Article
Reproductive Biology
Laura Abril-Parreno, Jack Morgan, Anette Krogenaes, Xavier Druart, Paul Cormican, Mary E. Gallagher, Colm Reid, Kieran Meade, Radka Saldova, Sean Fair
Summary: Poor cervical sperm transport in some ewe breeds following cervical artificial insemination using frozen-thawed semen could be due to differences in cervical sialic acid composition and the proportion of neutral and sialylated O-glycans. This study found specific alterations in sialylated mucin composition may be related to impaired cervical sperm transport in certain sheep breeds.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biophysics
Sai-Xi Yu, Yanan Liu, Yi Wu, Hao Luo, Rufei Huang, Ya-Jun Wang, Xuemei Wang, Hai Gao, Huijuan Shi, Guangyin Jing, Yan-Jun Liu
Summary: This study used hyaluronic acid as a substitute for cervical mucus and designed a cervix chip to study sperm selection and behavior. The results showed that hyaluronic acid can act as a filter to select active sperm.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Oncology
Maria Kyrgiou, Antonios Athanasiou, Marc Arbyn, Sigurd F. Lax, Maria Rosaria Raspollini, Pekka Nieminen, Xavier Carcopino, Jacob Bornstein, Murat Guitekin, Evangelos Paraskevaidis
Summary: This Series paper introduces the 2022 terminology for cone dimensions after local cervical treatment for SIL, CIN, or early invasive cervical cancer. It emphasizes the importance of personalized treatment and consistency in terminology to improve the effectiveness and safety of SIL or CIN treatment.
Article
Obstetrics & Gynecology
Anna Collins, Tanushree Motiwale, Olivia Barney, Frank Dudbridge, Penelope C. McParland, Esther L. Moss
Summary: The study found that a history of previous preterm birth has a greater impact on subsequent preterm birth risk compared to the depth of cervical excisional treatment. The value and nature of antenatal interventions should be investigated in the post-excision population.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Biochemistry & Molecular Biology
Arnaud Zuber, Adriana Peric, Nicola Pluchino, David Baud, Milos Stojanov
Summary: The human body is colonised by microorganisms, including the genital tract which has been linked to male infertility and pathological conditions like prostate cancer. However, research on the microbiota of the male genital tract remains lacking due to difficulties in sampling and low abundance of microbiota. This narrative review aims to present the results of studies using next-generation sequencing to examine bacterial colonisation patterns in different anatomical compartments of the male genital tract and highlight their findings and limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Erin L. McCullough, Emma Whittington, Akanksha Singh, Scott Pitnick, Mariana F. Wolfner, Steve Dorus
Summary: This study investigates the life history of Drosophila melanogaster sperm proteome and reveals substantial compositional changes after sperm are transferred to the female reproductive tract (FRT). Multiple seminal fluid proteins initially associate with sperm, but become undetectable after sperm storage. Female-derived proteins also associate with sperm immediately after mating, and contribute nearly 20% to the postmating sperm proteome after storage in the FRT. These female-derived proteins are enriched in processes associated with energy metabolism, suggesting their role in supporting sperm viability during the period between copulation and fertilization.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Manhee Lee, Jin Woo Park, Dongwon Kim, Hyojeong Kwon, Min Jeong Cho, Eun Ji Lee, Tai Eun Shin, Dae Keun Kim, Seungki Lee, Do Gyeung Byeun, Jung Jae Ko, Jae Ho Lee, Jung Kyu Choi
Summary: The microfluidic sperm-sorting chip developed with a viscous medium (polyvinylpyrrolidone: PVP) to imitate the biophysical environment of the human cervical canal shows promising results in selecting high-quality sperm with high motilities, normal morphologies, and high DNA integrity. This biomimetic chip is expected to improve male fertility by uncovering pathways and regulatory mechanisms involved in sperm transport through the female reproductive tract for egg fertilization.
Article
Reproductive Biology
L. Abril-Parreno, A. K. Krogenaes, C. J. Byrne, A. Donovan, S. Stuen, E. Caldas, M. Diskin, X. Druart, S. Fair
Summary: Differences in pregnancy rates following cervical AI in sheep breeds are related to cervical anatomy and cervicovaginal mucus properties, but not consistent with known differences in pregnancy rates.
Article
Medicine, General & Internal
Diede L. Loopik, Joris van Drongelen, Ruud L. M. Bekkers, Quirinus J. M. Voorham, Willem J. G. Melchers, Leon F. A. G. Massuger, Folkert J. van Kemenade, Albert G. Siebers
Summary: This study found a strong correlation between a volume of >= 0.5 cc excised cervical tissue and the odds of preterm birth, regardless of the severity of CIN. Caution should be taken when performing multiple biopsies or treatment for CIN in women of reproductive age, who may benefit from close surveillance during pregnancy.
Article
Reproductive Biology
E. M. Donnellan, P. Lonergan, K. G. Meade, S. Fair
Summary: Despite passing quality control checks, bulls with apparently normal semen quality may have low field fertility rates. This study assessed the interaction between spermatozoa and the female reproductive tract in bulls with divergent field fertility. The results showed that there were no significant differences in most sperm motility and functional parameters between high and low fertility bulls. However, high fertility bulls had a higher straight-line velocity and a stronger binding ability to oviductal explants. There was also a positive correlation between straight-line velocity and sperm rheotactic response.
Article
Obstetrics & Gynecology
Bianca Reijntjes, Manon Eising, Marjolein Kleppe, Erwin Geuken, Jorien M. Woolderink
Summary: This retrospective study of 567 patients who underwent LLETZ in Martini Hospital Groningen found that 9% and 4% of patients with affected margins and clear margins, respectively, had persistent cervical dysplasia after a median follow-up of 14 months. High-risk HPV infection, affected margins, and age were independent risk factors for cervical dysplasia. Therefore, individualized management based on these factors may be appropriate.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Shahpar Najmabadi, Karen C. Schliep, Sara E. Simonsen, Christina A. Porucznik, Marlene J. Egger, Joseph B. Stanford
Summary: The study examined the normal range of cervical mucus patterns and days with high probability of pregnancy based on cervical mucus secretion in women without subfertility. It found that parity and age are related to the patterns of cervical mucus, with parous and younger nulliparous women having more peak type mucus days and potentially fertile days. The quality of cervical mucus correlated with cycle fecundability, providing valuable insights into fertility parameters for women.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Laura Abril-Parreno, Hayden Wilkinson, Anette Krogenaes, Jack Morgan, Mary E. Gallagher, Colm Reid, Xavier Druart, Sean Fair, Radka Saldova
Summary: This study found that the O-glycan composition in cervical mucus is associated with female fertility. Different European ewe breeds had variations in the O-glycan composition of cervical mucus, which correlated with pregnancy rates. The low-fertility Suffolk breed had higher abundance of certain glycans, and the viscosity of cervical mucus was negatively correlated with certain glycans.
Article
Medicine, General & Internal
Francesco Sopracordevole, Nicolo Clemente, Maria Papiccio, Anna Del Fabro, Matteo Serri, Mariasole Fichera, Monica Buttignol, Giorgio Giorda, Giovanni Delli Carpini, Andrea Ciavattini
Summary: The histopathological findings in postmenopausal women who underwent hysterectomy for postsurgical cervical stenosis were analyzed to evaluate the incidental findings of preinvasive or invasive uterine and cervical disease.
Article
Medicine, General & Internal
Vincenzo Pinto, Miriam Dellino, Carla Mariaflavia Santarsiero, Gennaro Cormio, Vera Loizzi, Valentina Griseta, Antonella Vimercati, Gerardo Cazzato, Eliano Cascardi, Ettore Cicinelli
Summary: The study aimed to evaluate cervical regeneration after large loop excision of the transformation zone (LLETZ) by identifying a new sonographic reference point. Using trans-vaginal 3D ultrasound, the cervical length and volume were measured before LLETZ. The results showed that the average proportion of excised cervical volume was 25.50 +/- 17.43%, and the volume and length of the residual cervix were assessed up to six months post-excision.
