Article
Materials Science, Multidisciplinary
Farin Yazdan Parast, Moira K. O'Bryan, Reza Nosrati
Summary: Selection of high-quality sperm is crucial for assisted reproduction. This article introduces a scalable technology called 'sperm syringe' that mimics the 3D selection process in vivo to select high-quality sperm. Experimental results show that the sperm syringe significantly improves selected sperm morphology and DNA integrity, making it a promising assisted reproductive technology.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Biology
Katarzyna Jankowska, Natalia Suszczewicz, Michal Rabijewski, Piotr Dudek, Wojciech Zgliczynski, Radoslaw B. Maksym
Summary: Biochemical markers of spermatogenesis and fertility assessment are important in the management and prognosis of infertile males. Sperm count and inhibin B concentration are the best predictors of natural fertilization, and it is noteworthy that 81% of pregnancies were achieved without medically assisted reproduction.
Review
Medicine, General & Internal
Martina Balli, Anna Cecchele, Valerio Pisaturo, Sofia Makieva, Giorgia Carullo, Edgardo Somigliana, Alessio Paffoni, Paola Vigano'
Summary: This article reviews the advantages and limitations of conventional IVF and discusses fundamental questions related to the technique. It provides insights into the opportunities and best practices in human c-IVF in the field of reproductive medicine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Andrology
Mohammad H. Alkandari, Joseph Moryousef, Armand Zini
Summary: The study suggests that TESA or micro-TESE does not appear to worsen pre-existing spermatogenesis deficiencies in men with cryptozoospermia or severe oligozoospermia over a long-term period.
Article
Andrology
Maria Teresa Villani, Daria Morini, Giorgia Spaggiari, Angela Immacolata Falbo, Beatrice Melli, Giovanni Battista La Sala, Marilina Romeo, Manuela Simoni, Lorenzo Aguzzoli, Daniele Santi
Summary: The study found that sperm motility and morphology play important roles in predicting fertilization rate, pregnancy rate, and live birth rate in assisted reproductive technology. These parameters can be considered reliable tools to measure the male role in ART outcomes, potentially impacting the clinical management of infertile couples.
Article
Biology
Kathleen Hoi Kei Choy, Sze Yan Chan, William Lam, Jing Jin, Tingting Zheng, Tin Yu Samuel Law, Sidney Siubun Yu, Weiping Wang, Linxian Li, Gangcai Xie, Howard Chi Ho Yim, Hao Chen, Ellis Kin Lam Fok
Summary: This study established a protocol for the isolation and characterization of testicular extracellular vesicles (EVs). The results showed that testicular EVs can be efficiently taken up by somatic cells and germ cells. The proteome and small RNA cargoes of testicular EVs were analyzed, revealing the potential contributions from Leydig cells and testicular macrophages. The study also found that small molecule inhibition of EV secretion can perturb spermatogenesis through inter-compartmental communication.
Article
Multidisciplinary Sciences
Keisuke Shimada, Soojin Park, Haruhiko Miyata, Zhifeng Yu, Akane Morohoshi, Seiya Oura, Martin M. Matzuk, Masahito Ikawa
Summary: The study revealed the crucial role of ARMC12 in sperm mitochondrial sheath formation, with its absence leading to reduced sperm motility and male sterility. ARMC12, a mitochondrial peripheral membrane protein, functions by interacting with mitochondrial membrane proteins VDAC2 and VDAC3 to form the mitochondrial sheath.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Yangyang Wan, Wenjing Liu, Bo Xu, Xiaohua Jiang, Juan Hua
Summary: This study found that paternal MTHFR C677T polymorphism is not associated with embryo quality, pregnancy, or neonatal outcomes in ICSI treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Meghali Joshi, Syed Waseem Andrabi, Ranjeet Kumar Yadav, Satya Narayan Sankhwar, Gopal Gupta, Singh Rajender
Summary: Three miRNAs (hsa-miR-9-3p, hsa-miR-30b-5p, and hsa-miR-122-5p) have been found to have a strong linkage with infertility and high potential as sperm quality biomarkers.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Yasuhiro Yamauchi, Takafumi Matsumura, Jackson Bakse, Hayden Holmlund, Genevieve Blanchet, Emmaelle Carrot, Masahito Ikawa, Monika A. Ward
Summary: This study demonstrates that the loss of Y chromosome encoded Zfy1 and Zfy2 genes results in infertility and severe spermatogenesis defects in mice. The presence of at least one Zfy homolog is essential for male fertility and the normal development of functional sperm in unassisted fertilization. The loss of Zfy2 is mildly detrimental to spermatogenesis, while the loss of Zfy1 is benign.
BIOLOGY OF REPRODUCTION
(2022)
Review
Endocrinology & Metabolism
Aditi Sharma, Suks Minhas, Waljit S. Dhillo, Channa N. Jayasena
Summary: Male infertility due to testicular failure is a common issue, with multiple factors contributing to this condition. While new therapeutic approaches have been developed, there is currently a lack of high-quality clinical trial data available.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Andrology
Leonardo Seligra Lopes, Willy Baccaglini, Bruno von Muhlen, Felipe Placco Araujo Glina, Sergio Albertini Daiuto, Cristiano Linck Pazeto, Sidney Glina
Summary: The study showed that outcomes of ICSI cycles for patients with acquired azoospermia and those with congenital bilateral absence of the vas deferens were similar. However, the congenital group had a higher live birth rate compared to the vasectomy group.
Review
Biochemistry & Molecular Biology
Joao C. Ribeiro, Marco G. Alves, Marc Yeste, Yoon S. Cho, Giuseppe Calamita, Pedro F. Oliveira
Summary: AQPs are a family of channel proteins regulating water and solute transport across biological membranes, with a significant impact on infertility. Understanding the roles and regulation of AQPs in the reproductive system is crucial for improving infertility treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Gurbet Karahan, Josee Martel, Sophia Rahimi, Mena Farag, Fernando Matias, Amanda J. Macfarlane, Donovan Chan, Jacquetta Trasler
Summary: This study assessed the impact of paternal genetic and lifestyle factors on assisted reproductive technology (ART) outcomes. The findings suggest that paternal factors can potentially aggravate morphological and epigenetic defects in embryos conceived through ART.
HUMAN MOLECULAR GENETICS
(2023)
Article
Endocrinology & Metabolism
Songzhan Gao, Xianfeng Yang, Xiaoshuai Xiao, Shujun Yin, Yichun Guan, Jianhuai Chen, Yun Chen
Summary: IntroductionNonobstructive azoospermia (NOA) is a common and severe form of male infertility. Microdissection testicular sperm extraction (microTESE) combined with intracytoplasmic sperm injection (ICSI) is an optimal treatment for men with NOA. However, the outcomes and affecting factors of ICSI for NOA patients with different etiologies receiving microTESE treatment are still unclear.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Artemis Kyriakidou, Angeliki Kyriazou, Theocharis Koufakis, Yiannis Vasilopoulos, Maria Grammatiki, Xanthippi Tsekmekidou, Iakovos Avramidis, Stefanos Baltagiannis, Dimitrios G. Goulis, Pantelis Zebekakis, Kalliopi Kotsa
Summary: This study aimed to identify the genetic and clinical factors related to glycemic control and weight loss response to liraglutide in patients with T2DM. The study found that higher baseline HbA1c and lower baseline weight were associated with better glycemic control response, while higher baseline weight was associated with worse weight loss response.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Christine Aggeli, Maria Patelida, Maria G. Grammatikopoulou, Ekaterini-Avrakomi Matzaridou, Marina Berdalli, Xenophon Theodoridis, Konstantinos Gkiouras, Angeliki Persynaki, Kyriaki Tsiroukidou, Theodore Dardavessis, Christos Tzimos, Dimitrios G. Goulis, Tonia Vassilakou
Summary: Research examines the influence of maternal diet and characteristics on children's diet and household food insecurity. Findings show that maternal diet quality is compromised when facing financial constraints, with a higher prevalence of food insecurity in single-mother families. However, greater maternal education and conjugal family status are associated with lower food insecurity. Maternal adherence to the Mediterranean diet is inversely related to their children's adherence, suggesting potential sacrifices in maternal diet quality to afford a better diet for minors.
Review
Pediatrics
Anastasia Petropoulou, Georgia Bakounaki, Maria G. Grammatikopoulou, Dimitrios P. Bogdanos, Dimitrios G. Goulis, Tonia Vassilakou
Summary: Patients with cystic fibrosis (CF) are at increased risk of developing disordered eating behaviors and eating disorders (EDs) due to the emphasis placed on diet and ideal body weight. Body weight is a significant concern for CF patients, especially women. The onset of disordered eating is often linked to pulmonary infection. Research on the prevalence of EDs in CF patients is conflicting. More research is needed, considering factors such as comorbidities and important outcomes like lung health.
Review
Pharmacology & Pharmacy
Christos A. Venetis, Ben W. Mol
Summary: Biosimilars of follitropin alfa are cheaper alternatives to the reference product for ovarian stimulation in assisted reproductive technology cycles. However, a recent meta-analysis found that these biosimilars are associated with lower live birth and pregnancy rates compared to the reference product. A subsequent opinion paper challenges this analysis but fails to provide solid evidence against it.
DRUG DISCOVERY TODAY
(2023)
Article
Environmental Sciences
Iro-Spyridoula Gounitsioti, Dimitrios Poulimeneas, Maria G. Grammatikopoulou, Charalambos Kotzamanidis, Konstantinos Gkiouras, Meletios P. Nigdelis, Dimitrios Tsolakidis, Alexios Papanikolaou, Basil C. Tarlatzis, Dimitrios P. Bogdanos, Maria Tsigga, Dimitrios G. Goulis
Summary: This study assessed the post-operative versus pre-operative appetite levels in patients with gynecological cancers and found that ghrelin concentrations increased post-operatively while perceived appetite of patients remained unchanged. Tumor removal surgery decreased anthropometric indices and doubled the risk of malnutrition among patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Eleftheria Taousani, Dimitra Savvaki, Efrosini Tsirou, Maria G. Grammatikopoulou, Basil C. Tarlatzis, Dimitrios Vavilis, Dimitrios G. Goulis
Summary: Regular physical activity during pregnancy has a positive effect on both the mother and fetus. This study focused on the effect of exercise in pregnancies complicated by gestational diabetes mellitus (GDM). The results showed that moderate intensity exercise can increase the resting metabolic rate (RMR) in women with GDM, but does not alter substrate utilization.
Article
Obstetrics & Gynecology
Christos Venetis, Elena Keller, Georgina M. Chambers
Summary: Assisted reproductive technologies continue to evolve, with the recent introduction of the freeze-all policy. This policy involves cryopreserving all good-quality embryos for future use, instead of performing a fresh embryo transfer. The freeze-all policy has shown clinical advantages, especially for high responders, but further research and economic evaluations are needed to determine its cost-effectiveness in different patient populations and settings. Additionally, modern freeze-all-specific ovarian stimulation protocols need to be evaluated for their clinical and economic efficacy.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
C. A. Venetis, A. Storr, S. J. Chua, B. W. Mol, S. Longobardi, X. Yin, T. D'Hooghe
Summary: A systematic review and meta-analysis were conducted to evaluate the effectiveness and safety of different GnRH antagonist protocols for assisted reproductive technology (ART) treatments. The results indicated that these protocols have different effects on the probability of live birth and ongoing pregnancy. The available evidence, although of low quality and certainty, suggests that the protocols should not be considered as equivalent for clinical decision-making.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Nutrition & Dietetics
Alexandros Gerontidis, Maria G. Grammatikopoulou, Christos Tzimos, Konstantinos Gkiouras, Eleftheria Taousani, Loukas Athanasiadis, Dimitrios G. Goulis
Summary: This pilot cross-sectional study aimed to assess the prevalence of orthorexia nervosa tendencies and pica practices, as well as record diet practices in pregnant women. The majority of women reported improving their diet during pregnancy, while only a small number had pica tendencies. The use of oral nutrient supplements and the experience of severe nausea and emesis were common among participants.
Review
Pediatrics
Maria G. G. Grammatikopoulou, Konstantinos Gkiouras, Vasiliki Syrmou, Tonia Vassilakou, Theodora Simopoulou, Chistina G. G. Katsiari, Dimitrios G. G. Goulis, Dimitrios P. P. Bogdanos
Summary: Juvenile idiopathic arthritis (JIA) is a chronic autoimmune rheumatic musculoskeletal disease that is diagnosed before the age of 16. Chronic arthritis is a common symptom in all JIA subtypes. JIA and its treatment often lead to nutrition, gastrointestinal, and metabolic issues, particularly related to the use of methotrexate and glucocorticosteroids.
Article
Biochemistry & Molecular Biology
Kyriaki Tsiroukidou, Eleni G. G. Paschalidou, Maria G. G. Grammatikopoulou, John Androulakis, Anastasios Vamvakis, Kalliopi K. K. Gkouskou, Christos Tzimos, Theodoros N. N. Sergentanis, Tonia Vassilakou, Emmanuel Roilides, Dimitrios P. P. Bogdanos, Dimitrios G. G. Goulis
Summary: The International Society of Pediatric and Adolescent Diabetes (ISPAD) recommends the use of metformin (MET) for metabolic disturbances and hyperglycemia in children and adolescents. However, a potential concern of MET therapy is vitamin B-12 deficiency, which has mainly been observed in studies conducted on adults. In this case-control study, it was found that children and adolescents on MET therapy had suboptimal intake of vitamin B-12 and may experience synergistic reduction in circulating vitamin B-12 concentrations when paired with MET. Therefore, caution is needed when prescribing MET for this age group and vitamin B-12 replacement may be necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Maria G. Grammatikopoulou, Meletios P. Nigdelis, Anna-Bettina Haidich, Maria Kyrezi, Helga Ntine, Maria Papaioannou, Gesthimani Mintziori, Dimitrios P. Bogdanos, George Mavromatidis, Dimitrios G. Goulis
Summary: The FIGO nutrition checklist is a useful tool for healthcare professionals to discuss gestational weight gain and nutrition with pregnant women. This cross-sectional study applied the checklist to 200 pregnant women, revealing that 99% exhibited at least one nutritional risk factor. The results suggest a need for improving diet quality and emphasizing certain nutritional factors during prenatal care.
Article
Medicine, General & Internal
Christos Venetis, Stephanie K. Y. Choi, Louisa Jorm, Xian Zhang, William Ledger, Kei Lui, Alys Havard, Michael Chapman, Robert J. Norman, Georgina M. Chambers
Summary: This study investigated the role of underlying infertility and fertility treatment on the risks of congenital anomalies (CAs) in infants. The study found that infants conceived using assisted reproductive technologies (ARTs) had an increased risk for major genitourinary abnormalities, and intracytoplasmic sperm injection (ICSI) in couples without male infertility was associated with this risk.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Stavroula Veneti, Maria G. Grammatikopoulou, Evangelia Kintiraki, Gesthimani Mintziori, Dimitrios G. Goulis
Summary: Ketone bodies are produced in various physiological and pathological conditions, and can serve as an alternative energy source. The ketogenic diet has gained recognition as a therapeutic approach for metabolic disorders such as obesity and diabetes mellitus.
Review
Biochemistry & Molecular Biology
Maria Lantzanaki, Theofanis Vavilis, Vikentia C. Harizopoulou, Helen Bili, Dimitrios G. Goulis, Dimitrios Vavilis
Summary: This review presents the role of ceramides during pregnancy and obstetrical adverse outcomes, as well as their potential as biomarkers in such conditions.
