Article
Peripheral Vascular Disease
Yi-Bang Cheng, Lutgarde Thijs, Lucas S. Aparicio, Qi-Fang Huang, Fang-Fei Wei, Yu-Ling Yu, Jessica Barochiner, Chang-Sheng Sheng, Wen-Yi Yang, Teemu J. Niiranen, Jose Boggia, Zhen-Yu Zhang, Katarzyna Stolarz-Skrzypek, Natasza Gilis-Malinowska, Valerie Tikhonoff, Wiktoria Wojciechowska, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Kalina Kawecka-Jaszcz, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: This study investigated the relationship between cardiovascular risk and central and brachial systolic pressure and proposed thresholds to differentiate hypertension from normal blood pressure. Regardless of brachial blood pressure status, central hypertension was associated with increased cardiovascular and cerebrovascular risk, highlighting the importance of controlling central hypertension.
Article
Cardiac & Cardiovascular Systems
Yueliang Hu, Jiehui Zhao, Qian Wang, Huijuan Chao, Biwen Tang, Di Cheng, Isabella Tan, Mark Butlin, Alberto Avolio, Weiliang Wang, Junli Zuo
Summary: This study aimed to evaluate the associations between non-invasive central aortic and peripheral blood pressure and hypertension-mediated organ damage (HMOD) and atherosclerotic cardiovascular disease (ASCVD) risk. The results showed that blood pressure obtained by 24-hour ambulatory blood pressure monitoring (ABPM) was better correlated with HMOD than office blood pressure. Additionally, 24-hour central blood pressure had a superior prognostic value for the 10-year ASCVD risk compared to 24-hour peripheral blood pressure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Agne Laucyte-Cibulskiene, Chen-Huan Chen, John Cockroft, Pedro G. Cunha, Maryam Kavousi, Aleksandras Laucevicius, Maria Lorenza Muiesan, Ernst R. Rietzschel, Ligita Ryliskyte, Irina D. Strazhesko, Charalambos Vlachopoulos, Jorge Cotter, Ekatherina N. Dudinskaya, Nichola Gale, Fariba Ahmadizar, Francesco U. S. Mattace-Raso, Maggie Munnery, Pedro Oliveira, Anna Paini, Massimo Salvetti, Olga N. Tkacheva, Edward G. Lakatta, Peter M. Nilsson, Angelo Scuteri
Summary: This study aimed to investigate the effect of metabolic syndrome (MetS) and its components on central blood pressure (CBP). The results showed that individuals with MetS were 50% more likely to have higher CBP. Furthermore, specific clusters of MetS components were found to be associated with higher CBP, with some associations being more significant in women.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Rachel E. Luehrs, Dong Zhang, Gary L. Pierce, David R. Jacobs, Ravi Kalhan, Kara M. Whitaker
Summary: The association between chronic smoking and changes in blood pressure over a 30-year period differs among Black and White individuals. While consistent smokers had higher pulse pressure compared to never smokers, the differences in systolic and diastolic blood pressure were minimal. Increased pulse pressure in consistent smokers may contribute to the higher cardiovascular disease risk observed in this group.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Peripheral Vascular Disease
Lin Jin, Jianxiong Chen, Mengjiao Zhang, Lei Sha, Mengmeng Cao, Lanyue Tong, Qingqing Chen, Cuiqin Shen, Lianfang Du, Zhaojun Li, Liping Liu
Summary: This study included 4,311 participants aged 20 to 79 years and found that uncontrolled hypertension is associated with increased arterial stiffness and central artery pressure, which are important predictors of cardiovascular disease risk.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Lucas S. Aparicio, Qi-Fang Huang, Jesus D. Melgarejo, Dong-Mei Wei, Lutgarde Thijs, Fang-Fei Wei, Natasza Gilis-Malinowska, Chang-Sheng Sheng, Jose Boggia, Teemu J. Niiranen, Augustine N. Odili, Katarzyna Stolarz-Skrzypek, Jessica Barochiner, Daniel Ackermann, Kalina Kawecka-Jaszcz, Valerie Tikhonoff, Zhen-Yu Zhang, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Aletta E. Schutte, Wen-Yi Yang, Antti M. Jula, Angela J. Woodiwiss, Murielle Bochud, Gavin R. Norton, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: The IDCARS database includes 10,930 subjects from 13 studies across different regions, with prevalence rates of office hypertension and diabetes mellitus reported. The central and peripheral systolic/diastolic blood pressure, as well as aortic pulse wave velocity, were measured. Longitudinal studies showed a median follow-up of 4.2 years, with cardiovascular events and deaths reported during the follow-up period. The IDCARS database provides valuable information for investigating central hemodynamic measurements and may inform guidelines for managing hypertension.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Janis M. Nolde, Leslie Marisol Lugo-Gavidia, Dennis Kannenkeril, Justine Chan, Vance B. Matthews, Revathy Carnagarin, Omar Azzam, Marcio Galindo Kiuchi, Markus P. Schlaich
Summary: This study investigated the association between orthostatic hypertension phenotype and vascular hypertension-mediated organ damage (HMOD) in a cohort of 200 patients. The results showed that both an orthostatic BP drop and rise were associated with elevated pulse wave velocity (PWV), indicating a potential independent risk factor for vascular HMOD at any age.
JOURNAL OF HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Tatsuya Haze, Nobuhito Hirawa, Yuichiro Yano, Kouichi Tamura, Isao Kurihara, Hiroki Kobayashi, Mika Tsuiki, Takamasa Ichijo, Norio Wada, Takuyuki Katabami, Koichi Yamamoto, Kenji Oki, Nobuya Inagaki, Shintaro Okamura, Tatsuya Kai, Shoichiro Izawa, Masanobu Yamada, Yoshiro Chiba, Akiyo Tanabe, Mitsuhide Naruse
Summary: The study utilized a dataset from a Japanese nationwide registry of patients with primary aldosteronism to determine prognostic factors for cardiovascular diseases. It found that higher aldosterone-to-renin ratio before treatments, higher pulse pressure after treatments, and longer duration of hypertension were associated with increased risk of cardiovascular events. Early intervention may be important for preventing cardiovascular disease among patients with primary aldosteronism.
Review
Environmental Sciences
Gyeyoon Yim, Yuting Wang, Caitlin G. Howe, Megan E. Romano
Summary: This scoping review summarizes the literature on the cardiotoxicity of exposure to metal mixtures and identifies the trends and focus areas in the research. The majority of the studies were conducted in the United States and China, with an increase in publications in recent years. The commonly investigated metals included cadmium, lead, arsenic, and cobalt, with a focus on their impact on blood pressure, preeclampsia, dyslipidemia, and cardiovascular disease outcomes.
Article
Environmental Sciences
M. Carrasco-Rios, R. Ortola, M. Sotos-Prieto, A. Graciani, F. Rodriguez-Artalejo, J. R. Banegas, E. Garcia-Esquinas
Summary: The potential environmental determinants of blood pressure (BP) in older adults are less understood than their lifestyle risk factors. This study aimed to investigate the association between blood manganese (bMn) levels and various BP parameters in older adults. The results showed a non-linear association between bMn and daytime brachial and central systolic BP, with an increase in BP up to a certain level of Mn and then stabilization or slight decrease. Additionally, bMn levels were found to be a potential risk factor for increased levels of both brachial and central BPs in older adults, but further research is needed.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Teresa Dalla Zuanna, Erich Batzella, Gisella Pitter, Francesca Russo, Teresa Spadea, Cristina Canova
Summary: This study examined differences in cardiovascular risk factors between first-generation immigrants and Italians, and analyzed how migration pattern variables could affect health outcomes. The results showed that there were differences among immigrants from different regions and genders, and immigrants who had resided in Italy for more than 20 years had lower cholesterol levels compared to native-born individuals. The study suggests that targeted intervention for specific immigrant groups is necessary.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Moya-Amengual, Antonio Ruiz-Garcia, Vicente Pallares-Carratala, Adalberto Serrano-Cumplido, Miguel Angel Prieto-Diaz, Antonio Segura-Fragoso, Sergio Cinza-Sanjurjo
Summary: This study evaluated the prevalence of ePP in the adult primary care population and its association with other vascular risk factors, sTOD, and CVD. The results showed that ePP was present in a quarter of the sample and increased with age. ePP was more frequent in men, patients with HTN, other sTOD, and CVD, indicating a higher cardiovascular risk. Early identification of ePP can improve diagnostic and therapeutic management.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Jordan Berguig, Youssef Abdelmassih, Georges Azar, Justine Lafolie, Anne Sophie Alonso, Sophie Bonnin, Vivien Vasseur, Martine Mauget-Faysse
Summary: The objective of this study was to evaluate the risk factors and outcomes of central retinal vein occlusion (CRVO) in young patients (<40 years). The results showed that patients with high blood pressure and inflammation had lower final visual acuity compared to patients with no risk factors. Young patients with CRVO should be evaluated for the presence of risk factors and patients with high blood pressure or inflammatory findings should be followed carefully, as they have a worse outcome.
FRONTIERS IN MEDICINE
(2023)
Review
Nutrition & Dietetics
David A. Jaques, Gregoire Wuerzner, Belen Ponte
Summary: Excessive salt intake can lead to high blood pressure and various adverse consequences. Reducing salt consumption presents a potential strategy to reduce the burden of cardiovascular disease.
Article
Multidisciplinary Sciences
Abdul-Karim Iddrisu, Ishmael Besing Karadaar, Joseph Gurah, Bismark Ansu, Damoah-Asante Ernest
Summary: This study used multiple blood pressure measurements on 3809 Ghanaians to identify the risk factors associated with high blood pressure. The results showed that the risk of high blood pressure decreases for male participants and increases for those aged 60 and above. Those who engage in vigorous exercise and have been diagnosed with diabetes are also at a higher risk of high blood pressure. Additionally, higher education level, increasing weight, and decreasing height are associated with an increased risk of high blood pressure.
SCIENTIFIC REPORTS
(2023)
Letter
Critical Care Medicine
Marie Fisk, Ian Wilkinson
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Review
Peripheral Vascular Disease
Luca Zanoli, Dimitri P. Mikhailidis, Rosa Maria Bruno, Maria T. Abreu, Silvio Danese, Rami Eliakim, Paolo Gionchetti, Konstantinos H. Katsanos, Julien Kirchgesner, Ioannis E. Koutroubakis, Torsten Kucharzik, Peter L. Lakatos, Geoffrey C. Nguyen, Alfredo Papa, Stephan R. Vavricka, Ian B. Wilkinson, Pierre Boutouyrie
Review
Hematology
Ian B. Wilkinson, Kaisa M. Maki-Petaja, Gary F. Mitchell
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Geriatrics & Gerontology
Jilles M. Fermont, Divya Mohan, Marie Fisk, Charlotte E. Bolton, William Macnee, John R. Cockcroft, Carmel McEniery, Jonathan Fuld, Joseph Cheriyan, Ruth Tal-Singer, Hana Mullerova, Angela M. Wood, Ian B. Wilkinson, Michael Polkey
Summary: The study found that using the SPPB and its components as an alternative to the 6MWT in the BODE Index maintained a similar predictive ability for mortality in COPD patients.
Article
Peripheral Vascular Disease
Ai Ikeda, Andrew Steptoe, Martin Shipley, Ian B. Wilkinson, Carmel M. McEniery, Takeshi Tanigawa, Archana Singh-Manoux, Mika Kivimaki, Eric J. Brunner
Article
Radiology, Nuclear Medicine & Medical Imaging
Delphine L. Chen, Safia Ballout, Laigao Chen, Joseph Cheriyan, Gourab Choudhury, Ana M. Denis-Bacelar, Elise Emond, Kjell Erlandsson, Marie Fisk, Francesco Fraioli, Ashley M. Groves, Roger N. Gunn, Jun Hatazawa, Beverley F. Holman, Brian F. Hutton, Hidehiro Iida, Sarah Lee, William MacNee, Keiko Matsunaga, Divya Mohan, David Parr, Alaleh Rashidnasab, Gaia Rizzo, Deepak Subramanian, Ruth Tal-Singer, Kris Thielemans, Nicola Tregay, Edwin J. R. van Beek, Laurence Vass, Marcos F. Vidal Melo, Jeremy W. Wellen, Ian Wilkinson, Frederick J. Wilson, Tilo Winkler
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Medicine, General & Internal
Giulia Masini, Jasmine Tay, Carmel M. McEniery, Ian B. Wilkinson, Herbert Valensise, Grazia M. Tiralongo, Daniele Farsetti, Wilfried Gyselaers, Sharona Vonck, Christoph C. Lees
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biophysics
Ye Li, Alessandro Giudici, Ian B. Wilkinson, Ashraf W. Khir
Summary: Arterial function and wall mechanical properties play crucial roles in circulation hemodynamics. A novel non-invasive method for determining vessel distensibility and elastic modulus was proposed and validated, showing comparable results to invasive techniques. This new approach holds potential for clinical applications.
JOURNAL OF BIOMECHANICS
(2021)
Article
Medicine, General & Internal
Peter J. Hutchinson, Ellie Edlmann, Diederik Bulters, Ardalan Zolnourian, Patrick Holton, Nigel Suttner, Kevin Agyemang, Simon Thomson, Ian A. Anderson, Yahia Z. Al-Tamimi, Duncan Henderson, Peter C. Whitfield, Monica Gherle, Paul M. Brennan, Annabel Allison, Eric P. Thelin, Silvia Tarantino, Beatrice Pantaleo, Karen Caldwell, Carol Davis-Wilkie, Harry Mee, Elizabeth A. Warburton, Garry Barton, Aswin Chari, Hani J. Marcus, Andrew T. King, Antonio Belli, Phyo K. Myint, Ian Wilkinson, Thomas Santarius, Carole Turner, Simon Bond, Angelos G. Kolias
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Editorial Material
Rheumatology
Tania Gudu, Carmel Stober, Andrew P. Cope, Joseph Cheriyan, James Galloway, Ian B. Wilkinson, Michalis Kostapanos, David Jayne, Frances Hall
Article
Peripheral Vascular Disease
Kaisa M. Maki-Petaja, Adam McGeoch, Lucy L. Yang, Annette Hubsch, Carmel M. McEniery, Paul A. R. Meyer, Fraz Mir, Parag Gajendragadkar, Nicola Ramenatte, Gayathri Anandappa, Sara Santos Franco, Simon J. Bond, Carola-Bibiane Schonlieb, Yoeri Boink, Christoph Brune, Ian B. Wilkinson, Duncan Jodrell, Joseph Cheriyan
Summary: The study found that in patients receiving the VEGF inhibitor pazopanib, the drug led to hypertension, possibly through increasing peripheral vascular resistance and reducing microvascular density and diameter.
Review
Pharmacology & Pharmacy
Marie Fisk, Magnus Althage, Sven Moosmang, Peter J. Greasley, Andrew P. Cope, David R. W. Jayne, James Galloway, Frances Hall, Ian B. Wilkinson, Philip Ambery, Joseph Cheriyan
Summary: Treatment of COVID-19 requires a multi-faceted approach, and a combined therapeutic regimen of endothelin-A receptor antagonists and sodium glucose co-transporter-2 inhibitors may have beneficial effects in mitigating the manifestations of the disease. Randomized controlled clinical trials are needed to determine the efficacy and safety of these medicines in treating COVID-19.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Paul J. Cacciottolo, Michalis S. Kostapanos, Elena Hernan Sancho, Holly Pavey, Fotini Kaloyirou, Evangelia Vamvaka, Joanna Helmy, Annette Hubsch, Carmel M. McEniery, Ian B. Wilkinson, Joseph Cheriyan
Summary: This study aims to investigate the physiological mechanisms of cardiovascular benefits of LDL-C lowering through PCSK9 inhibition in patients with established cardiovascular disease. The study will observe changes in measures of endothelial function and vascular inflammation imaging following intervention. Participants will be randomly assigned to alirocumab or ezetimibe treatment groups and undergo repeat scans and assessments after 8 weeks.
Editorial Material
Peripheral Vascular Disease
Spoorthy Kulkarni, Anna F. Dominiczak, Rhian M. Touyz, J. David Spence, Daniel Batlle, Mohammed Barigou, Morris Brown, Robert M. Carey, Fernando Elijovich, Sandra Taler, Ian B. Wilkinson
Review
Engineering, Biomedical
Alessandro Giudici, Ian B. Wilkinson, Ashraf W. Khir
Summary: The arterial wall is composed of various components such as collagen and elastin fibers, proteoglycans, Vascular Smooth Muscle Cells (VSMCs) and ground matrix, which play different roles in determining the mechanical properties of the vascular tissue. Experimental methods including microscopy imaging and mechanical testing have been used to study the mechanical role of these structural proteins, but combining these methods provides a more complete understanding of the arterial micromechanics. Advances in imaging techniques allow for dynamic imaging of samples under a pseudo-physiological condition, overcoming the limitations of using either method separately. This review aims to describe the techniques available for studying arterial wall micromechanics and to identify gaps in current research on arterial mechanics.
IEEE REVIEWS IN BIOMEDICAL ENGINEERING
(2021)