Review
Biochemistry & Molecular Biology
Alessandro Zucchi, Francesco Claps, Antonio Luigi Pastore, Alessandro Perotti, Andrea Biagini, Luana Sallicandro, Rosaria Gentile, Concetta Caglioti, Federico Palazzetti, Bernard Fioretti
Summary: Bladder cancer is a common urinary system tumor, especially in males. Surgery and intravesical instillations can eliminate it, but recurrences and progression are frequent. Therefore, adjuvant therapy should be considered. Resveratrol has shown potential as an adjuvant therapy for bladder cancer, with anti-proliferative effects at high concentrations and anti-angiogenic action at low concentrations. This review examines the standard therapeutic approach to bladder cancer, preclinical studies on resveratrol in bladder cancer xenotransplantation models, and discusses molecular signals, particularly the STAT3 pathway and angiogenic growth factor modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Maria Belen Delsouc, Rocio Ayelem Conforti, Daiana Lujan Vitale, Laura Alaniz, Pablo Pacheco, Sebastian Andujar, Sandra Silvina Vallcaneras, Marilina Casais
Summary: In this study, the chelation of copper with ammonium tetrathiomolybdate (TM) was evaluated in an experimental endometriosis model, showing that TM treatment decreased copper and estradiol levels, inhibited cell proliferation and angiogenesis in endometriotic-like lesions, and modulated oxidative stress imbalance. The findings suggest that TM is a highly effective antiproliferative and antiangiogenic agent with potential as a non-hormonal treatment for endometriosis.
Article
Obstetrics & Gynecology
A. Nenicu, K. Yordanova, Y. Gu, M. D. Menger, M. W. Laschke
Summary: The study found that there were no differences in growth, microvessel density, and cell proliferation between endometriotic lesions forming from menstrual and non-menstrual tissue fragments in non-ovariectomized mice. However, lesion formation from non-menstrual tissue fragments was suppressed in ovariectomized mice, which could be reversed by estrogen supplementation. On the other hand, endometriotic lesions from menstrual tissue fragments showed smaller volume in ovxthornE2 mice, indicating reduced hormone sensitivity.
HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Minghua Wang, Yongqi Wu, Yunbiao He, Jing Liu, Yingxing Chen, Jieqiong Huang, Guolong Qi, Ping Li
Summary: This study found that the quantity of endometrial epithelial cells and stromal fibroblasts in endometriosis is correlated with the expression level of SIRT1. Overexpression of SIRT1 in endometrial epithelial cells triggers the EMT process, allowing them to escape senescence induced by damage or oncogenes. This observation supports the hypothesis that genetic and epigenetic factors help endometrial epithelial cells evade senescence and promote the EMT process in endometriosis.
SCIENTIFIC REPORTS
(2022)
Review
Nutrition & Dietetics
Ludovica Bartiromo, Matteo Schimberni, Roberta Villanacci, Jessica Ottolina, Carolina Dolci, Noemi Salmeri, Paola Vigano, Massimo Candiani
Summary: This systematic review found that phytoestrogens have anti-proliferative and anti-inflammatory effects on endometriosis in vitro and in animal models, reducing lesion growth and development. However, the actual impact on patients is still unclear due to inconsistent literature.
Review
Chemistry, Medicinal
Xia Cai, Min Liu, Bing Zhang, Shao-Jie Zhao, Shi-Wen Jiang
Summary: This article reviews the relationship between phytoestrogen intake and the risk of endometriosis, analyzing findings from in vitro experiments, rodent endometriotic models, and human intervention trials. While resveratrol, isoflavones, and puerarin showed favorable results in endometrial primary cultures and animal models, only resveratrol exhibited promising results in human intervention trials.
Review
Biochemistry & Molecular Biology
Geraldine Brichant, Ines Laraki, Laurie Henry, Carine Munaut, Michelle Nisolle
Summary: Endometriosis is a chronic inflammatory disease causing pain and infertility, with current treatments focusing on medication and surgery. Medical treatments have not been able to cure the disease, highlighting the need for new biomedical targets. Non-coding RNAs are emerging as potential key players in the treatment of endometriosis and other human diseases like cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Paul Pirtea, Nicolas Vulliemoz, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Endometriosis was traditionally diagnosed through laparoscopic surgery, but modern imaging techniques have provided a reliable alternative. In cases of infertility, endometriosis can be diagnosed or excluded based on past medical history and physical examination.
FERTILITY AND STERILITY
(2022)
Review
Chemistry, Medicinal
Mariana Hipolito-Reis, Ana Catarina Neto, Delminda Neves
Summary: This review provides evidence that curcumin, quercetin, and resveratrol can act as natural interventions to control endometriosis by targeting mechanisms such as inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis, angiogenesis, and glucose and lipid metabolism. However, further clinical studies are needed to determine the efficacy of these compounds in human endometriosis.
PHYTOTHERAPY RESEARCH
(2022)
Review
Food Science & Technology
Si-Xia Wu, Ruo-Gu Xiong, Si-Yu Huang, Dan-Dan Zhou, Adila Saimaiti, Cai-Ning Zhao, Ao Shang, Yun-Jian Zhang, Ren-You Gan, Hua-Bin Li
Summary: Cancer is a severe public health problem, and resveratrol, a natural compound with various bioactivities, has been shown to have preventive and therapeutic effects on different types of cancers. This review summarizes the effects and mechanisms of resveratrol in cancer prevention and treatment, providing guidance for the development of functional food, dietary supplements, or auxiliary agents for cancer management.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Engineering, Biomedical
Ruiqiang Hang, Jiahui Wang, Xue Tian, Ruifeng Wu, Ruiyue Hang, Yuyu Zhao, Yonghua Sun, Honggang Wang
Summary: Orthopedic implants are often used in elderly individuals to restore compromised bone tissues. However, the risk of failure is high due to an unfavorable immune microenvironment caused by senescent macrophages. This study suggests that resveratrol can induce autophagy in senescent macrophages, restore homeostasis, and create a favorable immune microenvironment for implant osseointegration. Resveratrol-loaded silk fibroin coatings on titanium implants can also improve the functions of senescent macrophages.
BIOMEDICAL MATERIALS
(2022)
Article
Obstetrics & Gynecology
Khaleque N. Khan, Akira Fujishita, Hideki Muto, Hiroshi Masumoto, Kanae Ogawa, Akemi Koshiba, Taisuke Mori, Kyoko Itoh, Satoshi Teramukai, Katsuya Matsuda, Masahiro Nakashima, Jo Kitawaki
Summary: The study found that treatment with a broad-spectrum antibiotic may decrease intrauterine infection and reduce tissue inflammation, cell proliferation, and angiogenesis in human endometriosis. This treatment also significantly decreased certain components of major bacterial genera in patients with endometriosis, leading to improvements compared to untreated groups.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Chemistry, Medicinal
Chunyan Wang, Zhengyun Chen, Xianlei Zhao, Cuicui Lin, Shenghui Hong, Yuhan Lou, Xiaomeng Shi, Mengdan Zhao, Xiaohang Yang, Min-Xin Guan, Yongmei Xi
Summary: The study demonstrated that resveratrol treatment exhibited efficient therapeutic effects for endometriosis model rats, potentially through its important roles in anti-inflammation, immunoregulation, and lipid-related metabolism regulation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Acoustics
E. Bean, J. Knez, T. Setty, A. Tetteh, D. Casagrandi, J. Naftalin, D. Jurkovic
Summary: In pregnancy, ovarian endometrioma and deep endometriotic nodules regress, but the morphological changes of endometriosis in pregnancy are difficult to differentiate from malignant lesions. Understanding the appearance of endometriosis in pregnancy is crucial for minimizing intervention and counseling women about their condition.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Liang-Hsuan Chen, Wei-Che Lo, Hong-Yuan Huang, Hsien-Ming Wu
Summary: Endometriosis is a chronic inflammatory disease that causes bothersome symptoms and long-term systemic impacts. It is characterized by the presence of endometrial-like tissue outside the uterus, leading to menstrual disorders, chronic pelvic pain, and infertility. The disease can also spread to extra-pelvic sites and cause systemic effects such as metabolic disorder, immune dysregulation, and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Frederike Nordmeier, Adrian A. Doerr, Stefan Potente, Nadja Walle, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer, Nadine Schaefer
Summary: The interpretation of analytical results in forensic postmortem cases is often challenging, especially due to possible postmortem redistribution phenomena. A controlled toxicokinetic study on pigs was performed to examine the tissue distribution and possible redistribution of synthetic opioids U-47700 and tramadol. The study found that these substances are only slightly prone to redistribution, and central blood might be the best matrix for quantification.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Vivien Becker, Xu Yuan, Anne S. Boewe, Emmanuel Ampofo, Elke Ebert, Johannes Hohneck, Rainer M. Bohle, Eckart Meese, Yingjun Zhao, Michael D. Menger, Matthias W. Laschke, Yuan Gu
Summary: The downregulation of miR-186 in endothelial cells (ECs) mediates hypoxia-stimulated angiogenesis in non-small cell lung cancer (NSCLC) by upregulating protein kinase C alpha (PKCa). In vitro and in vivo experiments showed that miR-186 mimic inhibited ECs' angiogenic activity, while miR-186 inhibitor exerted pro-angiogenic effects. The findings suggest that targeting miR-186 and PKCa could be a potential strategy for NSCLC treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Hematology
Laura Hertz, Daniel Flormann, Lutz Birnbaumer, Christian Wagner, Matthias W. Laschke, Lars Kaestner
Summary: The protein TRPC6 is present in mouse red blood cells but absent in human red blood cells. Transfusion experiments showed that TRPC6 could be restored in mice within 10 days. Mechanical stimulation experiments suggested that protein transfer to red blood cells can occur in the absence of translational machinery. This protein transfer mechanism has potential therapeutic applications for diseases involving red blood cells.
Review
Biotechnology & Applied Microbiology
Dominik Saul, Maximilian M. Menger, Sabrina Ehnert, Andreas K. Nuessler, Tina Histing, Matthias W. Laschke
Summary: Bone healing is a complex process involving various cellular components to restore osseous tissue. Failure of this process can have devastating effects, particularly in long bones. This review discusses the reasons for impaired bone healing, outlines the risk factors for non-unions, and explores therapeutic prospects and the applicability of biomarkers.
BIOENGINEERING-BASEL
(2023)
Article
Biophysics
Yazdan Rashidi, Greta Simionato, Qi Zhou, Thomas John, Alexander Kihm, Mohammed Bendaoud, Timm Krueger, Miguel O. Bernabeu, Lars Kaestner, Matthias W. Laschke, Michael D. Menger, Christian Wagner, Alexis Darras
Summary: The distribution of red blood cells in the microcirculation affects oxygen delivery and solute transport to tissues. Recent studies have shown deviations from the expected partitioning of red blood cells at bifurcations in the microvascular network. This behavior is influenced by the lingering of red blood cells near the bifurcation apex.
BIOPHYSICAL JOURNAL
(2023)
Letter
Immunology
Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J. Schunk, David Schmit, Rafael Kramann, Christina Koerbel, Emmanuel Ampofo, Matthias W. Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Gaul, Guenther Silbernagel, Martina Sester, Urban Sester, Gunter Assmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D. Menger, Lucia Rohrer, Winfried Maerz, Michael Boehm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A. Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer
Article
Hematology
Lynn M. M. Knowles, Carolin Wolter, Michael D. D. Menger, Matthias W. W. Laschke, Lars Beyer, Ulrich Gruen, Hermann Eichler, Jan Pilch
Summary: To determine the presence of recurrent inflammation in hemophilia, the acute-phase response was evaluated in hemophilia A and B patients. Elevated levels of IL-6, CRP, and LBP were observed in the entire cohort of hemophilia patients, with a stronger increase in obese patients. Nonobese patients with recent bleeding events showed a spike in IL-6, CRP, and LBP, along with an increase in sIL6Ra. IL-6 was identified as a marker of bleeding in hemophilia.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cell & Tissue Engineering
Ettore Limido, Andrea Weinzierl, Yves Harder, Michael D. Menger, Matthias W. Laschke
Summary: This review provides a comprehensive overview of strategies for enhancing vascularization of fat grafts in preclinical models. These strategies, if successfully applied in clinical practice, could greatly improve the outcomes of fat transplantation.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Andrea Weinzierl, Yves Harder, Daniel Schmauss, Michael D. Menger, Matthias W. Laschke
Summary: This study demonstrates that microvascular fragments (MVF) derived from adipose tissue can reduce flap necrosis by increasing angiogenesis, improving tissue perfusion, and suppressing apoptosis. These findings provide a promising strategy for reducing ischemia-induced flap necrosis in clinical practice by injecting MVF.
Article
Biotechnology & Applied Microbiology
Maximilian M. Menger, Ruben Manuschewski, Sabrina Ehnert, Mika F. Rollmann, Tanja C. Maisenbacher, Anne L. Tobias, Michael D. Menger, Matthias W. Laschke, Tina Histing
Summary: With a growing elderly population, trauma and reconstructive surgery face challenges in treating geriatric patients. The impact of aging on bone healing remains controversial, prompting an investigation on fracture healing in young adult and aged CD-1 mice. The study revealed delayed callus remodeling and impaired bending stiffness in aged animals, suggesting delayed fracture healing. However, the overall healing capacity of fractured femora was not affected by aging.
BIOENGINEERING-BASEL
(2023)
Article
Geriatrics & Gerontology
Maximilian M. Menger, Maximilian Stief, Claudia Scheuer, Mika F. Rollmann, Steven C. Herath, Benedikt J. Braun, Sabrina Ehnert, Andreas K. Nussler, Michael D. Menger, Matthias W. Laschke, Tina Histing
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are commonly used analgesic medication for traumatic injuries. However, there is increasing evidence that NSAIDs can impair fracture healing. This study found that diclofenac delays fracture healing in aged mice by affecting osteogenic growth factor expression and bone formation as well as osteoclast activity and callus remodeling.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ilinca T. Mihai, Jeannette Rudzitis-Auth, Michael D. Menger, Matthias W. Laschke
Summary: This study reveals that the presence of pre-existing endometriotic lesions promotes the growth of new lesions, not through cell exchange, but rather through peritoneal inflammation induced by established lesions. These findings indicate that the chronic nature of endometriosis may be driven by a lesion-induced inflammatory milieu in the peritoneal cavity, creating favorable conditions for the development of new lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Friederike C. Messner, Wolfgang Metzger, Julia E. Marschall, Caroline Bickelmann, Michael D. Menger, Matthias W. Laschke
Summary: MVF isolates generated by short-term enzymatic digestion are beneficial for tissue defect vascularization, isolates from obese mice lack connective tissue and exhibit improved in vivo vascularization.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Nutrition & Dietetics
Andrea Weinzierl, Maximilian Coerper, Yves Harder, Michael D. Menger, Matthias W. Laschke
Summary: This study demonstrates that a 30% reduction in caloric intake effectively prevents flap necrosis by maintaining microperfusion and inhibiting inflammation under ischemic stress.
Article
Obstetrics & Gynecology
Gerhard Leyendecker, Ludwig Wildt, Matthias W. Laschke, Gerhard Mall
Summary: This article presents a new concept of uterine adenomyosis, peritoneal and peripheral endometriosis, suggesting that tissue injury and repair play a key role in the pathogenesis. The disease may develop after onset of biomechanical injury in individuals with uterine hypercontractility, and preventive measures can be taken for high-risk individuals.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)