Article
Medicine, General & Internal
Ivete Matias Xavier, Ana Carolina Zimmermann Simoes, Ronnier de Oliveira, Yasha Emerenciano Barros, Ayane Cristine Alves Sarmento, Kleyton Santos de Medeiros, Ana Paula Ferreira Costa, Henri Korkes, Ana Katherine Goncalves
Summary: The objective of this study was to determine the adverse outcomes in pregnant women with hypertensive disorders of pregnancy. A cross-sectional study was conducted on women admitted to a university maternity hospital from August 2020 to August 2022. Women with preeclampsia/eclampsia had higher risks of cesarean section, preterm delivery, prolonged maternal hospitalization, neonatal intensive care unit admission, and perinatal mortality compared to those with chronic/gestational hypertension. Strategies for preventing and managing preeclampsia/eclampsia should be implemented to improve pregnancy outcomes.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Endocrinology & Metabolism
Xiujuan Su, Yang Liu, Guohua Li, Xiaosong Liu, Shijia Huang, Tao Duan, Qiaoling Du
Summary: This study found that hypothyroxinemia during pregnancy was associated with an increased risk of preeclampsia-eclampsia, especially in women with persistent hypothyroxinemia in early pregnancy. However, there was no significant association between hypothyroxinemia and gestational hypertension.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
Alisse Hauspurg, Arun Jeyabalan
Summary: High blood pressure in the postpartum period can occur in women with antenatal hypertensive disorders or develop de novo. The distinction between postpartum preeclampsia or eclampsia and those with antepartum onset is unclear. The diagnosis of postpartum preeclampsia should be considered in women with new-onset hypertension 48 hours to 6 weeks after delivery. There are limited evidence-based guidelines for the diagnosis and management of this condition. Risk factors for postpartum preeclampsia include older maternal age, black race, maternal obesity, and cesarean delivery. Prompt recognition and treatment are important, as delayed-onset postpartum preeclampsia can lead to maternal morbidity. Further research is needed to better understand the pathophysiology and specific risk factors. Improved understanding of postpartum preeclampsia is crucial for patient care, counseling, and reducing maternal morbidity and mortality in the postpartum period.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Kirti Balyan, Benchumi Y. Humtso, Bhawana Meena, Surbhi Sapna, Anjali Rana, Manisha Kumar
Summary: This study aimed to evaluate the impact of placental growth factor (PlGF) on maternal-fetal outcomes in high-risk women. The results showed that low PlGF levels at 28-30 weeks were associated with a high likelihood of developing early onset pre-eclampsia, and gestational age-specific cutoffs for PlGF should be considered.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Health Care Sciences & Services
Marija Majda Perisic, Klemo Vladimir, Sarah Karpov, Mario Storga, Ali Mostashari, Raya Khanin
Summary: Preeclampsia and gestational hypertensive disorders are common complications of pregnancy with long-term consequences. This study developed a risk score using machine learning to screen for GHD early. It confirmed that high BMI is a risk factor for GHD and explored the relationship between GHD and genetically constructed anthropometric measures and biomarkers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Emergency Medicine
Marina Boushra, Sreeja M. Natesan, Alex Koyfman, Brit Long
Summary: Eclampsia is a serious postpartum condition with high morbidity and mortality rates. It is often difficult to diagnose, but emergency clinicians can improve recognition and management by understanding its clinical features.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Obstetrics & Gynecology
Ibrahim Kale, Merve Dizdar
Summary: The study aimed to investigate the concentrations of cardiotrophin-1 (CT-1) in the serum of pregnant women with preeclampsia. A cross-sectional study was conducted with 88 pregnant women, including 44 diagnosed with preeclampsia and 44 healthy pregnant women as the control group. No significant difference was found in the maternal serum CT-1 concentrations between the preeclampsia and control groups. The role of CT-1 in the pathophysiology of preeclampsia remains unclear.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Mandy Goldberg, Mary Diaz-Santana, Katie M. O'Brien, Shanshan Zhao, Clarice R. Weinberg, Dale P. Sandler
Summary: This study examined the association between gestational hypertensive disorders and breast cancer in a cohort of women with a family history of breast cancer. The results showed that a history of gestational hypertensive disorder was not associated with breast cancer risk.
Review
Peripheral Vascular Disease
Natalie A. Cameron, Ian K. Everitt, Kristen A. Lee, Lynn M. Yee, Sadiya S. Khan
Summary: Hypertension is a significant risk factor for cardiovascular disease in the US, and its prevalence during pregnancy has almost doubled in the past decade. High blood pressure during pregnancy is concerning due to increased risks of maternal and fetal complications and long-term cardiovascular risks. Identifying chronic hypertension during pregnancy can provide insights into cardiovascular disease risk and offer opportunities for risk reduction. Equitable healthcare interventions during the peripartum period can have a significant impact on preventing chronic hypertension and reducing lifetime cardiovascular disease risk.
Article
Environmental Sciences
Sumonthip Leelawai, Chitkasaem Suwanrath, Nannapat Pruphetkaew, Pensri Chongphattararot, Pornchai Sathirapanya
Summary: This study investigated the association between gestational Bell's palsy and late obstetric complications, revealing a potential relationship between gestational Bell's palsy and lower birth weight in newborns, although the association with other complications remains inconclusive.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Cell Biology
Shanshan Lin, Lifang Zhang, Songying Shen, Dongmei Wei, Jinhua Lu, Xiaojuan Chen, Qiaozhu Chen, Xiaoyan Xia, Qiu Xiu
Summary: The study found that platelet parameters before 20 weeks of gestation are associated with hypertensive disorders of pregnancy, with increased platelet count and plateletcrit before 20 weeks linked to a higher risk of preeclampsia/eclampsia and gestational hypertension. Elevated MPV was only associated with gestational hypertension.
Article
Public, Environmental & Occupational Health
Wen Jiang, Guoqi Yu, Cuiping Wang, Shengju Yin, Yun Huang, Qian Chen, Kun Sun, Jun Zhang
Summary: This study investigated the associations between exposure to a mixture of air pollutants during the first and second trimesters of pregnancy and the risks of hypertensive disorders in pregnancy (HDP) and its subtypes. The results showed that exposure to carbon monoxide, fine particulate matter, and sulfur dioxide in the second trimester was positively associated with the risk of gestational hypertension, while exposure to ozone in the first trimester was associated with an increased risk of preeclampsia/eclampsia. The weighted quantile sum regression confirmed positive associations between the mixture of air pollutants and HDP subtypes.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Obstetrics & Gynecology
Kelly S. Gibson, C. Andrew Combs, Samuel Bauer, Rebecca Feldman Hamm, Andrew Healy, Jamie Morgan, Lorraine Toner, Amy Whitsel
Summary: Hypertensive disorders of pregnancy are a major cause of maternal morbidity and mortality, so it is necessary to establish corresponding follow-up metrics to improve the timely follow-up rate of patients with severe hypertension.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Clinical Neurology
Jason Raina, Amira El-Messidi, Ahmad Badeghiesh, Togas Tulandi, Tuong-Vi Nguyen, Eva Suarthana
Summary: This population-based retrospective study of over 9 million pregnant women in the United States found increasing rates of maternal mental disorders, with anxiety showing the greatest increase. Only anxiety was consistently associated with an increased risk of gestational hypertension, preeclampsia, and eclampsia. Targeted screening for mental disorders in pregnant women, particularly anxiety, may aid in timely prevention and surveillance of hypertensive disorders of pregnancy.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Medicine, General & Internal
Elzbieta Poniedzialek-Czajkowska, Radzislaw Mierzynski, Dominik Dluski, Bozena Leszczynska-Gorzelak
Summary: Hypertensive disorders of pregnancy, such as preeclampsia, pose significant risks to both mother and fetus. Aspirin is currently the only recommended pharmacological agent for prevention in high-risk groups, while metformin shows potential as an interesting option for prophylaxis, although further research is needed to clarify its effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Acoustics
M. H. Zafarmand, S. M. T. A. Goossens, P. Tajik, P. M. M. Bossuyt, E. Asztalos, G. J. Gardener, A. R. Willan, F. J. M. E. Roumen, B. W. Mol, Y. (Jon) Barrett
Summary: This secondary analysis of the Twin Birth Study demonstrated that the planned delivery mode (CD or VD) in twin pregnancies with the first twin in cephalic presentation may have different effects on perinatal outcomes depending on gestational age at delivery. For pregnancies delivered at 32-37 weeks, planned VD appeared to be favorable, while from around 37 weeks onwards, planned CD might be safer. Evaluating the risks and benefits of each delivery mode is crucial to optimize perinatal outcomes in twin pregnancies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Editorial Material
Peripheral Vascular Disease
Abhilash Koratala, Gajapathiraju Chamarthi, Rhian M. Touyz, Anna F. Dominiczak, Fernando Elijovich, J. David Spence, Clarence E. Grim, Sandra J. Taler, Rajesh Mohandas
Correction
Genetics & Heredity
Praveen Surendran, Elena V. Feofanova, Najim Lahrouchi, Ioanna Ntalla, Savita Karthikeyan, James Cook, Lingyan Chen, Borbala Mifsud, Chen Yao, Aldi T. Kraja, James H. Cartwright, Jacklyn N. Hellwege, Ayush Giri, Vinicius Tragante, Gudmar Thorleifsson, Dajiang J. Liu, Bram P. Prins, Isobel D. Stewart, Claudia P. Cabrera, James M. Eales, Artur Akbarov, Paul L. Auer, Lawrence F. Bielak, Joshua C. Bis, Vickie S. Braithwaite, Jennifer A. Brody, E. Warwick Daw, Helen R. Warren, Fotios Drenos, Sune Fallgaard Nielsen, Jessica D. Faul, Eric B. Fauman, Cristiano Fava, Teresa Ferreira, Christopher N. Foley, Nora Franceschini, He Gao, Olga Giannakopoulou, Franco Giulianini, Daniel F. Gudbjartsson, Xiuqing Guo, Sarah E. Harris, Aki S. Havulinna, Anna Helgadottir, Jennifer E. Huffman, Shih-Jen Hwang, Stavroula Kanoni, Jukka Kontto, Martin G. Larson, Ruifang Li-Gao, Jaana Lindstrom, Luca A. Lotta, Yingchang Lu, Jian'an Luan, Anubha Mahajan, Giovanni Malerba, Nicholas G. D. Masca, Hao Mei, Cristina Menni, Dennis O. Mook-Kanamori, David Mosen-Ansorena, Martina Muller-Nurasyid, Guillaume Pare, Dirk S. Paul, Markus Perola, Alaitz Poveda, Rainer Rauramaa, Melissa Richard, Tom G. Richardson, Nuno Sepulveda, Xueling Sim, Albert V. Smith, Jennifer A. Smith, James R. Staley, Alena Stanakova, Patrick Sulem, Sebastien Theriault, Unnur Thorsteinsdottir, Stella Trompet, Tibor V. Varga, Digna R. Velez Edwards, Giovanni Veronesi, Stefan Weiss, Sara M. Willems, Jie Yao, Robin Young, Bing Yu, Weihua Zhang, Jing-Hua Zhao, Wei Zhao, Wei Zhao, Evangelos Evangelou, Stefanie Aeschbacher, Eralda Asllanaj, Stefan Blankenberg, Lori L. Bonnycastle, Jette Bork-Jensen, Ivan Brandslund, Peter S. Braund, Stephen Burgess, Kelly Cho, Cramer Christensen, John Connell, Renee de Mutsert, Anna F. Dominiczak, Marcus Dorr, Gudny Eiriksdottir, Aliki-Eleni Farmaki, J. Michael Gaziano, Niels Grarup, Megan L. Grove, Goran Hallmans, Torben Hansen, Christian T. Have, Gerardo Heiss, Marit E. Jorgensen, Pekka Jousilahti, Eero Kajantie, Mihir Kamat, AnneMari Karajamaki, Fredrik Karpe, Heikki A. Koistinen, Csaba P. Kovesdy, Kari Kuulasmaa, I Laatikainen, Lars Lannfelt, I-Te Lee, Wen-Jane Lee, Allan Linneberg, Lisa W. Martin, Marie Moitry, Girish Nadkarni, Matt J. Neville, Colin N. A. Palmer, George J. Papanicolaou, Oluf Pedersen, James Peters, Neil Poulter, Asif Rasheed, Katrine L. Rasmussen, N. William Rayner, Reedik Magi, Frida Renstrom, Rainer Rettig, Jacques Rossouw, Pamela J. Schreiner, Peter S. Sever, Emil L. Sigurdsson, Tea Skaaby, Yan V. Sun, Johan Sundstrom, Gudmundur Thorgeirsson, Tonu Esko, Elisabetta Trabetti, Philip S. Tsao, Tiinamaija Tuomi, Stephen T. Turner, Ioanna Tzoulaki, Ilonca Vaartjes, Anne-Claire Vergnaud, Cristen J. Willer, Peter W. F. Wilson, Daniel R. Witte, Ekaterina Yonova-Doing, He Zhang, Naheed Aliya, Peter Almgren, Philippe Amouyel, Folkert W. Asselbergs, Michael R. Barnes, Alexandra I. Blakemore, Michael Boehnke, Michiel L. Bots, Erwin P. Bottinger, Julie E. Buring, John C. Chambers, Yii-Der Ida Chen, Rajiv Chowdhury, David Conen, Adolfo Correa, George Davey Smith, Rudolf A. de Boer, Ian J. Deary, George Dedoussis, Panos Deloukas, Emanuele Di Angelantonio, Paul Elliott, Stephan B. Felix, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W. Franks, Stephen Franks, Philippe Frossard, Giovanni Gambaro, Tom R. Gaunt, Leif Groop, Vilmundur Gudnason, Tamara B. Harris, Caroline Hayward, Branwen J. Hennig, Karl-Heinz Herzig, Erik Ingelsson, Jaakko Tuomilehto, Marjo-Riitta Jarvelin, J. Wouter Jukema, Sharon L. R. Kardia, Frank Kee, Jaspal S. Kooner, Charles Kooperberg, Lenore J. Launer, Lars Lind, Ruth J. F. Loos, Abdulla al Shafi. Majumder, Markku Laakso, Mark I. McCarthy, Olle Melander, Karen L. Mohlke, Alison D. Murray, Borge Gronne Nordestgaard, Marju Orho-Melander, Chris J. Packard, Sandosh Padmanabhan, Walter Palmas, Ozren Polasek, David J. Porteous, Andrew M. Prentice, Michael A. Province, Caroline L. Relton, Kenneth Rice, Paul M. Ridker, Olov Rolandsson, Frits R. Rosendaal, Jerome I. Rotter, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Naveed Sattar, Wayne H. -H. Sheu, Blair H. Smith, Nicole Soranzo, Timothy D. Spector, John M. Starr, Sylvain Sebert, Kent D. Taylor, Timo A. Lakka, Nicholas J. Timpson, Martin D. Tobin, Pim van der Harst, Peter van der Meer, Vasan S. Ramachandran, Niek Verweij, Jarmo Virtamo, Uwe Volker, David R. Weir, Eleftheria Zeggini, Fadi J. Charchar, Nicholas J. Wareham, Claudia Langenberg, Maciej Tomaszewski, Adam S. Butterworth, Mark J. Caulfield, John Danesh, Todd L. Edwards, Hilma Holm, Adriana M. Hung, Cecilia M. Lindgren, Chunyu Liu, Alisa K. Manning, Andrew P. Morris, Alanna C. Morrison, Christopher J. O'Donnell, Bruce M. Psaty, Danish Saleheen, Kari Stefansson, Eric Boerwinkle, Daniel I. Chasman, Daniel Levy, Christopher Newton-Cheh, Patricia B. Munroe, Joanna M. M. Howson
Meeting Abstract
Peripheral Vascular Disease
Linsay McCallum, Stefanie Lip, Francisco J. Rios, Karla B. Neves, Jason Kilmartin, Eleanor Murray, Salil Reetoo, Laura Knox, Maggie Rostron, Angela Lucas-Herald, Clea Du Toit, Tomasz J. Guzik, Christian Delles, Augusto C. Montezano, Anna F. Dominiczak, Sandosh Padmanabhan, Rhian M. Touyz
Meeting Abstract
Peripheral Vascular Disease
Stefanie Lip, Linsay McCallum, Clea du Toit, Jason Kilmartin, Eleanor Murray, Salil Reetoo, Laura Knox, Maggie Rostron, Tomasz J. Guzik, Christian Delles, Anna F. Dominiczak, Rhian M. Touyz, Sandosh Padmanabhan
Article
Obstetrics & Gynecology
Rehan Khan, Kim Hinshaw
Summary: The avoidance of harm is crucial in healthcare, especially in women's health. Human factors' training can reduce harm and improve safety culture, but it needs to be coupled with approaches to improving organizational culture and adopting safe systems in healthcare.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Editorial Material
Peripheral Vascular Disease
Antoine-Guy Lopez, Anna F. Dominiczak, Rhian Touyz, Markus Schlaich, Jean-Baptiste de Freminville, Laurence Amar
Editorial Material
Peripheral Vascular Disease
Scott Leopold, Rhian Touyz, Anna F. Dominiczak, Joseph T. Flynn, Anna Szyndler, Justin P. Zachariah
Article
Medicine, General & Internal
Peter W. Horby, Guilherme Pessoa-Amorim, Natalie Staplin, Jonathan R. Emberson, Mark Campbell, Enti Spata, Leon Peto, Nigel J. Brunskill, Simon Tiberi, Victor Chew, Thomas Brown, Hasan Tahir, Beate Ebert, David Chadwick, Tony Whitehouse, Rahuldeb Sarkar, Clive Graham, J. Kenneth Baillie, Buddha Basnyat, Maya H. Buch, Lucy C. Chappell, Jeremy Day, Saul N. Faust, Raph L. Hamers, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with COVID-19, aspirin was not associated with reductions in 28-day mortality or in the risk of progressing to invasive mechanical ventilation or death, but was associated with a small increase in the rate of being discharged alive within 28 days.
Editorial Material
Peripheral Vascular Disease
Jing Chen, Xin Chen, Anna F. Dominiczak, Robert M. Carey, Cheryl L. Laffer, Fernando Elijovich, Sandra J. Taler, Tanja Dudenbostel, Rhian M. Touyz, Ji-Guang Wang
Article
Genetics & Heredity
Nhu Ngoc Le, Tran Q. B. Tran, Stefanie Lip, Linsay McCallum, John McClure, Anna F. Dominiczak, Dipender Gill, Sandosh Padmanabhan
Summary: The genetic predisposition to high systolic blood pressure is associated with an increased risk of cardiovascular diseases such as coronary artery disease, stroke, heart failure, atrial fibrillation, and type 2 diabetes mellitus. Similarly, genetic predisposition to high diastolic blood pressure is associated with an increased risk of stroke and coronary artery disease.
Review
Peripheral Vascular Disease
Sheon Mary, Philipp Boder, Sandosh Padmanabhan, Martin W. McBride, Delyth Graham, Christian Delles, Anna F. Dominiczak
Summary: The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in kidney and cardiovascular research. Variants of uromodulin are associated with chronic kidney diseases and hypertension. Urinary and circulating uromodulin levels reflect kidney and cardiovascular health and overall mortality. Genetically driven levels of uromodulin have been shown to have a causal and adverse effect on kidney function. Uromodulin is involved in salt reabsorption and plays a significant role in the pathophysiology of hypertension. This review provides an overview of the multifaceted physiology and pathophysiology of uromodulin, including recent advances in its genetics, cellular trafficking, and mechanistic and clinical studies.
Article
Peripheral Vascular Disease
Catriona E. Brown, Helen Casey, Anna F. Dominiczak, Shona Kerr, Archie Campbell, Christian Delles
Summary: A study on the Scottish population found that women with a history of preeclampsia have a higher risk of cardiovascular events in the future. Among women with pregnancies, the proportion of cardiovascular events in the preeclampsia group was 25/5253, compared to 193/5253 in the normotensive group. The study highlights the importance of implementing uniform guidelines to improve the health of women with this medical history.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Medicine, General & Internal
Peter W. Horby, Jonathan R. Emberson, Marion Mafham, Mark Campbell, Leon Peto, Guilhenne Pessoa-Amorim, Enti Spata, Natalie Staplin, Catherine Lowe, David R. Chadwick, Christopher Brightling, Richard Stewart, Paul Collini, Abdul Ashish, Christopher A. Green, Ben Prudon, Timothy Felton, Anthony Kerry, J. Kenneth Baillie, Maya H. Such, Jeremy Day, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Marian Knight, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Richard Haynes, Martin J. Landray
Summary: This study evaluated the use of baricitinib in the treatment of patients hospitalized with COVID-19. The results showed that baricitinib significantly reduced the risk of death, although the effect size was slightly smaller than previous trials. Overall evidence suggests that JAK inhibitors can reduce mortality in hospitalized COVID-19 patients by about 20%.
Article
Medicine, General & Internal
Peter W. Horby, Marion Mafham, Leon Peto, Mark Campbell, Guilherme Pessoa-Amorim, Enti Spata, Natalie Staplin, Jonathan R. Emberson, Benjamin Prudon, Paul Hine, Thomas Brown, Christopher A. Green, Rahuldeb Sarkar, Purav Desai, Bryan Yates, Tom Bewick, Simon Tiberi, Tim Felton, J. Kenneth Baillie, Maya H. Bitch, Lucy C. Chappell, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, David M. Weinreich, Richard Haynes, Martin J. Landray
Summary: This study evaluated the efficacy and safety of the combination therapy of casirivimab and imdevimab in patients hospitalized with COVID-19. The results showed that this combination therapy reduced the 28-day mortality rate in patients without detectable antibodies to SARS-CoV-2 infection at baseline, but not in those with detectable antibodies.