Article
Biochemistry & Molecular Biology
Yu Zhang, Ying-Jie Zhu, Han-Ping Yu
Summary: Ultralong hydroxyapatite (HAP) nanowires have potential biomedical applications due to their similarity to bone composition and excellent properties. However, controlling their formation and the long synthesis time have been challenging. This study introduces an eco-friendly microwave hydrothermal method that uses adenosine 5'-triphosphate (ATP) as a bio-phosphorus source and water as the only solvent for rapid synthesis of ultralong HAP nanowires. The resulting nanowires show high flexibility, self-assemble into bundles, and have excellent bioactivity on chitosan scaffolds.
Article
Peripheral Vascular Disease
Jason G. E. Zelt, Virgilio Cadete, Yupu Deng, Rafael Godoy, Alexanne Cuillerier, Katelynn Rowe, Mohammad Abdul-Ghani, Lynn Megeney, Yan Burelle, Antonio Giulivi, Alexandre F. R. Stewart, Steeve Provencher, Sandra Breuils-Bonnet, Sebastien Bonnet, Robert deKemp, Rob Beanlands, Lisa M. Mielniczuk, Duncan J. Stewart
Summary: This study investigated the mechanism of maladaptive right ventricular remodeling in Fischer rats compared with Sprague-Dawley rats exposed to pressure overload. The results showed that Fischer rats exhibited poorer RV function and lower survival rate, along with significant AK1 deficiency and inefficient cardiac energetics. These findings provide a new direction for studying RV failure caused by chronic increases in afterload.
Article
Neurosciences
Yaru Xu, Ge Gao, Xiaoru Sun, Qidong Liu, Cheng Li
Summary: Postoperative delirium (POD) is a major complication after surgery with general anesthesia, and the neurotoxicity of general anesthetics plays a key role. Sevoflurane, a common general anesthetic, is shown to induce inflammatory response and caspase-3 activation through upregulation of ATPIF1 in microglia. ATP supplementation may be a potential therapeutic strategy for alleviating sevoflurane-induced POD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Miyo Kudo, Tomoe Osada, Kumiko Taguchi, Tsuneo Kobayashi
Summary: This study found that methylglyoxal (MGO) impairs relaxation induced by ATP and UTP in rat carotid arteries, mainly through suppressing P2Y(2) receptor-mediated signaling and reducing endothelial NO. Additionally, MGO contributes to vasoconstriction through increased oxidative stress and COX-derived prostanoids.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Microbiology
Catherine S. Nation, Akram A. Da'dara, Manal Elzoheiry, Patrick J. Skelly
Summary: Schistosomes promote Treg survival by cleaving NAD and ATP, creating a less hostile immune environment for the parasites.
Article
Chemistry, Multidisciplinary
Tie-Gang Meng, Jia-Ni Guo, Liu Zhu, Yike Yin, Feng Wang, Zhi-Ming Han, Lei Lei, Xue-Shan Ma, Yue Xue, Wei Yue, Xiao-Qing Nie, Zheng-Hui Zhao, Hong-Yong Zhang, Si-Min Sun, Ying-Chun Ouyang, Yi Hou, Heide Schatten, Zhenyu Ju, Xiang-Hong Ou, Zhen-Bo Wang, Catherine C. L. Wong, Zhonghan Li, Qing-Yuan Sun
Summary: The study reveals that NLRP14 is crucial for maintaining calcium oscillations and early embryonic development. Disruption of NLRP14 leads to impaired cytoplasmic function and calcium homeostasis due to altered mitochondrial distribution, morphology, and activity. The interaction between NLRP14 and the mitochondrial Na+/Ca2+ exchanger (NCLX) is essential for regulating calcium homeostasis and embryonic development.
Article
Multidisciplinary Sciences
Haruka Tani, Bo Li, Takashi Kusu, Ryu Okumura, Junichi Nishimura, Daisuke Okuzaki, Daisuke Motooka, Shoya Arakawa, Asuka Mori, Terukazu Yoshihara, Takayuki Ogino, Shih-Han Tsai, Yoki Furuta, Masato Muneta, Shota Nakamura, Eiichiro Fukusaki, Kimiko Yamamoto, Hideo Yagita, Hisako Kayama, Kiyoshi Takeda
Summary: Extracellular ATP released by mucosal immune cells and microbiota in the intestine modulates immune responses via P2 purinergic receptors, while overactivation of ATP signaling disrupts mucosal immunity and leads to inflammation. E-NTPD8 controls intestinal inflammation by regulating glycolysis in neutrophils, limiting the pathogenesis of colitis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Jack Greiner, Thomas Glonek
Summary: The lens and muscle tissues have high concentrations of ATP despite low metabolic requirements, suggesting a non-metabolic function of ATP in cellular and tissue function evolution.
Article
Biochemistry & Molecular Biology
Ioannis Nellas, K. Venkatesan Iyer, Juan M. Iglesias-Artola, Martin Pippel, Andre Nadler, Suzanne Eaton, Natalie A. Dye
Summary: The production and utilization of ATP play a crucial role in animal development. Researchers used a FRET-based sensor to monitor ATP levels in the developing tissue of Drosophila larvae and found spatial differences in metabolic behavior. The Hedgehog signaling pathway was identified as a regulator of ATP production through glycolysis. These findings enhance our understanding of the connection between developmental patterning genes and ATP production during animal tissue development.
Article
Neurosciences
Runan Yang, Junpei Du, Lin Li, Xiumei Xu, Shangdong Liang
Summary: Adenosine triphosphate (ATP) acts on P2 purinergic receptors as a signaling molecule, influencing inflammatory and pro-nociceptive responses in satellite glial cells (SGCs) and macrophages. The interaction between SGCs, macrophages, and neurons through P2X and P2Y receptors plays a role in promoting and maintaining inflammation-related neuropathic pain.
Review
Peripheral Vascular Disease
Damiano Rizzoni, Alessandro Mengozzi, Stefano Masi, Claudia Agabiti Rosei, Carolina De Ciuceis, Agostino Virdis
Summary: The structural and functional alterations of microvessels are closely associated with physiological aging and cardiometabolic diseases. Various methods, including micromyography and strain-gauge venous plethysmography, have been used to evaluate microvascular structure and endothelial function. Recently, noninvasive methods have been proposed to broaden the assessment of microvessels. However, more research is needed to confirm the predictive value of these methods.
Article
Chemistry, Analytical
Bin Yang, Ruowei Tian, Taiyu Guo, Wangbo Qu, Jiao Lu, Yong Li, Zhou Wu, Shihai Yan, Zhirong Geng, Zhilin Wang
Summary: This study reports the latest progress in using tetraphenylethylene (TPE) fluorophores as a tool for detecting intracellular adenosine triphosphate (ATP). Six different ATP probes were synthesized, and probes with dual positive charge sites showed better selectivity and sensitivity. Among them, P2, with a D-π-A structure, 1,4-bis(bromomethyl)benzene linker, and dual positive charge recognition sites, exhibited higher sensitivity and selectivity in ATP detection. This research has important application value in monitoring the fluctuations of mitochondrial ATP levels.
ANALYTICAL CHEMISTRY
(2023)
Review
Neurosciences
Edward Beamer, Manvitha Kuchukulla, Detlev Boison, Tobias Engel
Summary: Despite progress in understanding the pathogenesis of hyperexcitable networks and lowered seizure thresholds, treating epilepsy remains challenging. Many patients are resistant to current medications, which only provide symptomatic relief. Efforts are focused on finding new treatments with novel mechanisms of action to modify disease progression. Purines like ATP and adenosine play key roles in the epileptogenic process, with potential as targets for therapeutic strategies.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ruifang Hua, Baixiong Liu, Wenxiu He, Huilin Zhang, Yong Liu, Qiang Xie, Linjun Zhou, Fang Pei
Summary: Calcitriol reverses age-related hypertension in aged mice by regulating mitochondrial function and downregulating renal AP1/AT(1)R signaling pathway.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Chemistry, Analytical
Amir Khojastehnezhad, Faezeh Taghavi, Elnaz Yaghoobi, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: This article discusses the application of aptamer-based biosensors in the detection of ATP. These sensors, with high specificity, rapid response, and easy construction, can be divided into optical and electrochemical sensors, and further classified into metal-based and carbon-based materials based on QDs.
Article
Peripheral Vascular Disease
Zhengrong Guan, Jennifer S. Pollock, Anthony K. Cook, Janet L. Hobbs, Edward W. Inscho
Article
Peripheral Vascular Disease
Edward W. Inscho, Anthony K. Cook, Andrea Clarke, Shali Zhang, Zhengrong Guan
Review
Physiology
Wenguang Feng, Colton E. Remedies, Ijeoma E. Obi, Stephen R. Aldous, Samia Meera, Paul W. Sanders, Edward W. Inscho, Zhengrong Guan
Summary: Renal autoregulation is impaired in ischemia-reperfusion (IR) injury, possibly due to increased reactive oxygen species (ROS). Acute administration of antioxidants can restore autoregulatory capability in IR rats, suggesting a reversible impairment. This intervention may offer potential benefits in preserving renal function and preventing chronic kidney disease after acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Physiology
Zhengrong Guan, Matthew I. Giddens, David A. Osmond, Anthony K. Cook, Janet L. Hobbs, Shali Zhang, Tatsuo Yamamoto, Jennifer S. Pollock, David M. Pollock, Edward W. Inscho
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2013)
Article
Physiology
Zhengrong Guan, Barry S. Fuller, Tatsuo Yamamoto, Anthony K. Cook, Jennifer S. Pollock, Edward W. Inscho
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2010)
Review
Pharmacology & Pharmacy
Zhengrong Guan, David A. Osmond, Edward W. Inscho
TRENDS IN PHARMACOLOGICAL SCIENCES
(2007)
Review
Medicine, Research & Experimental
Zhengrong Guan, David A. Osmond, Edward W. Inscho
EXPERIMENTAL BIOLOGY AND MEDICINE
(2007)
Article
Physiology
Zhengrong Guan, Glenda Gobe, Desley Willgoss, Zoltan H. Endre
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2006)
Article
Urology & Nephrology
M Rahgozar, ZG Guan, A Matthias, GC Gobé, ZH Endre