Article
Engineering, Biomedical
Avinash Kondiboyina, Joseph J. Smolich, Michael M. H. Cheung, Jonathan P. Mynard
Summary: The authors propose a novel method for measuring the time shift in waveform between diastole and systole in the heart. They demonstrate the accuracy and robustness of this method by comparing it to a ground truth measurement. This is significant for studying the changes in backward waveform timing with aging.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Physiology
Chloe E. Athaide, Jeremy N. Cohen, Kailey A. Stevens, Andrew D. Robertson, Jason S. Au
Summary: This study used heating interventions on the lower and upper limbs to compare their contributions to wave reflection. The results showed that both limb heating interventions reduced the amplitude of central wave reflection, failing to support the hypothesis that the lower limbs are the primary source of wave reflection in humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Kunihiko Aizawa, Francesco Casanova, Phillip E. Gates, David M. Mawson, Kim M. Gooding, W. David Strain, Gerd Ostling, Jan Nilsson, Faisel Khan, Helen M. Colhoun, Carlo Palombo, Kim H. Parker, Angela C. Shore, Alun D. Hughes
Summary: Parameters derived from reservoir-excess pressure analysis can be used to assess cardiovascular disease risk in type 2 diabetes patients, indicating the potential prognostic value of these parameters in various populations.
Article
Physiology
Hasan Obeid, Vasiliki Bikia, Catherine Fortier, Mathilde Pare, Patrick Segers, Nikos Stergiopulos, Mohsen Agharazii
Summary: This study investigates the changes in arterial pressure and vascular stiffness in patients with chronic kidney disease caused by renal removal. The results show that blood pressure increases in cases of single kidney and no kidney, but systolic blood pressure is restored in the case of a transplanted kidney. Furthermore, all tested configurations lead to an increase in pulse wave velocity. The study suggests that the observed variations in pulse wave velocity with different stages of kidney disease may be due to biomechanical alterations of the arterial tree and their effect on blood pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Manoj Kumar Choudhary, Roosa-Maria Penninkangas, Arttu Eraranta, Onni Niemela, Charles Mangani, Kenneth Maleta, Per Ashorn, Ulla Ashorn, Ilkka Porsti
Summary: This study compared cardiovascular function between men and women in rural Malawi. The results showed that men had higher systolic blood pressure, systemic vascular resistance, and cardiac workload, while women had higher posture-related changes in vascular resistance and cardiac output.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Computer Science, Interdisciplinary Applications
Giuseppe De Nisco, Maurizio Lodi Rizzini, Roberto Verardi, Claudio Chiastra, Alessandro Candreva, Gaetano De Ferrari, Fabrizio D'Ascenzo, Diego Gallo, Umberto Morbiducci
Summary: This study demonstrates that assumptions on blood rheology have negligible impact on wall shear stress and helical flow profiles in computational fluid dynamics simulations of coronary hemodynamics.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Peripheral Vascular Disease
Lucas S. Aparicio, Qi-Fang Huang, Jesus D. Melgarejo, Dong-Mei Wei, Lutgarde Thijs, Fang-Fei Wei, Natasza Gilis-Malinowska, Chang-Sheng Sheng, Jose Boggia, Teemu J. Niiranen, Augustine N. Odili, Katarzyna Stolarz-Skrzypek, Jessica Barochiner, Daniel Ackermann, Kalina Kawecka-Jaszcz, Valerie Tikhonoff, Zhen-Yu Zhang, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Aletta E. Schutte, Wen-Yi Yang, Antti M. Jula, Angela J. Woodiwiss, Murielle Bochud, Gavin R. Norton, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: The IDCARS database includes 10,930 subjects from 13 studies across different regions, with prevalence rates of office hypertension and diabetes mellitus reported. The central and peripheral systolic/diastolic blood pressure, as well as aortic pulse wave velocity, were measured. Longitudinal studies showed a median follow-up of 4.2 years, with cardiovascular events and deaths reported during the follow-up period. The IDCARS database provides valuable information for investigating central hemodynamic measurements and may inform guidelines for managing hypertension.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Engineering, Biomedical
Arian Aghilinejad, Heng Wei, Niema M. Pahlevan
Summary: The clinical significance of wave intensity (WI) analysis for cardiovascular and cerebrovascular diseases is well-established, but its application in clinical practice is limited. To overcome this limitation, a Fourier-based machine learning (F-ML) approach was developed to evaluate WI using only pressure waveform measurement. The results show that the pressure-only F-ML approach provides accurate estimates for WI parameters, expanding the clinical usage of WI into inexpensive and non-invasive settings such as wearable telemedicine.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Marcos D. Polito, Rafael Papst, Karla Goessler
Summary: This study showed that resistance training with a single set may increase muscle strength without necessarily reducing resting blood pressure, while performing three sets can increase muscle strength and reduce resting blood pressure in individuals with hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Hasan Obeid, Catherine Fortier, Charles-Antoine Garneau, Mathilde Pare, Pierre Boutouyrie, Rosa Maria Bruno, Hakim Khettab, Remi Goupil, Mohsen Agharazii
Summary: The study validates the feasibility and reliability of radial-digital PWV as a measure of regional stiffness of small conduit arteries and investigates its response to changes in hydrostatic pressure. The results demonstrate that this method can be used for assessing the stiffness of small arteries and allows for a comprehensive evaluation of arterial stiffness gradient from larger to smaller arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Torjus L. Steffensen, Filip E. Schjerven, Hans M. Flade, Idar Kirkeby-Garstad, Emma Ingestroem, Fredrik S. Solberg, Martin Steinert
Summary: This study assesses the feasibility of using wrist acceleration ballistocardiogram (BCG) during exercise to estimate pulse transit time (PTT) for broader cardiovascular response studies and improved monitoring. The results showed that wrist BCG was successfully recorded during exercise. PTT exhibited a moderate negative correlation with systolic blood pressure and showed significant differences between supine and semirecumbent conditions at certain workloads. This study suggests that wrist BCG allows for convenient PTT and potentially stroke volume (SV) tracking during exercise, enabling studies of cardiovascular response and monitoring of cardiovascular performance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Victor N. Dorogovtsev, Dmitry S. Yankevich, Nandu Goswami
Summary: The study revealed that using the new standardized HUTT test protocol can induce typical hemodynamic responses during orthostatic loading. Individual analysis showed subclinical orthostatic disorders in up to 52% of the subjects. All test subjects demonstrated a significant increase in PWV during HUTT.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Louise Newman, John D. O'Connor, Roman Romero-Ortuno, Richard B. Reilly, Rose Anne Kenny
Summary: The study found that patients with supine hypertension displayed impaired blood pressure response, as well as dysfunction in cerebral oxygenation and autoregulation. In older patients, measuring supine hypertension and screening for orthostatic hypotension should be considered. Therapeutic studies are needed to further explore the relationship between cerebral oxygenation, medications, supine blood pressure, and orthostatic hypotension.
Article
Peripheral Vascular Disease
Takamichi Takahashi, Hiroki Nakano, Kazuki Shiina, Masatsune Fujii, Chisa Matsumoto, Kazuhiro Satomi, Akira Yamashina, Hirofumi Tomiyama, Taishiro Chikamori
Summary: Elevated central systolic blood pressure may be an independent risk factor for accelerated progression of arterial stiffness in middle-aged Japanese men.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Peripheral Vascular Disease
Daime Campos-Arias, Marc L. De Buyzere, Julio A. Chirinos, Ernst R. Rietzschel, Patrick Segers
Summary: Studies have shown that changes in the arterial system due to aging are complex and not fully understood, with differences in parameters such as pulse wave velocity, input impedance, and wave reflection between genders and age groups. The findings suggest that aortic dilation and elongation may play a crucial role in determining longitudinal age-related changes in impedance parameters in middle-aged individuals. Future research should focus on the interaction between geometric remodeling and wall stiffening as determinants of pulsatile hemodynamics.
Letter
Cardiac & Cardiovascular Systems
Rahna Rasouli, Jerome Baranger, Cameron Slorach, Minh Nguyen, Patrick Segers, Vitor Guerra, Mathieu Pernot, Wei Hui, Luc Mertens, Olivier Villemain
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Thierry C. Gillebert
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James E. E. Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine De Backer
Summary: The central blood pressure values estimated by radial artery tonometry in T1DM patients depend significantly on the method used for calibration of the radial waveforms. Using brachial MAP/DBP calibration resulted in higher central blood pressure compared to using brachial SBP/DBP calibration, indicating the importance of calibration approach for accurate estimation of central blood pressure using noninvasive methods.
JOURNAL OF HYPERTENSION
(2023)
Article
Engineering, Biomedical
Matthias Van Impe, Lisa Caboor, Violette Deleeuw, Margie Olbinado, Julie De Backer, Patrick Sips, Patrick Segers
Summary: This study successfully provides a biomechanical reference for the circulation in adult zebrafish by establishing 3D models of the cardiovascular system. By providing reference values for biomechanical stimuli in wild-type animals and a pipeline for image-based animal-specific computational biomechanical models, this study contributes to a more comprehensive understanding of the role of altered biomechanics and hemodynamics in heritable cardiovascular pathologies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Annette Caenen, Stephanie Bezy, Aniela Petrescu, Annegret Werner, Jens-Uwe Voigt, Jan D'hooge, Patrick Segers
Summary: Shear wave elastography (SWE) is a promising technique for assessing myocardial stiffness non-invasively. The study found that the transmural wave speed gradient can distinguish between intrinsic myocardial stiffening and stiffening caused by increased pressure. This gradient may have potential as a new diagnostic parameter for future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study investigates whether pulse wave velocity (PWV) can guide in determining appropriate parameter values for the Gasser-Ogden-Holzapfel (GOH) constitutive model. The results show that PWV80 and PWV110 are complementary measures that can reduce the parameter space in arterial models, particularly for media- and collagen-related parameters.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cardiac & Cardiovascular Systems
Kristian Sorensen, Solveig Fadnes, Luc Mertens, Matthew Henry, Patrick Segers, Lasse Lovstakken, Siri Ann Nyrnes
Summary: This study developed and validated the calculation of intraventricular pressure difference (IVPD) using blood speckle-tracking (BST) in children and investigated its potential role in assessing diastolic function. The results showed that BST is highly feasible and provides information on diastolic suction and early filling in children with heart disease. The IVPD was significantly reduced in children with dilated cardiomyopathies (DCMs) and hypertrophic cardiomyopathies (HCMs) compared to controls.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Biotechnology & Applied Microbiology
Sarah Vandenbulcke, Tim De Pauw, Frank Dewaele, Joris Degroote, Patrick Segers
Summary: Cerebrospinal fluid (CSF) dynamics are essential for maintaining a stable central nervous system environment, but the impact of different physiological processes on CSF flow is not well understood. This study presents a computational model that incorporates physiological processes as boundary conditions to simulate CSF pressures and velocities. The model's accuracy is validated by comparing the simulation results with in vivo measurements.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Thierry C. Gillebert
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Physiology
Sandra Sjostrand, Alice Widerstrom, Ingrid Svensson, Patrick Segers, Tobias Erlov, Asa Ryden Ahlgren, Magnus Cinthio
Summary: Longitudinal motion of the carotid arterial wall, as measured with ultrasound, is a promising indicator of vascular health, but its underlying mechanisms are not fully understood. Blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Tapered geometry and intramural friction between two parts of a vessel wall also influence the longitudinal displacement.
PHYSIOLOGICAL REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Edward Horton, Bryce Johnson, Mahesh Vidula, Soumya Kondaveety, Srinivas Denduluri, Patrick Segers, Howard C. Herrmann, Julio A. Chirinos
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study developed a computational model to simulate the thickening process of dissected aorta wall, considering the effects of stress and inflammation on elastin and collagen. The results showed that the model with transient inflammation pattern was able to reproduce the clinically observed membrane thickening rates, diameter expansion rates, and adaptations in microstructure.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marija Smoljkic, Jos Vander Sloten, Patrick Segers, Nele Famaey
Summary: This study provides an estimation method for material parameters in the study of continuous diseases using non-invasively measured human carotid artery data. Both different material models are able to simulate the behavior of the arteries, but the structural model provides more realistic results. Gender has a greater impact on mechanical properties, and there is a stiffening trend in arteries with age, body mass index, and blood pressure, although not strong. Meanwhile, there is a high intersubject variability.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Federico Cane, Lucas Delcour, Alberto Cesare Luigi Redaelli, Patrick Segers, Joris Degroote
Summary: Cardiovascular diseases can lead to chronic pathological conditions, and early diagnosis is crucial for treatment. Image-based patient-specific Computational Fluid Dynamics (CFD) models provide detailed information about cardiac blood flow, supporting clinicians in diagnosis and treatment planning. This study developed a Chimera-based method to build a patient-specific 3D CFD model of the heart, considering the challenges of left ventricle and mitral valve motion. The results suggest that the mitral valve plays a crucial role in intraventricular flow development.
FRONTIERS IN MEDICAL TECHNOLOGY
(2022)