Article
Genetics & Heredity
Serdar Coskun, Sateesh Maddirevula, Khalid Awartani, Meshael Aldeery, Wafa Qubbaj, Junaid Kashir, Fowzan S. Alkuraya
Summary: This study investigates two cases of recurrent spontaneous oocyte activation (SOA) to identify the underlying causes and potential treatments. The results show that there is no clear genetic or pathological factor causing SOA in these patients. Further research is needed to fully understand the molecular mechanisms of oocyte activation and calcium dynamics that contribute to recurrent SOA.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Hui-Jeong An, Sung-Hwan Cho, Han-Sung Park, Ji-Hyang Kim, Young-Ran Kim, Woo-Sik Lee, Jung-Ryeol Lee, Seong-Soo Joo, Eun-Hee Ahn, Nam-Keun Kim
Summary: This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. The study identified specific genotypes of miR-10a and miR-499 that are associated with increased RPL risk.
Article
Biochemistry & Molecular Biology
Sung-Hwan Cho, Ji-Hyang Kim, Hui-Jeong An, Young-Ran Kim, Eun-Hee Ahn, Jung-Ryeol Lee, Jung-Oh Kim, Jung-Jae Ko, Nam-Keun Kim
Summary: The study identified an association between polymorphisms in miR-604A>G and miR-938G>A and the risk of idiopathic recurrent pregnancy loss (RPL), suggesting potential effects on RPL in Korean women. The results indicate that these miRNA polymorphisms may play a role in RPL susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Review
Medicine, Research & Experimental
Yan Jiang, Ge Song, Jing-Chuan Yuan, Xu-Hui Zhang, Xiao-Hua Wu
Summary: This study reported a case of bilateral salpingectomy for recurrent parthenogenesis in an ectopic pregnancy over two IVF cycles. Genetic analysis of the embryos revealed abnormalities in copy number variation and single nucleotide polymorphism. However, intracytoplasmic sperm injection resulted in normal fertilization and a successful pregnancy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medicine, General & Internal
Panagiotis Cherouveim, Despoina Mavrogianni, Eirini Drakaki, Anastasios Potiris, Athanasios Zikopoulos, Myrto Papamentzelopoulou, Konstantina Kouvoutsaki, Nikolaos Machairiotis, Theodoros Karampitsakos, Chara Skentou, Ekaterini Domali, Nikolaos Vrachnis, Peter Drakakis, Sofoklis Stavros
Summary: This study demonstrates for the first time an association between RPL and ANRIL rs4977574 gene polymorphism (lower prevalence of allele A), while further research is needed to confirm a difference according to the number of pregnancy losses.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Hossein Ansariniya, Fateme Zare, Nariman Mosaffa, Farah Idali, Mahdi Shabani, Hossein Hadinedoushan
Summary: This review discusses the role of the immune system in mouse models of RSA. Research has shown that immune system alterations contribute to the development of RSA. These findings offer new possibilities for preventing RSA from an immunological perspective.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Siobhan Quenby, Katie Booth, Louise Hiller, Arri Coomarasamy, Paulien G. de Jong, Eva N. Hamulyak, Luuk J. Scheres, Thijs F. van Haaps, Lauren Ewington, Mariette Gojjin, Shreeya Tewary, Saskia Middeldorp
Summary: The use of low-molecular-weight heparin (LMWH) did not increase livebirth rates in women with recurrent pregnancy loss and inherited thrombophilia. Therefore, the use of LMWH is not recommended in these women.
Review
Obstetrics & Gynecology
Elias M. Dahdouh, William H. Kutteh
Summary: Genetic testing of products of conception (POC) can help explain over 55% of miscarriage cases and guide the treatment direction for patients with recurrent pregnancy loss (RPL).
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Mohamed A. Bedaiwy, Bahi Fayek, Emily C. Yang, Mahmoud S. Iews, Mohamed Elgendi, Amr O. Abdelkareem, Ahmed H. Abdellah, Yang Doris Liu, Adrian Jones, Ulrike Mayer, Faten F. Abdel Hafez
Summary: This study examined the impact of non-visualized pregnancy loss (NVPL) on future reproductive outcomes in patients with recurrent pregnancy loss (RPL). The results showed that the number of previous NVPLs is a significant predictor of subsequent live birth.
HUMAN REPRODUCTION
(2023)
Article
Plant Sciences
Yuling Lai, Yu Zhang, Huimin Zhang, Zhenyue Chen, Lihua Zeng, Gaopi Deng, Songping Luo, Jie Gao
Summary: This study explores the potential molecular mechanism of Modified Shoutai Pill (JSP) in treating recurrent pregnancy loss (RPL). The findings suggest that JSP alleviates RPL symptoms by inhibiting ferroptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Maryam Shahidi, Farzad Nazari, Hossein Ghanbarian, Robabeh Taheripanah, Mahsa Hajivalili, Davar Amani
Summary: This study aimed to elucidate the pathogenesis of unexplained recurrent spontaneous abortion (URSA) by comparing differentially expressed miRNAs in serum samples between URSA patients and healthy individuals. The expression levels of miR-520 h and miR-146b-5p were significantly up-regulated in URSA patients, suggesting their potential as biomarkers for URSA diagnosis.
BIOCHEMICAL GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Greta Barbaro, Annalisa Inversetti, Martina Cristodoro, Carlo Ticconi, Giovanni Scambia, Nicoletta Di Simone
Summary: Placentation is a process where maternal immune cells and trophoblastic cells interact to achieve immune balance. HLA-G, expressed on trophoblastic cells, plays a crucial role in modulating maternal immune response. Recurrent pregnancy loss (RPL), affecting 5% of pregnant women, with 40-60% cases unexplained, shares immunological similarities with allograft rejection. This review aims to explain how alterations in the HLA-G pathway disrupt immune balance and increase the risk of RPL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Ling-Jun Li, Ruochen Du, See Ling Loy, Yap Seng Chong, Jerry Kok Yen Chan, Tien Yin Wong, Johan G. Eriksson, Zhongwei Huang, Cuilin Zhang
Summary: This prospective study involving 1,032 Southeast Asian women found that retinal microvascular features were associated with the risk of spontaneous abortion.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Pedro Melo, Rima Dhillon-Smith, Md Asiful Islam, Adam Devall, Arri Coomarasamy
Summary: Approximately 80% of miscarriages occur within the first 12 weeks of gestation, with more than half resulting from genetic defects. Recent use of big data has led to the discovery of specific gene mutations that may be implicated in sporadic and recurrent miscarriages.
FERTILITY AND STERILITY
(2023)