Article
Medicine, General & Internal
Victor N. Dorogovtsev, Dmitry S. Yankevich, Nandu Goswami
Summary: The study revealed that using the new standardized HUTT test protocol can induce typical hemodynamic responses during orthostatic loading. Individual analysis showed subclinical orthostatic disorders in up to 52% of the subjects. All test subjects demonstrated a significant increase in PWV during HUTT.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Mawadah Staef, Christian Ott, Dennis Kannenkeril, Kristina Striepe, Mario Schiffer, Roland E. Schmieder, Agnes Bosch
Summary: In patients with type 2 diabetes mellitus, arterial stiffness is associated with increased cardiovascular and total mortality. A cross-sectional analysis of arterial stiffness in 266 patients in the early stage of type 2 diabetes mellitus was performed, and potential determinants of arterial stiffness were identified. Waist circumference, LDL-cholesterol, systolic office blood pressure, and diabetes duration were found to be potential determinants of central systolic blood pressure. Sex, age, systolic office blood pressure, and diabetes duration were found to be potential determinants of central pulse pressure. Age, systolic office blood pressure, and diabetes duration were found to be potential determinants of pulse wave velocity. These clinical parameters should be targeted in the treatment of patients in the early stage of type 2 diabetes mellitus to prevent progression of arterial stiffness and reduce cardiovascular mortality.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Dagnovar Aristizabal-Ocampo, Diego Alvarez-Montoya, Camilo Madrid-Munoz, Simon Fallon-Giraldo, Jaime Gallo-Villegas
Summary: This study analyzed the arterial hemodynamics of different hypertension subtypes using a new method. The results showed that isolated diastolic hypertension (IDH) had a higher cardiac index compared to the normotensive controls, while isolated systolic hypertension (ISH) and divergent systolic-diastolic hypertension (D-SDH) had lower total arterial compliance values. Additionally, D-SDH had the highest total peripheral resistance. This study provides a comprehensive assessment of arterial function for hypertension subtypes using a new method.
HYPERTENSION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Minghao Luo, Suxin Luo, Yuzhou Xue, Qing Chang, Hui Yang, Wenyu Dong, Ting Zhang, Shuyuan Cao
Summary: To investigate the effect of aerobic exercise on renal injury and epithelial-mesenchymal transformation (EMT) in spontaneously hypertensive rats (SHR), we conducted a 14-week aerobic treadmill training with different intensities. The results showed that low and moderate intensity exercise improved renal function and inhibited EMT by promoting irisin expression in SHR. However, high-intensity exercise had no effect on renal injury and EMT in SHR but activated STAT3 phosphorylation in the kidney.
Article
Peripheral Vascular Disease
Amelie Paquin, Ana Werlang, Thais Coutinho
Summary: This study evaluates the impact of persistent hypertension on arterial health in women after preeclampsia. The findings suggest that women with persistent hypertension after preeclampsia may have a higher cardiovascular risk and may benefit from targeted prevention strategies.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Engineering, Biomedical
Tomoyuki Kojima, Takashi Nakamura, Junichi Saito, Yuko Hidaka, Taisuke Akimoto, Hana Inoue, Christian Nanga Chick, Toyonobu Usuki, Makoto Kaneko, Etsuko Miyagi, Yoshihiro Ishikawa, Utako Yokoyama
Summary: Periodic hydrostatic pressurization under hypoxia enables the fabrication of scaffoldless human vascular mimetics with a spatial arrangement of cells and matrices. These mimetics show excellent mechanical properties and biocompatibility, making them suitable for clinical applications in cardiovascular diseases.
ACTA BIOMATERIALIA
(2023)
Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biology
Zhenzhen Chen, Haizeng Zhang, Yingnan Bai, Changting Cui, Shuangyue Li, Wenjie Wang, Yue Deng, Qiannan Gao, Lu Wang, Wei Qi, Lijun Zhang, Yan Yang, Bin Geng, Jun Cai
Summary: This study constructed a high-hydrostatic-pressure cell-culture system to simulate hypertension and identified novel molecular classifications of human aortic smooth muscle cells (HASMCs) through single-cell transcriptome analysis. Two new subsets of HASMCs, namely the inflammatory subset and the endothelial-function inhibitory subset, were discovered with distinct markers and functions, contributing to the pathogenesis of cardiovascular diseases in hypertension conditions. The expression of these two VSMC subsets was significantly increased in arterial media from patients with hypertension and experimental animal models.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Peripheral Vascular Disease
Kevin E. Boczar, Munir Boodhwani, Luc Beauchesne, Carole Dennie, Kwan Leung Chan, George A. Wells, Thais Coutinho
Summary: The study shows that measures of aortic stiffness and pulsatile hemodynamics are independently associated with future thoracic aortic aneurysm growth, providing novel insights into disease activity. These findings highlight the role of central hemodynamic assessment in tailoring new risk assessment and therapeutic strategies for patients with thoracic aortic aneurysm.
Article
Multidisciplinary Sciences
Eva Rumiz, Andres Cubillos, Juan Vicente Vilar, Pilar Garcia, Alberto Berenguer, Lorenzo Facila, Ernesto Valero, Veronica Vidal, Salvador Morell, Julio Nunez
Summary: The non-invasive estimation of pulmonary vascular resistance using CMR shows poor accuracy and limited capacity to discriminate increased PVR values in patients with acute heart failure.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Akram Khan, R. James White, Gisela Meyer, Tomas R. Pulido Zamudio, Carlos Jerjes-Sanchez, Dana Johnson, Rob Grover, Meredith Broderick, Aliou Ousmanou, Louis Holdstock, Evangelos Michelakis
Summary: Oral treprostinil has been shown to improve exercise capacity and delay disease progression in patients with pulmonary arterial hypertension (PAH). This study further demonstrates its positive effects on hemodynamics, including increased pulmonary artery compliance, cardiac output, and reduced pulmonary vascular resistance.
RESPIRATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Adhara Lazaro, Patrick Stoll, Dominik von Elverfeldt, Wolfgang Kreisel, Peter Deibert
Summary: This study investigated the potential correlation between mean arterial pressure (MAP) and portal venous pressure (PVP) in rats with healthy livers. The results showed that changes in MAP are followed by changes in PVP with a distinct time lag, indicating a cause-and-effect relationship. The study also revealed that Sildenafil influences portal pressure. Further studies should be conducted in a model with cirrhotic livers to evaluate the effects of vasoactive drugs for therapy of portal hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Kunihiko Aizawa, Alun D. Hughes, Francesco Casanova, Phillip E. Gates, David M. Mawson, Kim M. Gooding, Mark Gilchrist, Isabel Goncalves, Jan Nilsson, Faisel Khan, Helen M. Colhoun, Carlo Palombo, Kim H. Parker, Angela C. Shore
Summary: This study demonstrates that baseline reservoir pressure integral is associated with the decline in renal function in older adults, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.
Article
Environmental Sciences
Adjani A. Peralta, Diane R. Gold, Mahdieh Danesh Yazdi, Yaguang Wei, Joel Schwartz
Summary: Our study found an association between short-term PM2.5 exposure and markers of arterial stiffness and central hemodynamics.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yuliya Lytvyn, Karen Kimura, Nuala Peter, Vesta Lai, Josephine Tse, Leslie Cham, Bruce A. Perkins, Nima Soleymanlou, David Z. Cherney
Summary: This study assessed the cardiorenal effects of combining sodium-glucose cotransporter 2 inhibition and angiotensin-converting enzyme inhibition in patients with type 1 diabetes. The results showed that the combination treatment resulted in a decrease in glomerular filtration rate, suppression of oxidative stress, and a decline in blood pressure and total peripheral resistance.
Review
Oncology
John Kuruvilla, Sarit Assouline, David Hodgson, David MacDonald, Doug Stewart, Anna Christofides, Marina Komolova, Joseph Connors
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2015)
Article
Endocrinology & Metabolism
Stephane L. Bourque, Marina Komolova, Kristin McCabe, Michael A. Adams, Kanji Nakatsu
Article
Peripheral Vascular Disease
Stephane L. Bourque, Marina Komolova, Kanji Nakatsu, Michael A. Adams
Article
Peripheral Vascular Disease
Marina Komolova, Michael A. Adams
Article
Endocrinology & Metabolism
M. Komolova, S. L. Bourque, K. Nakatsu, M. A. Adams
INTERNATIONAL JOURNAL OF OBESITY
(2008)
Article
Peripheral Vascular Disease
Perrie F. O'Tierney, Marina Komolova, M. Yat Tse, Michael A. Adams, Stephen C. Pang
JOURNAL OF HYPERTENSION
(2008)
Article
Urology & Nephrology
Johanna L. Hannan, M. Tina Maio, Marina Komolova, Michael A. Adams
JOURNAL OF SEXUAL MEDICINE
(2009)
Article
Urology & Nephrology
M. Tina Maio, Johanna L. Hannan, Marina Komolova, Michael A. Adams
JOURNAL OF SEXUAL MEDICINE
(2012)