Article
Peripheral Vascular Disease
Yifei Zhu, Yuan Chu, Sheng Wang, Junjian Tang, Hu Li, Lei Feng, Fan Yu, Xin Ma
Summary: Smooth muscle cell TRPV4 plays a significant role in vascular contraction and blood pressure regulation, and its expression level may be associated with obesity. The study found that TRPV4(SMC) has different effects on vasomotor tone regulation compared to endothelial TRPV4, and the loss of TRPV4(SMC) can protect obese mice from vasoconstriction and hypertension.
Article
Biochemistry & Molecular Biology
Ruhui Zeng, Bin Liu, Tingting Guo, Jinwei Guo, Gang Yu, Yineng Xu, Rui Lin, Xiangzhai Tan, Kaiqi Xie, Yingbi Zhou
Summary: This study investigated the vasoconstrictor and vasodilator effects of PGF(2 alpha) in genetically altered mice. The results showed that the vasoconstrictor effects of PGF(2 alpha) were independent of the FP receptor but mediated by the TP and EP3 receptors. However, the vasodilator effects were not affected by the FP receptor. This suggests that the vasoconstrictor effects of PGF(2 alpha) are primarily derived from the TP and EP3 receptors, while the vasodilator effects are independent of the FP receptor.
Article
Pharmacology & Pharmacy
Tingting Guo, Bin Liu, Ruhui Zeng, Rui Lin, Jinwei Guo, Gang Yu, Yineng Xu, Xiangzhai Tan, Kaiqi Xie, Yingbi Zhou
Summary: Prostaglandin D2 (PGD2) acts on DP1, TP, and/or EP3 receptors to elicit vasoconstrictor activities in mouse renal vascular bed and/or mesenteric resistance arteries. These vasoconstrictor responses can override the vasodepressor activity mediated by DP1, leading to a slight or mild pressor response. The pressor response is reversed or reduced in mice lacking TP and/or EP3 receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tatiana Ivanova, Maria Churnosova, Maria Abramova, Denis Plotnikov, Irina Ponomarenko, Evgeny Reshetnikov, Inna Aristova, Inna Sorokina, Mikhail Churnosov
Summary: The aim of the study was to investigate the sex-specific features of the correlation between GWAS-significant polymorphisms and HTN. The study found differences in the involvement of HTN-associated SNPs between men and women in European subjects of Russia. BP/HTN-related genes and SNPs were characterized by pronounced polyvector functionality in both men and women, with immune mechanisms being the main signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew W. D'Souza, Sarah L. Hissen, Kazumasa Manabe, Ryosuke Takeda, Takuro Washio, Geoff B. Coombs, Belinda Sanchez, Qi Fu, J. Kevin Shoemaker
Summary: Sympathetic vascular transduction is attenuated in older adults compared to young adults, and there is an inverse relationship between the central and peripheral arcs of the baroreflex. Age and sex have independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Orna Reges, Amy E. Krefman, Shakia T. Hardy, Yuichiro Yano, Paul Muntner, Lindsay R. Pool, Penny Gordon-Larsen, Yaojie Wang, Donald M. Lloyd-Jones, Norrina B. Allen
Summary: This study aimed to assess the associations between age-related blood pressure slope and demographic, clinical, behavioral, psychosocial, and neighborhood characteristics in different race-sex groups. The results showed that there were variations in blood pressure increases among different groups, and these increases were associated with various factors.
Article
Peripheral Vascular Disease
Han Ma, Fangchao Liu, Jianxin Li, Jichun Chen, Jie Cao, Shufeng Chen, Xiaoqing Liu, Xueli Yang, Keyong Huang, Chong Shen, Ling Yu, Yingxin Zhao, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: Based on a study conducted in China, the association between socioeconomic status (SES) and hypertension remains uncertain. Individuals with lower SES are at a higher risk of developing hypertension compared to those with higher SES. Moreover, women are more susceptible to the adverse effects of lower SES on hypertension.
Article
Pharmacology & Pharmacy
Margaret A. Mouat, Kristy L. Jackson, James L. J. Coleman, Madeleine R. Paterson, Robert M. Graham, Geoffrey A. Head, Nicola J. Smith
Summary: GPR37L1(-/-) mice exhibit sex-specific cardiovascular changes, with female mice showing lower blood pressure and male mice being more susceptible to cardiovascular dysfunction. This suggests that loss of GPR37L1 affects autonomic maintenance of blood pressure.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Zeinab Bidel, Milad Nazarzadeh, Dexter Canoy, Emma Copland, Eva Gerdts, Mark Woodward, Ajay K. Gupta, Christopher M. Reid, William C. Cushman, Kristian Wachtell, Koon Teo, Barry R. Davis, John Chalmers, Carl J. Pepine, Kazem Rahimi
Summary: The effects of blood pressure-lowering treatment on cardiovascular outcomes do not differ by sex, regardless of baseline blood pressure levels and age categories.
Article
Peripheral Vascular Disease
Odayme Quesada, Brian Claggett, Fatima Rodriguez, Jianwen Cai, Ashley E. Moncrieft, Karin Garcia, Marina Del Rios Rivera, David B. Hanna, Martha L. Daviglus, Gregory A. Talavera, C. Noel Bairey Merz, Scott D. Solomon, Susan Cheng, Natalie A. Bello
Summary: In a study of Hispanic/Latino adults without diabetes or taking antihypertensive medications, insulin resistance was found to be positively associated with both systolic and diastolic blood pressure. The association between insulin resistance and systolic blood pressure was linear in men but nonlinear in women. Prediabetes status did not significantly affect the association between insulin resistance and blood pressure.
Article
Cardiac & Cardiovascular Systems
Satoshi Kanazawa, Hidehiro Kaneko, Yuichiro Yano, Yuta Suzuki, Akira Okada, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro
Summary: This study analyzed the association between hypertension and incident atrial fibrillation (AF) in a large sample of adults. The results showed that both men and women with hypertension had an increased risk of AF, but the risk was higher in women. This suggests a potential sex difference in the relationship between hypertension and incident AF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Zeyu Cai, Nan Xie, Ze Gong, Zhao Yang, Feng Lin, Zhiqing Li, Rongbo Dai, Yufei Chen, Siting Zhang, Shirong Zhu, Shuhua Zhou, Jingyu Lin, Fang Yu, Limei Liu, Jinpeng Sun, Jing Zhou, Wei Li, Chunyang Xiong, Yi Fu, Xin Cong, Wei Kong
Summary: In this study, the researchers found that ALK3 plays a critical role in maintaining the contractility of vascular smooth muscle cells. ALK3 deficiency leads to hypotension and impaired response to angiotensin II. Further investigation revealed that ALK3 regulates myosin light chain phosphorylation and vascular smooth muscle cell contraction through its direct interaction with G alpha q/G alpha 11.
Article
Peripheral Vascular Disease
Sarah J. Khaddage, Julie A. Patterson, Lana J. Sargent, Elvin T. Price, Dave L. Dixon
Summary: This study found age and sex differences in tolerability of ambulatory blood pressure monitoring, which should be considered to ensure patient acceptance and tolerability of the monitoring.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Alec L. E. Butenas, Rie Ishizawa, Korynne S. Rollins, Masaki Mizuno, Steven W. Copp
Summary: Stimulation of mechanically sensitive channels on sensory endings activates mechanoreflex, and capsaicin injection reduces the pressor and renal sympathetic nerve response to mechanoreflex activation in male rats but not female rats.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Peripheral Vascular Disease
Paul J. Connelly, Gemma Currie, Christian Delles
Summary: Sex differences play an important role in the prevalence, outcomes, and management of hypertension. Females experience a faster increase in blood pressure and higher prevalence of hypertension compared to males. They are also at higher risk of developing adverse cardiovascular outcomes at lower blood pressure thresholds. However, limited data are available to support sex-specific blood pressure targets.
CURRENT HYPERTENSION REPORTS
(2022)
Article
Hematology
Abhishek Joshi, Lukas E. Schmidt, Sean A. Burnap, Ruifang Lu, Melissa V. Chan, Paul C. Armstrong, Ferheen Baig, Clemens Gutmann, Peter Willeit, Peter Santer, Temo Barwari, Konstantinos Theofilatos, Stefan Kiechl, Johann Willeit, Timothy D. Warner, Anthony Mathur, Manuel Mayr
Summary: This study found that the proteome of platelets is altered during acute myocardial infarction (MI), and the elevated levels of S100A8 and S100A9 proteins are associated with neutrophil abundance. The study also demonstrated the transfer of proteins between platelets and neutrophils, and the negative correlation between plasma S100A8/A9 and platelet reactivity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Joseph Grech, Melissa Victoria Chan, Chinedu Ochin, Amber Lachapelle, Florian Thibord, Zoe Schneider, Bongani Brian Nkambule, Paul Charles John Armstrong, Catherine Wallace de Melendez, Katherine L. Tucker, Mahdi Garelnabi, Timothy David Warner, Ming-Huei Chen, Andrew Danner Johnson
Summary: Depression is associated with cardiovascular disease, and platelet reactivity is related to the use of antidepressants, especially those affecting serotonin.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biology
Manuel Spitschan, Nayantara Santhi, Amrita Ahluwalia, Dorothee Fischer, Lilian Hunt, Natasha A. Karp, Francis Levi, Ines Pineda-Torra, Parisa Vidafar, Rhiannon White
Summary: Growing evidence suggests that sex differences have a significant impact on various aspects of human biology. This review focuses on exploring the influence of sex on the circadian and sleep physiology of humans and identifies a data gap in investigating the non-visual effects of light. A virtual workshop on the biomedical implications of sex differences in sleep and circadian physiology highlights the need for inclusive and accessible research design, recruitment strategies to achieve a balanced sample size, utilization of data visualization to understand the influence of sex, statistical analyses that incorporate sex as a factor, and making participant-level data open for future meta-analytic efforts.
Article
Cell Biology
Jason Cunha, Melissa V. Chan, Bongani B. Nkambule, Florian Thibord, Amber Lachapelle, Robin E. Pashek, Ramachandran S. Vasan, Jian Rong, Emelia J. Benjamin, Naomi M. Hamburg, Ming-Huei Chen, Gary F. Mitchell, Andrew D. Johnson
Summary: Arterial tonometry and vascular calcification measures are valuable in assessing cardiovascular disease (CVD) risk. This study examined the relationship between arterial tonometry, platelet function, arterial calcium, and aortic diameter. The results suggest that higher arterial calcium may be associated with increased platelet reactivity, while larger aortic diameter may be linked to lower platelet reactivity. These findings indicate the potential interplay between subclinical atherosclerosis, platelet activation, and vascular structure.
Article
Medicine, Research & Experimental
Asad Shabbir, Ismita Chhetri, Rayomand S. Khambata, Tipparat Parakaw, Clement Lau, Muhammad A. B. N. Aubdool, Gianmichele Massimo, Nicki Dyson, Vikas Kapil, Thomas Godec, Vanessa Apea, Jan Flint, Chloe Orkin, Krishnaraj S. Rathod, Amrita Ahluwalia
Summary: This study aims to investigate the impact of sex or dietary factors on endothelial function and inflammatory responses in healthy volunteers after receiving the COVID-19 vaccine.
Article
Biochemistry & Molecular Biology
G. Massimo, R. S. Khambata, T. Chapman, K. Birchall, C. Raimondi, A. Shabbir, Nicki Dyson, K. S. Rathod, C. Borghi, A. Ahluwalia
Summary: XDH mutations have varying impacts on the biochemical activity of the enzyme, leading to potential harmful or protective influences on health. Targeting enzyme activity to enhance the nitrite-reductase profile may provide novel therapeutic options, especially in cardiovascular disease.
Meeting Abstract
Cardiac & Cardiovascular Systems
Krishnaraj Rathod, Helen Warren, Vincenzo Tufaro, Ajay Jain, Mutsumi Ono, Ismita Chhetri, Hector Garcia-Garcia, Christos Bourantas, Clement Lau, Djouhar Belgaid, Daniel Jones, Asad Shabbir, Rayomand Khambata, Anthony Mathur, Thomas Godec, Anantharam Ramasamy, Neil Poulter, Anne-Marie Beirne, Amrita Ahluwalia
Meeting Abstract
Cardiac & Cardiovascular Systems
Krishnaraj S. Rathod, Asad Shabbir, Daniel A. Jones, Rayomand S. Khambata, Clement Lau, Anne-Marie Beirne, Mutsumi Ono, Ismita Chhetri, Djouhar A. Belgian, Anantharaman Ramasamy, Vincenzo Tufaro, Ajay K. Jain, Helen Warren, Thomas Godec, Neil Poulter, Hector Garcia-Garcia, Christos Bourantas, Anthony Mathur, Amrita Ahluwalia
Meeting Abstract
Gastroenterology & Hepatology
Amrita Ahluwalia, Nils Lambrecht, Harleen K. Ahluwalia, Andrzej S. Tarnawski
Meeting Abstract
Pharmacology & Pharmacy
S. C. Stanford, Steve Alexander, Giuseppe Cirino, Christopher H. George, Paul A. Insel, Dave Kendall, Reynold A. Panettieri, Hemal H. Patel, Christopher G. Sobey, Barbara Stefanska, Gary Stephens, Mauro Teixeira, Nathalie Vergnolle, Amrita Ahluwalia
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Nicki Dyson, Rayomand Khambata, Gianmichele Massimo, Tipparat Parakaw, Krishnaraj Rathod, Amrita Ahluwalia
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Rayomand Khambata, Daniel Fernandes, Gianmichele Massimo, Ernesto Ruivo, Lorna Claire Gee, Julie Foster, Alison Goddard, Mike Curtis, Michael Barnes, William Wade, Thomas Godec, Marco Orlandi, Francesco D'Aiuto, Amrita Ahluwalia
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Gianmichele Massimo, Rayomand Khambata, Tim Chapman, Kristian Birchall, Claudio Borghi, Amrita Ahluwalia
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Krishnaraj Sinhji Rathod, Asad Shabbir, Rayomand Khambata, Clement Lau, Anne-Marie Beirne, Ismita Chhetri, Mutsumi Ono, Djhouhar Belgaid, Anantharaman Ramasamy, Vincenzo Tufaro, Ajay Jain, Helen Warren, Thomas Godec, Neil Poulter, Christos Bourantas, Daniel Jones, William Wade, Anthony Mathur, Amrita Ahluwalia
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Amrita Ahluwalia, Neil Hoa, Debbie Moreira, Daniel Aziz, Karanvir Singh, Khushin N. Patel, Ellis R. Levin
Summary: This study investigates the function of membrane estrogen receptor beta (ER beta) in opposing AngII-induced cardiac cell pathology. The results demonstrate that membrane ER beta plays a crucial role in mitigating cardiac cell pathology and provides insights into the mechanisms of cardiac hypertrophy and fibrosis.