Article
Gastroenterology & Hepatology
Jordi Rimola, Joana Torres, Shankar Kumar, Stuart A. Taylor, Torsten Kucharzik
Summary: Endoscopy, the reference standard for inflammatory bowel disease (IBD) diagnosis and assessment, has limitations. Cross-sectional imaging techniques such as magnetic resonance enterography (MRE) and intestinal ultrasound (IUS) are better tolerated, safer, and can examine the entire bowel. They also allow visualization of the small-bowel and assessment of extraintestinal disease, making them viable alternatives to colonoscopy for diagnosing and monitoring Crohn's disease.
Article
Public, Environmental & Occupational Health
Ren Nina, Huang Lingling, Li Qiushuang, Guo Honglin, Sun Liyuan, Zhang Yuting
Summary: This study aimed to evaluate the association between coffee intake and components of metabolic syndrome (MetS). Regardless of coffee type, coffee consumers had higher odds ratios of elevated fasting blood glucose (FBG) in both men and women. However, for women, drinking more than 1 serving of coffee per day was associated with a lower risk of elevated blood pressure.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjin Liu, Xiaoqin Huang, Xuebing Liu, Dakota Ortega, Li Chen, Zhensen Chen, Jie Sun, Lulu Wang, Thomas S. Hatsukami, Chun Yuan, Haige Li, Junwei Yang
Summary: The study found that uncontrolled hypertension is associated with subclinical cerebrovascular injury, affecting both small and medium-to-large arteries. The presence of intracranial plaque, vascular rarefaction, reduced cerebral blood flow, and increased white matter hyperintensity were all correlated with uncontrolled hypertension, particularly with uncontrolled diastolic blood pressure.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mahdi Saleh, David Gendy, Inga Voges, Eva Nyktari, Monika Arzanauskaite
Summary: Congenital heart disease is the most common group of congenital pathology, with advances in surgical treatment leading to an increasing population of adult patients. These patients often require repeat interventions and may experience various complications.
INSIGHTS INTO IMAGING
(2022)
Article
Peripheral Vascular Disease
Darius A. Gerlach, Jorge Manuel, Alex Hoff, Hendrik Kronsbein, Fabian Hoffmann, Karsten Heusser, Heimo Ehmke, Jens Jordan, Jens Tank, Florian Beissner
Summary: The study utilized high-resolution functional magnetic resonance imaging to reveal the hypothalamic and medullary responses to acute hypoxia in healthy men, providing insights into the central pathways integrating chemoreflexes and the potential for studying cardiovascular disease and responses to chemoreceptor modulation.
Article
Medicine, General & Internal
Michael Liu, Rahul Aggarwal, Zhaonian Zheng, Robert W. Yeh, Dhruv S. Kazi, Karen E. Joynt Maddox, Rishi K. Wadhera
Summary: In the past two decades, there has been an increase in hypertension among low-income middle-aged adults in the United States, while diabetes and obesity have increased among their higher-income counterparts. Income-based disparities in hypertension, diabetes, and smoking persist even after adjusting for other social determinants of health.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sanjay K. Mohanty, Sarang P. Pedgaonkar, Ashish Kumar Upadhyay, Fabrice Kampfen, Prashant Shekhar, Radhe Shyam Mishra, Jurgen Maurer, Owen O'Donnell
Summary: The study shows that hypertension prevalence is high among older adults in India, but rates of awareness, treatment, and control are low, indicating substantial management gaps. Individuals with lower socioeconomic status are more likely to neglect treatment and control of hypertension.
Article
Agriculture, Dairy & Animal Science
Marcos Fumero-Hernandez, Mario Encinoso, Ayose Melian, Himar Artiles Nuez, Doaa Salman, Jose Raduan Jaber
Summary: In this study, the anatomy of the CNS and associated structures of the puffin were described using anatomical cross-sections and advanced imaging techniques. The results obtained could contribute to future anatomical and pathological studies on related species.
Article
Neurosciences
Agnes Perez-Millan, Jose Contador, Jordi Junca-Parella, Beatriz Bosch, Laia Borrell, Adria Tort-Merino, Neus Falgas, Sergi Borrego-Ecija, Nuria Bargallo, Lorena Rami, Mircea Balasa, Albert Llado, Raquel Sanchez-Valle, Roser Sala-Llonch
Summary: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia with overlapping symptoms and brain signatures. This study used brain magnetic resonance imaging (MRI) and machine learning to accurately diagnose and classify AD and FTD. The algorithm achieved good accuracy in cross-sectional and longitudinal data.
HUMAN BRAIN MAPPING
(2023)
Article
Biology
Saskia Bollmann, Hendrik Mattern, Michael Bernier, Simon D. Robinson, Daniel Park, Oliver Speck, Jonathan R. Polimeni, Saad Jbabdi
Summary: This article presents a new method using TOF-MRA imaging technique to observe the arteries on the surface of the human brain. Through experimental verification, it is demonstrated that this method can detect small pial arteries with extremely high resolution. The research results indicate that the observation of pial arteries is no longer limited by blood flow velocity, but by image resolution.
Article
Public, Environmental & Occupational Health
Tingyu Mu, Rixiang Xu, Qianyin Zhu, Lingshan Chen, Die Dong, Jiayi Xu, Cuizhen Shen
Summary: This study investigated the diet-related knowledge, attitudes, and behaviors among young and middle-aged individuals with high-normal blood pressure in China. The results showed that individuals with a higher level of education, proactive in seeking nutrition knowledge, and those who liked to eat vegetables were more likely to have sufficient dietary knowledge literacy. High school/vocational education, college degree or above, knowledge about the Chinese Food Pagoda or Dietary Guidelines for Chinese Residents, and sufficient dietary knowledge literacy were associated with an increased likelihood of looking for nutrition knowledge.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Xianwei Guo, Yujie Ke, Birong Wu, Qiuxia Song, Chenyu Sun, Yaru Li, Hao Wang, Wanying Su, Qiwei Liang, Scott Lowe, Rachel Bentley, Evelyn J. Song, Bethany King, Qin Zhou, Ruijin Xie, Fang Deng
Summary: This study investigated the effect of organophosphate esters (OPEs) on high blood pressure (BP) among children and adolescents. The results showed that higher levels of specific OPEs and OPE metabolite mixtures were weakly associated with high BP. Further longitudinal studies are needed to better understand the relationship between OPE metabolites and high blood pressure in this population.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nutrition & Dietetics
IfeanyiChukwu O. Onor, Lashira M. Hill, Modupe M. Famodimu, Mallory R. Coleman, Carolkim H. Huynh, Robbie A. Beyl, Casey J. Payne, Emily K. Johnston, John I. Okogbaa, Christopher J. Gillard, Daniel F. Sarpong, Amne Borghol, Samuel C. Okpechi, Ifeyinwa Norbert, Shane E. Sanne, Shane G. Guillory
Summary: This study found a significant positive association between magnesium and systolic blood pressure among patients with hypertensive crises. This positive association of serum magnesium with systolic blood pressure was maintained after adjusting for covariates, suggesting a potential role of magnesium in blood pressure among patients with hypertensive crises.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Graefe, Stefan-Horia Simion, Maciej Rosolowski, Andreas Merkenschlager, Jens Frahm, Dirk Voit, Franz Wolfgang Hirsch
Summary: This study aimed to assess the deposition of gadobutrol in children and found evidence of its deposition in the globus pallidus and putamen.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiangyu Chen, Shiyong Teng, Jinming Li, Xuezhi Qiao, Weidong Zhao, Zhengjie Xue, Xudong Shi, Yuguang Wang, Wensheng Yang, Tie Wang
Summary: Magnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd-DTPA), have limited blood circulation time due to rapid clearance by the kidney, which hinders the improvement of contrast between tumors and normal tissue. To address this issue, a novel MRI contrast agent using deformable mesoporous organosilica nanoparticles (D-MON) incorporating Gd-DTPA is fabricated. In vivo distribution studies show that the D-MON-based contrast agent can prolong blood circulation time and achieve high-contrast imaging in tumor tissue, surpassing the performance of the clinical contrast agent Gd-DTPA.
ADVANCED MATERIALS
(2023)
Article
Clinical Neurology
Kelly M. Sunderland, Derek Beaton, Stephen R. Arnott, Peter Kleinstiver, Donna Kwan, Jane M. Lawrence-Dewar, Joel Ramirez, Brian Tan, Robert Bartha, Sandra E. Black, Michael Borrie, Donald Brien, Leanne K. Casaubon, Brian C. Coe, Benjamin Cornish, Allison A. Dilliott, Dar Dowlatshahi, Elizabeth Finger, Corinne Fischer, Andrew Frank, Julia Fraser, Morris Freedman, Barry Greenberg, David A. Grimes, Ayman Hassan, Wendy Hatch, Robert A. Hegele, Christopher Hudson, Mandar Jog, Sanjeev Kumar, Anthony Lang, Brian Levine, Wendy Lou, Jennifer Mandzia, Connie Marras, William McIlroy, Manuel Montero-Odasso, David G. Munoz, Douglas P. Munoz, Joseph B. Orange, David S. Park, Stephen H. Pasternak, Frederico Pieruccini-Faria, Tarek K. Rajji, Angela C. Roberts, John F. Robinson, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Christopher J. M. Scott, Dallas Seitz, Christen Shoesmith, Thomas D. L. Steeves, Michael J. Strong, Stephen C. Strother, Richard H. Swartz, Sean Symons, David F. Tang-Wai, Maria Carmela Tartaglia, Angela K. Troyer, John Turnbull, Lorne Zinman, Paula M. McLaughlin, Mario Masellis, Malcolm A. Binns
Summary: This is a multi-site, longitudinal, observational cohort study that aims to understand the impact of neurodegenerative and cerebrovascular diseases on dementia presentation. The study recruited 520 participants with prevalent neurodegenerative and cerebrovascular diseases and comprehensively assessed them. Results showed that the participants were predominantly White males with higher education levels. The data will be shared with the global scientific community to identify markers of disease severity, progression, and therapy targets.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Manon Vogrig, Anne-Emmanuelle Berger, Thomas Bourlet, Louis Waeckel, Alice Haccourt, Alice Chanavat, David Hupin, Frederic Roche, Elisabeth Botelho-Nevers, Bruno Pozzetto, Stephane Paul
Summary: This study compared the performance of Interferon Gamma Release Assay (IGRA) and anti-spike serological test with the gold standard plaque reduction neutralization test (PRNT). The results showed that IGRA and serology assay were predictive of neutralizing antibody titers and correlated with vaccine protection. Older patients had a reduced immune response, and heterologous schemes and mRNA-1273 vaccine showed better responses in younger patients. IGRA and serology tests can be used to monitor vaccine response and identify non-responding individuals.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Clinical Neurology
David J. Whiteside, Maura Malpetti, P. Simon Jones, Boyd C. P. Ghosh, Ian Coyle-Gilchrist, John C. van Swieten, Harro Seelaar, Lize Jiskoot, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Chris R. Butler, Isabel Santana, Isabelle Le Ber, Alexander Gerhard, Simon Ducharme, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Florence Pasquier, Arabella Bouzigues, Lucy L. Russell, Jonathan D. Rohrer, James B. Rowe, Timothy Rittman
Summary: This study investigated the role of changes in functional networks in predicting cognitive decline and conversion to symptomatic disease in familial frontotemporal dementia (FTD). The study found a characteristic pattern of dynamic network changes in FTD, which were correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was more prominent in those who later converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Elizabeth Finger, Rubina Malik, Martina Bocchetta, Kristy Coleman, Caroline Graff, Barbara Borroni, Mario Masellis, Robert Laforce, Caroline Greaves, Lucy L. Russell, Rhian S. Convery, Arabella Bouzigues, David M. Cash, Markus Otto, Matthis Synofzik, James B. Rowe, Daniela Galimberti, Pietro Tiraboschi, Robert Bartha, Christen Shoesmith, Maria Carmela Tartaglia, John C. van Swieten, Harro Seelaar, Lize C. Jiskoot, Sandro Sorbi, Chris R. Butler, Alexander Gerhard, Raquel Sanchez-Valle, Alexandre de Mendonca, Fermin Moreno, Rik Vandenberghe, Isabelle Le Ber, Johannes Levin, Florence Pasquier, Isabel Santana, Jonathan D. Rohrer, Simon Ducharme
Summary: This study investigates the hypothesis that genetic mutations causing frontotemporal dementia (FTD) have neurodevelopmental consequences. The researchers examined brain structure and function in young adult mutation carriers and found differences between preclinical mutation carriers and familial non-carriers at a mean age of 26 years. These findings have implications for therapeutic interventions and further studies on early pathophysiologic processes in FTD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qi Qi, Matthew S. Fox, Heeseung Lim, Rebecca Sullivan, Alex Li, Miranda Bellyou, Lise Desjardins, Andrew McClennan, Robert Bartha, Lisa Hoffman, Timothy J. Scholl, Ting-Yim Lee, Jonathan D. Thiessen
Summary: This study investigates the relationship between tumor glycolytic metabolism and tissue pH. By comparing different imaging techniques, it was found that the ratio of lactate to pyruvate is significantly correlated with tumor and peritumoral pH.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Editorial Material
Clinical Neurology
Frederic Roche, Vincent Pichot, Martin Garet, Mathieu Berger
Editorial Material
Clinical Neurology
Frederic Roche, Mathieu Berger
Article
Geriatrics & Gerontology
Frederico Pieruccini-Faria, Seyyed Mohammad Hassan, Nickolas W. Bray, Yanina Sarquis-Adamson, Robert Bartha, Manuel Montero-Odasso
Summary: Mild Cognitive Impairment (MCI) affects obstacle negotiation capabilities, potentially increasing the risk of falls in older adults. However, it is unclear whether smaller brain volumes typically observed in older individuals with MCI are related to the observed hazardous obstacle negotiation in this population.
Review
Clinical Neurology
Hugues Patural, Vincent Pichot, Frederic Roche, Antoine Giraud
Summary: The evaluation of autonomic reactivity in newborns through heart rate variability (HRV) analysis is a simple and essential method to identify pathological dysautonomia. By using HRV analysis, pediatricians can identify and monitor high-risk children who have insufficient capacity for cardiorespiratory self-regulation and may face life-threatening events. Mathematical algorithms that analyze variations in the length of the RR interval can provide insights into the autonomic maturation of newborns. HRV analysis is an important non-invasive tool to assess the functioning of the autonomic nervous system and the balance between parasympathetic and sympathetic activities. Despite its recognized diagnostic and therapeutic implications, the application of HRV analysis in neonatal medicine is still not well understood.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hourfil-Gabin Ntougou Assoumou, Vincent Pichot, Jean-Claude Barthelemy, Sebastien Celle, Arnauld Garcin, Thierry Thomas, Frederic Roche
Summary: This study analyzed the relationship between body fat composition and metabolic syndrome, and compared them with common obesity indicators. The study found that body fat index and body adiposity index were the best indicators to characterize overall obesity, while waist-hip ratio was highly predictive of the presence and severity of metabolic syndrome.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Public, Environmental & Occupational Health
Caroline Dupre, Marlene Bregere, Mathieu Berger, Vincent Pichot, Sebastien Celle, Martin Garet, Herve Fundenberger, Nathalie Barth, Jessica Guyot, Bienvenu Bongue, Jean-Claude Barthelemy, Frederic Roche, David Hupin
Summary: It is important to promote all activities including light intensity physical activity (LPA) rather than just focusing on moderate-to-vigorous intensity physical activity (MVPA) as stated in current international physical activity guidelines. The evidence on the effects of LPA and its relationship with sedentary behavior (SB) is currently limited. Clarification of these effects is crucial for promoting public health.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Anne-Noelle Heizmann, Celine Chapelle, Silvy Laporte, Frederic Roche, David Hupin, Claire Le Hello
Summary: This systematic review and meta-analysis aimed to evaluate the effectiveness of using wearable physical activity monitoring devices as an intervention to increase daily walking activity and improve physical capacities in patients with cardiovascular disease. The results showed that wearing physical activity monitoring devices with feedback significantly improved daily number of steps, particularly when the intervention duration was less than 3 months. Overall, wearable physical activity monitoring devices appear to be beneficial for increasing daily walking activity in patients with cardiovascular disease.
Article
Biochemistry & Molecular Biology
Maryam Mozaffari, Nivin N. N. Nystrom, Alex Li, Miranda Bellyou, Timothy J. J. Scholl, Robert Bartha
Summary: Pharmacologically induced acidification of cancerous tissue can be detected and monitored using magnetic resonance imaging. In this study, the sodium proton exchanger inhibitor Cariporide was tested to determine its effectiveness in acidifying C6 glioma tumors in rats with intact immune systems. CEST MRI was used to measure tissue intracellular pH, and the results showed that Cariporide significantly increased acidity in the tumors compared to pre-injection levels. This study highlights the sensitivity of CEST-based pH-weighted imaging in monitoring the response of tumors to pharmacologically induced acidification.
Article
Psychology, Clinical
Romain Ceresetti, Sebastien Celle, Frederic Roche, Jean-Claude Barthelemy, George A. Michael, Celine Borg
Summary: This study presents relevant norms for evaluating pathological aging in the French population over a 20-year period. It emphasizes the importance of educational level and gender in assessing memory and executive function in elderly individuals.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
