Article
Endocrinology & Metabolism
Bunpei Ishizuka, Masataka Furuya, Machiko Kimura, Eri Kamioka, Kazuhiro Kawamura
Summary: The study analyzed the effectiveness of HR treatment on patients with POI, showing that OS combined with HR therapy can increase fertility rates, especially in the IVF-1-a and IVF-2 groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Bijun Wang, Wenxia Liu, Yi Liu, Wen Zhang, Chenchen Ren, Yichun Guan
Summary: This study analyzed the impact of unexpected suboptimal response during ovulation induction on pregnancy rate and offspring safety, comparing patients with normal ovarian response and suboptimal ovarian response with a large amount of data. Results showed that factors such as age, BMI, and baseline FSH were associated with slow ovarian response, while initial dosage of Gn, FSH, and LH levels were protective factors against suboptimal response. Age-related differences in the number of retrieved oocytes suggest a decline in ovarian reserve in elderly patients with suboptimal response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaoyu Tu, Bingbing You, Miaomiao Jing, Chenxi Lin, Runju Zhang
Summary: The progestin-primed ovarian stimulation (PPOS) protocol is an effective alternative for advanced age women with diminished ovarian reserve (DOR), providing comparable reproductive outcomes and better control of premature LH surge. It also allows for a higher number of retrieved oocytes and top-quality embryos, which are positively associated with cumulative clinical pregnancy rate and cumulative live birth rate.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
N. Massin, I Abdennebi, G. Porcu-Buisson, N. Chevalier, E. Descat, C. Pietin-Vialle, S. Goro, M. Brussieux, M. Pinto, M. Pasquier, H. Bry-Gauillard
Summary: This study compares the effectiveness of two treatment protocols in assisting conception for patients with poor ovarian response, and the results show that there is no significant difference in the number of oocytes retrieved between the dual ovarian stimulation in the same cycle and two consecutive antagonist cycles.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Barbara Lawrenz, Laura Melado, Shieryl Digma, Junard Sibal, Carol Coughlan, Claus Yding Andersen, Human M. Fatemi
Summary: This study aimed to investigate the impact of systemic FSH concentrations during ovarian stimulation for IVF/intracytoplasmic sperm injection on systemic progesterone concentrations in the late follicular phase. The findings showed that high concentrations of circulatory FSH augment the production of progesterone, while ovarian response seems to be independent from the systemic FSH concentrations on the trigger day.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Hoon Kim, Soo Jin Han, Yun Soo Hong, Sung Woo Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim
Summary: The optimal number of oocytes for maximizing the rate of clinical pregnancy varies depending on the method of pituitary suppression. Too many oocytes may not lead to better clinical outcomes.
REPRODUCTIVE SCIENCES
(2021)
Article
Oncology
Oranite Goldrat, Manon De Cooman, Audrey Mailliez, Anne Delbaere, Emmanuelle D'Orazio, Isabelle Demeestere, Christine Decanter
Summary: This study compared the efficacy and safety of LetCOH and cCOH for FP in breast cancer patients. The results showed that LetCOH and cCOH had similar efficacy in FP. There were no safety concerns regarding cCOH in the adjuvant setting, but longer follow-up is needed.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Obstetrics & Gynecology
Peter Kovacs, Jayapriya Jayakumaran, Yao Lu, Steven R. Lindheim
Summary: This study compares the clinical outcomes of using a new recombinant follicle stimulation hormone, Follitropin-Delta, with Follitropin-alpha in routine IVF procedures. The results show that there were no significant differences in ovarian response, fertilization rate, embryo quality, and clinical pregnancy rate between the two groups. Furthermore, there were similar outcomes between patients who would have qualified and those who would have been disqualified based on previous randomized controlled trial inclusion criteria.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Review
Biology
Romualdo Sciorio, Federica Cariati, Steven Fleming, Carlo Alviggi
Summary: This paper provides an analytical review of the current literature on the correlation between ovarian stimulation procedures and oocyte/embryo quality. It discusses various aspects of oocyte quality, including morphological features, oocyte competence, and the surrounding environment. It also introduces the main noninvasive features and novel approaches to biomechanical parameters that may be correlated with the competence of embryos to produce a healthy pregnancy and live birth.
Review
Obstetrics & Gynecology
Francisca Martinez, Annalisa Racca, Ignacio Rodriguez, Nikolaos P. Polyzos
Summary: This systematic review aimed to summarize evidence on ovarian stimulation in oocyte donors. The review evaluated aspects such as ovarian response assessment, stimulation planning, risk control for complications, and fresh versus vitrified donated oocytes. GnRH agonist triggering is recommended for all oocyte donors due to high oocyte retrieval rates, practical elimination of OHSS, and no differences in pregnancy rates for recipients.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Endocrinology & Metabolism
Yang Wang, Meixiang Zhang, Hao Shi, Shiqi Yi, Qian Li, Yingchun Su, Yihong Guo, Linli Hu, Jing Sun, Ying-pu Sun
Summary: Oocyte retrieval is a common procedure in assisted reproduction technology, but technical difficulties and unsatisfactory number of oocytes obtained are rarely reported. This study found that patients in the unsatisfactory oocyte retrieval group were older, had longer infertility duration, higher hormone levels, and were more likely to have endometriosis. The follicular phase long-acting GnRH agonist protocol was more commonly used in the satisfactory oocyte retrieval group. Unsatisfactory oocyte retrieval did not affect the clinical pregnancy rate, miscarriage rate, or live birth rate during the fresh cycles, but significantly lowered the cumulative pregnancy rate and live birth rate.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Salvatore Giovanni Vitale, Marco Palumbo, Agnese Maria Chiara Rapisarda, Jose Carugno, Cristina Conde-Lopez, Nicolas Mendoza, Raquel Mendoza-Tesarik, Jan Tesarik
Summary: This study suggests that the administration of pentoxifylline during ovarian stimulation can improve the outcomes of in vitro fertilization (IVF) by increasing the quantity and quality of oocytes, improving the quality of zygotes and embryos, increasing serum estradiol concentrations, thickening the endometrium, and improving clinical IVF outcomes.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Eva M. E. Balkenende, Taghride Dahhan, Catharina C. M. Beerendonk, Kathrin Fleischer, Dominic Stoop, Annelies M. E. Bos, Cornelis B. Lambalk, Roel Schats, Jesper M. J. Smeenk, Leonie A. Louwe, Astrid E. P. Cantineau, Jan Peter de Bruin, Sabine C. Linn, Fulco van der Veen, Madelon van Wely, Mariette Goddijn
Summary: Alternative ovarian stimulation protocols with tamoxifen or letrozole did not affect the number of cumulus-oocyte complexes (COCs) retrieved at follicle aspiration in women with breast cancer.
HUMAN REPRODUCTION
(2022)
Article
Developmental Biology
Kaitlin R. Karl, Peter Z. Schall, Zaramasina L. Clark, Meghan L. Ruebel, Jose Cibelli, Robert J. Tempelman, Keith E. Latham, James J. Ireland
Summary: Excessive FSH doses during ovarian stimulation in heifers with small ovarian reserve can cause disruptions in cumulus cell and oocyte functions, leading to premature cumulus expansion and follicular hyperstimulation dysgenesis. These effects can impair the quality of cumulus-oocyte complexes and hinder successful fertilization.
MOLECULAR HUMAN REPRODUCTION
(2023)
Article
Oncology
Raffaella Cioffi, Luca Pagliardini, Antonio Quartucci, Enrico Papaleo, Valeria Stella Vanni, Salvatore Provenzano, Rossella Bertulli, Massimo Candiani, Giorgia Mangili
Summary: The study aimed to compare the performance of patients with sarcoma to age-matched healthy controls during controlled ovarian stimulation for oocyte cryopreservation. The results showed that patients with sarcoma can expect good oocyte retrieval outcomes after controlled ovarian stimulation. Therefore, oocyte cryopreservation should be recommended to these patients before gonadotoxic treatments.