complex role in CVD incidences.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Ahmed A. Rahman, Vanesa Stojanovska, Paul Pilowsky, Kulmira Nurgali
Summary: Chronic oxaliplatin treatment leads to increased MAP, sSNA, and PNf, and decreased HR and PNamp. Acute oxaliplatin has no effects on these parameters. Platinum accumulation in the brain may be responsible for the altered cardiovascular and respiratory functions as well as reflexes induced by oxaliplatin.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew W. D'Souza, Sarah L. Hissen, Kazumasa Manabe, Ryosuke Takeda, Takuro Washio, Geoff B. Coombs, Belinda Sanchez, Qi Fu, J. Kevin Shoemaker
Summary: Sympathetic vascular transduction is attenuated in older adults compared to young adults, and there is an inverse relationship between the central and peripheral arcs of the baroreflex. Age and sex have independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Physiology
Michael M. Tymko, Lindsey F. Berthelsen, Rachel J. Skow, Andrew R. Steele, Graham M. Fraser, Craig D. Steinback
Summary: This review discusses the relationship between sympathetic nerve activity and the vasculature, examining both static and dynamic methods of measuring sympathetic transduction. Although each method has its limitations, they all hold significant implications for cardiovascular diseases.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Yuanyuan Fan, Enshe Jiang, Huanjia Gao, Jeremy Bigalke, Bojun Chen, Chunxiu Yu, Qinghui Chen, Zhiying Shan
Summary: The study showed that hyperactivity of the orexin system activates CaMKII expression in the PVN, leading to increased sympathetic nerve activity and blood pressure. Furthermore, orexin-A treatment increases CaMKII expression and phosphorylation in OX1R-expressing PC12 cells, as well as CaMKII activation in cultured hypothalamic neurons. Additionally, optogenetic excitation of PVN CaMKII-expressing neurons results in robust increases in RSNA and BP in SD rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Dawn F. Wolfgram, Julia Novotny, Max J. Goodman, Alexis Visotcky, Purushottam Laud, Jill N. Barnes
Summary: The study found that cerebral perfusion may decline in hemodialysis patients during dialysis and is associated with changes in systemic blood pressure. This may be due to impaired cerebral autoregulation in hemodialysis patients. Risk factors for worse CA index include diabetes and a drop in systolic blood pressure greater than 20 mmHg during hemodialysis.
HEMODIALYSIS INTERNATIONAL
(2022)
Article
Peripheral Vascular Disease
Matthew D. Kobetic, Amy E. Burchell, Laura E. K. Ratcliffe, Sandra Neumann, Zoe H. Adams, Regina Nolan, Angus K. Nightingale, Julian F. R. Paton, Emma C. Hart
Summary: The study found that untreated hypertensive men have lower sympathetic transduction compared to normotensive individuals, indicating that higher levels of MSNA are required to produce the same level of vasoconstrictor tone.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Brandon G. Fico, Kathleen B. Miller, Leonardo A. Rivera-Rivera, Adam T. Corkery, Andrew G. Pearson, Nicole A. Eisenmann, Anna J. Howery, Howard A. Rowley, Kevin M. Johnson, Sterling C. Johnson, Oliver Wieben, Jill N. Barnes
Summary: Age and aortic stiffness are significant predictors of cerebral artery pulsatility index in healthy adults.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
Nathan E. Manghat, Elizabeth Robinson, Konstantina Mitrousi, Jonathan C. L. Rodrigues, Thomas Hinton, Julian F. R. Paton, Richard G. Wise, Angus K. Nightingale, Emma C. Hart
Summary: Variants in the posterior anatomy of the cerebral circulation are associated with hypertension and poor cerebral perfusion in young adults, indicating potential long-term consequences on cerebrovascular health.
Article
Physiology
Niklaus P. Zeller, Kathleen B. Miller, Ryan D. Zea, Anna J. Howery, Lawrence Labrecque, Stacey E. Aaron, Patrice Brassard, Sandra A. Billinger, Jill N. Barnes
Summary: There is a positive association between cardiorespiratory fitness and cognitive health, but the interaction between cardiorespiratory fitness and aging on cerebral hemodynamics is unclear. These potential interactions are further influenced by sex differences. Higher cardiorespiratory fitness is associated with a lower cerebral pulsatility index in all participants, and the significance remains only in women when adjusting for age.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Andrew G. Pearson, Kathleen B. Miller, Adam T. Corkery, Nicole A. Eisenmann, Anna J. Howery, Karly A. Cody, Nathaniel A. Chin, Sterling C. Johnson, Jill N. Barnes
Summary: This study found that lower sympathoexcitatory responses to isometric handgrip exercise are associated with greater white matter hyperintensities burden in middle-aged to older adults.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Physiology
Ronee E. Harvey, Shannon K. Laughlin-Tommaso, Elizabeth A. Stewart, Jacqueline K. Limberg, Timothy B. Curry, Michael J. Joyner, Jill N. Barnes
Summary: Women with uterine fibroids have a higher prevalence of hypertension, and the autonomic interactions with systemic hemodynamics are different in these women compared to women without uterine fibroids.
PHYSIOLOGICAL REPORTS
(2022)
Editorial Material
Medicine, Research & Experimental
Thomas P. Olson, Joshua R. Smith, Timothy B. Curry
Summary: Wahren and Jorfeldt's manuscript on leg blood flow during exercise, published over 50 years ago, utilized a novel approach to indicator dye dilution. Their study revealed the fundamental relationships between muscle blood flow, oxygen uptake, and exercise, and introduced the concept of mechanical efficiency, which is crucial in assessing muscle function. This manuscript laid the foundation for further research on muscle blood flow and exercise, and remains influential in modern research.
Article
Pharmacology & Pharmacy
Susanne B. Haga, Wendy K. Chung, Luis A. Cubano, Timothy B. Curry, Philip E. Empey, Geoffrey S. Ginsburg, Kara Mangold, Christina Y. Miyake, Siddharth K. Prakash, Laura B. Ramsey, Robb Rowley, Carolyn R. Rohrer Vitek, Todd C. Skaar, Julia Wynn, Teri A. Manolio
Summary: The fields of genetics and genomics have expanded in medicine, revealing genetic contributions to various traits and diseases. To ensure timely and appropriate utilization of this knowledge in patient care, accessible and sustainable online education resources are needed for healthcare providers. The National Human Genome Research Institute called for proposals in 2020 to develop such resources, and this paper describes the efforts of six awarded teams to meet this goal.
PERSONALIZED MEDICINE
(2023)
Review
Environmental Sciences
Jenna L. Taylor, Jill N. Barnes, Bruce D. Johnson
Summary: Adults with cardiovascular disease and heart failure have a higher risk of cognitive decline, primarily due to cerebral hypoperfusion. However, higher cardiorespiratory fitness can protect against brain atrophy and cognitive decline. Therefore, studying the role of high intensity interval training (HIIT) in improving cognitive aging is crucial for this population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Physiology
Adam T. Corkery, Kathleen B. Miller, Carissa A. Loeper, Laura H. Tetri, Andrew G. Pearson, Nicole A. Loggie, Anna J. Howery, Marlowe W. Eldridge, Jill N. Barnes
Summary: This study examined the relationship between prostacyclin and cerebrovascular reactivity in healthy young and older adults. The findings showed that there was no association between serum prostacyclin and cerebrovascular reactivity before or after administration of indomethacin in young adults. However, in older adults, higher levels of serum prostacyclin were related to a greater change in cerebrovascular reactivity after indomethacin administration.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Katrina Hope, Ben Chant, Thomas Hinton, Adrian H. Kendrick, Angus K. Nightingale, Julian F. R. Paton, Emma C. Hart
Summary: This study compared the V-E/VCO2 slope in patients with hypertension and normotensive individuals. It found that ventilatory efficiency is impaired in people with hypertension without heart failure. Future research is needed to determine if those hypertensive patients with elevated V-E/VCO2 slopes are at risk of developing heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Zoe H. Adams, Hazel C. Blythe, Nisha Charkoudian, Timothy B. Curry, Michael J. Joyner, Adrian H. Kendrick, Angus K. Nightingale, Ana P. Abdala Sheikh, Emma C. Hart
Summary: Respiratory modulation of sympathetic nerve activity is reduced in postmenopausal females, which is associated with higher resting blood pressure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Editorial Material
Physiology
Jill N. Barnes, Tracy Baynard, Patrice Brassard
EXPERIMENTAL PHYSIOLOGY
(2023)
Editorial Material
Physiology
Zoe H. Adams, Jill N. Barnes, Rachel N. Lord
EXPERIMENTAL PHYSIOLOGY
(2023)