Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yanhao Qiu, Mailin Gan, Xingyu Wang, Tianci Liao, Qiuyang Chen, Yuhang Lei, Lei Chen, Jinyong Wang, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: Excessive expansion of adipocytes can lead to ectopic fat deposition, increasing the risk of metabolic diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in fat cell differentiation and adipogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mahesha Gangadhariah, Triveni Pardhi, Jahnavi Ravilla, Subhash Chandra, Sridevi Annapurna Singh
Summary: PPAR gamma agonists are effective in treating type 2 diabetes but have severe side effects. Lemon contains eriocitrin, which may have potential as a PPAR gamma agonist.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Medicine, Research & Experimental
Jung Seok Hwang, Eunsu Kim, Hyuk Gyoon Lee, Won Jin Lee, Jun Pil Won, Jinwoo Hur, Junichi Fujii, Han Geuk Seo
Summary: The study shows that peroxisome proliferator-activated receptor delta (PPAR delta) inhibits ferroptosis in mouse embryonic fibroblasts (MEFs) derived from cysteine/glutamate transporter (xCT)-knockout mice by regulating catalase expression. The effects associated with PPAR delta are counteracted in the presence of a specific inhibitor of catalase, indicating the importance of catalase for the effect of PPAR delta on ferroptosis triggered by xCT deficiency.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Lara Senn, Anna-Maria Costa, Rossella Avallone, Katarzyna Socala, Piotr Wlaz, Giuseppe Biagini
Summary: The peroxisome proliferator-activated receptor gamma (PPAR gamma), known for its role in metabolic disorders, has been increasingly investigated for its potential involvement in neurological diseases, particularly in epilepsy. Epilepsy, a chronic neurological disorder, has a significant impact on patients' psychological, social, and economic well-being. With a global prevalence of 0.5%-1.0%, epilepsy ranks fourth in importance among neurological disorders. This review focuses on recent findings regarding the intracellular processes dependent on PPAR gamma and their potential anti-seizure effects, as well as promising results from clinical investigations involving PPAR gamma agonists and the ketogenic diet in epilepsy rodent models.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Hiroyuki Miyachi
Summary: Recent progress in understanding the structure and pharmacology of hPPAR gamma has allowed for investigation of various ligands and their effects on biological responses. These ligands serve as valuable tools for studying hPPAR gamma function and potential drugs for hPPAR gamma-related diseases. This review summarizes the medicinal chemistry research on the design, synthesis, and evaluation of hPPAR gamma antagonists based on the induction/inhibition concept of helix 12 (H12) and presents X-ray crystallographic analyses of their unique binding modes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Xiang-Yu Wu, Li Nie, Xin-Jiang Lu, Chen-Jie Fei, Jiong Chen
Summary: In this study, the role of PPAR gamma in immune regulation in teleost fish was investigated. Results showed that the expression of LcPPAR gamma changed during infection and DHA treatment, and was associated with the expression of immune-related genes.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Microbiology
Yi-Hsin Lai, Tai-Chieh Wu, Bo-Yang Tsai, Yuan-Pin Hung, Hsiao-Ju Lin, Yau-Sheng Tsai, Wen-Chien Ko, Pei-Jane Tsai
Summary: PPAR-γ plays an important role in the pathogenesis of CDI by regulating colonic inflammation and integrity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Review
Oncology
Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Cell Biology
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo
Summary: This review discusses the roles of peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma in transcriptional regulation, energy metabolism, inflammation regulation, cellular development, and differentiation. PPAR signaling pathways play important roles in the development of viral, bacterial, and parasitic infectious diseases. The review also explores the potential therapeutic uses of PPAR agonists/antagonists in infectious disease treatment.
Article
Agriculture, Dairy & Animal Science
Guoyan Wang, Jun Zhang, Shengru Wu, Senlin Qin, Yining Zheng, Chao Xia, Huijun Geng, Junhu Yao, Lu Deng
Summary: Cattle have a unique mechanism for efficient hepatic gluconeogenesis, involving the high expression of specific genes and the activation of the mTORC1 signaling pathway. These findings are important for understanding the mechanism underlying the quantitative differences in hepatic gluconeogenesis efficiency between cattle and non-ruminant animals.
Meeting Abstract
Cardiac & Cardiovascular Systems
Taishi Nakamura, Hisao Ogawa
JOURNAL OF CARDIAC FAILURE
(2015)
Article
Medicine, Research & Experimental
Taishi Nakamura, Mark J. Ranek, Dong I. Lee, Virginia Shalkey Hahn, Choel Kim, Philip Eaton, David A. Kass
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Cardiac & Cardiovascular Systems
Taishi Nakamura, Guangshuo Zhu, Mark J. Ranek, Kristen Kokkonen-Simon, Manling Zhang, Grace E. Kim, Kenichi Tsujita, David A. Kass
CIRCULATION-HEART FAILURE
(2018)
Article
Cardiac & Cardiovascular Systems
Shinsuke Hanatani, Yasuhiro Izumiya, Yoshiro Onoue, Tomoko Tanaka, Masahiro Yamamoto, Toshifumi Ishida, Satoru Yamamura, Yuichi Kimura, Satoshi Araki, Yuichiro Arima, Taishi Nakamura, Koichiro Fujisue, Seiji Takashio, Daisuke Sueta, Kenji Sakamoto, Eiichiro Yamamoto, Sunao Kojima, Koichi Kaikita, Kenichi Tsujita
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Manling Zhang, Eiki Takimoto, Dong-ik Lee, Celio X. C. Santos, Taishi Nakamura, Steven Hsu, Aiyang Jiang, Takahiro Nagayama, Djahida Bedja, Yuan Yuan, Philip Eaton, Ajay M. Shah, David A. Kass
Article
Cardiac & Cardiovascular Systems
Yoshiro Onoue, Yasuhiro Izumiya, Shinsuke Hanatani, Toshifumi Ishida, Yuichiro Arima, Satoru Yamamura, Yuichi Kimura, Satoshi Araki, Masanobu Ishii, Taishi Nakamura, Yu Oimatsu, Kenji Sakamoto, Eiichiro Yamamoto, Sunao Kojima, Koichi Kaikita, Kenichi Tsujita
CIRCULATION JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Masafumi Takae, Eiichiro Yamamoto, Koichiro Fujisue, Fumi Oike, Taiki Nishihara, Daisuke Sueta, Hiroki Usuku, Kota Motozato, Miwa Ito, Shinsuke Hanatani, Hisanori Kanazawa, Yuichiro Arima, Seiji Takashio, Taishi Nakamura, Satoru Suzuki, Kenji Sakamoto, Yasuhiro Izumiya, Hirofumi Soejima, Sunao Kojima, Hiroshige Yamabe, Koichi Kaikita, Kenichi Tsujita
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Junichi Matsubara, Seigo Sugiyama, Koichi Sugamura, Taishi Nakamura, Yukio Fujiwara, Eiichi Akiyama, Hirofumi Kurokawa, Toshimitsu Nozaki, Keisuke Ohba, Masaaki Konishi, Hirofumi Maeda, Yasuhiro Izumiya, Koichi Kaikita, Hitoshi Sumida, Hideaki Jinnouchi, Kunihiko Matsui, Shokei Kim-Mitsuyama, Motohiro Takeya, Hisao Ogawa
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2012)
Meeting Abstract
Cardiac & Cardiovascular Systems
Satoru Yamamura, Yasuhiro Izumiya, Satoshi Araki, Toshifumi Ishida, Masahiro Yamamoto, Taishi Nakamura, Yuichiro Arima, Kenichi Tsujita
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Multidisciplinary Sciences
Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, Brittany L. Dunkerly-Eyring, Miguel Pinilla Vera, Christian U. Oeing, Chirag H. Patel, Taishi Nakamura, Guangshuo Zhu, Djahida Bedja, Masayuki Sasaki, Ronald J. Holewinski, Jennifer E. Van Eyk, Jonathan D. Powell, Dong Ik Lee, David A. Kass
Article
Medicine, Research & Experimental
Kristen M. Kokkonen-Simon, Amir Saberi, Taishi Nakamura, Mark J. Ranek, Guangshuo Zhu, Djahida Bedja, Michaela Kuhn, Marc K. Halushka, Dong Ik Lee, David A. Kass
Meeting Abstract
Cardiac & Cardiovascular Systems
Taishi Nakamura, Guangshuo Zhu, Mark J. Ranek, Kenichi Tsujita, David Kass
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark J. Ranek, Kristen M. Kokkonen, Ronald J. Holewinski, Dong I. Lee, Taishi Nakamura, Guangshuo Zhu, Masayuki Sasaki, Jennifer E. Van Eyk, David A. Kass
Article
Peripheral Vascular Disease
Guangshuo Zhu, Dieter Groneberg, Gautam Sikka, Daijiro Hori, Mark J. Ranek, Taishi Nakamura, Eiki Takimoto, Nazareno Paolocci, Dan E. Berkowitz, Andreas Friebe, David A. Kass
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark J. Ranek, Taishi Nakamura, Ronald Holewinski, Dong-ik Lee, Guangshuo Zhu, Khalid Chakir, Philip Eaton, Jennifer Van Eyk, David A. Kass