Article
Biochemistry & Molecular Biology
Olga Tepla, Zinovij Topurko, Simona Jirsova, Martina Moosova, Eva Fajmonova, Radek Cabela, Katerina Komrskova, Irena Kratochvilova, Jaromir Masata
Summary: The aim of this study was to evaluate the efficiency of using meiotic spindle (MS) visibility and relative position to the polar body (PB) as indicators of oocyte maturation in order to optimize intracytoplasmic sperm injection (ICSI) timing. The visualization of MS influenced the pregnancy rate (PR) for patients over 35 years, but did not affect PR for patients under 35 years. Visualization of MS appears to be a useful parameter for assessment of oocyte maturity and ICSI timing for patients older than 35.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Alessandro Bartolacci, Giulia Intra, Giovanni Coticchio, Miriam dell'Aquila, Gilda Patria, Andrea Borini
Summary: This study aims to investigate the impact of oocyte dysmorphisms on the outcomes of assisted reproduction treatments based on the existing scientific literature. Eleven different dysmorphisms were identified, and the COC morphology, vacuoles, SER clusters, and granularity were found to be predominantly associated with negative outcomes.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Medicine, General & Internal
Houjin Dongye, Yizheng Tian, Dan Qi, Yanbo Du, Lei Yan
Summary: The influence of endometrioma on oocyte and embryo competence is inconclusive, and the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and explore whether surgery could improve oocyte and embryo competence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Bo Yu, Helena T. A. van Tol, Tom A. E. Stout, Bernard A. J. Roelen
Summary: This study confirms the presence of cellular fragments in the perivitelline space of bovine IVP blastocysts through mechanical hatching, but this is not an indicator of embryo quality. Surprisingly, there is no significant difference in embryo quality between expanded blastocysts with and without cellular fragments in the perivitelline space.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhe Han, Xin Hao, Cheng-Jie Zhou, Jun Wang, Xin Wen, Xing-Yue Wang, De-Jian Zhang, Cheng-Guang Liang
Summary: The study investigated the expression profiles and functional roles of CLTC in sheep oocytes and found that CLTC plays crucial regulatory roles in sheep oocyte maturation and early embryo development, especially in spindle dynamics and early embryo development. The results indicate that CLTC is essential for spindle formation and chromosomal alignment, as well as for proper early embryo development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Carlotta Scarafia, Martina Masciovecchio, Stefano Canosa, Andrea Roberto Carosso, Gianluca Gennarelli, Alberto Revelli, Chiara Benedetto
Summary: The study found that in women with ovarian endometriosis, ICSI can be performed without harming oocytes or affecting the outcome. Additionally, there is no advantage in removing endometrioma before ICSI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Ivan Valdebenito, Elias Figueroa, Matias Valdebenito, Luis Paiva
Summary: The study characterized different chorion alterations observed in samples collected from salmon and trout farms in southern Chile over a period of 14 years. Soft chorion was identified as the most common alteration, primarily affecting Atlantic and Coho Salmon. Rainbow Trout exhibited fewer chorion alterations compared to the other two species. Results suggest that these alterations may be linked to changes in environmental conditions affecting the incubation water.
Review
Medicine, General & Internal
Lauren Lacey, Sibte Hassan, Sebastian Franik, Mourad W. Seif, M. Ahsan Akhtar
Summary: The effects of assisted hatching (AH) on live birth rates are uncertain and may increase the risk of multiple pregnancies. Although AH may offer a slightly increased chance of achieving a clinical pregnancy, the quality of data is low, and it is uncertain whether it influences miscarriage rates.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Obstetrics & Gynecology
Martin Stimpfel, Nina Jancar, Eda Vrtacnik-Bokal
Summary: Collecting semen samples at home has a positive effect on sperm quality, but no significant differences in cycle outcomes are observed when these samples are used in IVF/ICSI cycles.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Biochemistry & Molecular Biology
Guangyi Cao
Summary: The correct assembly and regulation of the spindle apparatus are crucial for the precise separation of chromosomes in mouse oocytes. NUSAP1 is a spindle-associated protein that plays an important role in oocyte meiosis maturation. Its depletion leads to chromosome misalignment, aneuploidy, and abnormal spindle assembly.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Hao Qin, Yi Qu, Yi-Feng Yuan, Yang-Yang Li, Jie Qiao
Summary: This study revealed that RBM14 is down-regulated in oocytes from old mice and shows overlapped localization patterns with alpha-tubulin in different stages of meiosis. Knockdown of RBM14 may result in symmetric division of oocytes, spindle defects, and chromosome abnormalities. Additionally, RBM14 interacts with endogenous alpha-tubulin and modulates oocyte meiotic maturation by affecting alpha-tubulin acetylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Camille Robin, Audrey Uk, Christine Decanter, Helene Behal, Pierre Collinet, Chrystele Rubod, Anne-Laure Barbotin, Geoffroy Robin
Summary: The study aimed to evaluate the relationship between endometriosis and oocyte morphology after controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI) on a large oocyte cohort, finding that endometriosis does not have a negative impact on oocytes' morphology in IVF-ICSI.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Angus D. Macaulay, Chyna S. Ortman, Kevin R. J. Moore, Jay M. Baltz
Summary: The detachment of the fully grown mammalian oocyte from the zona pellucida is mediated by a metallopeptidase, which cleaves the transmembrane ZP proteins that attach the oocyte to the zona pellucida. Inhibitors targeting the M10 and M12 families of metallopeptidases prevent detachment.
BIOLOGY OF REPRODUCTION
(2022)
Article
Reproductive Biology
Chao Lv, Hua-Lin Huang, Da-Jing Yi, Tian-Liu Peng, Hang-Jing Tan, Ru-Ping Quan, Hong-Wen Deng, Hong-Mei Xiao
Summary: This study found that a mutation in the Zp1 gene resulted in the absence of ZP in rat oocytes, leading to infertility and loss of fertilization capacity.
BIOLOGY OF REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Yong-Jie Lu, Qin Li, Li-Xue Chen, Tian Tian, Jia Kang, Yong-Xiu Hao, Jian-Suo Zhou, Yuan-Yuan Wang, Li-Ying Yan, Rong Li, Liang Chang, Jie Qiao
Summary: This study reveals the impact of maternal MTHFR C677T/A1298C combination polymorphisms on oocyte maturation potential and embryo quality. The findings indicate that a reduction in maternal MTHFR activity leads to a decrease in oocyte maturation potential, while women with intermediate MTHFR activity have worse embryo quality.
HUMAN REPRODUCTION OPEN
(2022)