Article
Multidisciplinary Sciences
Nicholas W. Bateman, Christopher M. Tarney, Tamara S. Abulez, Brian L. Hood, Kelly A. Conrads, Ming Zhou, Anthony R. Soltis, Pang-Ning Teng, Amanda Jackson, Chunqiao Tian, Clifton L. Dalgard, Matthew D. Wilkerson, Michael D. Kessler, Zachary Goecker, Jeremy Loffredo, Craig D. Shriver, Hai Hu, Michele Cote, Glendon J. Parker, James Segars, Ayman Al-Hendy, John Risinger, Neil T. Phippen, Yovanni Casablanca, Kathleen M. Darcy, G. Larry Maxwell, Thomas P. Conrads, Timothy D. O'Connor
Summary: Characterization of ancestry-linked peptide variants in disease-relevant patient tissues is important for understanding the relationship between patient ancestry and disease pathogenesis. The study identifies peptide ancestry informative markers (pAIMs) to determine ancestry proportions and their correlation with patient race and genotype. The findings contribute to the understanding of the impact of ancestry on the human proteome and its relevance to uterine neoplasms.
Article
Biochemical Research Methods
Qiang Zhu, Yueyan Cao, Shu Zhang, Yuguo Huang, Yuhan Hu, Yijun Zhou, Haoyu Wang, Yufang Wang, Ji Zhang
Summary: The study showed that a highly informative InDel panel developed based on the CE platform has the potential for individual ancestry inference among Asian populations. 21 InDels with high F-ST values were selected and assembled into an ancestry informative insertion/deletion panel, enabling accurate ancestry inference among Asian populations.
Article
Respiratory System
Sooim Sin, Eun Ju Lee, Sungho Won, Woo Jin Kim
Summary: In this study, the long-term all-cause and cardiovascular mortality of patients with PRISm were investigated. Compared with normal individuals, PRISm patients did not show increased mortality risk.
BMC PULMONARY MEDICINE
(2023)
News Item
Medicine, General & Internal
Jennifer Abbasi
Summary: This article is an interview with the principal investigators on the Mediators of Atherosclerosis in South Asians Living in America (MASALA) prospective cohort study.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Psychiatry
Keane Lim, Jie Yin Yee, Yuen Mei See, Boon Tat Ng, Shushan Zheng, Charmaine Tang, Todd Lencz, Jimmy Lee, Max Lam
Summary: This study reveals an association between common risk variants for schizophrenia and treatment-resistant schizophrenia (TRS) status, suggesting that the genetic burden of schizophrenia may partly contribute to treatment resistance in individuals with schizophrenia. These findings propose the potential use of genetic risk factors for early TRS identification and timely access to clozapine. However, the ancestral background of the discovery sample is crucial for successfully implementing Polygenic risk score (PRS) in clinical settings.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Biological
Soyeon Kim, Kiwon Kim, Mi Yeong Hwang, Hyunwoong Ko, Sang-Hyuk Jung, Injeong Shim, Soojin Cha, Hyewon Lee, Beomsu Kim, Joohyun Yoon, Tae Hyon Ha, Doh Kwan Kim, Jinho Kim, Woong-Yang Park, Aysu Okbay, Bong-Jo Kim, Young Jin Kim, Woojae Myung, Hong-Hee Won
Summary: This study conducted a genetic association analysis of subjective well-being (SWB) in Korean and European populations, identifying several genetic loci associated with SWB. Significant cross-population genetic correlations were observed, indicating the shared genetic architecture of SWB. The study also found significant correlations between SWB and major depressive disorder, as well as enrichment of central nervous system-related polymorphisms heritability. This research highlights the importance of large-scale cross-population genome-wide association studies in understanding the genetic basis of SWB and mental health.
NATURE HUMAN BEHAVIOUR
(2022)
Review
Peripheral Vascular Disease
Lizzy M. Brewster, Amber S. Boermeester, Yackoob K. Seedat, Gert A. Van Montfrans
Summary: This study systematically reviewed randomized controlled trials on the effect of initial dual antihypertensive combination treatment in hypertensive African ancestry adults. The findings suggest that CCB + ACEI is more suitable than HCT + ACEI as the first-line initial combination therapy.
JOURNAL OF HYPERTENSION
(2022)
Article
Multidisciplinary Sciences
Noemi-Nicole Piga, Palwende Romuald Boua, Chisom Soremekun, Nick Shrine, Kayesha Coley, Jean-Tristan Brandenburg, Martin D. Tobin, Michele Ramsay, Segun Fatumo, Ananyo Choudhury, Chiara Batini
Summary: Smoking is a major risk factor for many causes of death globally. Most smokers live in low- and middle-income countries, where the number of deaths caused by tobacco use is expected to double in the next decade. Genetic studies have mainly focused on individuals of European ancestry or living in North America or Europe. This study examined the genetic factors related to smoking behaviors in African men from five African countries and the UK.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Segun Fatumo, Ville Karhunen, Tinashe Chikowore, Toure Sounkou, Brenda Udosen, Chisom Ezenwa, Mariam Nakabuye, Opeyemi Soremekun, Iyas Daghlas, David K. Ryan, Amybel Taylor, Amy M. Mason, Scott M. Damrauer, Marijana Vujkovic, Keith L. Keene, Myriam Fornage, Marjo-Riitta Jarvelin, Stephen Burgess, Dipender Gill
Summary: The study found that in African ancestry individuals, type 2 diabetes (T2D) liability and lipid traits were associated with an increased risk of ischemic stroke (IS), with Mendelian randomization estimates similar to those obtained in European ancestry individuals.
Article
Biochemical Research Methods
Yueyan Cao, Qiang Zhu, Yuguo Huang, Xi Li, Yifan Wei, Haoyu Wang, Ji Zhang
Summary: In forensic genetics, the use of ancestry informative single-nucleotide polymorphisms (AISNPs) panels can help estimate an individual's biogeographic ancestry and narrow down the direction of the investigation. This study successfully divided the global population of the 1000 Genomes Project (1KG) into five clusters and further divided the East Asian population into four clusters using 19 AISNPs. The findings suggest that the 19-AISNP panel could be a useful and cost-effective tool for forensic ancestry inference in East Asian populations.
Article
Medicine, General & Internal
Chun-Hung Ko, Hua-Ying Chuang, Shin-Jiuan Wu, Shou-Chun Yu, Yin-Fan Chang, Chin-Sung Chang, Chih-Hsing Wu
Summary: This study compared the prevalence of sarcopenia between the Asian Working Group for Sarcopenia (AWGS) 2019 and 2014 definitions. The study found that according to the 2019 definition, the prevalence of possible sarcopenia and sarcopenia among community-dwelling adults was 7.4% and 2.8% respectively. The 2019 definition showed high consistency in identifying sarcopenia in community-dwelling adults compared to the 2014 definition.
FRONTIERS IN MEDICINE
(2022)
Article
Psychiatry
Jessica O'Loughlin, Francesco Casanova, Amanda Hughes, Zammy Fairhurst-Hunter, Liming Li, Zhengming Chen, Jack Bowden, Ed Watkins, Rachel M. Freathy, Laura D. Howe, Robin G. Walters, Jessica Tyrrell
Summary: This study investigated the association between BMI and well-being in individuals of East Asian and European ancestry. The results showed that there were differences in the relationship between BMI and well-being in individuals of different ancestries, highlighting the importance of considering population-specific factors.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Plant Sciences
Feng-Luan Liu, Ya-Lan Dai, Thi Nga Hoang, Vichai Puripunyavanich, Primlarp Wasuwat Chukiatman, Mi Qin, Yan-Rong Fu, Yu-Chu Chen, Dai-Ke Tian
Summary: By studying the genetic diversity and ancestry of tropical lotus from Thailand and Vietnam, it was found that Thai lotus had higher genetic diversity compared to Vietnamese lotus, and the lotus germplasms from Thailand and Vietnam belong to two different gene pools or populations.
Article
Psychiatry
Jose de Leon
Summary: This review article argues against relying on standard clozapine references, such as the US package insert, due to their lack of up-to-date knowledge in pharmacokinetics, pharmacovigilance, and consideration of ethnic ancestry's impact on dosing. The article discusses the minimum therapeutic dose needed to achieve a therapeutic concentration in serum/plasma and highlights the differences in dosing based on ethnic background. It also mentions the existence of recent international guidelines for clozapine titration and monitoring.
PSYCHIATRY INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Suraj S. Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood, Babatunji-William Ogunkolade, Zahid Hassan, Ghattu Krishnaveni, Kalyanaraman Kumaran, Ramesh D. Potdar, Sirazul A. Sahariah, Murali Krishna, Chiara Di Gravio, Inder D. Mali, Alagu Sankareswaran, Akhtar Hussain, Biswajit W. Bhowmik, Abdul Kalam A. Khan, Bridget A. Knight, Timothy M. Frayling, Sarah Finer, Caroline H. D. Fall, Chittaranjan S. Yajnik, Rachel M. Freathy, Graham A. Hitman, Giriraj R. Chandak
Summary: Size at birth is influenced by various factors, including genetic effects. South Asians have a higher burden of low birth weight and cardiometabolic diseases, but studies on the genetic variations underlying these phenotypes are lacking. This study found that South Asians have smaller birth weights compared to Europeans, but the genetic effects on birth weight are similar. The study also showed that birth weight is strongly associated with body size in childhood and adolescence, while fetal genetic scores are associated with body size in childhood and head circumference, fasting glucose, and triglycerides in adults.
Article
Peripheral Vascular Disease
Xiao-Fei Ye, Chao-Ying Miao, Wei Zhang, Li-Nong Ji, Ji-Guang Wang, ATTEND Investigators
Summary: This study investigated the association between alcohol intake and dyslipidemia in male patients with hypertension and diabetes mellitus in China. The results showed that higher alcohol intake was associated with an increased risk of dyslipidemia. Additionally, there was a correlation between alcohol drinking habits and the prevalence of dyslipidemia across different provinces in China.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Yuan-Yuan Kang, Yang Chen, Qi-Hong Wu, Hui Dong, Yu-Bao Zou, Ping-Jin Gao, Jian-Zhong Xu, Xiong-Jing Jiang, Ji-Guang Wang
Summary: This study investigated the clinical characteristics of renal artery fibromuscular dysplasia (FMD) in patients in China. It also identified the cure rate of hypertension after angioplasty. The study found that multifocal FMD had a higher cure rate of hypertension than focal FMD after revascularization.
JOURNAL OF HYPERTENSION
(2023)
Review
Cardiac & Cardiovascular Systems
Ji-Guang Wang, Wei Zhang, Yan Li, Lisheng Liu
Summary: The prevalence of hypertension in China has been increasing steadily over the past two to three decades, mainly due to increased life expectancy and lifestyle changes. High prevalence of grade 3 hypertension was found in the general population, increasing with age to 5% among individuals aged 65 and above. The risk factors for hypertension in China, such as physical inactivity and obesity, have dramatically increased, while sodium and potassium intake remained largely the same. This review summarizes the latest epidemiological data on hypertension in China, discusses specific risk factors, and describes ongoing nationwide initiatives to control hypertension, especially in low-resource rural areas.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Ming-Xuan Li, Dong-Yan Zhang, Song-Tao Tang, Qi-Dong Zheng, Qi-Fang Huang, Chang-Sheng Sheng, Yan Li, Ji-Guang Wang
Summary: The control rate of ambulatory blood pressure is low in Chinese hypertensive patients, especially during the nighttime and morning time windows, and it may be associated with arterial stiffness.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Yi Cheng, Chang-Sheng Sheng, Jian-Feng Huang, Dong-Yan Zhang, Ming-Xuan Li, Yi-Bang Cheng, De-Wei An, Qian-Hui Guo, Ying Wang, Qi-Fang Huang, Ting-Yan Xu, Yan Li, Ji-Guang Wang
Summary: There is seasonal variation in nighttime blood pressure, with the highest levels in summer and the lowest levels in winter. Nighttime blood pressure is positively associated with renal injury in terms of urinary albumin excretion, as well as with other markers of target organ damage. The association between nighttime systolic blood pressure and urinary albumin excretion is stronger in summer compared to winter.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Tzung-Dau Wang, Takayoshi Ohkubo, Ma Lourdes Bunyi, Veerendra Melagireppa Chadachan, Yook Chin Chia, Kazuomi Kario, Cheol-Ho Kim, Hung-Ju Lin, Noriko Matsushita, Sungha Park, Ebtehal Salman, Apichard Sukonthasarn, Jam Chin Tay, Hoang Anh Tien, Isha Tomar, Yuda Turana, Huynh Van Minh, Narsingh Verma, Gurpreet Singh Wander, Ji-Guang Wang, Yi Zhou, Yutaka Imai
Summary: Uncontrolled hypertension is a significant problem in Asia, and home blood pressure monitoring (HBPM) is an effective tool to manage hypertension. However, the recognition and practice of HBPM in Asia are suboptimal, with barriers including lack of understanding and concerns about accuracy and reliability of HBPM devices.
HYPERTENSION RESEARCH
(2023)
Editorial Material
Peripheral Vascular Disease
Jia-Hui Xia, Dong-Yan Zhang, Yan Li, Ji-Guang Wang
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Tan V. Bui, Dean S. Picone, Martin G. Schultz, Xiaoqing Peng, J. Andrew Black, Nathan Dwyer, Philip Roberts-Thomson, Heath Adams, Chen-Huan Chen, Hao-min Cheng, Giacomo Pucci, Jiguang Wang, Remi Goupil, James E. Sharman
Summary: Automated cuff measured blood pressure is the global standard for diagnosing hypertension, but concerns exist regarding its accuracy. This study aimed to determine the relationship between individual variability in systolic blood pressure amplification and the accuracy of cuff blood pressure. It was found that cuff blood pressure significantly underestimated brachial blood pressure and that systolic blood pressure amplification correlated with cuff blood pressure accuracy.
HYPERTENSION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Guang Ning, Jiang He, Weiqing Wang, Yufang Bi, Dalong Zhu, Jiguang Wang, Shengdi Chen, Yu Xu, Lawrence J. Appel, William C. Cushman, Vivian A. Fonseca, Jeff D. Williamson, David M. Reboussi, Yaling Han, Hongbing Shen, Minghui Zhao, Hui Wang
Summary: The BPROAD study aims to assess the effects of intensive blood pressure control on cardiovascular disease and all-cause mortality among patients with type 2 diabetes. The study compares the occurrence of major cardiovascular events between the intensive blood pressure control group and the standard blood pressure control group. The findings of this study will provide important guidance for blood pressure management in patients with type 2 diabetes.
JOURNAL OF DIABETES
(2023)
Meeting Abstract
Peripheral Vascular Disease
Xiaodong Li, Shun He, Yuanyuan Lu, Jiguang Wang, Pingjin Gao
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Tan Bui, Dean Picone, Martin Schultz, Xiaoqing Peng, Andrew Black, Nathan Dwyer, Philip Roberts Thomson, Heath Adams, Chen Huan Chen, Hao Min Cheng, Giacomo Pucci, Jiguang Wang, Remi Goupil, James Sharman
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Jianfeng Huang, Dewei An, Yibang Cheng, Mingxuan Li, Qifang Huang, Changsheng Sheng, Dongyan Zhang, Qianhui Guo, Ying Wang, Chuhao Liu, Tingyan Xu, Jiguang Wang, Yan Li
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Yuanyuan Kang, Yang Chen, Qihong Wu, Hui Dong, Yubao Zou, Pinjin Gao, Jianzhong Xu, Xiongjing Jiang, Jiguang Wang
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Yuanyuan Kang, Jianzhong Xu, Jiguang Wang
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Grzegorz Bilo, Konstantinos Kyriakoulis, Chang Yuan Liu, Davide Soranna, Isabella Ceravolo, Silvia Cassago, Wei Zhang, Anastasios Kollias, Martino F. Pengo, Antonella Zambon, Jiguang Wang, George S. Stergiou, Gianfranco Parati
JOURNAL OF HYPERTENSION
(2023)