Review
Medicine, Research & Experimental
Amanda Sampaio Storch, Larissa Lirio Velasco, Antonio Claudio Lucas da Nobrega, Ronaldo Altenburg Odebrecht Curi Gismondi, Natalia Galito Rocha
Summary: Approximately 12-18% of hypertensive patients are diagnosed with resistant hypertension (RH). The risk of having worse cardiovascular outcomes is twice higher in those patients. Phosphodiesterase 5 (PDE-5) inhibitors improve blood pressure, vascular hemodynamics, and diastolic function parameters in patients with essential hypertension.
Review
Biochemistry & Molecular Biology
Martin Alexander Schick, Nicolas Schlegel
Summary: Phosphodiesterase 4 inhibitors play an important role in regulating physiological functions and treating diseases, but they also carry significant risks of serious side effects. This review aims to provide a comprehensive overview of the approaches and effects of phosphodiesterase 4 inhibition in different therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tetzi Oliveira Brandao, Eduardo Carvalho de Arruda Veiga, Rozeli Ferreira Levy, Enio Luis Damaso, Valeria Cristina Sandrim, Ricardo Carvalho Cavalli
Summary: This study found that ethnicity, self-reported hypertension, and gestational hypertension are associated with arterial hypertension measured by ABPM.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Ahmed K. Elhady, Dalia S. El-Gamil, Mohammad Abdel-Halim, Ashraf H. Abadi
Summary: This review provides an updated assessment of the crucial role played by phosphodiesterase 5 (PDE5) inhibitors in the nitric oxide/cGMP pathway and their potential in treating various diseases. It discusses the medicinal chemistry and drug discovery aspects of PDE5 inhibitors, as well as the breakthrough development of allosteric inhibitors. Furthermore, the concept of multi-targeted ligands in relation to PDE5 inhibitors is critically evaluated.
Review
Medicine, General & Internal
Ophir Eyal, Iddo Z. Ben-Dov
Summary: Background: The benefits of using blood pressure load (BPL) index in adults have not been clearly demonstrated. This review examines the associations of BPL with target organ damage (TOD) and clinical outcomes, and whether it has added benefit to average blood pressure indices on ambulatory blood pressure monitoring (ABPM) in predicting adverse outcomes. Methods: A PubMed search for English language papers on ABPM and BPL was conducted. Results: Although multiple studies have assessed the question, the cumulative sample size is small. While BPL is associated with various TODs, the available literature does not consistently support its added value over average blood pressure indices. Conclusions: More prospective studies are needed to evaluate the role of BPL in blood pressure measurement, as the current literature does not provide strong support for its use in clinical decisions.
Article
Urology & Nephrology
Marieta P. Theodorakopoulou, Maria-Eleni Alexandrou, Fotini Iatridi, Antonios Karpetas, Virginia Geladari, Eva Pella, Sophia Alexiou, Maria Sidiropoulou, Stavroula Ziaka, Aikaterini Papagianni, Pantelis Sarafidis
Summary: In hemodialysis patients with intradialytic hypertension (IDH), only averaged interdialytic blood pressure measurements showed reasonable agreement with ambulatory blood pressure load, while peridialytic and intradialytic measurements did not. Interdialytic blood pressure recordings could be used for diagnosing and managing hypertension in these patients, as they showed high sensitivity/specificity and strong agreement with ambulatory blood pressure monitoring. Scheduled interdialytic blood pressure had the highest accuracy, sensitivity, and specificity in diagnosing hypertension in this population.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Peripheral Vascular Disease
Andrew R. Heckel, Danielle M. Arcidiacono, Kailee A. Coonan, Alaina C. Glasgow, Jacob P. DeBlois, Brooks B. Gump, Joon Young Kim, Kevin S. Heffernan
Summary: Little is known about the effects of COVID-19 on blood pressure. This study compared the 24-hour hemodynamic load between adults recovering from mild-to-moderate COVID-19 and controls without a history of COVID-19. The results showed no differences in 24-hour brachial or central ambulatory blood pressure monitoring measures between the two groups.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Review
Biochemistry & Molecular Biology
Abimael Gonzalez-Hernandez, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M. M. Villalon
Summary: 5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter in various nervous system functions. Its actions are complex and depend on multiple factors, including the type of effector or receptor activated. This review summarizes and discusses the impact of 5-HT on blood pressure regulation and vascular-related diseases.
Article
Biochemistry & Molecular Biology
Mateusz Kwiatkowski, Aloysius Wong, Anna Kozakiewicz-Piekarz, Christoph Gehring, Krzysztof Jaworski
Summary: This passage discusses the roles of signaling molecules cAMP and cGMP, as well as Ca2+ in plants, and investigates the function of PDEs in monocot plants, identifying a candidate PDE from Brachypodium distachyon. The research shows that the PDE has a significant hydrolytic activity towards cAMP, which can be further enhanced by Ca2+ and CaM. Additionally, a comprehensive amino acid consensus sequence is constructed to aid in the identification of similar active sites in eukaryotes and prokaryotes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Medicine, General & Internal
Anuj A. Patel, David S. Goldfarb
Summary: This article compares first-line diuretics with other classes of antihypertensive drugs in the treatment of hypertension.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Arun Samidurai, Lei Xi, Anindita Das, Audra N. Iness, Navin G. Vigneshwar, Pin-Lan Li, Dinender K. Singla, Sakthivel Muniyan, Surinder K. Batra, Rakesh C. Kukreja
Summary: Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes that regulate the spatial and temporal relationship of second messenger signaling in the cellular system. The PDE1 sub-family consists of three subtypes with different affinities for cAMP and cGMP, and their catalytic activity is stimulated by binding to Ca2+/calmodulin, playing a critical role in various diseases.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Xinyue Du, Lingli Wang, Wenyi He, Xin Fu, Yingjiao Zhang, Wei Zhou, Yuying Han, Guolan Deng
Summary: The aim of this study was to explore the relationship between diurnal blood pressure pattern and season. The results showed that the diurnal blood pressure pattern significantly differed among seasons. Four types of blood pressure patterns were identified: dipper, non-dipper, riser, and extreme-dipper. Age difference among seasons was only significant in the dipper group. Multinomial logistic regression analysis revealed that season was an independent contributor to diurnal blood pressure pattern.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Scott A. Hubers, Siu-Hin Wan, Fadi W. Adel, Sherry L. Benike, John C. Jr Jr Burnett, Christopher Scott, Horng H. Chen
Summary: In patients with pre-heart failure, long-term tadalafil did not improve renal function or cardiorenal response after short-term volume load. This study does not support the use of PDEV inhibition to enhance renal response in patients with pre-heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Pharmacology & Pharmacy
Jing Shi, Yuanyuan Li, Yi Zhang, Jie Chen, Jianqing Gao, Tianyuan Zhang, Xiaoguang Shang, Xiangnan Zhang
Summary: The inhibition of phosphodiesterase 2 and 4 using baicalein may prevent Aβ-induced cognitive impairments by increasing intracellular cAMP/cGMP levels, ultimately regulating neuroplasticity pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
C. Venkata S. Ram, Sameer Dani, Abraham Oomman, Rakesh Gupta, K. O. Ramachari, G. Praveen Kumar, Jayanthi Swaminathan, Sathyanarayana Kondati, Ishita Sengupta
Summary: There is a good correlation between ABPM and OBPM in patients with newly diagnosed, controlled, or uncontrolled hypertension, with notable variation in diastolic BP readings. Further large-scale clinical studies are needed to detect the prevalence of hypertension, masked hypertension, and associated medical co-morbidities.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)