Article
Endocrinology & Metabolism
Xueqi Yan, Aiqing Zhu, Yexing Li, Ziyi Yang, Yuteng Wang, Li Liu, Wei Liu, Dan Liu, Fenghua Li, Juan Du, Fang Cheng, Xueying Gao, Junli Zhao
Summary: In recent years, the right 2D:4D digit ratio has been considered as a marker for prenatal testosterone exposure. There is an ongoing debate whether the ratio is reduced in the right hand of Polycystic Ovary Syndrome (PCOS) women compared to non-PCOS women. This study systematically measured various digit ratios and found significant differences, particularly in the left hand 2D ratios, suggesting that digit ratios can serve as anatomical markers of prenatal testosterone exposure and potentially of PCOS diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Haigang Ding, Juan Zhang, Feng Zhang, Songou Zhang, Xiaozhen Chen, Wenqing Liang, Qiong Xie
Summary: Polycystic ovary syndrome has a wide range of negative impacts on women's health and is one of the most frequent reproductive systemic endocrine disorders. It is mainly caused by increased levels of androgen (hyperandrogenemia) and insulin resistance. Understanding the effects of these two factors on the pathophysiology of symptoms related to PCOS is crucial for further research and potential treatments.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nathalie di Clemente, Chrystele Racine, Rodolfo A. Rey
Summary: This article reviews the main findings on anti-Mullerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. AMH has important roles in ovarian reserve, follicular development, and the differentiation of the genital tract. It is also used to assess Sertoli cell function in children and has potential implications for male fertility.
Article
Biochemistry & Molecular Biology
Licy L. Yanes Cardozo, Damian G. Romero
Summary: PCOS is the most common endocrine disorder in reproductive-age women, with heterogeneous clinical presentations and involvement of multiple abnormal physiological pathways. Women with PCOS also have a high prevalence of cardiometabolic risk factors, but there is limited evidence-based therapeutic agents available to treat these complications. Recent studies suggest opportunities for timely effective medical care for women with PCOS, highlighting the unmet need for effective and safe management of the cardiometabolic complications in these patients.
Article
Endocrinology & Metabolism
Linyi Song, Jin Yu, Danying Zhang, Xi Li, Lu Chen, Zailong Cai, Chaoqin Yu
Summary: Excess androgen could damage the mitochondrial ultrastructure and function of ovarian granulosa cells in PCOS model rats by down-regulating the expression of NDUFB8 and ATP5j.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Zhenyan Pan, Fangfang Zhu, Kai Zhou
Summary: Anogenital distance (AGD) reflects androgen exposure during gestational weeks 8-14 and has been linked to endocrine-disrupting compounds. Studies show that PCOS patients tend to have longer AGD, while endometriosis patients tend to have shorter AGD. Further well-designed studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Yi-Ru Tsai, Yen-Nung Liao, Hong-Yo Kang
Summary: Polycystic ovary syndrome (PCOS) is a common gynecological and endocrine disorder that affects the reproductive health of women. This article provides an overview of the latest cellular approaches used to study the pathophysiology of PCOS through in vitro cell models. It discusses abnormalities in folliculogenesis and explores potential treatments and underlying mechanisms, aiming to enhance our understanding of PCOS at a cellular level.
Article
Medicine, General & Internal
Robert Krysiak, Karolina Kowalcze, Witold Szkrobka, Boguslaw Okopien
Summary: The aim of this study was to determine if the androgen status modulates the impact of metformin on plasma prolactin levels in women. The results showed that the drug decreased total and monomeric prolactin and increased luteinizing hormone (LH) in control subjects. In women with polycystic ovary syndrome (PCOS), metformin reduced LH, LH/FSH ratio, testosterone, and free androgen index (FAI).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Nina M. M. Donaldson, Melanie Prescott, Amy Ruddenklau, Rebecca E. E. Campbell, Elodie Desroziers
Summary: PCOS patients often experience sexual dysfunction, and research has found that prenatally androgenized mouse models also show changes in sexual behavior. These findings suggest that androgen exposure may contribute to sexual dysfunction in PCOS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Mert Yesiladali, Melis G. K. Yazici, Erkut Attar, Fahrettin Kelestimur
Summary: Polycystic ovary syndrome (PCOS) is a common hyperandrogenic disorder in women, and it shares clinical features with adrenal-related androgen excess disorders. A thorough endocrinological investigation and testing are necessary to differentiate between PCOS and other hyperandrogenic disorders for a certain diagnosis.
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Endocrinology & Metabolism
Chuan Xing, Han Zhao, Jiaqi Zhang, Bing He
Summary: The study aimed to observe the effects of MET monotherapy and MET plus LIRA combination therapy on gonadal and metabolic profiles in overweight patients with PCOS. The results showed that both MET monotherapy and MET plus LIRA combination therapy improved glucose metabolism and relieved insulin resistance in overweight patients with PCOS. Furthermore, MET plus LIRA combination therapy was more effective in improving reproductive abnormalities and hyperandrogenemia compared to MET monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Miki Ohara, Hiromi Yoshida-Komiya, Miho Ono-Okutsu, Akiko Yamaguchi-Ito, Toshifumi Takahashi, Keiya Fujimori
Summary: Metformin affects the expression of androgen receptor (AR) and HOXA10 in the endometrium of women with PCOS, potentially improving the abnormal endometrial environment associated with excess androgen levels.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Faiza Manzoor, Mahr-Un Nisa, Abdul Shakoor, Liaqat Hussain, Abid Mahmood, Anam Younas
Summary: This study evaluated the effect of sodium alginate (SA) on serum insulin, blood sugar, lipid profile, estrogen, and testosterone in polycystic ovary syndrome (PCOS) females. The results showed improvements in various physical parameters in PCOS females, indicating the therapeutic potential of SA for weight management and improvement of serum testosterone levels.
Article
Endocrinology & Metabolism
Alok Kumar Dwivedi, Deepanjali Vishwakarma, Pallavi Dubey, Sireesha Reddy
Summary: Polycystic ovary syndrome (PCOS) is associated with multiple cardiovascular disease (CVD) outcomes among hospitalized women, particularly those aged ≤40 years. The association is mediated by obesity and metabolic syndrome conditions.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)